BACE1-AS

BACE1-AS
Identifiers
Aliases	BACE1-AS , BACE1 antisense RNA, BACE1-AS1, FJ573250, NCRNA00177
External IDs	OMIM: 614263; GeneCards: BACE1-AS; OMA:BACE1-AS - orthologs
Orthologs Species Human Mouse Entrez 100379571 n/a Ensembl ENSG00000278768 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
View/Edit Human

BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease. ^[2] BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.

Knocking down BACE1-AS reduces amyloid production and plaque deposition. ^[3]

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C (2008). "Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". Nat Med. 14 (7): 723–730. doi:10.1038/nm1784. PMC   2826895 . PMID   18587408.
3. Modarresi F, Faghihi MA, Patel NS, Sahagan BG, Wahlestedt C, Lopez-Toledano MA (2011). "Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis". Int. J. Alzheimer's Dis. 2011 929042. doi: 10.4061/2011/929042 . PMC   3139208 . PMID   21785702.

External links

• Human BACE1-AS genome location and BACE1-AS gene details page in the UCSC Genome Browser .