Anita Mahadevan-Jansen

Last updated
Anita Mahadaven-Jansen
Anita Mahadevan-Jansen 2019 (cropped).jpg
Alma mater University of Mumbai (BSc, MS)
University of Texas at Austin (MS, PhD)
Known forClinical Biophotonics
Surgical Guidance
Cancer Detection
Raman Spectroscopy
Fluorescence Spectroscopy
Neuromodulation
AwardsFellow of SPIE
Fellow of the Optical Society
Fellow of the Society for Applied Spectroscopy
Fellow of the American Society of Lasers in Medicine and Surgery
Fellow of the American Institute for Medical and Biological Engineering
Scientific career
FieldsBiomedical Engineering
Physics
Optics
Biophotonics
Institutions Vanderbilt University
Doctoral advisor Rebecca Richards-Kortum
Website www.vanderbilt.edu/vbc

Anita Mahadevan-Jansen is a Professor of Biomedical Engineering and holds the Orrin H. Ingram Chair in Biomedical Engineering at Vanderbilt University. Her research considers the development of optical techniques for clinical diagnosis and surgical guidance, particularly using Raman and fluorescence spectroscopy. She serves on the Board of Directors of SPIE, and is a Fellow of SPIE, The Optical Society, Society for Applied Spectroscopy, and the American Society for Lasers in Medicine and Surgery. [1] She was elected to serve as the 2020 Vice President of SPIE. With her election, Mahadevan-Jansen joined the SPIE presidential chain and served as President-Elect in 2021 and the Society's President in 2022. [2]

Contents

Early life and education

As a child Mahadevan-Jansen wanted to be a medical doctor. [3] She studied physics at the University of Mumbai, and earned her Bachelor's and master's degree there in 1990. [3] As an undergraduate student she was disinterested in optics. [4] Her professor, S.B. Patel, proposed that she applied to work in biomedical engineering. [3] [4] She moved to the University of Texas at Austin for her doctoral studies, where she completed a Master's and PhD in 1996. [5] [6] There, she began working with fluorescence spectroscopy under the supervision of Rebecca Richards-Kortum. [3]

Research and career

Mahadevan-Jansen joined the faculty at Vanderbilt University in 1996 and is currently Orrin H. Ingram Professor of Biomedical Engineering, Professor of Neurological Surgery. [7] She founded the Vanderbilt Biophotonics Center, where she works on optical diagnostics, surgical guidance, and neurophotonics. [8] [9] She is interested in translating optical technologies into in vivo diagnostic tools. [10] Mahadevan-Jansen pioneered the use of in vivo Raman spectroscopy for non-invasive diagnostics cervical dysplasia. [11] Her methodology is being developed for use in clinical medicine, for example, it may be used by surgeons in the treatment of breast and brain cancer. [12] She created optical blood testing methodologies for neonatal babies, which was selected by the Vanderbilt University Center for Technology Transfer as one of the "coolest inventions" of the year. [13] She developed sensors that can detect inflammation caused by bowel disease into a typical colonoscopy procedure. [14]

In 2005, Dr. Mahadevan-Jansen and collaborators (including her husband, Dr. E Duco Jansen [15] ) discovered the ability to control peripheral and central nervous system electrical activity label-free with short pulses of infrared light. [16] Termed infrared neural stimulation (INS), the field of label-free neuromodulation has evolved over the last decade built on these initial findings. [17] This technology has demonstrated as safe and clinically translatable in humans. [18]

In 2014, Mahadevan-Jansen was elected as conference co-chair to the 2018 Gordon Research Conference on Lasers in Medicine Biology with Paul French. She is exploring the use of Raman spectroscopy for investigating pre-term cervical remodeling. [11] In 2018, 10 years after Mahadevan-Jensen demonstrated that parathyroid gland tissues glow under near-infrared light, the Food and Drug Administration approved that the technology could be used for surgeries. [19] [20] Her technology, the PTeye, was tested in a 81 patient clinical trial, and enables in situ monitoring of the parathyroid tissue during thyroid surgery. [19] Before Mahadevan-Jansen's technology, surgeons relied on a visual assessment to identify the location of the parathyroid gland. [19] She is also working on a development of Raman spectroscopy for the early diagnosis of throat cancer related to HPV. [21] She leads a $3 million Vanderbilt University program that develops microscopy tools. [12] Both projects are part of the Trans-Institutional Programs (TIPs) program at Vanderbilt University. [21]

