Ann English

Last updated
Ann Marie English
Alma mater McGill University
University College Dublin
Known for Bioinorganic Chemistry
Mass Spectrometry
Scientific career
Institutions Concordia University
Thesis Spectral Studies on Group VIB Metal Chalcocarbonyls  (1980)
Doctoral advisor Ian S. Butler

Ann Marie English is an Irish Canadian scientist in bioinorganic chemistry and redox biology, recognized for her contribution to chemistry in Canada. [1]

Contents

Education

English received a BSc from University College Dubin in Ireland in 1971 and a PhD in Inorganic Chemistry from McGill University in Canada in 1980. [2]

Career

After graduation, English did post-doctoral research at California Institute of Technology as a research fellow in chemistry. [3] Under the direction of Harry B. Gray, she conducted research on electron transfer of copper proteins. [4] She began her academic career at Concordia University as assistant professor in 1982 [5] and was promoted to full professor in 1994. [2] Since 2018, she is Distinguished Professor Emerita and Honorary Concordia University Research Chair in the Department of Chemistry and Biochemistry at Concordia University. [6] She has mentored over 55 graduate students and 37 postdoctoral fellows and researchers. [7]

Her research field is in heme-protein chemistry and biochemistry, [8] [9] [10] including the effects of metal-induced oxidation on aging at the cellular level. [11] [12] [13] She has published over 130 peer-reviewed journal articles and book chapters. [14] With mass spectrometry being one of the techniques used in her research, [15] [16] [17] she established the Centre for Biological Applications of Mass Spectrometry in 2003. [7]

She was elected as Fellow of the Chemical Institute of Canada in 2014 [18] and Fellow of the Royal Society of Canada Academy of Science in 2024. [19] [20]

Awards

Related Research Articles

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A hemeprotein, or heme protein, is a protein that contains a heme prosthetic group. They are a very large class of metalloproteins. The heme group confers functionality, which can include oxygen carrying, oxygen reduction, electron transfer, and other processes. Heme is bound to the protein either covalently or noncovalently or both.

<span class="mw-page-title-main">Heme</span> Chemical coordination complex of an iron ion chelated to a porphyrin

Heme, or haem, is a ring-shaped iron-containing molecular component of hemoglobin, which is necessary to bind oxygen in the bloodstream. It is composed of four pyrrole rings with 2 vinyl and 2 propionic acid side chains. Heme is biosynthesized in both the bone marrow and the liver.

<span class="mw-page-title-main">Porphyrin</span> Heterocyclic organic compound with four modified pyrrole subunits

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<span class="mw-page-title-main">Cytochrome c peroxidase</span>

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<span class="mw-page-title-main">Ascorbate peroxidase</span> Enzyme

Ascorbate peroxidase (or L-ascorbate peroxidase, APX or APEX) (EC 1.11.1.11) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Protoporphyrin IX</span> Chemical compound

Protoporphyrin IX is an organic compound, classified as a porphyrin, that plays an important role in living organisms as a precursor to other critical compounds like heme (hemoglobin) and chlorophyll. It is a deeply colored solid that is not soluble in water. The name is often abbreviated as PPIX.

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Vicki Hopper Wysocki is an American scientist. She is a professor and the current chair of the School of Chemistry and Biochemistry at Georgia Tech

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Frances Ann Walker was an American chemist known for her work on heme protein chemistry. She was an elected fellow of the American Association for the Advancement of Science and the American Chemical Society.

