Beverley A. Orser | |
---|---|
Citizenship | Canada |
Occupation | Professor |
Academic background | |
Education | MD, 1981, Queen's University at Kingston PhD, medical science, 1995, University of Toronto |
Academic work | |
Institutions | University of Toronto Sunnybrook Health Sciences Centre |
Website | orserlab |
Beverley Anne Orser OOnt is a Canadian anesthesiologist. As a professor at the University of Toronto,Orser was elected a member of the National Academy of Medicine for "her discovery of the unique pharmacological properties of extrasynaptic GABA-A receptors and their mechanistic role in anesthetic- and inflammation-induced impairment of memory,and for her leadership in academic anesthesiology.
Born and raised in Canada,Orser lived in multiple cities in Ontario and Quebec. [1] Orser received her medical degree from Queen's University at Kingston in 1981 and subsequently earned a Fellowship from the Royal College of Physicians and Surgeons of Canada. Upon completing her fellowship,she earned a PhD in medical science from the University of Toronto (U of T) and completed her postgraduate clinical training at the Royal Columbian Hospital in British Columbia,McMaster University in Hamilton,Oxford University,and U of T. [2]
Upon completing her PhD,Orser joined the faculty at U of T where she focused her research on the molecular mechanisms of anesthetic agents. In the 1990s,her research cultivated in the observation that tonic GABAA currents in hippocampal neurons have distinct functional and pharmacologic properties. [1] In 2003,Orser became the first Canada Research Chair in Anesthesia where she conducted research on her project Anesthetic Drugs:From Molecular Mechanisms to Patient Safety. [2] During her tenure at U of T,she co-established the Perioperative Brain Health Centre at the Sunnybrook Health Sciences Centre [3] to determine what causes brain problems following surgery. [4] As a result,in 2017,Orser gained a United States patent for a class of drugs that helps patients with memory loss due to anesthesia and funding basic research. [5]
In 2018,Orser was elected a member of the National Academy of Medicine for "her discovery of the unique pharmacological properties of extrasynaptic GABA-A receptors and their mechanistic role in anesthetic- and inflammation-induced impairment of memory,and for her leadership in academic anesthesiology." [6] She was also recognized by the American Society of Anesthesiologists with their 2018 Excellence in Research Award in recognition of her "outstanding research accomplishments on the molecular mechanisms of anesthetic agents." [7]
During the COVID-19 pandemic,Orser published Recommendations for Endotracheal Intubation of COVID-19 Patients [8] and Locating and repurposing anesthetic machines as intensive care unit ventilators during the COVID-19 pandemic. [9] She later received the 2020 Canadian College of Neuropsychopharmacology Medal for having a "meritorious career in,and outstanding contribution to,neuropsychopharmacology in Canada as evidenced by their activities in education,administration and/or patient care." [10] Orser was made a Member of the Order of Ontario for the class of 2022. [11]
Orser and her husband Geordie have three children together,Kevin,Becky,and Sarah. [1]
Tracheal intubation,usually simply referred to as intubation,is the placement of a flexible plastic tube into the trachea (windpipe) to maintain an open airway or to serve as a conduit through which to administer certain drugs. It is frequently performed in critically injured,ill,or anesthetized patients to facilitate ventilation of the lungs,including mechanical ventilation,and to prevent the possibility of asphyxiation or airway obstruction.
General anaesthesia (UK) or general anesthesia (US) is a method of medically inducing loss of consciousness that renders a patient unarousable even with painful stimuli. This effect is achieved by administering either intravenous or inhalational general anaesthetic medications,which often act in combination with an analgesic and neuromuscular blocking agent. Spontaneous ventilation is often inadequate during the procedure and intervention is often necessary to protect the airway. General anaesthesia is generally performed in an operating theater to allow surgical procedures that would otherwise be intolerably painful for a patient,or in an intensive care unit or emergency department to facilitate endotracheal intubation and mechanical ventilation in critically ill patients.
Anesthesiology,anaesthesiology,or anaesthesia is the medical specialty concerned with the total perioperative care of patients before,during and after surgery. It encompasses anesthesia,intensive care medicine,critical emergency medicine,and pain medicine. A physician specialized in anesthesiology is called an anesthesiologist,anaesthesiologist,or anaesthetist,depending on the country. In some countries the terms are synonymous,while in other countries they refer to different positions and anesthetist is only used for non-physicians,such as nurse anesthetists.
