Chandan K. Sen is an Indian-American scientist who is known for contributions to the fields of regenerative medicine and wound care. He is currently the Director of the McGowan Institute for Regenerative Medicine of the University of Pittsburgh. [1] He is a University Endowed Professor of Surgery who also serves as the Chief Scientific Officer of wound care services of the University of Pittsburgh Medical Center health system. [2] At the University of Pittsburgh, Professor Sen serves as Associate Vice Chancellor for Life Sciences Innovation and Commercialization. [3] Dr. Sen is the current vice-chair and chair-elect of the National Institute of Health's [4] Diabetic Foot Consortium. [5]
Founded in 1992, McGowan Institute for Regenerative Medicine was initially established as the McGowan Center for Artificial Organ Development. Professor Sen moved with a large team of scientists from Indiana to Pittsburgh in July of 2023. [6] During 2018-2023, Professor Sen served as a Indiana University Distinguished Professor. [7] At Indiana University, Sen directed the Indiana Center for Regenerative Medicine and Engineering (ICRME) and held the J. Stanley Battersby Chair and Distinguished Professor of Surgery. [8] He also served as the Associate Dean of Research as well as Associate Vice President of Research. [9] In 2020, he was awarded the Bicentennial Medal by the University President's Office. [10]
In 2021, Sen was elected to the National Academy of Inventors. [9] Currently, he serves as Editor-in-Chief of Antioxidants & Redox Signaling as well as of Advances in Wound Care . [11] Sen is known for his co-invention of the tissue nanotransfection technology for in vivo tissue reprogramming. His team identified the vasculogenic fibroblasts in humans. [12] His work has included the study of the electroceutical management of infection, and tocotrienol form on natural vitamin E. Sen has an H-index of 116. [13]
Chandan Sen received his BS and MS from the Rajabazar Science College at Calcutta University where he received his Bachelor of Sciences (Honors in Physiology) in 1987 and his Masters of Science in Human Physiology in 1990. [14]
Sen then moved to Finland for further studies. In 1994, he received his PhD in Physiology from the School of Medicine at the University of Eastern Finland - Kuopio Campus. In January 1995, Sen went to the University of California Berkeley for his postdoctoral studies on redox signaling in the Molecular and Cell Biology department (1995-1996). In 1997, Sen received his first faculty position at the Lawrence Berkeley National Laboratory in Berkeley California. [8]
In 2000, Sen joined The Ohio State University. Here, he was promoted to full professor with tenure in 2004. Later he was recognized with the John H & Mildred C Lumley endowed chair of Surgery. [8] At Ohio State, Sen also served as the Associate Dean of Research. [15] He was the founding Executive Director of the OSU Comprehensive Wound Center, and the founding Director of the OSU Center for Regenerative Medicine & Cell-Based Therapies [16] While at Ohio State, his primary areas of research interest included tissue injury, repair, regeneration, and infection that he studied through his research in stroke, tissue reprogramming, and cutaneous wound healing. [17] This research led to the pioneering of Tissue Nanotransfection (TNT) technology in regenerative medicine. This in vivo tissue reprogramming technology was published in Nature Nanotechnology. [18] The technology won a 2018 Edison Awards for Innovation. [19] Sen’s work has also led to electroceutical management of tissue infection, which received the Frost & Sullivan award for new product innovation. [8] In 2021, Sen was elected Fellow of the National Academy of Inventors. [20]
In 2018 Sen was called “one of the world’s leading experts in the nascent field of regenerative medicine” by the Indianapolis Business Journal after he joined Indiana University as the Director of Indiana Center for Regenerative Medicine and Engineering (ICRME), Executive Director of IU Health Comprehensive Wound Center, J. Stanley Battersby Chair and Professor of Surgery, Associate Vice President of Research, Associate Dean for Entrepreneurial Research. [8] He brought a staff of 30 researchers and $10 million in research grants. [21] Sen is also Professor of Biomedical Engineering by courtesy of the Weldon School of Biomedical Engineering at Purdue University. [22] His research currently focuses on the use of nanotechnology in tissue regeneration. [23]
During the 2020 pandemic, Sen’s work discovered that electrical field can inactive coronavirus and that such approach can be used to develop person protective equipment employing an electroceutical fabric. [24]
The University of Texas Southwestern Medical Center is a public academic health science center in Dallas, Texas. With approximately 23,000 employees, more than 3,000 full-time faculty, and nearly 4 million outpatient visits per year, UT Southwestern is the largest medical school in the University of Texas System and the State of Texas.
