Cambrex Corporation

Last updated
Cambrex Corporation
Company typePrivate
Industry Pharmaceuticals
FoundedNew Jersey (1981)
Headquarters East Rutherford, NJ
Key people
Thomas Loewald, CEO
Number of employees
2,200+
Website cambrex.com

Cambrex Corporation is a Contract Development Manufacturing Organisation (CDMO) that provides drug substance, drug product and analytical services across the entire drug lifecycle, as well as active pharmaceutical ingredients (APIs). With over 2,200 employees in 7 countries across 13 locations, Cambrex operates in branded and generic markets for API and dosage form development and manufacturing.

Contents

Cambrex has cGMP manufacturing facilities in the US (Agawam, MA; Charles City, IA; Durham, NC; High Point, NC; Longmont, CO; Whippany, NJ), Canada (Mirabel, Québec) and Europe (Edinburgh, UK; Karlskoga, Sweden, Milan, Italy, and R&D centers in Tallinn, Estonia, Wiesbaden, Germany). The headquarters are located in East Rutherford, NJ.

History

Cambrex was founded in 1979, when the Ennis Family acquired the castor oil and derivatives product lines from NL Industries. In 1987, CasChem was renamed Cambrex Corporation and became listed on NASDAQ. In 1990, Cambrex was listed on the NYSE.

Cambrex entered the pharmaceutical market in 1994 with the acquisition of Nobel Pharma Chemistry business, now known as Cambrex Karlskoga AB and Cambrex Profarmaco.

Through multiple acquisitions during the late 1990s, the firm entered the bioscience and the chiral enzymatic catalyst markets. Cambrex acquired two contract biopharmaceutical manufacturing facilities in 2001, to bulk manufacture biologics and pharmaceutical ingredients from clinical to commercial scales. In 2007, the firm decided to focus on its core competencies and sold the biologics business to Lonza Group. [1]

In 2008, Prosyntest (now Cambrex Tallinn) was acquired, [2] and Steve Klosk was appointed CEO, while remaining President. [3]

To broaden their biocatalysis platform, Cambrex acquired IEP in 2010, now known as Cambrex IEP. [4]

In 2013, Cambrex completed a major 7,000 sq. ft. facility expansion at Charles City, IA to increase API manufacturing capabilities for both existing products and a new product. Investment continued at Charles City, IA with a 45,000 sq. ft temperature and humidity-controlled cGMP warehouse space in 2015. [5]

Cambrex continued to invest in its sites in 2016. Charles City, IA saw a significant expansion of its cGMP API manufacturing and storage capabilities, [6] while large-scale manufacturing capabilities in Karlskoga, Sweden increased with the installation of new multi-purpose reactors and control room upgrades. [7] Additional investment in 2016 saw Cambrex open a new pilot plant at its site in Paullo (Milan) Italy, allowing greater speed and flexibility for small scale API production. [8] In 2016, Cambrex also expanded in its clinical stage API capabilities with the acquisition of PharmaCore, Inc. in High Point, NC, a leading early phase chemistry specialist with expertise in developing, scaling up and manufacturing small molecule APIs for clinical phase projects. [9]

In 2017, Cambrex invested in new small scale capacity at its Charles City, IA facility with the installation of two 500 gallon glass lined reactors and created a third small scale work center, further increasing flexibility for customer projects. [10] Additional investment in Charles City, IA was seen in the form of a new $24 million facility to manufacture highly potent APIs (HPAPIs). [11] Cambrex also expanded its newly acquired High Point, NC facility with the addition of a new $3.2 million, 11,000 sq.ft. analytical laboratory, in response to growing customer demand for analytical development and validation services in support of cGMP products at the clinical stage. [12] Investment in 2017 at the Karlskoga, Sweden facility saw new capacity and continuous flow technology for the production of high purity intermediates. [13]

In 2018, Cambrex acquired Halo Pharma for $425 million adding drug product development and manufacturing capabilities to existing API services. [14] In addition, Cambrex invested $5 million to expand its laboratory facilities in Karlskoga, Sweden which would help increase capacity for process development and scale up, handling of potent substances, crystallization studies and solid phase characterization. [15] Cambrex continued to invest in continuous flow technology at its High Point, NC facility. [16]

