Chan Zuckerberg Biohub

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Chan Zuckerberg Biohub
CZ Biohub logo 2022.svg
Established2016;7 years ago (2016)
President Joseph DeRisi
Endowment US$600 million
Location
Mission Bay
,
San Francisco
,
California
,
United States
Coordinates 37°45′57″N122°23′16″W / 37.765807°N 122.387716°W / 37.765807; -122.387716
Website www.czbiohub.org OOjs UI icon edit-ltr-progressive.svg

Chan Zuckerberg Biohub (CZ Biohub), or simply Biohub, is a nonprofit research organization. [1] [2] [3] [4] [5] In addition to supporting and conducting original research, CZ Biohub acts as a hub and fosters science collaboration between UC Berkeley, UC San Francisco (UCSF) and Stanford. [6] [7] The Biohub is funded by a $600 million contribution from Facebook CEO and founder Mark Zuckerberg and his wife Priscilla Chan. It was co-led by Stephen Quake and Joseph DeRisi from its inception in 2016 until 2022, when Quake left to become president of the Biohub Network. Sandra Schmid joined as Chief Scientific Officer in 2020. [8] [9]

Contents

History

The idea for CZ Biohub originated in 2015 when DeRisi and Quake, along with Chan and Zuckerberg, agreed on the need for a collaborative alliance of Stanford University, UC San Francisco and UC Berkeley devoted to fundamental biomedical research. [10] The organization was established in 2016, funded by a $600 million endowment from Chan and Zuckerberg. [11] DeRisi and Quake led the organization as co-presidents [12] for the first five years, before Quake became the president of the CZ Biohub Network when that initiative launched in 2022. [13] Gajus Worthington was named as Biohub's Chief Operating Officer in 2017; he left the position in 2022.

In 2017, CZ Biohub selected an initial group of scientists for its first cohort of Investigators, individuals chosen from the three partner universities to each receive $1 million in funding for five years of innovative research in the life sciences. [14] [15] In total, the organization provided $50 million to 47 individuals in research positions working on a range of projects. [16] [17]

In 2021, Chan and Zuckerberg announced that they intended to provide a further $800 million to $1 billion to CZ Biohub over 10 years, extending the organization's funding through 2031. [18] [19]

The organization selected its second cohort of Investigators in 2022. It awarded grants of $1 million each to 86 individual researchers from multiple science and health-related disciplines at Stanford University, UC Berkeley, and UCSF to support five years of research. [20]

Organization

The Biohub is a non-profit biomedical research organization [21] that was created to support the Chan Zuckerberg Initiative's efforts to cure, prevent, or manage all disease by the end of the century. [22] Its aim is to facilitate collaboration between medical, scientific, and engineering researchers from three Bay Area institutions: Stanford University, the University of California, Berkeley (UC Berkeley), and UC San Francisco (UCSF). [13] It also supports research by its own scientists and engineers in its own facilities. It is organized as both a research institute and a network for researchers to find overlap between their own work and scientists and engineers working in different areas or disciplines, to help accelerate research. [12]

The organization's president is Joseph DeRisi, a professor of Biochemistry and Biophysics at UCSF. DeRisi is known for inventing genomic tools to rapidly identify unknown pathogens, work for which he was named a MacArthur Fellow in 2004. [23] [24] Sandra Schmid joined the organization as its chief scientific officer in 2020. [8] [9] As of 2020, the Biohub had 100 employees including operations staff, scientists, data scientists and engineers. [12] Its headquarters are located In San Francisco, adjacent to UCSF's Mission Bay campus. [25]

Research programs

The Biohub's research is organized around two main projects: a quantitative approach to cell science, [26] including mapping different types of cells; and an infectious disease initiative, [27] which includes research on infection and immunity as well as developing techniques for early detection of emerging pathogens around the world. [24] Additionally, the organization's technology platform teams develop new technology and tools for biomedical research, and for clinical and public health applications. [25] [28]

The Biohub allocates one third of its funding towards its extramural programs. [12] The Investigator Program provides five years of funding to scientists from a variety of disciplines who are faculty members at Stanford University, UC Berkeley, and UCSF. [20] As a requirement of the program, investigators meet up twice a month to share findings. The meetings are intended to encourage collaboration and accelerate development of scientific and medical advancements through finding commonalities investigators might not otherwise have known about. [12] The investigator grants are unrestricted, and focused on supporting research that may not be sufficiently developed to qualify for funding from the pharmaceutical industry or the National Institutes of Health. [25]

To increase access to scientific research and promote open science, CZ Biohub requires its Investigators and staff scientists to post submitted manuscripts and related data on preprint servers such as bioRxiv at the same time they are submitted to journals for publication. [6] [12]

