| Acetyl-CoA carboxytransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 The enzyme as folded by AlphaFold | |||||||||
| Identifiers | |||||||||
| EC no. | 2.3.1.253 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Acety-CoA carboxytransferase (known also as accAD and N6-carboxybiotinyl-L-lysine:acetyl-CoA:carboxytransferase) is a transferase enzyme that catalyses the transfer of a carboxyl group from a biotinylated biotin carboxyl carrier protein (abbrev. BCCP) to acetyl-CoA (acetyl-Coenzyme A), yielding malonyl-CoA. [1] In some species, this is part of a multi-domain protein that also has the carrier protein as well as biotin carboxylase. Some enzymes can also carry out the carboxylation of propanonyl-CoA and butanoyl-CoA. [2] The enzyme catalyzes the following reaction,
- N6-carboxybiotinylysyl + acetyl-CoA = N6-biotinylysyl + malonyl-CoA
The enzyme is involved in several biochemical pathways, including the 3-hydroxypropanoate cycle, 4-hydroxybutanate cycle, the assembly of biotin-carboxyl carrier proteins, candicidin biosynthesis, fatty acid biosynthesis and glyoxylate assimilation. [3]