Artificial iris

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An artificial iris is an intraocular implant (implant inside the eye) that is used as both a cosmetic and to treat those with aniridia (missing or damaged irises) or other eye trauma. [1] People with this condition experience photophobia, or increased sensitivity to light. [2] The artificial iris, made from silicone, acts as a replacement iris. The artificial iris is implanted in the eye using different surgery techniques depending on the patient's eye trauma. Most of the major artificial iris manufacturers are European and the treatment is used sparingly in the United States because of limited FDA approval, in part due to possibility of vision loss and other risks. [3]

Contents

Medical function

The iris controls how much light enters the eye, so if a person has a damaged iris or lacks an iris (aniridia), they can experience large amounts of glare from normal daylight. [4] They may also have other visual disturbances such as seeing arcs or halos. Implanting an artificial iris allows the patient's eye to regulate light. After implantation, patients saw an improvement in overall visual acuity, contrast sensitivity, depth of focus, and a decrease in perceived glare. [5]

The artificial iris treats those who were born with aniridia or who have experienced eye trauma that lead to a damaged iris, such as a complication from eye surgeries like ruptured globe repair. It is only recommended to get surgical implants if the patient has aphakic (absence of lens) or pseudophakic (artificial lens) eyes. The artificial iris is an alternative to eyepatches, sunglasses, or blackout contact lenses. [6]

Cosmetic function

Artificial irises may be implanted into people with healthy eyes to change their eye color. These cosmetic irises are marketed as an alternative to cosmetic contact lenses. Cosmetic implants are criticized by ophthalmologists as they can lead to vision loss in healthy eyes. [3]

Use

Each artificial iris is custom-made for the patient's eye, using an image of their undamaged iris, or any other iris as reference. [7] [6] Artificial irises are made from silicone or other polymer matrix composites into a disk shape with a hole in the middle. Encased inside, is the color design. Before implantation, the iris' size is adjusted to fit the eye. The implants can be made with a tough fiber mesh so that they can be sewn onto a damaged iris. When there is no iris to attach to, the implants are made without the mesh to be more flexible to adapt to the eye's shape. [6] [7]

The artificial iris is implanted in the area of the eye behind the iris and in front of the ciliary body (what focuses your eye) in an area called the ciliary sulcus. Multiple techniques can be used to implant artificial irises that involve the use of forceps, injector systems, and suturing. [2] The artificial iris is folded and placed in a cartridge on the side of the injector that is then injected into the ciliary sulcus like a syringe. [8] All operations are performed with the patient under general anesthesia. [2]

Segment-shaped artificial iris implantation

When only part of the iris is damaged, surgeons cut the artificial iris into a segment that covers the damaged area. The segment is folded and inserted into a clear corneal incision using an injector or forceps. That segment is then unfolded and sutured to the damaged iris. [2] [9]

Complete artificial iris implantation

When the patient has complete aniridia, the artificial iris can be folded and inserted through a corneal or scleral incision via an injector system or forceps. After the iris is unfolded, it does not need to be sutured. This version of the artificial iris is more flexible and will adapt to the shape of the eye. [9]

Complications

Artificial Iris as a Silicone Oil Diaphragm

To prevent hemorrhaging of the eye, ophthalmologists use silicone oil as a tamponade (block bleeding). The oil surrounds the eye and it is viscous enough to prevent bleeding. [11] Some patients who have eye trauma require a long-term silicone oil tamponade. To prevent the silicone oil from touching the cornea and causing corneal dystrophy, a diaphragm made of polymethylacrylate (PMMA) is installed to seal the area around the cornea. [12] For patients needing a long-term silicone oil tamponade, it is possible to implant an artificial iris that will act as this diaphragm while also appearing as a natural iris. [7] However, if the patient's eyes are hypotonic (have low pressure), there is still a chance of silicone oil breaching the diaphragm. [5]

