Catherine Freudenreich

Last updated
Catherine H. Freudenreich
Catherine Freudenreich (molecular biologist).jpg
Alma mater Rice University (BA) Duke University (PhD)
Scientific career
FieldsMolecular biology
Institutions Tufts University
Doctoral advisor Kenneth Kreuzer
Other academic advisors Virginia Zakian (postdoctoral)
Website https://as.tufts.edu/biology/freudenreich-lab

Catherine Freudenreich is an American molecular biologist at Tufts University. Since 2019, Freudenreich has served as chair of the Department of Biology. [1]

Contents

Life and career

Freudenreich spent her childhood in Los Alamos, New Mexico, before attending Rice University, where she graduated in 1988 with a B.A in biology. [2] She received her PhD in 1994 from Duke University, where she studied inhibitor binding sites of Type II topoisomerases in the lab of Kenneth Kreuzer, and continued to do so as a postdoctoral researcher in the same lab. [3] Freudenreich then undertook further postdoctoral research at Princeton University with Virginia Zakian, studying CTG repeats in yeast. [4] [1]

After her postdoctoral studies, Freudenreich was appointed to an assistant professor position in the Department of Biology at Tufts University in 1999, where she is currently professor and department chair. [1]

Research

Freudenreich’s lab studies genome instability in yeast, with the aim of uncovering mechanisms of genetic disease and cancer. In particular, much of her research has focused on conserved trinucleotide repeat sequences, specifically CAG/CTG, and their contributions to genome fragility and instability. [5] [6] [7] Recently, Freudenreich’s group looked at CAG/CTG repeats in Huntington’s disease, finding that the cells’ attempts to repair CAG sequences often lead to large, deleterious deletions. [8] [9] [10]

Freudenreich has also notably studied how DNA repeat sequences contribute to DNA structures that can cause DNA breaks, and how the cell protects against genomic damage from these mechanisms. [5] [11] [12] [13]

Notable publications

  1. Freudenreich, Catherine H.; Kantrow, Sara M.; Zakian, Virginia A. (1998-02-06). "Expansion and Length-Dependent Fragility of CTG Repeats in Yeast". Science. 279 (5352): 853–856. doi:10.1126/science.279.5352.853. ISSN  0036-8075. [4]
  2. Lahiri, Mayurika; Gustafson, Tanya L; Majors, Elizabeth R; Freudenreich, Catherine H (2004-07-23). "Expanded CAG Repeats Activate the DNA Damage Checkpoint Pathway". Molecular Cell. 15 (2): 287–293. doi:10.1016/j.molcel.2004.06.034. ISSN  1097-2765. [6]
  3. Polleys, Erica J.; Del Priore, Isabella; Haber, James E.; Freudenreich, Catherine H. (2023-04-29). "Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks". Nature Communications. 14 (1): 2469. doi:10.1038/s41467-023-37901-2. ISSN  2041-1723. [9]
  4. Zhang, Haihua; Freudenreich, Catherine H. (2007-08). "An AT-Rich Sequence in Human Common Fragile Site FRA16D Causes Fork Stalling and Chromosome Breakage in S. cerevisiae". Molecular Cell. 27 (3): 367–379. doi:10.1016/j.molcel.2007.06.012. ISSN  1097-2765. PMC  2144737. PMID  17679088. [12]
  5. Kerrest, Alix; Anand, Ranjith P.; Sundararajan, Rangapriya; Bermejo, Rodrigo; Liberi, Giordano; Dujon, Bernard; Freudenreich, Catherine H.; Richard, Guy-Franck (2009-01-11). "SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination". Nature Structural & Molecular Biology. 16 (2): 159–167. doi:10.1038/nsmb.1544. ISSN  1545-9985. [14]
  6. House, Nealia C.M.; Yang, Jiahui H.; Walsh, Stephen C.; Moy, Jonathan M.; Freudenreich, Catherine H. (2014-09-18). "NuA4 Initiates Dynamic Histone H4 Acetylation to Promote High-Fidelity Sister Chromatid Recombination at Postreplication Gaps". Molecular Cell. 55 (6): 818–828. doi:10.1016/j.molcel.2014.07.007. ISSN  1097-2765. PMC  4169719. PMID  25132173. [15]
  7. Su, Xiaofeng A.; Freudenreich, Catherine H. (2017-10-03). "Cytosine deamination and base excision repair cause R-loop–induced CAG repeat fragility and instability in Saccharomyces cerevisiae". Proceedings of the National Academy of Sciences. 114 (40). doi:10.1073/pnas.1711283114. ISSN  0027-8424. PMC  5635916. PMID  28923949. [16]

