Bayesian estimation of templates in computational anatomy

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Statistical shape analysis and statistical shape theory in computational anatomy (CA) is performed relative to templates, therefore it is a local theory of statistics on shape. Template estimation in computational anatomy from populations of observations is a fundamental operation ubiquitous to the discipline. Several methods for template estimation based on Bayesian probability and statistics in the random orbit model of CA have emerged for submanifolds [1] [2] and dense image volumes. [3]

Contents

The deformable template model of shapes and forms via diffeomorphic group actions

Linear algebra is one of the central tools to modern engineering. Central to linear algebra is the notion of an orbit of vectors, with the matrices forming groups (matrices with inverses and identity) which act on the vectors. In linear algebra the equations describing the orbit elements the vectors are linear in the vectors being acted upon by the matrices. In computational anatomy the space of all shapes and forms is modeled as an orbit similar to the vectors in linear-algebra, however the groups do not act linear as the matrices do, and the shapes and forms are not additive. In computational anatomy addition is essentially replaced by the law of composition.

The central group acting CA defined on volumes in are the diffeomorphisms which are mappings with 3-components , law of composition of functions , with inverse .

Groups and group are familiar to the Engineering community with the universal popularization and standardization of linear algebra as a basic model

A popular group action is on scalar images, , with action on the right via the inverse.

For sub-manifolds , parametrized by a chart or immersion , the diffeomorphic action the flow of the position

Several group actions in computational anatomy have been defined.

Geodesic positioning via the Riemannian exponential

For the study of deformable shape in CA, a more general diffeomorphism group has been the group of choice, which is the infinite dimensional analogue. The high-dimensional diffeomorphism groups used in computational anatomy are generated via smooth flows which satisfy the Lagrangian and Eulerian specification of the flow fields satisfying the ordinary differential equation:

Showing the Lagrangian flow of coordinates
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with associated vector fields
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{\displaystyle v_{t},t\in [0,1]}
satisfying ordinary differential equation
ph
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t
=
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,
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{\displaystyle {\dot {\phi }}_{t}=v_{t}(\phi _{t}),\phi _{0}=id}
. Lagrangian flow.png
Showing the Lagrangian flow of coordinates with associated vector fields satisfying ordinary differential equation .

with the vector fields on termed the Eulerian velocity of the particles at position of the flow. The vector fields are functions in a function space, modelled as a smooth Hilbert space with the vector fields having 1-continuous derivative . For , with the inverse for the flow given by

and the Jacobian matrix for flows in given as

Flows were first introduced [4] [5] for large deformations in image matching; is the instantaneous velocity of particle at time . with the vector fields termed the Eulerian velocity of the particles at position of the flow. The modelling approach used in CA enforces a continuous differentiability condition on the vector fields by modelling the space of vector fields as a reproducing kernel Hilbert space (RKHS), with the norm defined by a 1-1, differential operator, Green's inverse . The norm according to where for a generalized function or distribution, then . Since is a differential operator, finiteness of the norm-square includes derivatives from the differential operator implying smoothness of the vector fields.

To ensure smooth flows of diffeomorphisms with inverse, the vector fields must be at least 1-time continuously differentiable in space [6] [7] which are modelled as elements of the Hilbert space using the Sobolev embedding theorems so that each element has 3-square-integrable derivatives. Thus embed smoothly in 1-time continuously differentiable functions. [6] [7] The diffeomorphism group are flows with vector fields absolutely integrable in Sobolev norm:

The Bayes model of computational anatomy

The central statistical model of computational anatomy in the context of medical imaging is the source-channel model of Shannon theory; [8] [9] [10] the source is the deformable template of images , the channel outputs are the imaging sensors with observables . The variation in the anatomical configurations are modelled separately from the Medical imaging modalities Computed Axial Tomography machine, MRI machine, PET machine, and others. The Bayes theory models the prior on the source of images on , and the conditional density on the observable imagery , conditioned on . For images with diffeomorphism group action , then the prior on the group induces the prior on images , written as densities the log-posterior takes the form

