Akkermansia biwaensis

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Akkermansia biwaensis
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Kingdom: Pseudomonadati
Phylum: Verrucomicrobiota
Class: Verrucomicrobiae
Order: Verrucomicrobiales
Family: Akkermansiaceae
Genus: Akkermansia
Species:
A. biwaensis
Binomial name
Akkermansia biwaensis
Kobayashi et al. 2023

Akkermansia biwaensis is a species of bacteria found in the human gut microbiome.

Contents

Discovery

The type strain of A. biwaensis was isolated in Japan in 2023 from the feces of healthy adults. [1] It was delineated from other Akkermansia species on the basis of differences in the 16S gene sequence; in previous studies, it was considered to be a phylogroup of Akkermansia muciniphila , specifically the AmIV phylogroup. It is named after Lake Biwa, which is near the place of origin of the type strain. [1]

Growth and morphology

Akkermansia biwaensis is oval-shaped, gram-negative, catalase-positive, and non-motile, with cell lengths ranging from 0.5–1.0 µm. [1] Growth has been observed between 25–45°C, with optimal temperatures ranging between 30–37°C. Colonies have been described cream-colored with round edges. [1]

Like other Akkermansia spp., A. biwaensis is capable of utilizing mucin as a sole source of carbon and nitrogen. Other available energy sources include glucose and lactose; no growth has been observed on other common sugars such as galactose, fructose, or fucose. [1]

Role in human health

Akkermansia biwaensis, although relatively rare in the human gut microbiome, may be linked to lower obesity rates in children; however, its low prevalence makes it difficult to study its impact on human health. [2] It is capable of metabolizing human milk oligosaccharides, enabling it to colonize infants. [3]

Host species

In addition to humans, A. biwaensis has also been found to colonize mouse microbiomes. [4]

References

  1. 1 2 3 4 5 Kobayashi, Yodai; Kawahara, Tomohiro; Inoue, Shoichiro; Kohda, Noriyuki (2023). "Akkermansia biwaensis sp. nov., an anaerobic mucin-degrading bacterium isolated from human faeces". International Journal of Systematic and Evolutionary Microbiology. 73 (1): 005697. doi:10.1099/ijsem.0.005697. ISSN   1466-5034.
  2. Mueller, Katherine D.; Panzetta, M. Emilia; Davey, Lauren; McCann, Jessica R.; Rawls, John F.; Flores, Gilberto E.; Valdivia, Raphael H. (2024). "Pangenomic analysis identifies correlations between Akkermansia species and subspecies and human health outcomes". Microbiome Research Reports. 3 (3): 33. doi:10.20517/mrr.2024.09. ISSN   2771-5965. PMC   11480726 . PMID   39421249.
  3. Luna, Estefani; Parkar, Shanthi G.; Kirmiz, Nina; Hartel, Stephanie; Hearn, Erik; Hossine, Marziiah; Kurdian, Arinnae; Mendoza, Claudia; Orr, Katherine; Padilla, Loren; Ramirez, Katherine; Salcedo, Priscilla; Serrano, Erik; Choudhury, Biswa; Paulchakrabarti, Mousumi (2022-01-11). "Utilization Efficiency of Human Milk Oligosaccharides by Human-Associated Akkermansia Is Strain Dependent". Applied and Environmental Microbiology. 88 (1): e01487–21. Bibcode:2022ApEnM..88E1487L. doi:10.1128/AEM.01487-21.
  4. Molteni, Cristian; Forni, Diego; Cagliani, Rachele; Sironi, Manuela (2025-07-24). "The genus Akkermansia is populated by a multitude of biological species with a wide distribution in the animal kingdom". Biology Direct. 20 (1): 90. doi: 10.1186/s13062-025-00680-5 . ISSN   1745-6150. PMC   12288247 . PMID   40707972.