Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types of arthritis, other organs are also affected. Onset can be gradual or sudden.
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. The disease may also affect other parts of the body, including skin, eyes, lungs, heart, nerves, and blood. This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often, symptoms come on gradually over weeks to months.
Rheumatology is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones, muscles, joints, and internal organs. Rheumatology covers more than 100 different complex diseases, collectively known as rheumatic diseases, which includes many forms of arthritis as well as lupus and Sjögren's syndrome. Doctors who have undergone formal training in rheumatology are called rheumatologists.
Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease. It can be given by mouth or by injection.
Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including arthritis and "non-articular rheumatism", also known as "regional pain syndrome" or "soft tissue rheumatism". There is a close overlap between the term soft tissue disorder and rheumatism. Sometimes the term "soft tissue rheumatic disorders" is used to describe these conditions.
Juvenile idiopathic arthritis (JIA), formerly known as juvenile rheumatoid arthritis (JRA), is the most common chronic rheumatic disease of childhood, affecting approximately 3.8 to 400 out of 100,000 children. Juvenile, in this context, refers to disease onset before 16 years of age, while idiopathic refers to a condition with no defined cause, and arthritis is inflammation within the joint.
Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, cytokine release syndrome, COVID‑19, and systemic sclerosis-associated interstitial lung disease (SSc-ILD). It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer. Tocilizumab was jointly developed by Osaka University and Chugai, and was licensed in 2003 by Hoffmann-La Roche.
The Crohn's & Colitis Foundation is a volunteer fueled non-profit organization in the US that works to fund research to find cures for Crohn's disease and ulcerative colitis, collectively known as inflammatory bowel disease (IBD), and to improve the quality of life of children and adults affected by these digestive diseases. Founded by Shelby and William Modell, Suzanne and Irwin Rosenthal, and Dr. Henry Janowitz, it was launched publicly on September 12, 1967, as the National Foundation for Ileitis and Colitis. It was incorporated on December 17, 1965. The Foundation serves millions of patients diagnosed with IBD in the U.S., through its national headquarters in NYC, and more than 30 chapters nationwide.
Childhood arthritis is an umbrella term used to describe any rheumatic disease or chronic arthritis-related condition which affects individuals under the age of 16. There are several subtypes that differentiate themselves via prognosis, complications, and treatments. Most types are autoimmune disorders, where an individual's immune system may attack its own healthy tissues and cells.
Allen Caruthers Steere is an American rheumatologist. He is a professor of rheumatology at Harvard University and previously at Tufts University and Yale University. Steere and his mentor, Stephen Malawista of Yale University, are credited with discovering and naming Lyme disease, and he has published almost 300 scholarly articles on Lyme disease during his more than 40 years of studies of this infection. At a ceremony in Hartford, Connecticut in 1998, Governor John G. Rowland declared September 24 to be "Allen C. Steere Day".
The American College of Rheumatology is an organization of and for physicians, health professionals, and scientists that advances rheumatology through programs of education, research, advocacy and practice support relating to the care of people with arthritis and rheumatic and musculoskeletal diseases.
Michael D. Lockshin is an American professor and medical researcher. He is known for his work as a researcher of autoimmune diseases, with focus on antiphospholipid syndrome and lupus. He is Professor Emeritus of Medicine and the Director Emeritus of the Barbara Volcker Center for Women and Rheumatic Disease at Hospital for Special Surgery. He retired from HSS on January 31, 2023.
Arthritis of the knee is typically a particularly debilitating form of arthritis. The knee may become affected by almost any form of arthritis.
Systemic-onset juvenile idiopathic arthritis (sJIA), also known as Still disease, Still's disease, and systemic juvenile idiopathic arthritis, is a subtype of juvenile idiopathic arthritis (JIA) that is distinguished by arthritis, a characteristic erythematous skin rash, and remitting fever. Fever is a common symptom in patients with sJIA, characterized by sudden temperature rise above 39 °C and then a sudden drop. Over 80% of patients have a salmon-colored macular or maculopapular rash, which can be migratory and nonpruritic. Arthritis can develop weeks, months, or even years after onset and can affect various joints. SJIA is characterized by splenic and lymph node enlargements, with prominent symmetrical lymphadenopathy. Pericardial involvement is common, with 81% of children with active systemic symptoms having abnormal echocardiographic findings and 36% having an effusion or pericardial thickening. Around one-third of children with sJIA have occult macrophage activation syndrome (MAS), a potentially fatal illness causing T cells and macrophages to rapidly multiply and activate, resulting in a "cytokine storm."
Arthritis Australia is a charitable not-for-profit organisation advocating for people with arthritis and musculoskeletal conditions.
Terri H. Finkel is an American pediatric rheumatologist and immunologist who is the Children's Foundation of Memphis Endowed Chair and tenured professor of pediatrics at the University of Tennessee Health Science Center and St. Jude Children's Research Hospital. Previously, she was the pediatrician-in-chief, chair of pediatrics and chief scientific officer at Nemours Children's Hospital. She is known for her research into autoimmunity, AIDS, juvenile rheumatoid arthritis, lupus, and cancer. Her work has been recognized in more than 200 publications, 10 U.S. patents, and 4 licensed technologies. Finkel has been placed in the top one percent of American pediatric rheumatologists by U.S. News & World Report. Her numerous honors include being named among America's Top Doctors by Castle Connolly every year since 2011 and induction into the Colorado Women's Hall of Fame in 1996.
International League of Associations of Rheumatology (ILAR) is an international body of the associations of Rheumatologists from around the world. It comprises partner organisations PANLAR, Pan American League of Associations for Rheumatology, EULAR, European League against Rheumatism, APLAR, Asia Pacific League of Associations of Rheumatology and AFLAR, African League of Associations for Rheumatology. ILAR has taken leadership in the development of global consensus on the diagnosis of rheumatological diseases especially juvenile idiopathic arthritis It published the ILAR Journal.
Dafna D. Gladman is a Canadian doctor and medical researcher working in the fields of psoriatic arthritis, systemic lupus erythematosus, and rheumatoid arthritis. She is a professor at the University of Toronto Faculty of Medicine and Senior Scientist at the Krembil Research Institute. She is Deputy Director, Centre for Prognosis Studies in the Rheumatic Diseases, Co-Director, Lupus Clinic, Toronto Western Hospital (TWH) and Director, Psoriatic Arthritis Program, Toronto Western Hospital.
Ross E. Petty is a Canadian pediatric rheumatologist. He is a professor emeritus in the Department of Pediatrics at the University of British Columbia and a pediatric rheumatologist at BC Children’s Hospital in Vancouver, Canada. He established Canada’s first formal pediatric rheumatology program at the University of Manitoba in 1976, and three years later, he founded a similar program at the University of British Columbia.
Michelle Leech is the Deputy Dean of Medicine at Monash University and an academic clinician-scientist. Leech oversees the delivery of the Monash medical program and maintains an active research profile and clinical practice as a rheumatologist.