Structure and funding

CZ Biohub is structured as a nonprofit, tax-exempt organization, but it has retained close control of the outcomes of its efforts, including patent rights. [29] The Biohub operates independently from CZI but partners with it on some initiatives and programs. [21] In 2016, CZI formed the Biohub with a $600 million endowment over 10 years. [12] In December 2021, CZI announced it was committing up to $1 billion in further funding to support the Biohub's operations through 2031. [18] [19]

Biohub Network

In December 2021, Chan and Zuckerberg announced that they were providing $1 billion in funding to develop a network of Biohubs to focus on their goal of longer-term research over 10 to 15 years into "scientific challenges". [18] The Chan Zuckerberg Biohub Network was launched with the goal of connecting co-located scientific institutions in other areas of the US, beyond the initial CZ Biohub group in the Bay Area, to work together on research into major issues. [19] [13]

Stephen Quake is the president of the CZ Biohub Network, and head of science at the Chan Zuckerberg Institute. [13] [30]

Related Research Articles

<span class="mw-page-title-main">University of California, San Francisco</span> Public university in San Francisco, California

The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It conducts research and teaching in medical and biological sciences.

<span class="mw-page-title-main">Joseph DeRisi</span> American biochemist

Joseph Lyman DeRisi is an American biochemist, specializing in molecular biology, parasitology, genomics, virology, and computational biology.

<span class="mw-page-title-main">Nicholas Dirks</span> American indologist, historian and former university administrator

Nicholas B. Dirks is an American academic and the former Chancellor of the University of California, Berkeley. Dirks is the author of numerous books on South Asian history and culture, primarily concerned with the impact of British colonial rule. In June 2020, Dirks was named president and CEO of The New York Academy of Sciences.

<span class="mw-page-title-main">California Institute for Quantitative Biosciences</span>

The California Institute for Quantitative Biosciences (QB3) is a nonprofit research and technology commercialization institute affiliated with three University of California campuses in the San Francisco Bay Area: Berkeley, San Francisco, and Santa Cruz. QB3's domain is the quantitative biosciences: areas of biology in which advances are chiefly made by scientists applying techniques from physics, chemistry, engineering, and computer science.

<span class="mw-page-title-main">Peter S. Kim</span> American scientist

Peter S. Kim is an American scientist. He was president of Merck Research Laboratories (MRL) 2003–2013 and is currently Virginia & D.K. Ludwig Professor of Biochemistry at Stanford University, Institute Scholar at Stanford ChEM-H, and Lead Investigator of the Infectious Disease Initiative at the Chan Zuckerberg Biohub.

<span class="mw-page-title-main">Sandra Schmid</span> Canadian biologist

Sandra Louise Schmid is the first Chief Scientific Officer of the Chan-Zuckerberg Biohub. She is a Canadian cell biologist by training; prior to her move to CZI, she was Professor and Chair of the Cell Biology Department at the University of Texas Southwestern Medical Center. Throughout her academic career, she has authored over 105 publications on the molecular mechanism and regulation of clathrin-mediated endocytosis and the structure and function of the GTPase dynamin and mechanisms governing membrane fission. She was the first to identify dynamin's key role in endocytosis. She is a co-founder of the journal Traffic and has been the Editor-in-Chief of Molecular Biology of the Cell, and the President of the American Society for Cell Biology.

<span class="mw-page-title-main">Chan Zuckerberg Initiative</span> American philanthropic organization

The Chan Zuckerberg Initiative (CZI) is an organization established and owned by Facebook founder Mark Zuckerberg and his wife Priscilla Chan with an investment of 99 percent of the couple's wealth from their Facebook shares over their lifetime. The CZI is set up as a limited liability company (LLC) and is an example of philanthrocapitalism. CZI has been deemed likely to be "one of the most well-funded philanthropies in human history". Its creation was announced on 1 December 2015, for the birth of their daughter, Maxima Chan Zuckerberg. Priscilla Chan has said that her background as a child of immigrant refugees and experience as a teacher and pediatrician for vulnerable children influences how she approaches the philanthropy's work in science, education, immigration reform, housing, criminal justice, and other local issues.

Michael Andrew Fischbach is an American chemist, microbiologist, and geneticist. He is an associate professor of Bioengineering and ChEM-H Faculty Fellow at Stanford University and a Chan Zuckerberg Biohub Investigator.

Katja Brose is an American neuroscientist and a science program officer at the Chan Zuckerberg Initiative (CZI) where she leads CZI's efforts in neurodegenerative diseases.

<span class="mw-page-title-main">Nevan Krogan</span> Canadian molecular and systems biologist

Nevan J. Krogan is a Canadian molecular and systems biologist. He is a professor and the Director of the Quantitative Biosciences Institute (QBI) at the University of California San Francisco (UCSF), as well as a senior investigator at the J. David Gladstone Institutes.