Propofol is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia. It is chemically termed 2,6-diisopropylphenol. The formulation was originally approved under the brand name Diprivan. Numerous generic offerings of this formulation now exist. Intravenous administration is used to induce unconsciousness after which anesthesia may be maintained using a combination of medications. It is manufactured as part of a sterile injectable emulsion formulation using soybean oil and lecithin,giving it a white milky coloration.
Awareness under anesthesia,also referred to as intraoperative awareness or accidental awareness during general anesthesia (AAGA),is a rare complication of general anesthesia where patients regain varying levels of consciousness during their surgical procedures. While anesthesia awareness is possible without resulting in any long-term memory of the experience,it is also possible for victims to have awareness with explicit recall,where they can remember the events related to their surgery.
Mivacurium chloride is a short-duration non-depolarizing neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs,used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
In the United States,anesthesia can be administered by physician anesthesiologists,an anesthesiologist assistant,or nurse anesthetist.
Cardiothoracic anesthesiology is a subspeciality of the medical practice of anesthesiology,devoted to the preoperative,intraoperative,and postoperative care of adult and pediatric patients undergoing cardiothoracic surgery and related invasive procedures.
Gantacurium chloride is a new experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs,used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Gantacurium is not yet available for widespread clinical use:it is currently undergoing Phase III clinical development.
Neurosurgical anesthesiology,neuroanesthesiology,or neurological anesthesiology is a subspecialty of anesthesiology devoted to the total perioperative care of patients before,during,and after neurological surgeries,including surgeries of the central (CNS) and peripheral nervous systems (PNS). The field has undergone extensive development since the 1960s correlating with the ability to measure intracranial pressure (ICP),cerebral blood flow (CBF),and cerebral metabolic rate (CMR).
Throughout recorded history,attempts at producing a state of general anesthesia can be traced back to the writings of ancient Sumerians,Babylonians,Assyrians,Egyptians,Indians,and Chinese. Despite significant advances in anatomy and surgical technique during the Renaissance,surgery remained a last-resort treatment largely due to the pain associated with it. However,scientific discoveries in the late 18th and early 19th centuries paved the way for the development of modern anesthetic techniques.
BW A444U was an experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs,intended to be used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It was synthesized and developed in the early 1980s.
Certified anesthesiologist assistants (CAAs) are highly trained master’s degree level non-physician anesthesia care providers. CAAs are integral members of the anesthesia care team as described by the American Society of Anesthesiologists (ASA). This designation must be disambiguated from the Certified Clinical Anesthesia Assistant (CCAA) designation conferred by the Canadian Society of Respiratory Therapists. All CAAs possess a baccalaureate degree,and complete an intensive didactic and clinical program at a postgraduate level. CAAs are trained in the delivery and maintenance of all types of anesthesia care as well as advanced patient monitoring techniques. The goal of CAA education is to guide the transformation of student applicants into competent clinicians.
The following outline is provided as an overview of and topical guide to anesthesia:
Miller's Anesthesia is an authoritative textbook on anesthesiology.
Obstetric anesthesia or obstetric anesthesiology,also known as ob-gyn anesthesia or ob-gyn anesthesiology,is a sub-specialty of anesthesiology that provides peripartum pain relief (analgesia) for labor and anesthesia for cesarean deliveries ('C-sections').
Seshagiri Rao Mallampati is an Indian anesthesiologist. He is best known for proposing the eponymous Mallampati score in 1985,a non-invasive method to assess the ease of endotracheal intubation.
Alex Bekker is a physician,author and academic. He is a professor and chair at the Department of Anesthesiology,Rutgers New Jersey Medical School. He is also professor at the Department of Physiology,Pharmacology &Neurosciences. He serves as the Chief of Anesthesiology Service at the University Hospital in Newark.
George Alexander Mashour is an American anesthesiologist.
Talmage D. Egan is an anesthesiologist,academic,entrepreneur,and author. He is a professor and chair in the department of anesthesiology,and an adjunct professor in the departments of pharmaceutics,bioengineering,and neurosurgery at the University of Utah School of Medicine.
Beverley A. Orser publications indexed by Google Scholar