| Singles | |
|---|---|
| 2024 Santa Cruz Challenger | |
| Champion |  Camilo Ugo Carabelli |
| Runner-up |  Murkel Dellien |
| Score | 6–4, 6–2 |
Mariano Navone was the defending champion [1] but chose not to defend his title.
Camilo Ugo Carabelli won the title after defeating Murkel Dellien 6–4, 6–2 in the final. [2]
Thiago Monteiro (semifinals) Francisco Comesaña (second round, withdrew) Camilo Ugo Carabelli (champion) Hugo Dellien (first round) Román Andrés Burruchaga (quarterfinals) Juan Manuel Cerúndolo (quarterfinals) Genaro Alberto Olivieri (second round)
Marco Cecchinato (first round)| Semifinals | Final | ||||||||||||
| 1/WC | Thiago Monteiro | 4 | 5 | ||||||||||
| 3 | Camilo Ugo Carabelli | 6 | 7 | ||||||||||
| 3 | Camilo Ugo Carabelli | 6 | 6 | ||||||||||
| Murkel Dellien | 4 | 2 | |||||||||||
| Murkel Dellien | 6 | 2 | 4 | ||||||||||
| Renzo Olivo | 1 | 6 | 2r | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | T Monteiro | 6 | 6 | ||||||||||||||||||||||||
| Edoardo Lavagno | 2 | 2 | 1/WC | T Monteiro | 6 | 6 | |||||||||||||||||||||
| Q | V Aboian | 6 | 5 | 6 | Q | V Aboian | 3 | 3 | |||||||||||||||||||
| PR |  P Jubb | 3 | 7 | 3 | 1/WC | T Monteiro | 6 | 6 | |||||||||||||||||||
| M Pucinelli de Almeida | 6 | 6 | P Sakamoto | 1 | 4 | ||||||||||||||||||||||
| A Collarini | 1 | 1 | M Pucinelli de Almeida | 7 | 0 | 4 | |||||||||||||||||||||
| P Sakamoto | 6 | 6 | P Sakamoto | 5 | 6 | 6 | |||||||||||||||||||||
| 8 | M Cecchinato | 4 | 4 | 1/WC | T Monteiro | 4 | 5 | ||||||||||||||||||||
| 3 | C Ugo Carabelli | 712 | 5 | 4 | 3 | C Ugo Carabelli | 6 | 7 | |||||||||||||||||||
| WC |  AD Vallejo | 610 | 7 | 0r | 3 | C Ugo Carabelli | 77 | 6 | |||||||||||||||||||
| FA Gómez | 4 | 0 | WC | JC Prado Ángelo | 63 | 1 | |||||||||||||||||||||
| WC | JC Prado Ángelo | 6 | 6 | 3 | C Ugo Carabelli | 4 | 77 | 6 | |||||||||||||||||||
 G Oliveira | 6 | 6 | G Oliveira | 6 | 61 | 1 | |||||||||||||||||||||
| Alexander Weis | 3 | 3 | G Oliveira | 6 | 6 | ||||||||||||||||||||||
| F Passaro | 2 | 2 | 7 | GA Olivieri | 4 | 2 | |||||||||||||||||||||
| 7 | GA Olivieri | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | RA Burruchaga | 6 | 6 | ||||||||||||||||||||||||
| Q | M Kestelboim | 2 | 4 | 5 | RA Burruchaga | 712 | 6 | ||||||||||||||||||||
| G Mager | 6 | 6 | G Mager | 610 | 1 | ||||||||||||||||||||||
 G Bueno | 1 | 1 | 5 | RA Burruchaga | 2 | 6 | 4 | ||||||||||||||||||||
 B Bicknell | 6 | 2 | 3 | M Dellien | 6 | 2 | 6 | ||||||||||||||||||||
 L Draxl | 3 | 6 | 6 | L Draxl | 3 | 6 | 5 | ||||||||||||||||||||
| M Dellien | 7 | 6 | M Dellien | 6 | 3 | 7 | |||||||||||||||||||||
| 4 | H Dellien | 5 | 1 | M Dellien | 6 | 2 | 4 | ||||||||||||||||||||
| 6 | JM Cerúndolo | 6 | 6 | R Olivo | 1 | 6 | 2r | ||||||||||||||||||||
| Q | Guido Iván Justo | 3 | 2 | 6 | JM Cerúndolo | 6 | 6 | ||||||||||||||||||||
| Q |  GA Boitan | 6 | 6 | Q | GA Boitan | 3 | 1 | ||||||||||||||||||||
| Q | G Villanueva | 0 | 3 | 6 | JM Cerúndolo | 3 | 64 | ||||||||||||||||||||
| Q | JB Torres | 3 | 1 | R Olivo | 6 | 77 | |||||||||||||||||||||
| R Olivo | 6 | 6 | R Olivo | w/o | |||||||||||||||||||||||
 P Sekulic | 77 | 3 | 1 | 2 | F Comesaña | ||||||||||||||||||||||
| 2 | F Comesaña | 65 | 6 | 6 | |||||||||||||||||||||||
Daniel Elahi Galán was the defending champion, but chose not to defend his title.
Sebastián Báez was the defending champion but chose not to participate.
This was the first edition of the tournament as part of the Legión Sudamericana.
Camilo Ugo Carabelli was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion and successfully defended his title, defeating Jesper de Jong 6–3, 2–6, 6–2 in the final.
Hugo Dellien was the defending champion and successfully defended his title after defeating Thiago Seyboth Wild 3–6, 6–3, 6–3 in the final.
Paul Jubb was the defending champion but chose not to defend his title.
Jan Choinski was the defending champion but lost in the second round to Andrea Pellegrino.
Agustín Velotti was the defending champion from when the tournament was last held in 2016 but didn't defend his title as he retired from professional tennis.
Facundo Díaz Acosta defeated Nicolás Jarry in the final, 6–3, 6–4 to win the singles tennis title at the 2024 Argentina Open. He did not lose a set en route to his first ATP Tour title and became the first wildcard to win the Argentina Open, as well as the first unseeded player to win the title since Alexandr Dolgopolov in 2017.
Hugo Dellien was the defending champion but lost in the quarterfinals to Facundo Bagnis.
Mariano Navone was the defending champion but chose not to defend his title.
Camilo Ugo Carabelli was the defending champion but chose not to defend his title.
Alejandro Tabilo was the defending champion but chose not to defend his title.
Camilo Ugo Carabelli was the defending champion but lost in the second round to Juan Ignacio Londero.
Mariano Navone was the defending champion but chose not to defend his title.
Nicolás Kicker was the defending champion but lost in the first round to Gustavo Heide.
Thiago Monteiro was the defending champion but chose not to defend his title.
Hugo Dellien was the defending champion but retired from his first round match against José Pereira.
Facundo Díaz Acosta was the defending champion but chose not to defend his title.