Since 1995, Mahadevan-Jansen is listed as co-inventor on more than 20 USPTO patents, several of which being licensed towards commercial development. [22]

Academic service

Dr. Mahadevan-Jansen has served as an reviewer for nearly two dozen journals over her career, including her role on the editorial board for the Journal of Biomedical Optics from 2007 to 2014. She started the Biomedical Vibrational Spectroscopy conference at SPIE's Photonics West BiOS conference in 2002, which has been running ever since. [23] In 2007 she featured in the SPIE Women in Optics planner. [24] Her advocacy for improving diversity and inclusion in optics and photonics has led to her chairing the SPIE Equity, Diversity, and Inclusion Committee. [25] She is a Fellow of SPIE and served on the Board of Directors from 2014 to 2019. [26] [27] In 2014 Mahadaevan-Jansen was the second woman to be elected Chair of the Gordon Research Conference on Lasers in Medicine & Biology. [28] She also serves as a Fellow of The Optical Society and the American Institute for Medical and Biological Engineering. [29] [30] She and her students have received numerous awards for research excellence and mentoring, for which she remains a strong advocate. [31]

Selected publications

Her publications include;

Personal life

Mahadevan-Jansen is married to Duco Jansen, a Professor of Biomedical Engineering at Vanderbilt University. [3] Together they have two children. [32]

Related Research Articles

Naomi J. Halas is the Stanley C. Moore Professor in Electrical and Computer Engineering, and professor of biomedical engineering, chemistry and physics at Rice University. She is also the founding director of Rice University Laboratory for Nanophotonics, and the Smalley-Curl Institute. She invented the first nanoparticle with tunable plasmonic resonances, which are controlled by their shape and structure, and has won numerous awards for her pioneering work in the field of nanophotonics and plasmonics. She was also part of a team that developed the first dark pulse soliton in 1987 while working for IBM.

SPIE is an international not-for-profit professional society for optics and photonics technology, founded in 1955. It organizes technical conferences, trade exhibitions, and continuing education programs for researchers and developers in the light-based fields of physics, including: optics, photonics, and imaging engineering. The society publishes peer-reviewed scientific journals, conference proceedings, monographs, tutorial texts, field guides, and reference volumes in print and online. SPIE is especially well-known for Photonics West, one of the laser and photonics industry's largest combined conferences and tradeshows which is held annually in San Francisco. SPIE also participates as partners in leading educational initiatives, and in 2020, for example, provided more than $5.8 million in support of optics education and outreach programs around the world.

<span class="mw-page-title-main">Bruce J. Tromberg</span> American chemist

Bruce J. Tromberg is an American photochemist and a leading researcher in the field of biophotonics. He is the director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) within the National Institutes of Health (NIH). Before joining NIH, he was Professor of Biomedical Engineering at The Henry Samueli School of Engineering and of Surgery at the School of Medicine, University of California, Irvine. He was the principal investigator of the Laser Microbeam and Medical Program (LAMMP), and the Director of the Beckman Laser Institute and Medical Clinic at Irvine. He was a co-leader of the Onco-imaging and Biotechnology Program of the NCI Chao Family Comprehensive Cancer Center at Irvine.

<span class="mw-page-title-main">Andreas Mandelis</span> Physicist (b. 1952)

Andreas Mandelis is a professor and researcher at the department of Mechanical and Industrial Engineering at the University of Toronto and director of the Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT). He is an internationally recognized expert in thermophotonics. His research encompasses the non-destructive evaluation of materials with industrial and biomedical applications. He is considered a pioneer in the fields of diffusion-wave, photothermal and photoacoustic sciences and related technologies. He is the inventor of a photothermal imaging radar which can detect tooth decay at an early stage.

