Charles Surh

Last updated
Charles Surh
Charles D. Surh scientist.jpg
Born
서동철

1961
Seoul, South Korea
Died7 October 2017
Alma mater University of California, San Diego, University of California, Davis
Awards Ho-Am Prize in Medicine, 100 Leaders in Korea, Scientist of the Year Award
Scientific career
Fields Memory T cells, naïve T cells, immune system, microbiota
Institutions The Scripps Research Institute, Pohang University of Science and Technology, Institute for Basic Science, La Jolla Institute for Immunology
Korean name
Hangul
서동철 [1]
Revised Romanization Seo Dongcheol
McCune–Reischauer Sŏ Tongch'ŏl
Website Academy of Immunology and Microbiology

Charles D. Surh was a leading scientist in the field of immunology. [2] [3] He was a professor at both The Scripps Research Institute and Pohang University of Science and Technology (POSTECH), director of the Academy of Immunology and Microbiology in Pohang, and associate editor of the journal Pleura and Peritoneum. [4] He died from cancer in 2017.

Contents

Early life and education

Charles majored in biochemistry at the University of California, San Diego for his undergrad graduating in 1983. He then went to the University of California, Davis, where he obtained his Ph.D. in immunology in 1989. He research topic was on target antigens for autoantibody formation associated with primary biliary cirrhosis.

Career

Working as a postdoc at The Scripps Research Institute in the Department of Immunology, he researched T cells focusing on the function and structure thymus and the physiology and lifespan of mature T cells. [4] Staying at Scripps, he became an assistant professor, associate professor, gained tenure, and then a full professor. In 2009, the Korean government recruited him as part of their World Class University (WCU) program. He worked as a WCU professor in the Division of Integrative Bioscience and Biotechnology, POSTECH

From 2012 until his death in 2017, he worked as an adjunct professor in both the Department of Immunology at The Scripps Research Institute and also in the Division of Development Immunology at La Jolla Institute for Immunology. He also started a professorship at the Division of Integrative Bioscience and Biotechnology in POSTECH. Also within POSTECH, he was the founding and only director of the Academy of Immunology and Microbiology (AIM) for the Institute for Basic Science (IBS). [5] The Academy researched chronic diseases of the immune system with the "belief that a significant proportion of the chronic diseases arise from aberrant interactions between the host’s immune systems with the components of the diet as well as with the commensal microbes that co-exist with the host." [6] After failing to find a suitable replacement, AIM closed in October 2019.

Death

Diagnosed with cancer in early 2015, he continued his research while receiving treatment. He succumbed to the disease on October 7, 2017 in San Diego, U.S. [7]

Awards and honors

Selected publications

  1. Kaech, Susan M.; Tan, Joyce T.; Wherry, E. John; Konieczny, Bogumila T.; Surh, Charles D.; Ahmed, Rafi (16 November 2003). "Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells". Nature Immunology. 4 (12): 1191–1198. doi:10.1038/ni1009. PMID   14625547. S2CID   8178667.
  2. Surh, Charles D.; Sprent, Jonathan (3 November 1994). "T-cell apoptosis detected in situ during positive and negative selection in the thymu". Nature. 372 (6501): 100–103. Bibcode:1994Natur.372..100S. doi:10.1038/372100a0. PMID   7969401. S2CID   4350111.
  3. Surh, Charles D.; Sprent, Jonathan (19 December 2008). "Homeostasis of Naive and Memory T Cells". Immunity. 29 (6): 848–862. doi: 10.1016/j.immuni.2008.11.002 . PMID   19100699.
  4. Tan, Joyce T.; Dudl, Eric; LeRoy, Eric; Murray, Richard; Sprent, Jonathan; Weinberg, Kenneth I.; Surh, Charles D. (17 July 2001). "IL-7 is critical for homeostatic proliferation and survival of naïve T cells". PNAS. 98 (15): 8732–8737. Bibcode:2001PNAS...98.8732T. doi: 10.1073/pnas.161126098 . PMC   37504 . PMID   11447288.
  5. Tan, Joyce T.; Ernst, Bettina; Kieper, William C.; LeRoy, Eric; Sprent, Jonathan; Surh, Charles D. (17 June 2002). "Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells". J Exp Med. 195 (12): 1523–1532. doi: 10.1084/jem.20020066 . PMC   2193564 . PMID   12070280.