In 2019, Cambrex acquired Avista Pharma Solutions for $252m to become a fully integrated CDMO. [17] In late 2019, Cambrex was acquired by an affiliate of the Permira funds. [18]

In 2020, Cambrex completed a major expansion at its Edinburgh, UK facility known for solid form screening [19] alongside a biopharmaceutical expansion at its Durham, NC facility. [20] Thomas Loewald was also appointed CEO of Cambrex in September 2020. [21]

In November 2022, it was announced Cambrex had acquired the Waltham-headquartered chemical process development services provider, Snapdragon Chemistry. [22]

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References

  1. ↑ "CDMO | News | Sale of Bio Business Completed". Cambrex. 2007-02-06. Retrieved 2021-10-04.
  2. ↑ "CDMO | News | Cambrex Signs Agreement to Acquire Prosyntest AS". Cambrex. 2008-01-07. Retrieved 2021-10-04.
  3. ↑ "CDMO | News | Steven Klosk Appointed as President and CEO". Cambrex. 2008-05-15. Retrieved 2021-10-04.
  4. ↑ "CDMO | News | Cambrex Acquires IEP GmbH". Cambrex. 2010-03-22. Retrieved 2021-10-04.
  5. ↑ "CDMO | News | Expansion of Large Scale API Capacity". Cambrex. 2015-02-06. Retrieved 2021-10-04.
  6. ↑ "CDMO| News | Investment in Large Scale API Manufacture in Charles City". Cambrex. 2016-07-12. Retrieved 2021-10-04.
  7. ↑ "CDMO | News | Investment and Expansion at Karlskoga Facility". Cambrex. 2016-09-06. Retrieved 2021-10-04.
  8. ↑ "CDMO | News | New Pilot Plant in Milan". Cambrex. 2016-10-03. Retrieved 2021-10-04.
  9. ↑ "CDMO | News | Acquisition of PharmaCore, Inc". Cambrex. 2016-10-07. Retrieved 2021-10-04.
  10. ↑ "CDMO | News | New Small Scale Capacity at Charles City, IA". Cambrex. 2017-11-08. Retrieved 2021-10-04.
  11. ↑ "CDMO | News | New HPAPI Manufacturing Capacity in Charles City, IA". Cambrex. 2017-08-08. Retrieved 2021-10-04.
  12. ↑ "CDMO | News | New Analytical Development & Method Validation Lab". Cambrex. 2017-08-30. Retrieved 2021-10-04.
  13. ↑ "CDMO | News | New Capacity & Continuous Flow Technology in Karlskoga". Cambrex. 2017-05-30. Retrieved 2021-10-04.
  14. ↑ Corporation, Cambrex (2018-09-12). "Cambrex Completes Acquisition of Halo Pharma". GlobeNewswire News Room (Press release). Retrieved 2020-05-18.
  15. ↑ "CDMO | News | New Laboratory Expansion in Karlskoga". Cambrex. 2018-05-31. Retrieved 2021-10-04.
  16. ↑ "CDMO | News | New Continuous Flow Technology at High Point, NC". Cambrex. 2018-04-17. Retrieved 2021-10-04.
  17. ↑ outsourcing-pharma.com (21 November 2018). "Cambrex acquires Avista for $252m, becomes integrated CDMO". outsourcing-pharma.com. Retrieved 2020-05-18.
  18. ↑ "CDMO | News | Completed Acquisition by The Permira Funds". Cambrex. 2019-12-04. Retrieved 2021-09-29.
  19. ↑ "CDMO | News | Expansion Completed at Edinburgh Facility". Cambrex. 2020-10-12. Retrieved 2021-10-04.
  20. ↑ "CDMO | News | Biopharmaceutical Expansion at Durham, NC". Cambrex. 2020-04-07. Retrieved 2021-10-04.
  21. ↑ "CDMO | News | Announcement of Thomas Loewald as CEO". Cambrex. 2020-06-18. Retrieved 2021-10-04.
  22. ↑ "Cambrex set to acquire Snapdragon Chemistry". www.manufacturingchemist.com. Retrieved 2022-11-22.
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