The Beckman Laser Institute is an interdisciplinary research center for the development of optical technologies and their use in biology and medicine. Located on the campus of the University of California, Irvine in Irvine, California, an independent nonprofit corporation was created in 1982, under the leadership of Michael W. Berns, and the actual facility opened on June 4, 1986. It is one of a number of institutions focused on translational research, connecting research and medical applications. Researchers at the institute have developed laser techniques for the manipulation of structures within a living cell, and applied them medically in treatment of skin conditions, stroke, and cancer, among others.

<span class="mw-page-title-main">Stephen A. Boppart</span>

Stephen A. Boppart is a principal investigator at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign, where he holds an Abel Bliss Professorship in engineering. He is a faculty member in the departments of electrical and computer engineering, bioengineering, and internal medicine. His research focus is biophotonics, where he has pioneered new optical imaging technologies in the fields of optical coherence tomography, multi-photon microscopy, and computational imaging.

Elizabeth M. C. Hillman is a British-born academic who is Professor of Biomedical Engineering and Radiology at Columbia University. She was awarded the 2011 Adolph Lomb Medal from The Optical Society and the 2018 SPIE Biophotonics Technology Innovator Award.

Time-domain diffuse optics or time-resolved functional near-infrared spectroscopy is a branch of functional near-Infrared spectroscopy which deals with light propagation in diffusive media. There are three main approaches to diffuse optics namely continuous wave (CW), frequency domain (FD) and time-domain (TD). Biological tissue in the range of red to near-infrared wavelengths are transparent to light and can be used to probe deep layers of the tissue thus enabling various in vivo applications and clinical trials.

Anna Wang Roe is an American neuroscientist, the director of the Interdisciplinary Institute of Neuroscience and Technology (ZIINT), and full-time professor at the Zhejiang University, Hangzhou, China. She is known for her studies on the functional organization and connectivity of cerebral cortex and for bringing interdisciplinary approaches to address questions in systems neuroscience.

Kristen Carlson Maitland is an associate professor at Texas A&M University. She develops optical instrumentation for the detection and diagnosis of diseases, including infection and cancer. She has served on the Board of Directors of SPIE.

Laura Marcu is an American scientist and a professor of biomedical engineering and neurological surgery at the University of California, Davis. She is also a Fellow of numerous professional societies: the Biomedical Engineering Society, SPIE, The Optical Society and the National Academy of Inventors.

Nirmala "Nimmi" Ramanujam is the Robert W. Carr Professor of Biomedical Engineering, and a faculty member in the Global Health Institute and the Department of Pharmacology & Cell Biology at Duke University. She is the director of the Center of Global Women's Health Technologies (GWHT) and founder of Zenalux Biomedical Inc. and Calla Health. Ramanujam has spent the last two decades developing precision diagnostics and more recently precision therapeutics for breast and cervical cancer, with a focus on addressing global health disparities. She has more than 20 patents and over 150 publications for screening, diagnostic, and surgical applications, and has raised over $30M of funding to pursue these innovations through a variety of funding mechanisms, including NIH R01s and R21s, NIH Bioengineering Partnerships, NCI Academic Industry Partnerships, NIH Small Business grants and USAID funding. As the founding director of the Center for Global Women's Health Technologies at Duke University, she has developed a consortium of over 50+ partners including international academic institutions and hospitals, non-governmental organizations, ministries of health, and commercial partners; this consortium is working to ensure that the technologies developed at the center are adopted by cancer control programs in geographically and economically diverse healthcare settings.

<span class="mw-page-title-main">Christine P. Hendon</span> American electrical engineer and computer scientist

Christine P. Hendon is an electrical engineer and computer scientist and an associate professor in the Department of Electrical Engineering at Columbia University in New York City. Hendon is a pioneer in medical imaging. She develops biomedical optics technologies, using optical coherence tomography and near infrared spectroscopy systems, that enable physicians to perform guided interventional procedures and allow for structure-function dissection of human tissues and organs. Her advances in imaging technologies have led to improved diagnostic abilities and treatments for cardiac arrhythmias as well as breast cancer and preterm birth. She has been recognized for her development of optical imaging catheters for cardiac wall imaging by Forbes 30 under 30, the MIT Technology Review’s 35 Innovators Under 35, and by President Obama with the Presidential Early Career Awards in 2017.