See also

Related Research Articles

<span class="mw-page-title-main">WEHI</span> Medical research institute in Victoria, Australia

WEHI, previously known as the Walter and Eliza Hall Institute of Medical Research, and as the Walter and Eliza Hall Institute, is Australia's oldest medical research institute. Sir Frank Macfarlane Burnet, who won the Nobel Prize in 1960 for his work in immunology, was director from 1944 to 1965. Burnet developed the ideas of clonal selection and acquired immune tolerance. Later, Professor Donald Metcalf discovered and characterised colony-stimulating factors. As of 2015, the institute hosted more than 750 researchers who work to understand, prevent and treat diseases including blood, breast and ovarian cancers; inflammatory diseases (autoimmunity) such as rheumatoid arthritis, type 1 diabetes and coeliac disease; and infectious diseases such as malaria, HIV and hepatitis B and C.

<span class="mw-page-title-main">Harald von Boehmer</span> German-Swiss immunologist

Harald von Boehmer was a German-Swiss immunologist best known for his work on T cells.

<span class="mw-page-title-main">Young-Tae Chang</span> South Korean chemist

Young-Tae Chang is a South Korean chemist. He is a professor of chemistry at Pohang University of Science and Technology (POSTECH) and Associate Director under Kim Kimoon at the Center for Self-assembly and Complexity at the Institute for Basic Science located on the POSTECH campus.

<span class="mw-page-title-main">Jared Purton</span>

Jared Franklin Purton was an Australian-born immunologist who contributed to the understanding of how T cells function through his academic research. After his death in a car accident in 2009, the Jared F. Purton Foundation was set up in his memory to support charitable causes in the San Diego area.

<span class="mw-page-title-main">Hee-Sup Shin</span> South Korean neuroscientist (born 1950)

Hee-sup Shin is a South Korean neuroscientist whose work focuses on brain research of genetically engineered mice via gene knockout in order to better understand the human brain. His research resulted in him being named a National Scientist by the Korean Ministry of Science and Technology. He is a former co-director of the Center for Cognition and Sociality leading the Social Neuroscience Group in the Institute for Basic Science (IBS) located at Korea Advanced Institute of Science and Technology (KAIST).

<span class="mw-page-title-main">Hong Gil Nam</span> South Korean scientist

Hong Gil Nam is a South Korean biologist teaching in the Department of New Biology of Daegu Gyeongbuk Institute of Science and Technology and leading research as director of the Center for Plant Aging Research. His research interests include comparative aging in diverse kingdoms, including plant and animals, to reveal aging mechanisms among species, cross-kingdom interaction between plants and animals, and biochemistry at nano and micro levels. He is the founder and former director of the Biological Research Information Center, a member of the Korean Academy of Science and Technology, and has served on the editorial board in Molecular Plant since 2013.

<span class="mw-page-title-main">Akiko Iwasaki</span> Immunobiologist

Akiko Iwasaki is a Sterling Professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University. She is also a principal investigator at the Howard Hughes Medical Institute. Her research interests include innate immunity, autophagy, inflammasomes, sexually transmitted infections, herpes simplex virus, human papillomavirus, respiratory virus infections, influenza infection, T cell immunity, commensal bacteria, COVID-19 and Long COVID.

<span class="mw-page-title-main">Arturo Casadevall</span> Cuban-American scientist

Arturo Casadevall is a Bloomberg Distinguished Professor of Molecular Microbiology & Immunology and Infectious Diseases at the Johns Hopkins Bloomberg School of Public Health and Johns Hopkins School of Medicine, and the Alfred and Jill Sommer Professor and Chair of the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. He is an internationally recognized expert in infectious disease research, with a focus on fungal and bacterial pathogenesis and basic immunology of antibody structure-function. He was elected a member of the National Academy of Sciences in 2022.

