BPY2

BPY2
Identifiers
Aliases	BPY2 , BPY2A, VCY2, VCY2A, basic charge, Y-linked, 2, basic charge Y-linked 2
External IDs	OMIM: 400013 GeneCards: BPY2
Gene location (Human)
Chr.	Y chromosome (human)
End	23,005,465 bp
Gene ontology
Molecular function	• GO:0001948 protein binding ; • HECT domain binding ;
Cellular component	• cell nucleus ;
Biological process	• spermatogenesis ; • single fertilization ;
	Sources:Amigo / QuickGO
Orthologs
	9083
	n/a
	ENSG00000183753
	n/a
	O14599
	n/a
	NM_004678
	n/a
	NP_001002760
	n/a
	Wikidata
View/Edit Human

Last updated December 31, 2020

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.^[3]

Function

This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palindromic region.^[4]

Related Research Articles

Azoospermia factor (AZF) refers to one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa, AZFb and AZFc. AZF microdeletions are one of the major causes of male infertility for azoospermia and severe oligozoospermia males. AZF is the term used by the HUGO Gene Nomenclature Committee.

USP26 is a peptidase enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26. The USP26 gene is found at Xq26.2 on the X-chromosome as a single exon. The enzyme that this gene encodes comprises 913 amino acid residues and it is 104 kilodalton in size, which is transcribed from a sequence of 2794 nucleotide base-pairs on the X-chromosome. The USP26 enzyme is a deubiquitinating enzyme that places a very significant role in the regulation of protein turnover during spermatogenesis. It is a testis-specific enzyme that is solely express in spermatogonia and can prevent the degradation of ubiquitinated USP26 substrates.

Deleted in azoospermia 1, also known as DAZ1, is a protein which in humans is encoded by the DAZ1 gene.

Ubiquitin specific peptidase 9, Y-linked , also known as USP9Y, is an enzyme which in humans is encoded by the USP9Y gene. It is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene.

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.

Deleted in azoospermia protein 2 is a protein that in humans is encoded by the DAZ2 gene.

E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.

Testis-specific chromodomain protein Y 1 is a protein that in humans is encoded by the CDY1 gene.

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.

Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene.

E3 ubiquitin-protein ligase UBR2 is an enzyme that in humans is encoded by the UBR2 gene.

Sperm protein associated with the nucleus on the X chromosome A is a protein that in humans is encoded by the SPANXA1 gene.

UDP-N-acetylhexosamine pyrophosphorylase is an enzyme that in humans is encoded by the UAP1 gene.

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.

Y-box-binding protein 2 is a protein that in humans is encoded by the YBX2 gene.

Eppin is a protein that in humans is encoded by the SPINLW1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183753 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.
↑ "Entrez Gene: RPS4Y1 ribosomal protein S4, Y-linked 1".

External links

Human BPY2 genome location and BPY2 gene details page in the UCSC Genome Browser .

Repping S, van Daalen SK, Korver CM, et al. (2004). "A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region". Genomics. 83 (6): 1046–52. doi:10.1016/j.ygeno.2003.12.018. PMID 15177557.
Tse JY, Wong EY, Cheung AN, et al. (2003). "Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility". Biol. Reprod. 69 (3): 746–51. doi: 10.1095/biolreprod.103.015792 . PMID 12724276.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi: 10.1038/nature01722 . PMID 12815422.
Choi J, Koh E, Suzuki H, et al. (2007). "Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype". Int. J. Urol. 14 (5): 431–5. doi:10.1111/j.1442-2042.2007.01741.x. PMID 17511727.
Yang Y, Ma M, Li L, et al. (2009). "Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population". International Journal of Andrology. 33 (5): 745–54. doi: 10.1111/j.1365-2605.2009.01015.x . PMID 20039973.
Wong EY, Tse JY, Yao KM, et al. (2004). "Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein". Biol. Reprod. 70 (3): 775–84. doi: 10.1095/biolreprod.103.018531 . PMID 14627543.
Wong EY, Tse JY, Yao KM, et al. (2002). "VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A". Biochem. Biophys. Res. Commun. 296 (5): 1104–11. doi:10.1016/S0006-291X(02)02040-5. PMID 12207887.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183753 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9381176-3] Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.

[entrez_9083-4] "Entrez Gene: RPS4Y1 ribosomal protein S4, Y-linked 1".

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BPY2

Contents

Function

Related Research Articles

References

External links

Further reading