Anna Marie Pyle

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Anna Marie Pyle
Alma materPrinceton University, Columbia University
Scientific career
InstitutionsYale University, University of Colorado

Anna Marie Pyle is an American academic who is a Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Chemistry at Yale University. and an Investigator for Howard Hughes Medical Institute. [1] Pyle is the president of the RNA Society, [2] the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section [3] at the National Institutes of Health.

Contents

Early life and education

Pyle grew up in Albuquerque, New Mexico, and it was there that she first became interested in science. [4] But it wasn't until after earning her bachelor's degree from Princeton University that she committed to a career in chemistry. [4] In 1990, she graduated from Columbia University with a Ph.D. in chemistry. Pyle went on to postdoc at the University of Colorado until in 1992 she established a research group at Columbia University Medical Center in the Department of Biochemistry and Molecular Biophysics. In 2002, she moved to Yale University. [1]

Research

Pyle joined Yale University in 2002. She researches the architectural features of large RNA molecules and RNA remodeling enzymes using experimental biochemistry and crystallography. such as self-splicing introns and other noncoding RNAs. She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA. Specifically, she was successful in crystallizing and solving the structure of a group IIC intron from the bacterium Oceanobacillus iheyensis [5] and moves through the stages of splicing. [6] Pyle's research may be helpful in drug development as RNA's tertiary structure could provide insight into druggable biomolecules. [7] [8]

Selected awards and honors

References

  1. 1 2 "Anna Marie Pyle, Ph.D. | Molecular, Cellular and Developmental Biology". mcdb.yale.edu. Retrieved 2019-03-01.
  2. ↑ "RNA Society" . Retrieved 2019-03-01.
  3. ↑ "MSFA | NIH Center for Scientific Review". public.csr.nih.gov. Retrieved 2019-03-01.
  4. 1 2 "2016 Annual Meeting Plenary Lecturer: Pyle". www.asbmb.org. Retrieved 2019-03-01.
  5. ↑ Toor, Navtej; Keating, Kevin S.; Fedorova, Olga; Rajashankar, Kanagalaghatta; Wang, Jimin; Pyle, Anna Marie (January 2010). "Tertiary architecture of the Oceanobacillus iheyensis group II intron". RNA. 16 (1): 57–69. doi:10.1261/rna.1844010. ISSN   1355-8382. PMC   2802037 . PMID   19952115.
  6. ↑ Pyle, A. M.; Marcia, M. (2012). "Visualizing Group II Intron Catalysis through the Stages of Splicing". Cell. 151 (3): 497–507. doi:10.2210/pdb4e8k/pdb. PMC   3628766 . PMID   23101623. Archived from the original on 2019-03-27. Retrieved 2019-03-01.
  7. ↑ "Targeting RNA's tertiary structure". Chemical & Engineering News. Retrieved 2019-03-01.
  8. ↑ Pyle, Anna Marie; Zandt, Michael C. Van; Lin Yuan; Adams, Rebecca L.; Jagdmann, G. Erik; Fedorova, Olga (December 2018). "Small molecules that target group II introns are potent antifungal agents". Nature Chemical Biology. 14 (12): 1073–1078. doi:10.1038/s41589-018-0142-0. ISSN   1552-4469. PMC   6239893 . PMID   30323219.
  9. ↑ "2023 NAS Election". National Academy of Sciences. 2023-05-02. Retrieved 2023-05-02.
  10. ↑ "Anna Marie Pyle appointed Sterling Professor". YaleNews. 2018-07-19. Retrieved 2019-03-01.
  11. ↑ "Historic Fellows". American Association for the Advancement of Science. Retrieved 2019-03-01.
  12. ↑ "Anna Marie Pyle". American Academy of Arts & Sciences. Retrieved 2019-03-01.
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