<span class="mw-page-title-main">Institute for Basic Science</span> Science institute in South Korea

The Institute for Basic Science is a Korean government-funded research institute that conducts basic science research and relevant pure basic research. Comprising approximately 30 research centers with more than 60 research groups across the nation and a headquarters in Daejeon, IBS has approximately 1,800 researchers and doctoral course students. Around 30% of the researchers are from countries outside South Korea. The organization is under the Ministry of Science and ICT.

Persephone Borrow is a viral immunologist specialising in T-cell responses in acute and early HIV-1 infections. She has been at the University of Oxford since 2005 and in 2016 was made a professor there.

<span class="mw-page-title-main">Rafi Ahmed</span> 20th and 21st-century Indian-American virologist and immunologist

Rafi Ahmed is an Indian-American virologist and immunologist. He is the Charles Howard Candler Professor of Microbiology and Immunology at Emory University, where he is also the director of the Emory Vaccine Center and a Georgia Research Alliance Eminent Scholar in Vaccine Research. In 2009, he was elected to the National Academy of Sciences.

Howard Chi Hang is an American chemist and professor in the Department of Immunology and Microbiology and Department of Chemistry at The Scripps Research Institute. He was previously Richard E. Salomon Family Associate Professor and the head of the Laboratory of Chemical Biology and Microbial Pathogenesis at the Rockefeller University in New York City. He won the Eli Lilly Award in Biological Chemistry in 2017.

Shane Patrick Crotty is a professor of immunology in the Center for Infectious Disease and Vaccine Research at La Jolla Institute for Immunology.

<span class="mw-page-title-main">Myung Kyungjae</span>

Myung Kyungjae is a biologist researching DNA repair pathways at the molecular level. He is a Distinguished Professor at the Ulsan National Institute of Science and Technology (UNIST) and the Director of the IBS Center for Genomic Integrity located on the UNIST campus. He is on the editorial board of various peer-reviewed journals and is a member of multiple scientific societies.

<span class="mw-page-title-main">Cha Meeyoung</span> South Korean data scientist (born 1979)

Cha Meeyoung, sometimes known as Mia, is an associate professor at KAIST in the School of Computing and a chief investigator in the Pioneer Research Center for Mathematical and Computational Sciences at the Institute for Basic Science. Her research focuses on network and data science with an emphasis on modeling, analyzing complex information propagation processes, machine learning-based computational social science, and deep learning. In June 2024, she will become the scientific director of the Max Planck Institute for Security and Privacy. She has served on the editorial boards of the journals PeerJ and ACM Transactions on Social Computing.

<span class="mw-page-title-main">Choi Kiwoon</span> South Korean physicist (born 1959)

Choi Kiwoon is a theoretical particle physicist researching focusing on particle theory and cosmology. He was a research professor at Chonbuk National University and a full professor at KAIST. He is the founding director of the Institute for Basic Science Center for Theoretical Physics of the Universe. He is a member of the Korean Academy of Science and Technology.

<span class="mw-page-title-main">Changjoon Justin Lee</span>

Changjoon Justin Lee is an American neuroscientist specializing in the field of glioscience. He served as the Director of Center for Neuroscience at the Korea Institute of Science and Technology and later founded the WCI Center for Functional Connectomics as part of the World Class Institute Program. In 2015, he established the Center for Glia-Neuron Interaction before becoming co-director of the IBS Center for Cognition and Sociality and head of the Cognitive Glioscience Group in 2018. He has been on the editorial boards of the journals Molecular Brain and Molecular Pain and is a chief editor of Experimental Neurobiology.

<span class="mw-page-title-main">Kim Jin-soo (biologist)</span> Korean scientist

Kim Jin-Soo is a chemist, biologist, and entrepreneur. He was CEO and CSO, ToolGen, Inc., is a professor in the Department of Chemistry of Seoul National University and director of the Center for Genome Engineering. His research team has developed and improved several types of programmable nucleases, specifically zinc finger nucleases (ZFNs), TAL effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs). In 2018, he was a Clarivate Analytics Highly Cited Researcher in the cross-field category and in the biology and biochemistry category in 2019.

