COX6C

COX6C
Identifiers
Aliases	COX6C , cytochrome c oxidase subunit 6C
External IDs	OMIM: 124090; HomoloGene: 136781; GeneCards: COX6C; OMA:COX6C - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q22.2 Start 99,873,200 bp [1] End 99,893,707 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons ventricle of the heart left ventricle body of tongue right ventricle superior vestibular nucleus Skeletal muscle tissue of rectus abdominis apex of heart biceps brachii right auricle of heart n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytochrome-c oxidase activity Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion Biological process proton transmembrane transport generation of precursor metabolites and energy electron transport chain mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1345 102640946 Ensembl ENSG00000164919 n/a UniProt P09669 n/a RefSeq (mRNA) NM_004374 n/a RefSeq (protein) NP_004365 n/a Location (UCSC) Chr 8: 99.87 – 99.89 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene. ^{[4] [5]}

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000164919 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID   10072584.
5. "Entrez Gene: COX6C cytochrome c oxidase subunit VIc".

External links

• Human COX6C genome location and COX6C gene details page in the UCSC Genome Browser .

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–44. doi: 10.1016/S0079-6603(08)60830-2 . ISBN   9780125400619. PMID   9752724.
• Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID   17516841. S2CID   2286919.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kish SJ, Mastrogiacomo F, Guttman M, et al. (1999). "Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?". J. Neurochem. 72 (2): 700–7. doi: 10.1046/j.1471-4159.1999.0720700.x . PMID   9930743. S2CID   32587972.
• Wang FL, Wang Y, Wong WK, et al. (1996). "Two differentially expressed genes in normal human prostate tissue and in carcinoma". Cancer Res. 56 (16): 3634–7. PMID   8705997.
• Otsuka M, Mizuno Y, Yoshida M, et al. (1989). "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc". Nucleic Acids Res. 16 (22): 10916. doi:10.1093/nar/16.22.10916. PMC   338951 . PMID   2849755.