Awards and honors

References

  1. 1 2 3 "Catherine Freudenreich Faculty Profile". facultyprofiles.tufts.edu. Retrieved 2024-06-18.
  2. ↑ "Catherine H. Freudenreich | Brief bio". Frontiers Loop.
  3. ↑ Freudenreich, C H; Kreuzer, K N (1994-11-08). "Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex". Proceedings of the National Academy of Sciences. 91 (23): 11007–11011. Bibcode:1994PNAS...9111007F. doi: 10.1073/pnas.91.23.11007 . ISSN   0027-8424. PMC   45155 . PMID   7971998.
  4. 1 2 Freudenreich, Catherine H.; Kantrow, Sara M.; Zakian, Virginia A. (1998-02-06). "Expansion and Length-Dependent Fragility of CTG Repeats in Yeast" . Science. 279 (5352): 853–856. Bibcode:1998Sci...279..853F. doi:10.1126/science.279.5352.853. ISSN   0036-8075. PMID   9452383.
  5. 1 2 "Research Overview | Department of Biology". as.tufts.edu. Retrieved 2024-06-18.
  6. 1 2 Lahiri, Mayurika; Gustafson, Tanya L; Majors, Elizabeth R; Freudenreich, Catherine H (2004-07-23). "Expanded CAG Repeats Activate the DNA Damage Checkpoint Pathway". Molecular Cell. 15 (2): 287–293. doi:10.1016/j.molcel.2004.06.034. ISSN   1097-2765. PMID   15260979.
  7. ↑ Howard, Marjorie. "New fellowship offers undergraduate research opportunities". web.mit.edu. Retrieved 2024-07-12.
  8. ↑ "How DNA Repair Can Go Wrong and Lead to Disease | Tufts Now". now.tufts.edu. 2023-05-10. Retrieved 2024-06-18.
  9. 1 2 Polleys, Erica J.; Del Priore, Isabella; Haber, James E.; Freudenreich, Catherine H. (2023-04-29). "Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks". Nature Communications. 14 (1): 2469. Bibcode:2023NatCo..14.2469P. doi:10.1038/s41467-023-37901-2. ISSN   2041-1723. PMC   10148874 . PMID   37120647.
  10. ↑ "Understanding the Link Between DNA Mutations & Repair Dysfunction | Genetics And Genomics". Labroots. Retrieved 2024-06-24.
  11. ↑ Pennisi, Elizabeth (2006-06-09). "DNA's Molecular Gymnastics" . Science. 312 (5779): 1467–1468. doi:10.1126/science.312.5779.1467. ISSN   0036-8075. PMID   16763129.
  12. 1 2 Zhang, Haihua; Freudenreich, Catherine H. (2007-08-03). "An AT-Rich Sequence in Human Common Fragile Site FRA16D Causes Fork Stalling and Chromosome Breakage in S. cerevisiae". Molecular Cell. 27 (3): 367–379. doi:10.1016/j.molcel.2007.06.012. ISSN   1097-2765. PMC   2144737 . PMID   17679088.
  13. ↑ "Mapping the Kinks in Faulty DNA | Tufts Now". now.tufts.edu. 2019-08-01. Retrieved 2024-06-18.
  14. ↑ Kerrest, Alix; Anand, Ranjith P.; Sundararajan, Rangapriya; Bermejo, Rodrigo; Liberi, Giordano; Dujon, Bernard; Freudenreich, Catherine H.; Richard, Guy-Franck (2009-01-11). "SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination". Nature Structural & Molecular Biology. 16 (2): 159–167. doi:10.1038/nsmb.1544. ISSN   1545-9985. PMC   4454460 . PMID   19136956.
  15. ↑ House, Nealia C.M.; Yang, Jiahui H.; Walsh, Stephen C.; Moy, Jonathan M.; Freudenreich, Catherine H. (2014-09-18). "NuA4 Initiates Dynamic Histone H4 Acetylation to Promote High-Fidelity Sister Chromatid Recombination at Postreplication Gaps". Molecular Cell. 55 (6): 818–828. doi:10.1016/j.molcel.2014.07.007. ISSN   1097-2765. PMC   4169719 . PMID   25132173.
  16. ↑ Su, Xiaofeng A.; Freudenreich, Catherine H. (2017-10-03). "Cytosine deamination and base excision repair cause R-loop–induced CAG repeat fragility and instability in Saccharomyces cerevisiae". Proceedings of the National Academy of Sciences. 114 (40): E8392 –E8401. Bibcode:2017PNAS..114E8392S. doi: 10.1073/pnas.1711283114 . ISSN   0027-8424. PMC   5635916 . PMID   28923949.
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