Betaenone

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Betaenones are phytotoxins found in the fungus Pleospora betae . [1] The compounds were found to inhibit a variety of protein kinases. [2]

Members of this class of chemical compounds include:

Betaenone ABC skeletal.svg

Two further betaenones were found in a species of the fungus Microsphaeropsis , which was isolated from the marine sponge Aplysina aerophoba . [3]

References

  1. ↑ Ichihara A.; Oikawa, Hideaki; Hayashi, Kazuko; Sakamura, Sadao; Furusaki, Akio; Matsumoto, Takeshi (1983). "Structures of Betaenones A and B, Novel Phytotoxins from Phoma betae Fr". J. Am. Chem. Soc. 105 (9): 2907–2908. Bibcode:1983JAChS.105.2907I. doi:10.1021/ja00347a070.
  2. ↑ Patrick, D.; Heimbrook, D (1996). "Protein kinase inhibitors for the treatment of cancer". Drug Discovery Today. 1 (8): 325–330. doi:10.1016/1359-6446(96)10030-1.
  3. ↑ Brauers, G. (2000). "Anthraquinones and Betaenone Derivatives from the Sponge-Associated Fungus Microsphaeropsis Species: Novel Inhibitors of Protein Kinases". Journal of Natural Products. 63 (6): 739–745. Bibcode:2000JNAtP..63..739B. doi:10.1021/np9905259. PMID   10869191.
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