AB-MDMSBA

AB-MDMSBA

Legal status
Legal status	AU:Unscheduled(No known pharmacological activity) DE: NpSG (Industrial and scientific use only)
Identifiers
IUPAC name N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]-3-(dimethylsulfamoyl)-4-methylbenzamide
PubChem CID	172872001
ChemSpider	129395436
Chemical and physical data
Formula	C15H23N3O4S
Molar mass	341.43 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=C(C=C(C=C1)C(=O)N[C@@H](C(C)C)C(=O)N)S(=O)(=O)N(C)C
InChI InChI=InChI=1S/C15H23N3O4S/c1-9(2)13(14(16)19)17-15(20)11-7-6-10(3)12(8-11)23(21,22)18(4)5/h6-9,13H,1-5H3,(H2,16,19)(H,17,20)/t13-/m0/s1 Key:KYNAATZHNRULED-ZDUSSCGKSA-N

AB-MDMSBA is a novel synthetic compound that has been sold as a designer drug. It has been detected by drug checking services in Australia and New Zealand being misrepresented as a benzodiazepine. ^{[1] [2]}

It is structurally similar to other arylsulfonamide-based synthetic cannabinoids such as QMPSB. ^[3] This class of synthetic cannabinoid has previously been targeted toward greater selectivity of the cannabinoid receptor CB₂ over CB₁. ^[4] The activity of AB-MDMSBA against either cannabinoid receptor is unknown.

See also

• 2F-QMPSB

References

1. "Synthetic cannabinoid AB-MDMSBA found in 'benzodiazepine' samples - The Know". theknow.org.au. 2024-12-10. Retrieved 2025-06-10.
2. "New synthetic cannabinoid misrepresented as a benzodiazepine". High Alert. Retrieved 2025-06-10.
3. Lebon F, Christophe B, Burton M, De Ryck M, Quéré L, Lambeng N (January 2007). "Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: Identification of a lead and initial SAR studies" . Bioorganic & Medicinal Chemistry Letters. 17 (1): 272–277. doi:10.1016/j.bmcl.2006.09.049. PMID   17027269.
4. Ajello CW, Worm K, Bourdonnec BL, Savolainen MA, O'Hare H, Cassel JA, Stabley GJ, DeHaven RN, LaBuda CJ, Koblish M, Little PJ, Brogdon BL, Smith SA, Dolle RE, Goodman AJ (January 2009). "CB2 selective sulfamoyl benzamides: Optimization of the amide functionality" . Bioorganic & Medicinal Chemistry Letters. 19 (2): 309–313. doi:10.1016/j.bmcl.2008.11.091. PMID   19091565.