History

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References

  1. ↑ Shahreef, Farah J. (April 2016). "Engineering a Light-Attenuating Artificial Iris". iovs.arvojournals.org. Retrieved 2023-10-17.
  2. 1 2 3 4 Mayer, Christian; Tandogan, Tamer; Hoffmann, Andrea E.; Khoramnia, Ramin (2017-06-01). "Artificial iris implantation in various iris defects and lens conditions". Journal of Cataract & Refractive Surgery. 43 (6): 724–731. doi: 10.1016/j.jcrs.2017.06.003 . ISSN   0886-3350.
  3. 1 2 Charters, Lynda (2022-04-30). "Cosmetic iris implants pose high risk of vision loss". MJH Life Sciences. Retrieved 2024-06-29.
  4. ↑ Galehouse, Maggie (2019-06-03). "Building a durable, flexible iris". TMC News. Retrieved 2023-10-24.
  5. 1 2 3 4 Rickmann, Annekatrin; Szurman, Peter; Januschowski, Kai; Waizel, Maria; Spitzer, Martin S.; Boden, Karl T.; Szurman, Gesine B. (2016-07-01). "Long-term results after artificial iris implantation in patients with aniridia". Graefe's Archive for Clinical and Experimental Ophthalmology. 254 (7): 1419–1424. doi:10.1007/s00417-016-3292-3. ISSN   1435-702X.
  6. 1 2 3 "The Artificial Iris: Technically Challenging and Unusually Rewarding". American Academy of Ophthalmology. 2022-05-01. Retrieved 2023-10-24.
  7. 1 2 3 4 Szurman, P.; Jaissle, G. (2011-08-01). "Künstliche Iris". Der Ophthalmologe (in German). 108 (8): 720–727. doi:10.1007/s00347-011-2367-0. ISSN   1433-0423.
  8. ↑ Sugiura, Takeshi; Kaji, Yuichi; Tanaka, Yoshikazu (2019-06-01). "Ciliary sulcus suture fixation of intraocular lens using an auxiliary device". Journal of Cataract & Refractive Surgery. 45 (6): 711–718. doi: 10.1016/j.jcrs.2019.01.021 . ISSN   0886-3350.
  9. 1 2 Pfeifer, Vladimir; Marzidovšek, Miha; Lužnik, Zala (2022), Alió, Jorge L.; Dick, H. Burkhard; Osher, Robert H. (eds.), "Artificial Iris Implantation: Overview of Surgical Techniques", Cataract Surgery : Advanced Techniques for Complex and Complicated Cases, Essentials in Ophthalmology, Cham: Springer International Publishing, pp. 321–338, doi:10.1007/978-3-030-94530-5_29, ISBN   978-3-030-94530-5 , retrieved 2023-10-24
  10. ↑ Mayer, Christian S.; Laubichler, Andrea E.; Khoramnia, Ramin; Tandogan, Tamer; Prahs, Philipp; Zapp, Daniel; Reznicek, Lukas (2018-09-23). "Challenges and Complication Management in Novel Artificial Iris Implantation". Journal of Ophthalmology. 2018: e3262068. doi: 10.1155/2018/3262068 . ISSN   2090-004X.
  11. ↑ Ophthalmologists & Retina Specialists of Vitreous Retina Macula Consultants of New York. "Silicone Oil". Vitreous Retina Macula Consultants of New York. Retrieved 2023-11-07.
  12. ↑ Heimann, K; Konen, W (1992-01-01). "Artificial iris diaphragm and silicone oil surgery". Retina (Philadelphia, Pa.). 12 (3 Suppl): S90–4. doi:10.1097/00006982-199212031-00019. ISSN   1539-2864. PMID   1455092.
  13. 1 2 Pfeifer, Vladimir; Marzidovšek, Miha; Lužnik, Zala (2022), Alió, Jorge L.; Dick, H. Burkhard; Osher, Robert H. (eds.), "Artificial Iris Implantation: Overview of Surgical Techniques", Cataract Surgery : Advanced Techniques for Complex and Complicated Cases, Essentials in Ophthalmology, Cham: Springer International Publishing, pp. 321–338, doi:10.1007/978-3-030-94530-5_29, ISBN   978-3-030-94530-5 , retrieved 2023-11-09
  14. 1 2 3 4 13 Iris Prosthesis Implantation (2019 ed.). Thieme Verlag. 2019. doi:10.1055/b-0039-172073?update=true&ersessiontoken=mzkx2fqerwp6kgo6cxuouj3nxxemsx2fj3xxx2fj-18x2dpg7ppo5x2bkxojrrz45h82sgx3dx3dtsffokvradvwuoth7n4o5gx3dx3d-d4x2frgr0sqp5kuk8uh7xqkwx3dx3d-6gokcciajjgorkjfx2vu8gx3dx3d#. ISBN   978-1-68420-097-9.
  15. ↑ "FDA clears first artificial iris by HumanOptics". American Academy of Ophthalmology. 2018-06-04. Retrieved 2023-11-09.
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