CELA2B

CELA2B
Identifiers
Aliases	CELA2B , ELA2B, chymotrypsin like elastase family member 2B, chymotrypsin like elastase 2B
External IDs	OMIM: 609444; HomoloGene: 88835; GeneCards: CELA2B; OMA:CELA2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.21 Start 15,465,909 bp [1] End 15,491,395 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas testicle islet of Langerhans pancreatic epithelial cell pancreatic ductal cell left adrenal cortex right adrenal cortex right hemisphere of cerebellum left ovary stromal cell of endometrium n/a More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51032 n/a Ensembl ENSG00000215704 n/a UniProt P08218 n/a RefSeq (mRNA) NM_015849 n/a RefSeq (protein) NP_056933 n/a Location (UCSC) Chr 1: 15.47 – 15.49 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene. ^{[3] [4] [5]}

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000215704 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Kawashima I, Tani T, Shimoda K, Takiguchi Y (April 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID   3646943.
4. Szepessy E, Sahin-Tóth M (2006). "Inactivity of Recombinant ELA2B Provides a New Example of Evolutionary Elastase Silencing in Humans". Pancreatology. 6 (1–2): 117–22. doi:10.1159/000090031. PMC   1447606 . PMID   16327289.
5. "Entrez Gene: chymotrypsin-like elastase family".

External links

• Human CELA2B genome location and CELA2B gene details page in the UCSC Genome Browser .

Further reading

• Fletcher TS, Shen WF, Largman C (1987). "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (23): 7256–61. doi:10.1021/bi00397a010. PMID   3427074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hosgood HD, Zhang L, Shen M, et al. (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC   2928224 . PMID   19773279.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.