ALC-0159

ALC-0159

Names
Other names 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
Identifiers
CAS Number	1849616-42-7
3D model (JSmol)	Interactive image
ChemSpider	112747193
UNII	PJH39UMU6H
InChI InChI=1S/C33H67NO3/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-34(33(35)32-37-31-30-36-3)29-27-25-23-21-19-17-15-13-11-9-7-5-2/h4-32H2,1-3H3 Key: BPWFJNQUTKVHIR-UHFFFAOYSA-N
SMILES CCCCCCCCCCCCCCN(CCCCCCCCCCCCCC)C(=O)COCCOC
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristyl amide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (0.05 mg per dose) ^[1] that contains the active ingredient tozinameran. ^[2]

See also

Pfizer–BioNTech COVID-19 vaccine nanoparticle ingredients

• ALC-0315
• 1,2-distearoyl-sn-glycero-3-phosphocholine
• Cholesterol

Others

• Polyethoxylated tallow amine

References

1. Schoenmaker, Linde; Witzigmann, Dominik; Kulkarni, Jayesh A.; Verbeke, Rein; Kersten, Gideon; Jiskoot, Wim; Crommelin, Daan J. A. (2021-05-15). "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability". International Journal of Pharmaceutics. 601 120586. doi: 10.1016/j.ijpharm.2021.120586 . ISSN   0378-5173. PMC   8032477 . PMID   33839230.
2. "Public Assessment Report Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection" (PDF). Regulation 174. MHRA. 15 December 2020.

• Assessment report, Comirnaty, Common name: COVID-19 mRNA vaccine (nucleoside-modified); Procedure No. EMEA/H/C/005735/0000 - gives structural formula for the compound (p. 24)