Antimicrobial resistance (AMR) occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials. All classes of microbes can evolve resistance where the drugs are no longer effective. Fungi evolve antifungal resistance. Viruses evolve antiviral resistance. Protozoa evolve antiprotozoal resistance, and bacteria evolve antibiotic resistance. Together all of these come under the umbrella of antimicrobial resistance. Microbes resistant to multiple antimicrobials are called multidrug resistant (MDR) and are sometimes referred to as a superbugs. Although antimicrobial resistance is a naturally occurring process, it is often the result of improper usage of the drugs and management of the infections.
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection.
Sir Richard Brook Sykes is a British microbiologist, the chair of the Royal Institution, the UK Stem Cell Foundation, and the trustees at King Edward VII's Hospital, and chancellor of Brunel University. As of June 2021, he is chair of the UK's Vaccine Taskforce, where he is responsible for overseeing the delivery of the COVID-19 vaccination programme, including preparations for booster programmes and encouraging vaccine innovation in the UK.
Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories. Antimicrobial categories are classifications of antimicrobial agents based on their mode of action and specific to target organisms. The MDR types most threatening to public health are MDR bacteria that resist multiple antibiotics; other types include MDR viruses, parasites.
Antibiotic misuse, sometimes called antibiotic abuse or antibiotic overuse, refers to the misuse or overuse of antibiotics, with potentially serious effects on health. It is a contributing factor to the development of antibiotic resistance, including the creation of multidrug-resistant bacteria, informally called "super bugs": relatively harmless bacteria can develop resistance to multiple antibiotics and cause life-threatening infections.
One Health Trust, formerly the Center for Disease Dynamics, Economics & Policy (CDDEP), is a public health research organization with headquarters in Washington, D.C., and Bangalore, India.
Dame Sally Claire Davies is a British physician. She was the Chief Medical Officer from 2010 to 2019 and Chief Scientific Adviser at the Department of Health from 2004 to 2016. She worked as a clinician specialising in the treatment of diseases of the blood and bone marrow. She is now Master of Trinity College, Cambridge, appointed on 8 February 2019, with effect from 8 October 2019. She is one of the founders of the National Institute for Health and Care Research.
Multidrug resistant Gram-negative bacteria are a type of Gram-negative bacteria with resistance to multiple antibiotics. They can cause bacteria infections that pose a serious and rapidly emerging threat for hospitalized patients and especially patients in intensive care units. Infections caused by MDR strains are correlated with increased morbidity, mortality, and prolonged hospitalization. Thus, not only do these bacteria pose a threat to global public health, but also create a significant burden to healthcare systems.
Antimicrobial stewardship is the systematic effort to educate and persuade prescribers of antimicrobials to follow evidence-based prescribing, in order to stem antimicrobial overuse, and thus antimicrobial resistance. AMS has been an organized effort of specialists in infectious diseases, both in Internal Medicine and Pediatrics with their respective peer-organizations, hospital pharmacists, the public health community and their professional organizations since the late 1990s. It has first been implemented in hospitals. In the U.S., within the context of physicians' prescribing freedom, AMS had largely been voluntary self-regulation in the form of policies and appeals to adhere to a prescribing self-discipline until 2017, when the Joint Commission prescribed that hospitals should have an Antimicrobial Stewardship team, which was expanded to the outpatient setting in 2020.
Sharon Jayne Peacock is a British microbiologist who is Professor of Public Health and Microbiology in the Department of Medicine at the University of Cambridge.
Professor Graham Cooke is a clinician scientist and NIHR Professor of Infectious Diseases at the Wright-Fleming Institute of Imperial College London. He is best known for his work on viral hepatitis, particularly hepatitis C.
The Society of Infectious Diseases Pharmacists (SIDP) is a non-profit association of pharmacists and other allied health professionals who specialize in infectious diseases and antimicrobial stewardship. According to the Board of Pharmaceutical Specialties, clinical pharmacists specializing in infectious diseases are trained in the use of microbiology and pharmacology to develop, implement, and monitor drug regimens that incorporate the pharmacodynamics and pharmacokinetics of antimicrobials for patients.
Judith Breuer is a British virologist who is professor of virology and director of the Pathogen Genomics Unit at University College London. She was elected a Fellow of the Academy of Medical Sciences in 2019. Breuer is part of the United Kingdom genome sequencing team that looks to map the spread of the coronavirus disease 2019.
Jasmine R. Marcelin is a Caribbean-American infectious disease physician and an Assistant Professor in the Department of Internal Medicine at the University of Nebraska Medical Center (UNMC). Marcelin is also the Associate Medical Director of the Antimicrobial Stewardship Program and as well as the Co-Director of Digital Innovation and Social Media Strategy at UNMC. Marcelin is dedicated to advancing diversity, inclusion, and equity in her communities and is a founding member of the Infectious Diseases Society of America Inclusion, Diversity, Access & Equity Taskforce. Marcelin uses social media to advance medicine, diversity, and patient advocacy and has published articles on how to effectively use social media for these purposes.
Ibrahim Ibrahim Abubakar is a British-Nigerian epidemiologist who is Professor in Infectious Disease Epidemiology at University College London and Dean of the UCL Faculty of Population Health Sciences.
Alasdair Macintosh Geddes is Emeritus Professor of Infection at the University of Birmingham Medical School. In 1978, as the World Health Organization (WHO) was shortly to announce that the world's last case of smallpox had occurred a year earlier in Somalia, Geddes diagnosed a British woman with the disease in Birmingham, England. She was found to be the index case of the outbreak and became the world's last reported fatality due to the disease, five years after he had gained experience on the frontline of the WHO's smallpox eradication programme in Bangladesh in 1973.
The Centre for Genomic Pathogen Surveillance is a computational genomics research institute in Oxfordshire.
Associate Professor Asha Bowen is an Australian Paediatric Infectious Diseases clinician-scientist and a leading voice and advocate for children's health and well-being. She is Head of the Department of Infectious Diseases at Perth Children's Hospital, Head of the Healthy Skin and ARF Prevention team and Program Head of the End Rheumatic Heart Disease program at the Telethon Kids Institute. Bowen leads a large body of skin health research in partnership with healthcare workers and community in the Kimberley while expanding her team and work to understand skin health in urban Aboriginal children better. She has been widely acknowledged and awarded for her contributions towards improving the health and well-being of Australian children, and addressing existing health inequities faced by First Nations Australian children and their families. Throughout the COVID-19 pandemic she contributed her knowledge and expertise to clinical research, guideline development and on several national committees. She has published widely in the area of paediatric infectious diseases and is a recognized expert in the field who regularly contributes to popular Australian media sources such as The Conversation.
Lucy Chappell is a British professor of obstetrics at King’s College London and the Chief Scientific Adviser (CSA) for the UK Department of Health and Social Care. As part of her CSA role, she oversees the National Institute for Health and Care Research (NIHR) as Chief Executive Officer. Her research areas include medical problems during pregnancy such as pre-eclampsia, and the safety of medicines in pregnancy.
