Anthony Dickenson | |
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Born | Anthony Henry Dickenson England, United Kingdom |
Alma mater | University of Reading |
Awards | FMedSci |
Scientific career | |
Fields | Neuropharmacology |
Institutions | University College London National Institute for Medical Research |
Doctoral advisor | Jean-Marie Besson |
Anthony Dickenson is a professor of neuropharmacology [1] at University College, London.
Tony Dickenson was appointed to the Department of Pharmacology at University College in 1983. He conducted research into the mechanisms of pain and how pain can be controlled in both normal and patho-physiological conditions and how to translate basic science to the patient.
Dickenson has supervised more than 20 completed PhD students as well as contributing to undergraduate science and medical teaching. He is a founding and continuing member of the London Pain Consortium, a Wellcome Trust Integrated Physiology Initiative, which funds a group of scientists in London and Oxford studying pain mechanisms and educating young scientists in this field. [2]
He has authored more than 330 refereed publications [3] including Science and Nature, edited three books and written many chapters. He has also been quoted in the media and in magazine articles as an expert on pain remediation.
At UCL, the focus of his group's research has been based on understanding the transmission and control of pain, how neuronal systems alter in pathophysiological states and how novel and licensed drugs produce their effects with the aim of translating the basic research into clinical applications.
Early studies described the neuronal basis of Diffuse Noxious Inhibitory controls (DNIC). Tony's group was also the first to show the NMDA receptor mediation of wind-up and its role in persistent pain. Continuing work on central hyperexcitability has been seminal in understanding of pain in animals and humans.
Studies include collaborations with Prof Frank Porreca of the Department of Pharmacology at the University of Arizona, investigating opioid pathways; collaborations with Prof John Wood of the Molecular Nociception Group, examining tissue specific deletion of targets and studies with Prof Annette Dolphin involving the role of voltage-dependent Ca2+ channels in pathological states.
The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS-funded scientists investigate how living systems work at a range of levels, from molecules and cells to tissues and organs, in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacity throughout the country.
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Sten Grillner is a Swedish neurophysiologist and distinguished professor at the Karolinska Institute's Nobel Institute for Neurophysiology in Stockholm where he is the director of that institute. He is considered one of the world's foremost experts in the cellular bases of motor behaviour. His research is focused on understanding the cellular bases of motor behaviour; in particular, he has shown how neuronal circuits in the spine help control rhythmic movements, such as those needed for locomotion. He is the current secretary general of the International Brain Research Organization (IBRO) and president of the Federation of European Neuroscience Societies (FENS). For his work, in 2008 he was awarded the $1 million Kavli Prize for deciphering the basic mechanisms which govern the development and functioning of the networks of cells in the brain and spinal cord. This prize distinguish the recipient from the Nobel prizes in basic medical sciences.
The wide dynamic range (WDR) neuron was first discovered by Mendell in 1966. Early studies of this neuron established what is known as the gate control theory of pain. The basic concept is that non-painful stimuli block the pathways for painful stimuli, inhibiting possible painful responses. This theory was supported by the fact that WDR neurons are responsible for responses to both painful and non-painful stimuli, and the idea that these neurons could not produce more than one of these responses simultaneously. WDR neurons respond to all types of somatosensory stimuli, make up the majority of the neurons found in the posterior grey column, and have the ability to produce long range responses including those responsible for pain and itch.
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