Alec C. Kimmelman

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Alec C. Kimmelman is an American physician and researcher who is dean of NYU Grossman School of Medicine and chief executive officer of NYU Langone Health. [1]

Contents

Early life and education

Kimmelman earned his bachelor's degree from Cornell University and completed a dual MD/PhD through the Medical Scientist Training Program at the Icahn School of Medicine at Mount Sinai. [2] He joined Harvard Medical School as a clinical fellow, completing his residency in radiation oncology and a postdoctoral fellowship at Dana-Farber. [1] [2]

Career

Kimmelman ran a research program at Dana-Farber Cancer Institute focused on pancreatic cancer. [2] He was also an attending physician at Brigham and Women's Hospital and Dana-Farber Cancer Institute, where he specialized in gastrointestinal malignancies, including pancreatic cancer. [3] [4]

Kimmelman joined NYU Langone in 2016 and has held several leadership roles at the medical center. [5] He served as director of NYU Langone's Laura and Isaac Perlmutter Cancer Center, the Laura and Isaac Perlmutter Professor of Radiation Oncology, the Anita Steckler and Joseph Steckler Chair of the Department of Radiation Oncology, and chair of the Department of Radiation Oncology at NYU Grossman School of Medicine. [6] [5] He was also associate dean of cancer research at the school, served on the Executive Management Committee of the Perlmutter Cancer Center, and co-led its Cancer Cell Biology Program. [5]

In 2025, Kimmelman was appointed dean of NYU Grossman School of Medicine and chief executive officer of NYU Langone Health. [1]

Research

Kimmelman is a National Institutes of Health–funded investigator whose work has primarily focused on pancreatic cancer and the key biological functions of Ras oncogenes. [7] [2] Kimmelman's laboratory was focused on the basic and translational science of pancreatic cancer. [8] His research identified unique metabolic pathways and revealed how the Kras oncogene reprograms tumor metabolism. [8]

Kimmelman's research has been published in Cell, Science, Nature,Cancer Cell,Cancer Discovery and Genes & Development. [9] [10] [11] [12] [13] [14]

Milestones

In 2023, Kimmelman received a $1.7 million Drug Discovery Award from the Mark Foundation for Cancer Research. [15] Under his leadership, the Perlmutter Cancer Center established the Center for Molecular Oncology in October 2024. [16]

References

  1. 1 2 3 Gioia, Amelia Hernandez; Kantheti, Lekhya (2025-04-02). "NYU Langone names new dean and CEO". Washington Square News. Retrieved 2025-10-13.
  2. 1 2 3 4 "NYU Langone Appoints Alec Kimmelman, MD, PhD, as Chair of Radiation Oncology". ascopost.com. Retrieved 2025-10-13.
  3. "Alec Kimmelman, MD, PhD". Pancreatic Cancer Action Network. Retrieved 2025-10-13.
  4. "Alec C. Kimmelman Appointed As Next CEO Of Leading Medical Institution | The Lifesciences Magazine". 2025-04-01. Retrieved 2025-10-13.
  5. 1 2 3 "Alec Kimmelman named director of Perlmutter Cancer Center, quickly replacing ousted Benjamin Neel". The Cancer Letter. 2023-12-01. Retrieved 2025-10-13.
  6. Communications, NYU Web. "More than Two Dozen NYU Researchers Among the World's Most Cited". www.nyu.edu. Retrieved 2025-10-13.
  7. Staff, Brooklyn Eagle (2025-04-02). "NYU Langone Health appoints cancer specialist as medical school's new CEO and dean". Brooklyn Eagle. Retrieved 2025-10-13.
  8. 1 2 "Pancreatic Cancer Loophole | Harvard Medical School". hms.harvard.edu. 2013-04-01. Retrieved 2025-10-13.
  9. Yang, Annan; Herter-Sprie, Grit; Zhang, Haikuo; Lin, Elaine Y.; Biancur, Douglas; Wang, Xiaoxu; Deng, Jiehui; Hai, Josephine; Yang, Shenghong; Wong, Kwok-Kin; Kimmelman, Alec C. (2018-03-01). "Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms". Cancer Discovery. 8 (3): 276–287. doi:10.1158/2159-8290.CD-17-0952. ISSN   2159-8274. Archived from the original on 2025-06-13.
  10. Chan, Tung O.; Rodeck, Ulrich; Chan, Andrew M.; Kimmelman, Alec C.; Rittenhouse, Susan E.; Panayotou, George; Tsichlis, Philip N. (2002-03-01). "Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit". Cancer Cell. 1 (2): 181–191. doi:10.1016/S1535-6108(02)00033-8. ISSN   1535-6108. PMID   12086876.
  11. Encarnación-Rosado, Joel; Sohn, Albert S. W.; Biancur, Douglas E.; Lin, Elaine Y.; Osorio-Vasquez, Victoria; Rodrick, Tori; González-Baerga, Diana; Zhao, Ende; Yokoyama, Yumi; Simeone, Diane M.; Jones, Drew R.; Parker, Seth J.; Wild, Robert; Kimmelman, Alec C. (2024). "Targeting pancreatic cancer metabolic dependencies through glutamine antagonism". Nature Cancer. 5 (1): 85–99. doi:10.1038/s43018-023-00647-3. ISSN   2662-1347.
  12. Kimmelman, Alec C. (2011-10-01). "The dynamic nature of autophagy in cancer". Genes & Development. 25 (19): 1999–2010. doi:10.1101/gad.17558811. ISSN   0890-9369. PMID   21979913.
  13. Mukhopadhyay, Subhadip; Encarnación-Rosado, Joel; Lin, Elaine Y.; Sohn; Zhang, Huan; Mancias, Joseph D.; Kimmelman, Alec C. (2023-04-19). "Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer". Science Advances. 9 (16) eadf9284. doi:10.1126/sciadv.adf9284. PMC   10115412 . PMID   37075122.
  14. Biancur, Douglas E.; Kapner, Kevin S.; Yamamoto, Keisuke; Banh, Robert S.; Neggers, Jasper E.; Sohn, Albert S. W.; Wu, Warren; Manguso, Robert T.; Brown, Adam; Root, David E.; Aguirre, Andrew J.; Kimmelman, Alec C. (2021-01-05). "Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer". Cell Metabolism. 33 (1): 199–210.e8. doi:10.1016/j.cmet.2020.10.018. ISSN   1550-4131. PMID   33152323.
  15. "The Mark Foundation for Cancer Research Announces More Than $2 Million in Funding for Two New Drug Discovery Awards for Pancreatic Cancer and Anticancer Therapeutics". The Mark Foundation for Cancer Research. 2023-02-08. Retrieved 2025-10-13.
  16. HealthLeaders. "How to Establish a Molecular Oncology Program". www.healthleadersmedia.com. Retrieved 2025-10-13.