Antifungal protein

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Antifungal_prot
	solution structure of the antifungal protein from aspergillus giganteus. evidence for disulphide configurational isomerism
Identifiers
Symbol	Antifungal_prot
Pfam	PF11402
InterPro	IPR022706
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Last updated September 12, 2020

In molecular biology, proteins in the antifungal protein family consist of five antiparallel beta strands which are highly twisted creating a beta barrel stabilised by four internal disulphide bridges.^[1] A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid binding site.^[1]

Human Epithelium produce antifungal proteins.^[2] The proteins kill fungi by inducing apoptosis and/or forming pores on the cell membrane.^[2]

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References

1 2 Campos-Olivas R, Bruix M, Santoro J, Lacadena J, Martinez del Pozo A, Gavilanes JG, Rico M (March 1995). "NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism". Biochemistry. 34 (9): 3009–21. doi:10.1021/bi00009a032. PMID 7893713.
1 2 Hein, Kyaw Zaw; Takahashi, Hitoshi; Tsumori, Toshiko; Yasui, Yukihiko; Nanjoh, Yasuko; Toga, Tetsuo; Wu, Zhihong; Grötzinger, Joachim; Jung, Sascha (2015-10-20). "Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide". Proceedings of the National Academy of Sciences of the United States of America. 112 (42): 13039–13044. Bibcode:2015PNAS..11213039H. doi:10.1073/pnas.1511197112. ISSN 1091-6490. PMC 4620902 . PMID 26438863.

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[pmid7893713-1] 1 2 Campos-Olivas R, Bruix M, Santoro J, Lacadena J, Martinez del Pozo A, Gavilanes JG, Rico M (March 1995). "NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism". Biochemistry. 34 (9): 3009–21. doi:10.1021/bi00009a032. PMID 7893713.

[Hein_13039–13044-2] 1 2 Hein, Kyaw Zaw; Takahashi, Hitoshi; Tsumori, Toshiko; Yasui, Yukihiko; Nanjoh, Yasuko; Toga, Tetsuo; Wu, Zhihong; Grötzinger, Joachim; Jung, Sascha (2015-10-20). "Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide". Proceedings of the National Academy of Sciences of the United States of America. 112 (42): 13039–13044. Bibcode:2015PNAS..11213039H. doi:10.1073/pnas.1511197112. ISSN 1091-6490. PMC 4620902 . PMID 26438863.