Aristolochia longa | |
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Scientific classification | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Magnoliids |
Order: | Piperales |
Family: | Aristolochiaceae |
Genus: | Aristolochia |
Species: | A. longa |
Binomial name | |
Aristolochia longa | |
Aristolochia longa or long aristolochia is a species of pipevine.
Like all plants in the Aristolochia genus, Aristolochia longa contains aristolochic acid, a carcinogenic and nephrotoxic substance. [1]
Historically, plants within the Aristolochia genus were used to treat a wide variety of ailments. The fact that their use leads to kidney failure was only discovered in 1815. [2] Various species of Aristolochia including Aristolochia longa remain in use in some forms of traditional medicine. [3] Essential oil extracted from the roots of Aristolochia longa has various antimicrobial properties. [4]
According to one study conducted in Morocco, 63 cases of kidney poisoning were reported to the Antipoison and Pharmacovigilance Center of Morocco between 2011 and 2018, 76% of which were due to the consumption of Aristolochia longa, most often as part of an attempt to treat cancer through traditional medicine. [5]
Ginger is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. It is a herbaceous perennial which grows annual pseudostems about one meter tall, bearing narrow leaf blades. The inflorescences bear flowers having pale yellow petals with purple edges, and arise directly from the rhizome on separate shoots.
Vancomycin is a glycopeptide antibiotic medication used to treat a number of bacterial infections. It is used intravenously as a treatment for complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus. Blood levels may be measured to determine the correct dose. Vancomycin is also taken orally as a treatment for severe Clostridium difficile colitis. When taken orally it is poorly absorbed.
Gentamicin is an antibiotic used to treat several types of bacterial infections. This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. It is not effective for gonorrhea or chlamydia infections. It can be given intravenously, by intramuscular injection, or topically. Topical formulations may be used in burns or for infections of the outside of the eye. It is often only used for two days until bacterial cultures determine what specific antibiotics the infection is sensitive to. The dose required should be monitored by blood testing.
Aristolochic acids are a family of carcinogenic, mutagenic, and nephrotoxic phytochemicals commonly found in the flowering plant family Aristolochiaceae (birthworts). Aristolochic acid (AA) I is the most abundant one. The family Aristolochiaceae includes the genera Aristolochia and Asarum, which are commonly used in Chinese herbal medicine. Although these compounds are widely associated with kidney problems, liver and urothelial cancers, the use of AA-containing plants for medicinal purposes has a long history. The FDA has issued warnings regarding consumption of AA-containing supplements.
Asarum is a genus of plants in the birthwort family Aristolochiaceae, commonly known as wild ginger.
Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter. It comes in two forms: colistimethate sodium can be injected into a vein, injected into a muscle, or inhaled, and colistin sulfate is mainly applied to the skin or taken by mouth. Colistimethate sodium is a prodrug; it is produced by the reaction of colistin with formaldehyde and sodium bisulfite, which leads to the addition of a sulfomethyl group to the primary amines of colistin. Colistimethate sodium is less toxic than colistin when administered parenterally. In aqueous solutions it undergoes hydrolysis to form a complex mixture of partially sulfomethylated derivatives, as well as colistin. Resistance to colistin began to appear as of 2015.
Aristolochia is a large plant genus with over 500 species that is the type genus of the family Aristolochiaceae. Its members are commonly known as birthwort, pipevine or Dutchman's pipe and are widespread and occur in the most diverse climates. Some species, like A. utriformis and A. westlandii, are threatened with extinction.
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. There are various forms, and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius that is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas.
Aristolochia californica, the California pipevine, California Dutchman's-pipe, or California snakeroot is a perennial woody vine of western North America.
Balkan endemic nephropathy (BEN) is a form of interstitial nephritis causing kidney failure. It was first identified in the 1920s among several small, discrete communities along the Danube River and its major tributaries, in the modern countries of Croatia, Bosnia and Herzegovina, Serbia, Kosovo, Romania, and Bulgaria. It is caused by small long-term doses of aristolochic acid in the diet. The disease primarily affects people 30 to 60 years of age. Doses of the toxin are usually low and people moving to endemic areas typically develop the condition only when they have lived there for 10–20 years. People taking higher doses of aristolochic acid have developed kidney failure after shorter durations of exposure.
Aristolochia clematitis, the (European) birthwort, is a twining herbaceous plant in the family Aristolochiaceae, which is native to Europe. The leaves are heart shaped and the flowers are pale yellow and tubular in form. The plant seeks light by ascending the stems of surrounding plants.
Aristolochia rotunda, commonly known as smearwort or round-leaved birthwort, is a herbaceous perennial plant native to Southern Europe.
Aristolochia grandiflora, the pelican flower, is a deciduous vine with one of the world's largest flowers that emits an odor that smells like rotting meat, attracting flies.
Aristolochia indica is a creeper plant found in Southern India and also Sri Lanka. It Is known as 'sapsada' in Sri Lanka and is critical to the survival of the southern birdwing and common birdwing, as well as crimson and common rose butterflies. It reaches a height of several metres on trees and cover the branches with thick foliage. It is commonly found in forest floor, rocky hillslopes. It flowers once a year to produce seeds. It can also be propagated by roots. The plant has a number of historical medicinal uses.
Aristolochia didyma, or yawar panga is a plant found in South America of the genus Aristolochia. It is a powerful purgative, sometimes used in traditional rites to purify the body a few days before an Ayahuasca session.
Aristolochia chilensis, known locally as orejas de zorro, is a herbaceous perennial plant native to Chile.
Aristolochia contorta, commonly known as northern pipevine, also known as birthwort, is a climbing perennial shrub.
Aristolochia paucinervis is a herbaceous plant in the family Aristolochiaceae endemic to the western Mediterranean Basin.