Albumin I

Last updated
Albumin_I
PDB 1p8b EBI.jpg
Solution structure of PA1b. PDB entry 1p8b [1]
Identifiers
SymbolAlbumin_I
Pfam PF08027
Pfam clan CL0083
InterPro IPR012512
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

Albumin I (PA1b) is a hormone-like peptide found in the seeds of legumes such as the pea plant ( Pisum sativum ) [2] or soya bean (Glycine max) [3] which have been shown to have insecticidal properties. [2] It stimulates kinase activity upon binding a membrane bound 43 kDa receptor within the plant which affects cell proliferation. [3] The structure reveals an inhibitor cystine knot (knottin)-like fold, comprising three beta strands. [1] [2]

Related Research Articles

<span class="mw-page-title-main">Pea</span> Species of flowering plant with edible seeds in the family Fabaceae

The pea is most commonly the small spherical seed or the seed-pod of the flowering plant species Pisum sativum. Each pod contains several peas, which can be green or yellow. Botanically, pea pods are fruit, since they contain seeds and develop from the ovary of a (pea) flower. The name is also used to describe other edible seeds from the Fabaceae such as the pigeon pea, the cowpea, and the seeds from several species of Lathyrus.

<span class="mw-page-title-main">Fabaceae</span> Family of legume flowering plants

The Fabaceae or Leguminosae, commonly known as the legume, pea, or bean family, are a large and agriculturally important family of flowering plants. It includes trees, shrubs, and perennial or annual herbaceous plants, which are easily recognized by their fruit (legume) and their compound, stipulate leaves. The family is widely distributed, and is the third-largest land plant family in number of species, behind only the Orchidaceae and Asteraceae, with about 765 genera and nearly 20,000 known species.

<span class="mw-page-title-main">Legume</span> Plant in the family Fabaceae

A legume is a plant in the family Fabaceae, or the fruit or seed of such a plant. When used as a dry grain, the seed is also called a pulse. Legumes are grown agriculturally, primarily for human consumption, for livestock forage and silage, and as soil-enhancing green manure. Well-known legumes include beans, soybeans, chickpeas, peanuts, lentils, lupins, mesquite, carob, tamarind, alfalfa, and clover. Legumes produce a botanically unique type of fruit – a simple dry fruit that develops from a simple carpel and usually dehisces on two sides.

The globulins are a family of globular proteins that have higher molecular weights than albumins and are insoluble in pure water but dissolve in dilute salt solutions. Some globulins are produced in the liver, while others are made by the immune system. Globulins, albumins, and fibrinogen are the major blood proteins. The normal concentration of globulins in human blood is about 2.6-3.5 g/dL.

<span class="mw-page-title-main">Cowpea</span> Species of plant

The cowpea is an annual herbaceous legume from the genus Vigna. Its tolerance for sandy soil and low rainfall have made it an important crop in the semiarid regions across Africa and Asia. It requires very few inputs, as the plant's root nodules are able to fix atmospheric nitrogen, making it a valuable crop for resource-poor farmers and well-suited to intercropping with other crops. The whole plant is used as forage for animals, with its use as cattle feed likely responsible for its name.

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In biochemistry, cyclotides are small, disulfide-rich peptides isolated from plants. Typically containing 28-37 amino acids, they are characterized by their head-to-tail cyclised peptide backbone and the interlocking arrangement of their three disulfide bonds. These combined features have been termed the cyclic cystine knot (CCK) motif. To date, over 100 cyclotides have been isolated and characterized from species of the families Rubiaceae, Violaceae, and Cucurbitaceae. Cyclotides have also been identified in agriculturally important families such as the Fabaceae and Poaceae.

<i>Alfalfa mosaic virus</i> Species of virus

Alfalfa mosaic virus (AMV), also known as Lucerne mosaic virus or Potato calico virus, is a worldwide distributed phytopathogen that can lead to necrosis and yellow mosaics on a large variety of plant species, including commercially important crops. It is the only Alfamovirus of the family Bromoviridae. In 1931 Weimer J.L. was the first to report AMV in alfalfa. Transmission of the virus occurs mainly by some aphids, by seeds or by pollen to the seed.

<i>Didymella pinodes</i> Species of fungus

Didymella pinodes is a hemibiotrophic fungal plant pathogen and the causal agent of ascochyta blight on pea plants. It is infective on several species such as Lathyrus sativus, Lupinus albus, Medicago spp., Trifolium spp., Vicia sativa, and Vicia articulata, and is thus defined as broadrange pathogen.

