Anita Hopper

Last updated
Anita Carol Klein Hopper
Alma mater University of Illinois at Chicago
University of Illinois Urbana-Champaign
Scientific career
Institutions Ohio State University
Pennsylvania State University
University of Massachusetts Medical School
Thesis An investigation into the replication of satellite tobacco necrosis virus and tobacco necrosis virus RNA genomes.  (1972)

Anita Hopper is an American molecular geneticist who is a professor at the Ohio State University. She studies the mechanisms of distribution of RNA between the nucleus and cytoplasm. She is a Fellow of the American Academy of Microbiology and the American Association for the Advancement of Science and was elected a Member of the National Academy of Sciences in 2021.

Contents

Early life and education

Hopper was an undergraduate student at the University of Illinois at Chicago, where she studied biology. She moved to the University of Illinois Urbana-Champaign for her graduate studies, where she specialized in cell biology. Hopper studied the replication of satellite tobacco necrosis virus. [1] After completing her doctoral research she moved to the University of Washington, where she spent four years as a postdoctoral research associate.[ citation needed ]

Research and career

Hopper joined the faculty at the University of Massachusetts Medical School, and was promoted to associate professor.[ citation needed ] She was appointed professor at the Pennsylvania State University in 1979, where she spent almost thirty years before joining the Ohio State University as chair of the Department of Molecular Genetics. [2]

Hopper makes use of Saccharomyces cerevisiae (yeast) as a model system to study processing and intracellular trafficking of tRNAs. [3] Almost all RNAs involved in protein synthesis are generated in the nucleus but function in the cytoplasm (and vice versa). Hopper both processes occur along nuclear export pathways, where export quality is controlled by the translation machinery itself. She showed that tRNAs from the cytoplasm accumulate in the nucleus under particular stress conditions.[ citation needed ]

Hopper's area expertise include: [4] intracellular trafficking of RNA and proteins, RNA processing and yeast genetics and genomics.

Awards and honors

Selected publications

Personal life

Hopper was married to biochemist James Hopper, with whom she had one daughter. [12]

Related Research Articles

<span class="mw-page-title-main">Cell nucleus</span> Eukaryotic membrane-bounded organelle containing DNA

The cell nucleus is a membrane-bound organelle found in eukaryotic cells. Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm; and the nuclear matrix, a network within the nucleus that adds mechanical support.

<i>Tobacco mosaic virus</i> Virus affecting plants of the Solanaceae family

Tobacco mosaic virus (TMV) is a positive-sense single-stranded RNA virus species in the genus Tobamovirus that infects a wide range of plants, especially tobacco and other members of the family Solanaceae. The infection causes characteristic patterns, such as "mosaic"-like mottling and discoloration on the leaves. TMV was the first virus to be discovered. Although it was known from the late 19th century that a non-bacterial infectious disease was damaging tobacco crops, it was not until 1930 that the infectious agent was determined to be a virus. It is the first pathogen identified as a virus. The virus was crystallised by Wendell Meredith Stanley. It has a similar size to the largest synthetic molecule, known as PG5.

Pamela Ann Silver is an American cell and systems biologist and a bioengineer. She holds the Elliot T. and Onie H. Adams Professorship of Biochemistry and Systems Biology at Harvard Medical School in the Department of Systems Biology. Silver is one of the founding Core Faculty Members of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

<span class="mw-page-title-main">Pseudouridine</span> Chemical compound

Pseudouridine is an isomer of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond.

<span class="mw-page-title-main">DSIF</span>

DSIF is a protein complex that can either negatively or positively affect transcription by RNA polymerase II. It can interact with the negative elongation factor (NELF) to promote the stalling of Pol II at some genes, which is called promoter proximal pausing. The pause occurs soon after initiation, once 20-60 nucleotides have been transcribed. This stalling is relieved by positive transcription elongation factor b (P-TEFb) and Pol II enters productive elongation to resume synthesis till finish. In humans, DSIF is composed of hSPT4 and hSPT5. hSPT5 has a direct role in mRNA capping which occurs while the elongation is paused.

Carlo Maria Croce is an Italian-American professor of medicine at Ohio State University, specializing in oncology and the molecular mechanisms underlying cancer. Croce and his research have attracted public attention because of multiple allegations of scientific misconduct.

Ellen Mosley-Thompson is a glaciologist and climatologist. She is a Distinguished University Professor at Ohio State University and director of their Byrd Polar and Climate Research Center. She is known as a pioneer in the use of ice cores from the Polar Regions for paleoclimatic research and is an influential figure in climate science. She is an elected fellow of the American Association for the Advancement of Science, the American Geophysical Union and an elected member of the National Academy of Sciences.

<span class="mw-page-title-main">Lynne E. Maquat</span> American biochemist

Lynne Elizabeth Maquat is an American biochemist and molecular biologist whose research focuses on the cellular mechanisms of human disease. She is an elected member of the American Academy of Arts and Sciences, the National Academy of Sciences and the National Academy of Medicine. She currently holds the J. Lowell Orbison Endowed Chair and is a professor of biochemistry and biophysics, pediatrics and of oncology at the University of Rochester Medical Center. Professor Maquat is also Founding Director of the Center for RNA Biology and Founding Chair of Graduate Women in Science at the University of Rochester.

Susan Wente is an American cell biologist and academic administrator currently serving as the 14th President of Wake Forest University. From 2014 to 2021 she was Provost and Vice Chancellor for Academic Affairs at Vanderbilt University. Between August 15, 2019 and June 30, 2020, she served as interim Chancellor at Vanderbilt.

