A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis. This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. Common examples of non-radioactive carcinogens are inhaled asbestos, certain dioxins, and tobacco smoke. Although the public generally associates carcinogenicity with synthetic chemicals, it is equally likely to arise from both natural and synthetic substances. Carcinogens are not necessarily immediately toxic; thus, their effect can be insidious.
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum. Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and fatigue. Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red meat, processed meat, and alcohol. Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. It typically starts as a benign tumor, often in the form of a polyp, which over time becomes cancerous.
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies. Immunotherapy is under preliminary research for its potential to treat various forms of cancer.
A public health journal is a scientific journal devoted to the field of public health, including epidemiology, biostatistics, and health care. Public health journals, like most scientific journals, are peer-reviewed. Public health journals are commonly published by health organizations and societies, such as the Bulletin of the World Health Organization or the Journal of Epidemiology and Community Health. Many others are published by a handful of large publishing corporations that includes Elsevier, Wolters Kluwer, Wiley-Blackwell, Springer Science+Business Media, and Informa, each of which has many imprints. Many societies partner with such corporations to handle the work of producing their journals.
The abortion–breast cancer hypothesis posits that having an induced abortion can increase the risk of getting breast cancer.This hypothesis is at odds with mainstream scientific opinion and is rejected by major medical professional organizations; despite this, it continues to be widely propagated as pseudoscience, typically in service of an anti-abortion agenda.
An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet.
Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and computational biology. The journal was established in 1974 by Benjamin Lewin and is published twice monthly by Cell Press, an imprint of Elsevier.
Houston Lee Moffitt Cancer Center & Research Institute is a nonprofit cancer treatment and research center located in Tampa, Florida. Established in 1981 by the Florida Legislature, the hospital opened in October 1986 on the University of South Florida's campus. Moffitt is one of two National Cancer Institute-designated Comprehensive Cancer Centers based in Florida. In 2021, U.S. News & World Report ranked Moffitt Cancer Center as a top 30 cancer hospital in the United States.
Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. Topics covered include immunology, inflammation, infectious disease, hematopoiesis, cancer, stem cells and vascular biology. The journal has no single editor-in-chief, but thirteen academic editors.
Cancer Science is a monthly peer-reviewed medical journal covering research in oncology, which is published by Wiley-Blackwell on behalf of the Japanese Cancer Association. Established in 1907, the journal publishes original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational, and clinical cancer research. The editor-in-chief is Kohei Miyazono. According to the Journal Citation Reports, the journal has a 2020 impact factor of 6.71, ranking it 50 out of 242 journals in the category "Oncology".
The Journal of Clinical Pathology (JCP) is a peer-reviewed medical journal covering all aspects of pathology, published by the BMJ Group and co-owned by the Association of Clinical Pathologists. Diagnostic and research areas covered include histopathology, virology, haematology, microbiology, cytopathology, chemical pathology, molecular pathology, forensic pathology, dermatopathology, neuropathology, and immunopathology. Each issue contains reviews, original articles, short reports, case reports, correspondence, and book reviews.
Oncogene is a peer-reviewed scientific journal published under the Nature Portfolio addressing cancer cell genetics and the structure and function of oncogenes. The journal has editorial office in London, England under the publishing company Springer Nature. The journal was established in 1987. An open access online-only sister journal, Oncogenesis, was established in 2012 by Douglas R. Green, who was then Oncogene's editor-in-chief.
Clinical Cancer Research is a peer-reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer, medical and hematological oncology, radiation therapy, pediatric oncology, pathology, surgical oncology, and clinical genetics. The applications of the disciplines of pharmacology, immunology, cell biology, and molecular genetics to intervention in human cancer are also included. One of the main interests of Clinical Cancer Research is on clinical trials that evaluate new treatments together with research on pharmacology and molecular alterations or biomarkers that predict response or resistance to treatment. Another priority for Clinical Cancer Research is laboratory and animal studies of new drugs as well as molecule-targeted agents with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of the malignant phenotype, and metastatic disease. The journal is published by the American Association for Cancer Research.
Cancer Epidemiology, Biomarkers & Prevention is a peer-reviewed medical journal devoted to research in the field of cancer epidemiology. Topics include descriptive, analytical, biochemical, and molecular epidemiology, the use of biomarkers to study the neoplastic and preneoplastic processes in humans, chemoprevention and other types of prevention trials, and the role of behavioral factors in cancer etiology and prevention. It is published by the American Association for Cancer Research and co-sponsored by the American Society of Preventive Oncology.
The European Journal of Cancer is a peer-reviewed medical journal devoted to cancer research on experimental oncology, clinical oncology, and on cancer epidemiology and prevention. It is the official journal of the European Organisation for Research and Treatment of Cancer (EORTC) and the European Society of Breast Cancer Specialists (EUSOMA). The editor-in-chief is Alexander M. M. Eggermont.
The Journal of the National Cancer Institute (JNCI) is a peer-reviewed medical journal covering research in oncology that was established in August 1940. It is published monthly by Oxford University Press and is edited by Patricia A. Ganz. It was merged with Cancer Treatment Reports in January 1988. JNCI used to be the official journal of the National Cancer Institute (NCI); however, in 1996, the NCI and JNCI agreed to grow apart. Over the next five years, JNCI became independent of the NCI.
Current Medicinal Chemistry is a peer-reviewed medical journal published by Bentham Science Publishers. The editor-in-chief is Atta-ur-Rahman, FRS. The journal covers developments in medicinal chemistry and rational drug design and publishes original research reports and review papers.
Big Pharma conspiracy theories are conspiracy theories which claim that the medical community in general and pharmaceutical companies in particular, especially large corporations, operate for sinister purposes and against the public good, that they conceal effective treatments, or even cause and worsen a wide range of diseases for the purpose of profitability, or for other nefarious reasons. Some theories have included the claim that natural alternative remedies to health problems are being suppressed, the claim that drugs for the treatment of HIV/AIDS are ineffective and harmful, the claim that a cure for all cancers has been discovered but hidden from the public, claims that COVID-19 vaccines are ineffective, and that alternative cures are available for COVID-19. In each case the conspiracy theorists have blamed pharmaceutical companies' search for profits. A range of authors have shown these claims to be false, though some of these authors nevertheless maintain that other criticisms of the pharmaceutical industry are legitimate.
Prostate Cancer and Prostatic Diseases is a quarterly peer-reviewed medical journal covering all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. It was established in 1997 with Roger Kirby as the founding editor, with Judd Moul becoming co-editor alongside Kirby in 2003. It is published by Springer Nature Publishing Group. The outgoing editor-in-chief is Stephen J. Freedland and will be replaced by Cosimo De Nunzio from 1 January 2022. According to the Journal Citation Reports, the journal has a 2020 impact factor of 5.554, ranking it 16th out of 90 journals in the category "Urology & Nephrology" and 77th out of 242 journals in the category "Oncology".
Anti-Cancer Agents in Medicinal Chemistry is a peer-reviewed academic journal covering the disciplines of medicinal chemistry and drug design relating to chemotherapeutic agents in cancer. It is published by Bentham Science Publishers and the editor-in-chief is Simone Carradori. The journal covers developments in "medicinal chemistry and rational drug design for the discovery of anti-cancer agents" and publishes original research reports and review papers.
