Cas2

Last updated
CRISPR-associated protein 2
Streptococcus pyogenes Cas2 PDB 4qr2.png
Streptococcus pyogenes Cas2. PDB: 4QR2 ​
Identifiers
Symbolcas2
Pfam PF09827
InterPro IPR019199
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

Cas2 is a protein associated with CRISPR that is involved with spacer acquisition. Representative cas2 proteins have been characterized as endonucleases that cleave single-stranded RNAs preferentially within U-rich regions, [1] or as metal-dependent endonucleases targeting double-stranded (ds)DNA [2]

References

  1. ↑ Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, et al. (July 2008). "A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats". The Journal of Biological Chemistry. 283 (29): 20361–71. doi: 10.1074/jbc.M803225200 . PMC   2459268 . PMID   18482976.
  2. ↑ Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A (October 2012). "Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein". The Journal of Biological Chemistry. 287 (43): 35943–52. doi: 10.1074/jbc.M112.382598 . PMC   3476262 . PMID   22942283.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.