Maximum a posteriori estimation (MAP) estimation is central to modern statistical theory. Parameters of interest take many forms including (i) disease type such as neurodegenerative or neurodevelopmental diseases, (ii) structure type such as cortical or subcortical structures in problems associated to segmentation of images, and (iii) template reconstruction from populations. Given the observed image , MAP estimation maximizes the posterior:

Shown are shape templates of amygdala, hippocampus, and ventricle generated from 754 ADNI samples` Top panel denotes the localized surface area group differences between normal aging and Alzheimer disease (positive represents atrophy in Alzheimer whereas negative suggests expansion). Bottom panel denotes the group differences in the annualized rates of change in the localized surface areas (positive represents faster atrophy rates (or slower expansion rates) in Alzheimer whereas negative suggests faster expansion rates (or slower atrophy rates) in Alzheimer); taken from Tang et al. Xiaoying Tang ADNI template.png
Shown are shape templates of amygdala, hippocampus, and ventricle generated from 754 ADNI samples` Top panel denotes the localized surface area group differences between normal aging and Alzheimer disease (positive represents atrophy in Alzheimer whereas negative suggests expansion). Bottom panel denotes the group differences in the annualized rates of change in the localized surface areas (positive represents faster atrophy rates (or slower expansion rates) in Alzheimer whereas negative suggests faster expansion rates (or slower atrophy rates) in Alzheimer); taken from Tang et al.

This requires computation of the conditional probabilities . The multiple atlas orbit model randomizes over the denumerable set of atlases . The model on images in the orbit take the form of a multi-modal mixture distribution

Surface templates for computational neuroanatomy and subcortical structures

The study of sub-cortical neuroanatomy has been the focus of many studies. Since the original publications by Csernansky and colleagues of hippocampal change in Schizophrenia, [14] [15] [16] [17] Alzheimer's disease, [18] [19] [20] and Depression, [21] [22] many neuroanatomical shape statistical studies have now been completed using templates built from all of the subcortical structures for depression, [23] Alzheimer's, [11] [12] [24] [25] [26] [27] Bipolar disorder, ADHD, [28] autism, [29] and Huntington's Disease. [30] [31] Templates were generated using Bayesian template estimation data back to Ma, Younes and Miller. [32]

Shown in the accompanying Figure is an example of subcortical structure templates generated from T1-weighted magnetic resonance imagery by Tang et al. [11] [12] [13] for the study of Alzheimer's disease in the ADNI population of subjects.

Surface estimation in cardiac computational anatomy

Showing population atlases identifying regional differences in radial thickness at end-systolic cardiac phase between patients with hypertrophic cardiomyopathy (left) and hypertensive heart disease (right). Gray mesh shows the common surface template to the population, with the color map representing basilar septal and anterior epicardial wall with larger radial thickness in patients with hypertrophic cardiomyopathy vs. hypertensive heart disease. Siamak atlas.tif
Showing population atlases identifying regional differences in radial thickness at end-systolic cardiac phase between patients with hypertrophic cardiomyopathy (left) and hypertensive heart disease (right). Gray mesh shows the common surface template to the population, with the color map representing basilar septal and anterior epicardial wall with larger radial thickness in patients with hypertrophic cardiomyopathy vs. hypertensive heart disease.

Numerous studies have now been done on cardiac hypertrophy and the role of the structural integraties in the functional mechanics of the heart. Siamak Ardekani has been working on populations of Cardiac anatomies reconstructing atlas coordinate systems from populations. [34] [35] [36] The figure on the right shows the computational cardiac anatomy method being used to identify regional differences in radial thickness at end-systolic cardiac phase between patients with hypertrophic cardiomyopathy (left) and hypertensive heart disease (right). Color map that is placed on a common surface template (gray mesh) represents region ( basilar septal and the anterior epicardial wall) that has on average significantly larger radial thickness in patients with hypertrophic cardiomyopathy vs. hypertensive heart disease (reference below). [33]

MAP Estimation of volume templates from populations and the EM algorithm

Generating templates empirically from populations is a fundamental operation ubiquitous to the discipline. Several methods based on Bayesian statistics have emerged for submanifolds and dense image volumes. For the dense image volume case, given the observable the problem is to estimate the template in the orbit of dense images . Ma's procedure takes an initial hypertemplate as the starting point, and models the template in the orbit under the unknown to be estimated diffeomorphism , with the parameters to be estimated the log-coordinates determining the geodesic mapping of the hyper-template .

