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Microfluidics refers to a system that manipulates a small amount of fluids using small channels with sizes ten to hundreds micrometres. It is a multidisciplinary field that involves molecular analysis, molecular biology, and microelectronics. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening. Microfluidics emerged in the beginning of the 1980s and is used in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies.
A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (μTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids. However, strictly regarded "lab-on-a-chip" indicates generally the scaling of single or multiple lab processes down to chip-format, whereas "μTAS" is dedicated to the integration of the total sequence of lab processes to perform chemical analysis.
Biological engineering or bioengineering is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products. Biological engineering employs knowledge and expertise from a number of pure and applied sciences, such as mass and heat transfer, kinetics, biocatalysts, biomechanics, bioinformatics, separation and purification processes, bioreactor design, surface science, fluid mechanics, thermodynamics, and polymer science. It is used in the design of medical devices, diagnostic equipment, biocompatible materials, renewable energy, ecological engineering, agricultural engineering, process engineering and catalysis, and other areas that improve the living standards of societies.
Bio-MEMS is an abbreviation for biomedical microelectromechanical systems. Bio-MEMS have considerable overlap, and is sometimes considered synonymous, with lab-on-a-chip (LOC) and micro total analysis systems (μTAS). Bio-MEMS is typically more focused on mechanical parts and microfabrication technologies made suitable for biological applications. On the other hand, lab-on-a-chip is concerned with miniaturization and integration of laboratory processes and experiments into single chips. In this definition, lab-on-a-chip devices do not strictly have biological applications, although most do or are amenable to be adapted for biological purposes. Similarly, micro total analysis systems may not have biological applications in mind, and are usually dedicated to chemical analysis. A broad definition for bio-MEMS can be used to refer to the science and technology of operating at the microscale for biological and biomedical applications, which may or may not include any electronic or mechanical functions. The interdisciplinary nature of bio-MEMS combines material sciences, clinical sciences, medicine, surgery, electrical engineering, mechanical engineering, optical engineering, chemical engineering, and biomedical engineering. Some of its major applications include genomics, proteomics, molecular diagnostics, point-of-care diagnostics, tissue engineering, single cell analysis and implantable microdevices.
Shu Chien is a Chinese–American physiologist and bioengineer. His work on the fluid dynamics of blood flow has had a major impact on the diagnosis and treatment of cardiovascular diseases such as atherosclerosis. More recently, Chien's research has focused on the mechanical forces, such as pressure and flow, that regulate the behaviors of the cells in blood vessels. Chien is currently President of the Biomedical Engineering Society.
Michelle Khine is an American bioengineer who is a distinguished scientist and innovator at the University of California, Irvine, co-founder of Fluxion Biosciences Inc., the scientific founder of the Shrink nano-technology platform, as well as the Assistant and Founding Professor of the School of Engineering at UC Merced. Khine, an associate biomedical engineering professor in the Henry Samueli School of Engineering, is responsible for experimenting with childhood toys Shrinky Dinks to build microfluidic channels. Her research has enabled technological advances in industries including biological research and medical diagnostics.
Suman Chakraborty is a professor at the Indian Institute of Technology Kharagpur and Sir J. C. Bose National Fellow. He has been the first in the history of IIT Kharagpur to be bestowed by the National Award for Teachers in the Higher Education Category by the honourable President of India. He is also Institute Chair Professor Awardee of 2023. He has served as the Dean, Research and Development, Associate Dean and the Head of the School of Medical Science and Technology of the Institute. He has also been National Academy of Engineering Chair Professor. He joined the Institute in 2002 as Assistant Professor and has been a Full Professor since 2008.
Dimitris Drikakis, PhD, FRAeS, CEng, is a Greek-British applied scientist, engineer and university professor. His research is multidisciplinary. It covers fluid dynamics, computational fluid dynamics, acoustics, heat transfer, computational science from molecular to macro scale, materials, machine learning, and emerging technologies. He has applied his research to diverse fields such as Aerospace & Defence, Biomedical, and Energy and Environment Sectors. He received The William Penney Fellowship Award by the Atomic Weapons Establishment to recognise his contributions to compressible fluid dynamics. He was also the winner of NEF's Innovator of the Year Award by the UK's Institute of Innovation and Knowledge Exchange for a new generation carbon capture nanotechnology that uses carbon nanotubes for filtering out carbon dioxide and other gases.