Audrey K. Ellerbee Bowden is an American engineer and Dorothy J. Wingfield Phillips Chancellor's Faculty Fellow at Vanderbilt University, as well as an Associate Professor of Biomedical Engineering and Electrical Engineering. She is a Fellow of Optica, the American Institute for Medical and Biological Engineering and the International Society for Optics and Photonics (SPIE).

Stefan Andersson-Engels is a Swedish biophysicist specializing in the field of biophotonics. He is professor at University College Cork and the deputy director of the Irish Photonics Integration Center (IPIC) within the Science Foundation Ireland. Before joining University College Cork, he was Professor of Biomedical Engineering at Lund University. He has co-founded 3 biophotonics companies Spectracure, Lumito, BioPixS. He also co-founded biannual biophotonics summer school.

Melissa Caroline Skala is an American biomedical engineer who is a professor at the Morgridge Institute for Research. Her research considers photonics-based technologies for personalised medical therapies. She is a Fellow of The Optical Society, SPIE and American Institute for Medical and Biological Engineering.

Irene Georgakoudi is a Greek biophysicist and Professor of Biomedical Engineering at Tufts University, where her work focuses on developing non-invasive medical imaging techniques based on optical spectroscopy for applications in medical diagnostics and therapeutics.

Jennifer Kehlet Barton is an American biomedical engineer who is Director of the BIO5 Institute at the University of Arizona. Barton develops optical techniques for the detection and treatment of cancer.

Katarina Svanberg is a Swedish physician who is Professor and Chief Consultant of Oncology at the Skåne University Hospital. Her research considers the use of fluorescence-based tumour imaging and photodynamic therapy. She served as President of SPIE in 2011 and was awarded the SPIE Gold Medal in 2017.

<span class="mw-page-title-main">Igor Meglinski</span> British Biomedical Engineer, Biophotonics and Optical Physicist

Igor Meglinski is a scientist studying the imaging of cells and biological tissues utilising polarised light, dynamic light scattering and computational imitation of light propagation within complex tissue-like scattering medium. He is the Professor of Biomedical Engineering and Biophotonics at Aston University and holds the Professor of Opto-Electronics and Biophotonics at Oulu University.