In the Bayesian random orbit model of computational anatomy the observed MRI images are modelled as a conditionally Gaussian random field with mean field , with a random unknown transformation of the template. The MAP estimation problem is to estimate the unknown template given the observed MRI images.

Ma's procedure for dense imagery takes an initial hypertemplate as the starting point, and models the template in the orbit under the unknown to be estimated diffeomorphism . The observables are modelled as conditional random fields, a conditional-Gaussian random field with mean field . The unknown variable to be estimated explicitly by MAP is the mapping of the hyper-template , with the other mappings considered as nuisance or hidden variables which are integrated out via the Bayes procedure. This is accomplished using the expectation–maximization (EM) algorithm.

The orbit-model is exploited by associating the unknown to be estimated flows to their log-coordinates via the Riemannian geodesic log and exponential for computational anatomy the initial vector field in the tangent space at the identity so that , with the mapping of the hyper-template. The MAP estimation problem becomes

The EM algorithm takes as complete data the vector-field coordinates parameterizing the mapping, and compute iteratively the conditional-expectation

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Group actions are central to Riemannian geometry and defining orbits. The orbits of computational anatomy consist of anatomical shapes and medical images; the anatomical shapes are submanifolds of differential geometry consisting of points, curves, surfaces and subvolumes,. This generalized the ideas of the more familiar orbits of linear algebra which are linear vector spaces. Medical images are scalar and tensor images from medical imaging. The group actions are used to define models of human shape which accommodate variation. These orbits are deformable templates as originally formulated more abstractly in pattern theory.

Computational anatomy (CA) is the study of shape and form in medical imaging. The study of deformable shapes in computational anatomy rely on high-dimensional diffeomorphism groups which generate orbits of the form . In CA, this orbit is in general considered a smooth Riemannian manifold since at every point of the manifold there is an inner product inducing the norm on the tangent space that varies smoothly from point to point in the manifold of shapes . This is generated by viewing the group of diffeomorphisms as a Riemannian manifold with , associated to the tangent space at . This induces the norm and metric on the orbit under the action from the group of diffeomorphisms.

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Computational anatomy (CA) is a discipline within medical imaging focusing on the study of anatomical shape and form at the visible or gross anatomical scale of morphology. The field is broadly defined and includes foundations in anatomy, applied mathematics and pure mathematics, including medical imaging, neuroscience, physics, probability, and statistics. It focuses on the anatomical structures being imaged, rather than the medical imaging devices. The central focus of the sub-field of computational anatomy within medical imaging is mapping information across anatomical coordinate systems most often dense information measured within a magnetic resonance image (MRI). The introduction of flows into CA, which are akin to the equations of motion used in fluid dynamics, exploit the notion that dense coordinates in image analysis follow the Lagrangian and Eulerian equations of motion. In models based on Lagrangian and Eulerian flows of diffeomorphisms, the constraint is associated to topological properties, such as open sets being preserved, coordinates not crossing implying uniqueness and existence of the inverse mapping, and connected sets remaining connected. The use of diffeomorphic methods grew quickly to dominate the field of mapping methods post Christensen's original paper, with fast and symmetric methods becoming available.

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Diffeomorphometry is the metric study of imagery, shape and form in the discipline of computational anatomy (CA) in medical imaging. The study of images in computational anatomy rely on high-dimensional diffeomorphism groups which generate orbits of the form , in which images can be dense scalar magnetic resonance or computed axial tomography images. For deformable shapes these are the collection of manifolds , points, curves and surfaces. The diffeomorphisms move the images and shapes through the orbit according to which are defined as the group actions of computational anatomy.

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