Alexander Marson is an American biologist and infectious disease doctor who specializes in genetics, human immunology, and CRISPR genome engineering. He is the Director of the Gladstone-UCSF Institute of Genomic Immunology, and a tenured Professor with a dual appointment in the Department of Medicine and the Department of Microbiology & Immunology at the University of California, San Francisco (UCSF).

<span class="mw-page-title-main">Laura Waller</span> Computer scientist

Laura Ann Waller is a computer scientist and Ted Van Duzer Endowed Associate Professor at the University of California, Berkeley. She was awarded a Chan Zuckerberg Initiative Fellowship to develop microscopes to image deep structures within the brain in 2017 and won the 2018 SPIE Early Career Award.

Tanja Kortemme is a bioengineering professor at University of California, San Francisco. She has been recognized for outstanding contributions in computational protein design, including energy functions, sampling algorithms, and molecules to rewire cellular control circuits. She was an inaugural Chan Zuckerberg Biohub investigator and was inducted into American Institute for Medical and Biological Engineering College of Fellows.

Lisa Gunaydin is an American neuroscientist and assistant professor at the Weill Institute for Neurosciences at the University of California San Francisco. Gunaydin helped discover optogenetics in the lab of Karl Deisseroth and now uses this technique in combination with neural and behavioral recordings to probe the neural circuits underlying emotional behaviors.

Polly Fordyce is an Associate Professor of Genetics and Bioengineering and fellow of the ChEM-H Institute at Stanford University. Her laboratory's research focuses on developing and applying new microfluidic platforms for quantitative, high-throughput biophysics and biochemistry and single-cell genomics.

<span class="mw-page-title-main">Amy Herr</span> Professor of Bioengineering

Amy Elizabeth Herr is the John D. and Catherine T. MacArthur Professor at the University of California, Berkeley, where she is attached to the Department of Bioengineering. At Berkeley she was also the founding executive director of the Bakar Bioenginuity Hub. Herr is a Chan Zuckerberg BioHub Investigator and the Chief Technology Officer of the Chan Zuckerberg Biohub Network, a fellow of both the National Academy of Inventors and the American Institute of Medical and Biological Engineering, as well as a co-founder of Zephyrus Biosciences, a biotechnology company that was acquired by Bio-Techne.

Katherine Snowden Pollard is the Director of the Gladstone Institute of Data Science and Biotechnology and a professor at the University of California, San Francisco (UCSF). She is a Chan Zuckerberg Biohub Investigator. She was awarded Fellowship of the International Society for Computational Biology in 2020 and the American Institute for Medical and Biological Engineering in 2021 for outstanding contributions to computational biology and bioinformatics.

Donald "Don" Emil Ganem is an American physician, virologist, professor emeritus of microbiology and medicine, and former global head of infectious disease research at Novartis Institutes for BioMedical Research (NIBR).

<span class="mw-page-title-main">Peter J. Turnbaugh</span> American microbiologist (born c. 1981)

Peter J. Turnbaugh is a microbiologist and a professor at University of California, San Francisco. He is known for his research on the metabolic activities performed by the trillions of microbes that colonize humans' adult bodies. Turnbaugh and his research group use interdisciplinary approaches in preclinical models and human cohorts to study the mechanisms through which the gut microbiome influences nutrition and pharmacology.

Aaron Michael Streets is an African American bioengineer and assistant professor in the Department of Engineering at the University of California, Berkeley in Berkeley, California. He is the principal investigator at the Streets Lab, where he and his team use tools from mathematics, physics, and engineering to study biology. Streets is currently developing microfluidic technology for single-cell measurements due to its high-resolution imaging.