References

  1. "Anita Mahadevan-Jansen, PhD – Beckman Laser Institute" . Retrieved 2019-08-11.
  2. "Anita Mahadevan-Jansen of Vanderbilt University elected to SPIE presidential chain".
  3. 1 2 3 4 5 "Anita Mahadevan-Jansen, Ph.D. 1996". UTexas. Retrieved 2019-08-11.
  4. 1 2 "Anita Mahadevan-Jansen - 2007 SPIE Women in Optics Planner". spie.org. Retrieved 2019-08-11.
  5. "Mahadevan-Jansen [1096] | Vanderbilt-Ingram Cancer Center". www.vicc.org. Retrieved 2019-08-11.
  6. Oldenburg, A. L.; Chen, Y.; Krapf, D.; Mahadevan-Jansen, A.; Rolland, J.; Tunnell, J. (2016). "Introduction to the Issue on Biophotonics". IEEE Journal of Selected Topics in Quantum Electronics. 22 (3): 4–6. Bibcode:2016IJSTQ..22....4O. doi:10.1109/JSTQE.2016.2562238. ISSN   1077-260X.
  7. "Bio". School of Engineering. Retrieved 2019-08-14.
  8. "Anita Mahadevan-Jansen". Vanderbilt Biophotonics Center. Retrieved 2019-08-11.
  9. "Engineering dean announces creation of Biophotonics Center at Vanderbilt". Vanderbilt University. Retrieved 2019-08-12.
  10. "Anita Mahadevan-Jansen". Vanderbilt Biophotonics Center. Retrieved 2019-08-14.
  11. 1 2 "Device in Use for Pre-term Birth". www.wsmv.com. Retrieved 2019-08-11.
  12. 1 2 "Biomedical Microscopy – Immersion, Innovation, Discovery (BioMIID) at VBC". Vanderbilt University. Retrieved 2019-08-14.
  13. "Engineers lead 6 of 10 'cool inventions' of 2014: CTTC". Vanderbilt University. Retrieved 2019-08-12.
  14. "Researchers' sensor integrates inflammatory bowel disease detection into colonoscopy procedure". Vanderbilt University. Retrieved 2019-08-12.
  15. "Bio". School of Engineering. Retrieved 2019-08-15.
  16. Mahadevan-Jansen, Anita; M.d, Peter E. Konrad; Jansen, E. Duco; M.d, Chris Kao; Wells, Jonathon D. (November 2005). "Application of infrared light for in vivo neural stimulation". Journal of Biomedical Optics. 10 (6): 064003. Bibcode:2005JBO....10f4003W. doi: 10.1117/1.2121772 . ISSN   1083-3668. PMID   16409069. S2CID   15714776.
  17. Roe, Anna Wang; Chen, Gang; Zhang, Xiaotong; Mahadevan-Jansen, Anita; Jansen, E. Duco; Cayce, Jonathan M.; Chernov, Mykyta M.; Sun, Yi; Song, Xuemei (2019-04-01). "Focal infrared neural stimulation with high-field functional MRI: A rapid way to map mesoscale brain connectomes". Science Advances. 5 (4): eaau7046. Bibcode:2019SciA....5.7046X. doi: 10.1126/sciadv.aau7046 . ISSN   2375-2548. PMC   6482007 . PMID   31032400.
  18. Cayce, Jonathan M.; Wells, Jonathon D.; Malphrus, Jonathan D.; Kao, Chris; Thomsen, Sharon; Tulipan, Noel B.; Konrad, Peter E.; Jansen, E. Duco; Mahadevan-Jansen, Anita (January 2015). "Infrared neural stimulation of human spinal nerve roots in vivo". Neurophotonics. 2 (1): 015007. doi:10.1117/1.NPh.2.1.015007. ISSN   2329-423X. PMC   4478764 . PMID   26157986.
  19. 1 2 3 "FDA approves device based on Vanderbilt invention to ID parathyroid during head and neck surgeries". Vanderbilt University. Retrieved 2019-08-12.
  20. Commissioner, Office of the (2019-02-13). "FDA permits marketing of two devices that detect parathyroid tissue in real-time during surgery". FDA. Retrieved 2019-08-15.
  21. 1 2 "Vanderbilt Biophotonics Center collaboration seeks earlier diagnosis of throat cancer". Vanderbilt University. Retrieved 2019-08-12.
  22. "Anita Mahadevan-Jansen - Google Scholar Citations". scholar.google.com. Retrieved 2019-08-15.
  23. "Conference Detail for Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry". spie.org. Retrieved 2019-08-15.
  24. "Anita Mahadevan-Jansen - 2007 SPIE Women in Optics Planner". spie.org. Retrieved 2019-08-15.
  25. "Equity, Diversity, and Inclusion Committee". spie.org. Retrieved 2019-08-12.
  26. "Anita Mahadevan-Jansen SPIE Profile". spie.org. Retrieved 2019-08-11.
  27. "Mahadevan-Jansen elected a director of international optics society". Vanderbilt University. Retrieved 2019-08-12.
  28. "Anita Mahadevan-Jansen Mahadevan-jansen Elected Chair of Gordon Research Conference - AIMBE" . Retrieved 2019-08-11.
  29. "OSA 2018 Fellows". osa.org.
  30. "Anita Mahadevan-Jansen, Ph.D. COF-1447 - AIMBE" . Retrieved 2019-08-12.
  31. "Video: Anita Mahadevan-Jansen on teaching and learning in biophotonics". spie.org. Retrieved 2019-08-15.
  32. "Professors Jansen: A story of life, love and research". Vanderbilt University. Retrieved 2019-08-15.