The Indiana University School of Medicine (IUSM) is a major, multi-campus medical school located throughout the U.S. state of Indiana and is the graduate medical school of Indiana University. There are nine campuses throughout the state; the principal research, educational, and medical center is located on the campus of Indiana University Indianapolis. With 1,461 MD students, 195 PhD students, and 1,442 residents and fellows in the 2023–24 academic year, IUSM is the largest medical school in the United States. The school offers many joint degree programs including an MD/PhD Medical Scientist Training Program. It has partnerships with Purdue University's Weldon School of Biomedical Engineering, other Indiana University system schools, and various in-state external institutions. It is the medical school with the largest number of graduates licensed in the United States per a 2018 Federation of State Medical Boards survey with 11,828 licensed physicians.
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs.
Articles related specifically to biomedical engineering include:
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David M. Brienza is a professor of rehabilitation science at the University of Pittsburgh School of Health and Rehabilitation Sciences. He holds additional professorial appointments in bioengineering and electrical engineering.
Following is a list of topics related to life extension:
Peter W. Zandstra, is a Canadian scientist who is the Director of the Michael Smith Laboratories at the University of British Columbia.
Gordana Vunjak-NovakovicFRSC is a Serbian American biomedical engineer and university professor. She is a University Professor at Columbia University, as well as the Mikati Foundation Professor of Biomedical Engineering and Medical Sciences. She also heads the laboratory for Stem Cells and Tissue Engineering at Columbia University. She is part of the faculty at the Irving Comprehensive Cancer Center and the Center for Human Development, both found at Columbia University. She is also an honorary professor at the Faculty of Technology and Metallurgy at the University of Belgrade, an honorary professor at the University of Novi Sad, and an adjunct professor at the Department of Biomedical Engineering at Tufts University.
Martin (Maish) L. Yarmush is an academic, American scientist, physician, and engineer known for his work in biotechnology and bioengineering. His faculty career began in 1984 at MIT in the Department of Chemical Engineering as a Principal Research Associate and Lucille P. Markey Scholar in Biomedical Science. In 1988 he joined Rutgers University, as Professor of Chemical and Biochemical Engineering and a member of the Center of Advanced Biotechnology and Medicine. In 1995, he returned to the Boston area to serve as the Helen Andrus Benedict Professor of Surgery and Bioengineering in the Harvard-MIT Division of Health Sciences and Technology, and to establish the Center for Engineering in Medicine at the Harvard Affiliated Teaching Hospitals. In 2007 he returned to Rutgers to hold the Paul and Mary Monroe Endowed Chair in Science and Engineering and serve as Distinguished Professor in the Department of Biomedical Engineering. He also holds a Lecturer in Surgery and Bioengineering position at Harvard Medical School, and is a member of the Senior Scientific Staff at the Shriners children's hospital in Boston.
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Tooth regeneration is a stem cell based regenerative medicine procedure in the field of tissue engineering and stem cell biology to replace damaged or lost teeth by regrowing them from autologous stem cells.
Regeneration in humans is the regrowth of lost tissues or organs in response to injury. This is in contrast to wound healing, or partial regeneration, which involves closing up the injury site with some gradation of scar tissue. Some tissues such as skin, the vas deferens, and large organs including the liver can regrow quite readily, while others have been thought to have little or no capacity for regeneration following an injury.
McGowan Institute for Regenerative Medicine is a medical research institute which is a partnership between the University of Pittsburgh and the University of Pittsburgh Medical Center and is located in Pittsburgh, Pennsylvania, United States. It is directed by Professor Chandan K Sen.
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Guillermo Antonio Ameer is the Daniel Hale Williams Professor of biomedical engineering at the Robert R. McCormick School of Engineering and Applied Science and Surgery at the Feinberg School of Medicine of Northwestern University and is a fellow of the American Institute for Medical and Biological Engineering, Biomedical Engineering Society, American Institute of Chemical Engineers, American Association for the Advancement of Science, Materials Research Society, and American Academy of Arts and Sciences. He is an engineer, inventor, and entrepreneur.
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Kenneth Lutchen is a biomedical engineer, researcher, professor, and university leader. He was named university provost and chief academic officer ad interim of Boston University in July 2023.
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