References

  1. ↑ Anwar, Yasmin (September 21, 2016). "UC Berkeley to partner in $600M Chan Zuckerberg science 'Biohub'". Berkeley News.
  2. ↑ Farley, Pete; Anwar, Yasmin; Adams, Amy (October 24, 2018). "$600M Chan Zuckerberg 'Biohub' led by UCSF, UC Berkeley announced". University of California.
  3. ↑ "CZ BIOHUB Trademark Application of Chan Zuckerberg Biohub, Inc. - Serial Number 87375113". Justia Trademarks.
  4. ↑ Hatmaker, Taylor (April 29, 2020). "CZI teams up with UCSF and Stanford to research COVID-19's prevalence in the Bay Area". techcrunch.com. Retrieved November 18, 2020.
  5. ↑ Lewis, Michael (April 16, 2020). "Notes From A Pandemic: The Covid Test Lab That Could Save America". bloomberg.com. Retrieved November 18, 2020.
  6. 1 2 Kaiser, Jocelyn (February 8, 2017). "Chan Zuckerberg Biohub funds first crop of 47 investigators". sciencemag.com. AAAS . Retrieved November 18, 2020.
  7. ↑ McGrane, Clare (October 3, 2018). "Chan Zuckerberg Biohub launches open-access database of mouse cells to fuel research". geekwire.com. Retrieved November 18, 2020.
  8. 1 2 "Dr. Sandra Schmid". bizjournals.com. May 4, 2020. Retrieved November 18, 2020.
  9. 1 2 Yong, Ed (October 16, 2018). "A Simpler Way to Get to the Bottom of Mysterious Illnesses in Poor Countries". theatlantic.com. Retrieved November 18, 2020.
  10. ↑ Bai, Nina (September 21, 2016). "Joe DeRisi on How the Biohub Will Create Opportunities for Research Collaboration". UC San Francisco. Retrieved September 9, 2022.
  11. ↑ Offord, Catherine (December 9, 2021). "CZI Pledges Billions More Dollars in Science Funding". The Scientist. Retrieved September 13, 2022.
  12. 1 2 3 4 5 6 7 DeFrancesco, Laura (October 1, 2020). "The making of the Biohub". Nature Biotechnology. 38 (10): 1116ñ1120. doi: 10.1038/s41587-020-0685-y . ISSN   1546-1696 . Retrieved May 13, 2022.
  13. 1 2 3 4 Leuty, Ron (December 7, 2021). "Chan Zuckerberg Initiative outlines multibillion-dollar plans to extend Chan Zuckerberg Initiative's Bay Area Biohub, build out imaging institute - San Francisco Business Times". San Francisco Business Times. Retrieved May 10, 2022.
  14. ↑ "Chan Zuckerberg Biohub Awards $50M+ to 47 Investigators". Genetic Engineering & Biotechnology News. February 8, 2017.
  15. ↑ Kaiser, Jocelyn (February 7, 2017). "Chan Zuckerberg Biohub funds first crop of 47 investigators". Science. AAAS.
  16. ↑ Ramsey, Lydia (February 8, 2017). "Here's how the Chan Zuckerberg Biohub picked scientists as part of its plan to cure all diseases". Business Insider.
  17. ↑ Buhr, Sarah (February 7, 2017). "The Chan Zuckerberg Biohub invests $50 million in its first 47 research initiatives". TechCrunch.
  18. 1 2 3 "Chan Zuckerberg Initiative announces biomedical science initiative". Philanthropy News Digest (PND). December 8, 2021. Retrieved May 16, 2022.
  19. 1 2 3 Hadero, Haleluya (December 7, 2021). "Zuckerberg, Chan to invest up to $3.4B for science advances". AP News. Retrieved May 16, 2022.
  20. 1 2 "Chan Zuckerberg Biohub awards $86 million in investigator grants". Philanthropy News Digest (PND). January 13, 2022. Retrieved May 17, 2022.
  21. 1 2 Alexander, Donovan (January 6, 2019). "Mark Zuckerbergís $5 Billion Project to End Disease Within a Generation". Interesting Engineering. Retrieved May 17, 2022.
  22. ↑ Farr, Christina (September 15, 2018). "Mark Zuckerberg is selling up to $13 billion of Facebook stock to fund an ambitious project to end disease: Here's an early look inside". CNBC. Retrieved May 10, 2022.
  23. ↑ "UCSF virus hunter DeRisi wins Heinz award". sfgate.com. September 10, 2008. Retrieved November 18, 2020.
  24. 1 2 Kahn, Jennifer (June 10, 2021). "The Disease Detective". The New York Times. ISSN   0362-4331 . Retrieved May 18, 2022.
  25. 1 2 3 Siu, Antoinette (February 23, 2017). "Staked with $600 million, the Chan Zuckerberg Biohub is writing new rules for life science research". San Francisco Business Times. Retrieved May 10, 2022.
  26. ↑ "CZ Biohub | Quantitative Cell Science". CZ Biohub. Retrieved May 17, 2022.
  27. ↑ Park, Andrea (December 9, 2021). "Chan Zuckerberg Initiative to pour $3.4B over 10 years into AI, imaging and other tech to unravel biomedical challenges". Fierce Biotech. Retrieved May 17, 2022.
  28. ↑ "CZ Biohub | Technology Platforms". CZ Biohub. Retrieved May 17, 2022.
  29. ↑ Levine, Martin (November 4, 2016). "CZI's Biohub: Who Will Benefit If It Hits a Health Homerun?". Nonprofit Quarterly.
  30. ↑ "Chan Zuckerberg Initiative: Cori Bargmann Steps Down As Science Head, Stephen Quake To Take Over". ABP Live. June 24, 2022. Retrieved October 3, 2022.
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