References

  1. 1 2 "Clara Benson Award". The Chemical Institute of Canada. Retrieved 2025-01-02.
  2. 1 2 "Ann English - Concordia University". www.concordia.ca. Retrieved 2025-01-02.
  3. ↑ "INFORMATION FOR STUDENTS 1980-81" (PDF). CALIFORNIA INSTITUTE OF TECHNOLOGY. September 1980. Retrieved 2025-01-01.
  4. ↑ English, Ann M.; DeLaive, Patricia J.; Gray, Harry B.; Lum, Vanessa R. (1982-02-01). "Metalloprotein electron-transfer mechanisms. Quenching of electronically excited tris(2,2'-bipyridine)ruthenium(II) by reduced blue copper proteins". Journal of the American Chemical Society. 104 (3): 870–871. Bibcode:1982JAChS.104..870E. doi:10.1021/ja00367a047. ISSN   0002-7863.
  5. ↑ "A celebration of internal research awards - Concordia Journal - Concordia University - Montreal, Quebec, Canada". cjournal.concordia.ca. Retrieved 2025-01-02.
  6. ↑ "Faculty members - Concordia University". www.concordia.ca. Retrieved 2025-01-02.
  7. 1 2 Miller, Harry (2024-02-20). "Concordia's Ann English wins Lifetime Achievement Award for her seminal work in bioinorganic chemistry – Concordia University News". Canada News Media. Retrieved 2025-01-02.
  8. ↑ Smulevich, Giulietta; Mauro, J. Matthew; Fishel, Laurence A.; English, Ann M.; Kraut, Joseph; Spiro, Thomas G. (1988-07-01). "Heme pocket interactions in cytochrome c peroxidase studied by site-directed mutagenesis and resonance Raman spectroscopy". Biochemistry. 27 (15): 5477–5485. doi:10.1021/bi00415a014. ISSN   0006-2960. PMID   2846039.
  9. ↑ English, Ann M.; Tsaprailis, George (1995-01-01), Sykes, A. G. (ed.), Catalytic Structure–Function Relationships in Heme Peroxidases, Advances in Inorganic Chemistry, vol. 43, Academic Press, pp. 79–125, doi:10.1016/s0898-8838(08)60116-6, ISBN   978-0-12-023643-5 , retrieved 2025-01-02
  10. ↑ Shadrina, Maria S.; Laterreur, Julie; Peslherbe, Gilles H.; English, Ann M. (2024). "Hemoglobin's β-subunit is primed to synergize oxygen delivery with nitric oxide-mediated increased blood flow". Journal of Porphyrins and Phthalocyanines. 28 (6): 370–382. doi:10.1142/S1088424624500305. ISSN   1088-4246.
  11. ↑ "Unlocking the secrets of aging - Concordia University". www.concordia.ca. Retrieved 2025-01-02.
  12. ↑ Martins, Dorival; English, Ann M. (2012-11-01). "Cysteine 146 of CuZnSOD is Oxidized to Sulfonic Acid During Aging of Yeast: A Potential Mechanism Underlying Sporadic ALS Onset". Free Radical Biology and Medicine. SFRBM's 19th Annual Meeting: Program and Abstracts. 53: S126. doi:10.1016/j.freeradbiomed.2012.10.313. ISSN   0891-5849.
  13. ↑ English, Ann M (2010-01-01). "The Heme Peroxidase CCP is Released from Mitochondria during Chronological Aging of Yeast". Free Radical Biology and Medicine. SFRBM's 17th Annual Meeting: Program and Abstracts. 49: S79. doi:10.1016/j.freeradbiomed.2010.10.196. ISSN   0891-5849.
  14. ↑ "Ann English". scholar.google.com. Retrieved 2025-01-02.
  15. ↑ Jahangiri, Soran; Timerghazin, Qadir K.; Jiang, Heng; Peslherbe, Gilles H.; English, Ann M. (2018-06-01). "Dramatic CC bond activation on protonation of the persistent nitroxyl radical TEMPO". International Journal of Mass Spectrometry. Terry B. McMahon 70th Birthday Special Issue: Mass Spectrometry and its Application to the Physical Chemistry of Gaseous Ions. 429: 182–188. Bibcode:2018IJMSp.429..182J. doi:10.1016/j.ijms.2017.08.007. ISSN   1387-3806.
  16. ↑ Kathiresan, Meena; English, Ann M. (2017-01-30). "LC-MS/MS suggests that hole hopping in cytochrome c peroxidase protects its heme from oxidative modification by excess H2O2". Chemical Science. 8 (2): 1152–1162. doi:10.1039/C6SC03125K. ISSN   2041-6539. PMC   5369544 . PMID   28451256.
  17. ↑ Papp, Robert; Ekiel, Irena; English, Ann M (2003). "ESI-MS and FTIR studies of the interaction between the second PDZ domain of hPTP1E and target peptides". Biochemistry and Cell Biology. 81 (2): 71–80. doi:10.1139/o03-036. ISSN   0829-8211. PMID   12870871.
  18. ↑ "CIC Fellows" (PDF). Chemical Institute of Canada. Retrieved 2025-01-01.
  19. ↑ "Concordia celebrates a record year at the Royal Society of Canada - Concordia University". www.concordia.ca. Retrieved 2025-01-02.
  20. ↑ "ROYAL SOCIETY OF CANADA - CLASS OF 2024" (PDF). ROYAL SOCIETY OF CANADA. Retrieved 2025-01-01.
  21. ↑ "Society of Porphyrins & Phthalocyanines". www.icpp-spp.org. Retrieved 2025-01-02.
  22. ↑ "Lossing Award". csms.clientwebdev.com. Retrieved 2025-01-02.
  23. ↑ Oct 12; Finalists, 2018 | Outstanding Graduate Mentorship; Prizes. "Finalist – 2018 Award for Outstanding Graduate Mentorship – Dr. Ann English | CAGS | ACES" . Retrieved 2025-01-02.{{cite web}}: CS1 maint: numeric names: authors list (link)
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