Elisa Izaurralde was an Uruguayan biochemist and molecular biologist. She served as Director and Scientific Member of the Department of Biochemistry at the Max Planck Institute for Developmental Biology in Tübingen from 2005 until her death in 2018. In 2008, she was awarded the Gottfried Wilhelm Leibniz Prize, shared with Elena Conti, for "fundamental new insights into intracellular RNA transport and RNA metabolism". Together with Conti, she helped characterize proteins important for exporting mRNA out of the nucleus and later in her career she helped elucidate mechanisms of mRNA silencing, translational repression, and mRNA decay.

Glenna Shirleen Roeder is a geneticist known for identifying and characterizing the yeast genes that regulate the process of meiosis with particular emphasis on synapsis.

Anne-Claude Gingras is a senior investigator at Lunenfeld-Tanenbaum Research Institute, and a professor in the department of molecular genetics at the University of Toronto. She is an expert in mass spectrometry based proteomics technology that allows identification and quantification of protein from various biological samples.

Asifa Akhtar is a Pakistani biologist who has made significant contributions to the field of chromosome regulation. She is Senior Group Leader and Director of the Department of Chromatin Regulation at the Max Planck Institute of Immunobiology and Epigenetics. Akhtar was awarded EMBO membership in 2013. She became the first international and female Vice President of the Max Planck Society's Biology and Medicine Section in July 2020.

Lucia Beatriz Rothman-Denes is an Argentinian American microbiologist who is the A. J. Carlson Professor in the Department of Molecular Genetics at the University of Chicago. She is known for studying the regulation of transcription and host interactions that occur during bacterial virus infection. She was elected to the National Academy of Sciences (NAS) in 2014.

Alice Barkan is an American molecular biologist and a professor of biology at the University of Oregon. She is known for her work on chloroplast gene regulation and protein synthesis.

<span class="mw-page-title-main">CCR4-Not</span> Multiprotein complex used in gene expression

Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. The exonuclease activity of CCR4-Not shortens the poly(A) tail found at 3' end of almost every eukaryotic mRNA. The complex is present both in the nucleus where it regulates transcription and in the cytoplasm where it associates with translating ribosomes and RNA processing bodies. In mammalian cell, it has a function in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair in nucleus. Ccr4–Not complex plays an important role in mRNA decay and protein quality control in the cytoplasm.

Karin Musier-Forsyth, an American biochemist, is an Ohio Eminent Scholar on the faculty of the Department of Chemistry & Biochemistry at Ohio State University. Musier-Forsyth's research involves biochemical, biophysical and cell-based approaches to understand the interactions of proteins and RNAs involved in protein synthesis and viral replication, especially in HIV.

<span class="mw-page-title-main">Paula Cohen</span> British-American geneticist

Paula Elaine Cohen is a British-American geneticist who is a professor and Associate Vice Provost for Life Sciences at Cornell University. Her research considers DNA repair mechanisms and the regulation of crossing over during mammalian meiosis. She was awarded the National Down Syndrome Society Charles J. Epstein Down Syndrome Research Award in 2004 and elected Fellow of the American Association for the Advancement of Science in 2021.

The TREX (TRanscription-EXport) complex is a conserved eukaryotic multi-protein complex that couples mRNA transcription and nuclear export. The TREX complex travels across transcribed genes with RNA polymerase II. TREX binds mRNA and recruits transport proteins NXF1 and NXT1, which shuttle the mRNA out of the nucleus. The TREX complex plays an important role in genome stability and neurodegenerative diseases.

Anita Hargrave Corbett is an American biochemist who is the Samuel C. Dobbs Professor in the Department of Biology at Emory University. Her research investigates the molecular basis for disease, the regulation of protein import and mRNA export. She is a Fellow of the American Association for the Advancement of Science and the American Society for Biochemistry and Molecular Biology.

References

  1. Hopper, Anita Carol Klein (1972). An investigation into the replication of satellite tobacco necrosis virus and tobacco necrosis virus RNA genomes (Thesis). Urbana. OCLC   77219389.
  2. 1 2 "Ohio State University: Anita Hopper elected to National Academy of Sciences". India Education | Latest Education News India | Global Educational News | Recent Educational News. 2021-04-28. Retrieved 2021-05-06.
  3. "Anita Hopper". molgen.osu.edu. Retrieved 2021-05-06.
  4. "Anita Hopper". molgen.osu.edu. Retrieved 2021-05-08.
  5. https://www.rnasociety.org/assets/Newsletters/Fall2009.pdf#page=4
  6. "American Association for the Advancement of Science". Office of Academic Affairs, The Ohio State University. 2017-07-20. Retrieved 2021-05-06.
  7. "Fall 2009 - RNA Society" (PDF).
  8. "Anita Hopper wins The 2012 Distinguished Scholar Award". molgen.osu.edu. Retrieved 2021-05-06.
  9. Biology, Center for RNA (30 January 2015). "Anita Hopper: RNA Society Lifetime Achievement Award | The Center for RNA Biology" . Retrieved 2021-05-06.
  10. "Anita Hopper and Anna Dobritsa Honored as Mentors". molgen.osu.edu. Retrieved 2021-05-06.
  11. "2021 NAS Election". www.nasonline.org. Retrieved 2021-05-06.
  12. "Dr. James E. Hopper, 1942-2017". Penn State Health News. 30 January 2017. Retrieved 2021-05-06.