Carla F. Kim

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Carla Faith Bender Kim is a professor at the Department of Genetics at Harvard Medical School [1] and a Principal Investigator at the Stem Cell Program at Boston Children’s Hospital. [2] She is also a Principal Faculty member at the Harvard Stem Cell Institute, [3] where she also serves as part of the Executive Committee. [4]

Harvard Medical School Medical school in Boston, MA

Harvard Medical School (HMS) is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood in Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consistently ranked 1st among research-oriented medical schools by U.S. News and World Report. Unlike most other leading medical schools, HMS does not operate in conjunction with a single hospital but is directly affiliated with several teaching hospitals in the Boston area. The HMS faculty comprises of approximately 2,900 full- and part-time voting faculty members consisting of assistant, associate, and full professors, and over 5,000 full- and part-time, non-voting instructors. The majority of the faculty receive their appointments through an affiliated teaching hospital.

Boston Childrens Hospital Hospital in Massachusetts, United States

Boston Children's Hospital is a 404-licensed-bed children's hospital in the Longwood Medical and Academic Area of Boston, Massachusetts. At 300 Longwood Avenue, Children's is adjacent both to its teaching affiliate, Harvard Medical School, and to Dana-Farber Cancer Institute. Dana-Farber and Children's jointly operate Dana-Farber/Children's Hospital Cancer Care, a 60-year-old partnership established to deliver comprehensive care to patients and survivors of all types of childhood cancers. Children's was ranked #1 in 8 out of 10 clinical specialties by the U.S. News & World Report, and as the nation's number one pediatric hospital for 2018/9.

Contents

Early life and education

Kim was born in Fremont, Ohio. Kim received her bachelor's degree from Ohio Northern University (1997) and a Ph.D. in Genetics from the University of Wisconsin-Madison (2002). Kim completed her postdoctoral training in the Tyler Jacks Laboratory at MIT (2006) [2] with the support of the Jane Coffin Childs Research Fellowship. [5]

Fremont, Ohio City in Ohio, United States

Fremont is a city in and the county seat of Sandusky County, Ohio, United States, located along the west bank of the Sandusky River. It is about 40 miles from Toledo. The population was 16,734 at the 2010 census.

Ohio Northern University private, United Methodist Church-affiliated university in Ada, Ohio, U.S.

Ohio Northern University is a private, United Methodist Church–affiliated university in Ada, Ohio. Founded by Henry Solomon Lehr in 1871, ONU is accredited by The Higher Learning Commission.

University of Wisconsin–Madison Public university in Wisconsin, USA

The University of Wisconsin–Madison is a public research university in Madison, Wisconsin. Founded when Wisconsin achieved statehood in 1848, UW–Madison is the official state university of Wisconsin, and the flagship campus of the University of Wisconsin System. It was the first public university established in Wisconsin and remains the oldest and largest public university in the state. It became a land-grant institution in 1866. The 933-acre (378 ha) main campus, located on the shores of Lake Mendota, includes four National Historic Landmarks. The University also owns and operates a historic 1,200-acre (486 ha) arboretum established in 1932, located 4 miles (6.4 km) south of the main campus.

During her time in the Jacks Lab, Kim discovered the first stem cell population in the adult mouse lung, bronchioalveolar stem cells (BASCs). [6]

Research

Working with genetically engineered mouse models that accurately represent human lung cancer, Kim’s group was the first to identify cancer stem cell populations in the two most frequent types of lung cancer in patients. [7] [8] Her lab’s knowledge in lung stem cells has revealed a new combination therapy approach for particular subsets of lung cancer patients. [9] Most recently, Kim’s lab has developed a 3D lung organoid system that makes it possible to derive specialized lung cells from lung stem cells. [10] Kim’s work has been recognized by a variety of organizations, she has received the Forbeck Scholar Award, [11] V Scholar award, [12] the Basil O’Connor Scholar award from the March of Dimes, [13] the American Cancer Society’s Research Scholar award, [14] and most recently the William Rippe Award for Distinguished Research in Lung Cancer from the Lung Cancer Research Foundation. [15] Kim’s work and lab are supported by federal funding from the National Institutes of Health. [16]

Lung cancer cancer in the lung

Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. This growth can spread beyond the lung by the process of metastasis into nearby tissue or other parts of the body. Most cancers that start in the lung, known as primary lung cancers, are carcinomas. The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). The most common symptoms are coughing, weight loss, shortness of breath, and chest pains.

