| Ankylosing vertebral hyperostosis with tylosis | |
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| Specialty | Medical genetics |
Ankylosing vertebral hyperostosis with tylosis is a rare autosomal dominant genetic disorder characterized by ossification of the paraspinal ligament, sclerosis of the sacroiliac joint, and punctate hyperkeratosis (affecting the soles and palms). [1] Some people with the condition are actually asymptomatic, which means they're relatively unaffected by it, the people who do show symptoms of it usually only show chronic/recurring back pain ranging from mild to moderate and, occasionally, obesity. [2] [3] It has only been described in 8 members of a 2-generation Greek Cypriot family. [4] [5] It is a type of dysostosis.