<span class="mw-page-title-main">Snow pea</span>

The snow pea is an edible-pod pea with flat pods and thin pod walls. It is eaten whole, with both the seeds and the pod, while still unripened.

<i>Clitoria ternatea</i> Species of legume

Clitoria ternatea, commonly known as Asian pigeonwings, bluebellvine, blue pea, butterfly pea, cordofan pea or Darwin pea is a plant species belonging to the family Fabaceae, endemic and native to the Indonesian island of Ternate.

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4-Chloroindole-3-acetic acid (4-Cl-IAA) is an organic compound that functions as a plant hormone.

In enzymology, a leghemoglobin reductase (EC 1.6.2.6) is an enzyme that catalyzes the chemical reaction

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Legumin is family of globular proteins obtained from beans, peas, lentils, vetches, hemp and other leguminous seeds. Edestin is a biologically active legumin protein that is digestible for human bodies. Garden peas are a common nutritional source for humans that contains legumin.

<i>Acyrthosiphon pisum</i> Species of true bug

Acyrthosiphon pisum, commonly known as the pea aphid, is a sap-sucking insect in the family Aphididae. It feeds on several species of legumes worldwide, including forage crops, such as pea, clover, alfalfa, and broad bean, and ranks among the aphid species of major agronomical importance. The pea aphid is a model organism for biological study whose genome has been sequenced and annotated.

The Legume Information System (LIS) is legume sciences portal specifically for legume breeders and researchers, established and supported by the Agricultural Research Service of the United States Department of Agriculture. The mission of the Legume Information System is "to facilitate discoveries and crop improvement in the legumes," in particular to improve crop yields, their nutritional value, and our understanding of basic legume science.

<span class="mw-page-title-main">Pea protein</span>

Pea protein is a food product and protein supplement derived and extracted from yellow and green split peas, Pisum sativum. It can be used as a dietary supplement to increase an individual's protein or other nutrient intake, or as a substitute for other food products. As a powder, it is used as an ingredient in food manufacturing, such as a thickener, foaming agent, or an emulsifier.

Plastoglobulins is a family of proteins prominent found in lipid globules in plastids of flowering plants. It shows sequence similarities to the PAP/fibrillin family. PGL and similar proteins can be found in most algae, cyanobacteria and plants, but no other life forms; it suggests a role for PGL in oxygenic photosynthesis.

<span class="mw-page-title-main">Pisatin</span> Chemical compound

Pisatin (3-hydroxy-7-methoxy-4′,5′-methylenedioxy-chromanocoumarane) is the major phytoalexin made by the pea plant Pisum sativum. It was the first phytoalexin to be purified and chemically identified. The molecular formula is C17H14O6.

Peptide therapeutics are peptides or polypeptides which are used to for the treatment of diseases. Naturally occurring peptides may serve as hormones, growth factors, neurotransmitters, ion channel ligands, and anti-infectives; peptide therapeutics mimic such functions. Peptide Therapeutics are seen as relatively safe and well-tolerated as peptides can be metabolized by the body.

References

  1. 1 2 Jouvensal, L.; Quillien, L.; Ferrasson, E.; Rahbé, Y.; Guéguen, J.; Vovelle, F. O. (2003). "PA1b, an Insecticidal Protein Extracted from Pea Seeds (Pisum sativum): 1H-2-D NMR Study and Molecular Modeling†,‡". Biochemistry. 42 (41): 11915–11923. doi:10.1021/bi034803l. PMID   14556622.
  2. 1 2 3 Da Silva, P.; Rahioui, I.; Laugier, C.; Jouvensal, L.; Meudal, H.; Chouabe, C.; Delmas, A. F.; Gressent, F. (2010). "Molecular Requirements for the Insecticidal Activity of the Plant Peptide Pea Albumin 1 Subunit b (PA1b)". Journal of Biological Chemistry. 285 (43): 32689–32694. doi: 10.1074/jbc.M110.147199 . PMC   2963353 . PMID   20660598.
  3. 1 2 Yamazaki T, Takaoka M, Katoh E, Hanada K, Sakita M, Sakata K, Nishiuchi Y, Hirano H (March 2003). "A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes". Eur. J. Biochem. 270 (6): 1269–76. doi:10.1046/j.1432-1033.2003.03489.x. PMID   12631285.
This article incorporates text from the public domain Pfam and InterPro: IPR012512