Cancer stem cell

Cancer stem cells (CSCs) are cancer cells that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease.

March of Dimes United States nonprofit organization

March of Dimes is a United States nonprofit organization that works to improve for the health of mothers and babies. According to its website, "We believe that every baby deserves the best possible start. Unfortunately, not all babies get one. We are changing that."

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References

  1. ↑ "Carla Bender Kim, Ph.D. | HMS Department of Genetics". genetics.med.harvard.edu. Retrieved 2016-08-02.
  2. 1 2 "The Kim Lab | Boston Children's Hospital". stemcell.childrenshospital.org. Retrieved 2016-08-02.
  3. ↑ "Carla F. Kim, PhD". hsci.harvard.edu. Retrieved 2016-08-02.
  4. ↑ "Leadership" . Retrieved 2016-08-02.
  5. ↑ "Carla Kim, PhD | Boston Children's Hospital". stemcell.childrenshospital.org. Retrieved 2016-08-02.
  6. ↑ Kim, Carla F. Bender; Jackson, Erica L.; Woolfenden, Amber E.; Lawrence, Sharon; Babar, Imran; Vogel, Sinae; Crowley, Denise; Bronson, Roderick T.; Jacks, Tyler (2005-06-17). "Identification of bronchioalveolar stem cells in normal lung and lung cancer". Cell. 121 (6): 823–835. doi:10.1016/j.cell.2005.03.032. ISSN   0092-8674. PMID   15960971.
  7. ↑ Xu, Chunxiao; Fillmore, Christine M.; Koyama, Shohei; Wu, Hongbo; Zhao, Yanqiu; Chen, Zhao; Herter-Sprie, Grit S.; Akbay, Esra A.; Tchaicha, Jeremy H. (2014-05-12). "Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression". Cancer Cell. 25 (5): 590–604. doi:10.1016/j.ccr.2014.03.033. ISSN   1878-3686. PMC   4112370  Lock-green.svg. PMID   24794706.
  8. ↑ Curtis, Stephen J.; Sinkevicius, Kerstin W.; Li, Danan; Lau, Allison N.; Roach, Rebecca R.; Zamponi, Raffaella; Woolfenden, Amber E.; Kirsch, David G.; Wong, Kwok-Kin (2010-07-02). "Primary tumor genotype is an important determinant in identification of lung cancer propagating cells". Cell Stem Cell. 7 (1): 127–133. doi:10.1016/j.stem.2010.05.021. ISSN   1875-9777. PMC   2908996  Lock-green.svg. PMID   20621056.
  9. ↑ Fillmore, Christine M.; Xu, Chunxiao; Desai, Pooja T.; Berry, Joanne M.; Rowbotham, Samuel P.; Lin, Yi-Jang; Zhang, Haikuo; Marquez, Victor E.; Hammerman, Peter S. (2015-04-09). "EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors". Nature. 520 (7546): 239–242. doi:10.1038/nature14122. ISSN   1476-4687. PMC   4393352  Lock-green.svg. PMID   25629630.
  10. ↑ Lee, Joo-Hyeon; Bhang, Dong Ha; Beede, Alexander; Huang, Tian Lian; Stripp, Barry R.; Bloch, Kenneth D.; Wagers, Amy J.; Tseng, Yu-Hua; Ryeom, Sandra (2014-01-30). "Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis". Cell. 156 (3): 440–455. doi:10.1016/j.cell.2013.12.039. ISSN   1097-4172. PMC   3951122  Lock-green.svg. PMID   24485453.
  11. ↑ "2007 Scholar Retreat – Summary - William Guy Forbeck Research Foundation". 2007-01-30. Retrieved 2016-08-02.
  12. ↑ "Grants Awarded by State | The V Foundation for Cancer Research". www.jimmyv.org. Retrieved 2016-08-02.
  13. ↑ "Speakers" . Retrieved 2016-08-02.
  14. ↑ "'Window of Vulnerability' | HMS". hms.harvard.edu. Retrieved 2016-08-02.
  15. ↑ "Lung Cancer Research Foundation Awards $2.1 Million In Grants To Further Critical Research | News & Views". Lung Cancer Research Foundation. Retrieved 2016-08-02.
  16. ↑ "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results". projectreporter.nih.gov. Retrieved 2016-08-02.
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