CELA2B

CELA2B
Identifiers
Aliases	CELA2B , ELA2B, chymotrypsin like elastase family member 2B, chymotrypsin like elastase 2B
External IDs	OMIM: 609444 HomoloGene: 88835 GeneCards: CELA2B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	15,491,395 bp
Gene ontology
Molecular function	• peptidase activity ; • serine-type peptidase activity ; • hydrolase activity ; • serine-type endopeptidase activity ;
Cellular component	• extracellular region ; • extracellular space ;
Biological process	• proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	51032
	n/a
	ENSG00000215704
	n/a
	P08218
	n/a
	NM_015849
	n/a
	NP_056933
	n/a
	Wikidata
View/Edit Human

Last updated August 23, 2021

Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.^[3]^[4]^[5]

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.^[5]

Related Research Articles

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins founded by ovalbumin.

Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene.

Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B gene.

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.

28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28 gene.

39S ribosomal protein L18, mitochondrial is a protein that in humans is encoded by the MRPL18 gene.

Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

28S ribosomal protein S17, mitochondrial is a protein that in humans is encoded by the MRPS17 gene.

Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene.

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.

60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene.

Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene.

Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.

Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B.

Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000215704 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kawashima I, Tani T, Shimoda K, Takiguchi Y (April 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID 3646943.
↑ Szepessy E, Sahin-Tóth M (2006). "Inactivity of Recombinant ELA2B Provides a New Example of Evolutionary Elastase Silencing in Humans". Pancreatology. 6 (1–2): 117–22. doi:10.1159/000090031. PMC 1447606 . PMID 16327289.
1 2 "Entrez Gene: chymotrypsin-like elastase family".

External links

Human CELA2B genome location and CELA2B gene details page in the UCSC Genome Browser .

Fletcher TS, Shen WF, Largman C (1987). "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (23): 7256–61. doi:10.1021/bi00397a010. PMID 3427074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hosgood HD, Zhang L, Shen M, et al. (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224 . PMID 19773279.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000215704 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3646943-3] Kawashima I, Tani T, Shimoda K, Takiguchi Y (April 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID 3646943.

[pmid16327289-4] Szepessy E, Sahin-Tóth M (2006). "Inactivity of Recombinant ELA2B Provides a New Example of Evolutionary Elastase Silencing in Humans". Pancreatology. 6 (1–2): 117–22. doi:10.1159/000090031. PMC 1447606 . PMID 16327289.

[entrez-5] 1 2 "Entrez Gene: chymotrypsin-like elastase family".

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CELA2B

Contents

Function

Related Research Articles

References

External links

Further reading