Elaine Surick Oran is an American physical scientist and is considered a world authority on numerical methods for large-scale simulation of physical systems. She has pioneered computational technology to solve complex reactive flow problems, unifying concepts from science, mathematics, engineering, and computer science in a new methodology. An incredibly diverse range of phenomena can be modeled and better understood using her techniques for numerical simulation of fluid flows, ranging from the tightly grouped movements of fish in Earth's oceans to the explosions of far-flung supernovae in space. Her work has contributed significantly to the advancement of the engineering profession.
Klavs Flemming Jensen is a chemical engineer who is currently the Warren K. Lewis Professor at the Massachusetts Institute of Technology (MIT).
Andrew James deMello is a British chemist and Professor of Biochemical Engineering at ETH Zürich.
Ricardo Luis Armentano Feijoo is an Uruguayan professor and researcher who has worked in biomedical engineering and cardiovascular systems. He currently serves as the director of the GIBIO research group at the National Technological University — Buenos Aires Regional Faculty (Argentina). Also he is the director of the Department of Biological Engineering, University of the Republic (Uruguay). He has two doctoral degrees, two post-doctoral degrees, and has authored more than 300 research articles and 20 books/book chapters.
Omolola (Lola) Eniola-Adefeso is a Nigerian-American chemical engineer and the University Diversity and Social Transformation Professor of Chemical Engineering, Biomedical Engineering, and Macromolecular Science and Engineering at the University of Michigan. Eniola-Adefeso is also a co-founder and chief scientific officer of Asalyxa Bio. Her research looks to design biocompatible functional particles for targeted drug delivery.
Rosemarie Wesson is the Associate Dean of Research at City College of New York. She was the first African-American woman to receive a PhD in chemical engineering from the University of Michigan. She has worked at the National Science Foundation, Louisiana State University and Dow Chemical Company.
Gilda A. Barabino is the president of the Olin College of Engineering, where she is also a professor of biomedical and chemical engineering. Previously, she served as the dean of The Grove School of Engineering at the City College of New York, and as a professor in the Departments of Biomedical Engineering and Chemical Engineering and the CUNY School of Medicine. On March 4, 2021, she became the President-Elect of the American Association for the Advancement of Science.
Minami Yoda is an American mechanical engineer and the chairperson of mechanical engineering at Michigan State University. Her research concerns experimental fluid dynamics, with applications ranging from fusion power to nanofluidics, and including the measurement of fluid flows using the evanescent field.
Audrey K. Ellerbee Bowden is an American engineer and Dorothy J. Wingfield Phillips Chancellor's Faculty Fellow at Vanderbilt University, as well as an Associate Professor of Biomedical Engineering and Electrical Engineering. She is a Fellow of Optica, the American Institute for Medical and Biological Engineering and the International Society for Optics and Photonics (SPIE).
Rustem F. Ismagilov is a Russian-American chemist. He is the John W. and Herberta M. Miles Professor of Chemistry and Chemical Engineering at the California Institute of Technology.
Shelley Lynn Anna is an American chemical engineer and experimental fluid dynamics researcher who studies droplets, multiphase flow, and the effects of surfactants in microfluidics, the rheology of extensional and interfacial flows, and microscale transport. She is a professor of chemical engineering and associate dean for faculty and graduate affairs and strategic initiatives in the Carnegie Mellon University College of Engineering.
Sibani Lisa Biswal is an American chemical engineer, materials scientist, and academic administrator who researches the physics of colloids, surfactants, lipids, and polymers. She is the William M. McCardell professor in chemical engineering with a dual appointment as professor in materials science and nanoengineering as well as a senior associate dean in the George R. Brown School of Engineering at Rice University.
References
- 1 2 3 4 5 6 7 "Adrienne Minerick | Chemical Engineering | Michigan Tech". www.mtu.edu. Retrieved 2024-03-05.
- ↑ Mills, Allison (2018-05-24). "Minerick Shifts Gears as the New Dean of the School of Technology". Michigan Technological University. Retrieved 2024-03-05.
- ↑ "Second dean candidate for School of Engineering to present Oct. 25". KU News. Retrieved 2024-03-05.
- 1 2 Minerick, Adrienne Robyn (2003). Medical Diagnostic Microfluidics and Physiological Blood Flow Dynamics (Ph.D. thesis). Michigan Technological University. OCLC 54792686.