<span class="mw-page-title-main">Oh Yong-Geun</span>

Oh Yong-Geun is a mathematician and distinguished professor at the Pohang University of Science and Technology and founding director of the IBS Center for Geometry and Physics located on that campus. His fields of study have been on symplectic topology, Floer homology, Hamiltonian mechanics, and mirror symmetry He was in the inaugural class of fellows of the American Mathematical Society and has been a member of Institute for Advanced Study, Korean Mathematical Society, and National Academy of Sciences of the Republic of Korea and is on the editorial boards of Journal of Gokova Geometry and Topology and Journal of Mathematics of Kyoto University.

<span class="mw-page-title-main">Eui-Cheol Shin</span> Korean immunologist

Eui-Cheol Shin is a South Korean medical immunologist, academic, and author. He is a professor at the Graduate School of Medical Science and Engineering at the Korea Advanced Institute of Science and Technology (KAIST), and director of The Center for Viral Immunology at the Institute for Basic Science (IBS), a Korean government-funded research institute.

References

  1. 이근영 (9 October 2017). "서동철 기초과학연구원 단장 별세". The Hankyoreh (in Korean). Retrieved 29 March 2020. 찰스 서(한국이름 서동철)
  2. 1 2 "Director Charles Surh". Academy of Immunologyand Microbiology. Institute for Basic Science . Retrieved 29 March 2020. Charles Surh is a professor at POSTECH and a world-leading scientist in the field of immunology.
  3. 1 2 이부용 (10 October 2017). "세계적 면역학자 찰스 서 IBS 연구단장 별세". 대경일보 (in Korean). Retrieved 29 March 2020.
  4. 1 2 Reymond, Marc A. (March 2018). "In memory of the late Associate Editor of the journal "Pleura and Peritoneum", Prof. Charles D. Surh". Pleura and Peritoneum. 3 (1). doi:10.1515/pp-2018-0105. PMC   6405006 .
  5. "교수진 Charles Surh 교수 Profile". Life Sciences. POSTECH . Retrieved 29 March 2020.
  6. "Introduction". Academy of Immunology and Microbiology. Institute for Basic Science . Retrieved 29 March 2020. It is our belief that a significant proportion of the chronic diseases arise from aberrant interactions between the host's immune systems with the components of the diet as well as with the commensal microbes that co-exist with the host. The genetic diversity of the commensal microbes is massive, i.e., two orders of magnitude greater than that of the host genome, and together with the large amounts of antigens in the food, the host immune system is continuously exposed to a myriad of foreign antigens.
  7. 1 2 "Director Charles D. SURH named Scientist of the Year by Journalists". Institute for Basic Science . 30 November 2017. Retrieved 29 March 2020.
  8. 유용하 (15 November 2017). "올해의 과학자상에 故 찰스 서 박사". Seoul Shinmun (in Korean). Retrieved 29 March 2020.
  9. 김윤진 (15 November 2017). "올해의 과학자상 찰스 서·임명신·중력파 연구단". 매일경제 (in Korean). Retrieved 29 March 2020.
  10. 원호섭 (9 October 2017). "찰스 서 IBS 단장 별세". 매일경제 (in Korean). Retrieved 29 March 2020.
  11. 박주영 (9 October 2017). "세계적 면역학자 찰스 서 IBS 연구단장 별세". Yonhap News Agency (in Korean). Retrieved 29 March 2020.
  12. 조진형 (9 October 2017). "세계적 면역학자 찰스 서 IBS 단장 별세". JoongAng Ilbo (in Korean). Retrieved 29 March 2020.
  13. 박희진 (9 October 2017). "'호암 의학상' 찰스 서 IBS단장 겸 포스텍 교수 별세". News1뉴스 (in Korean). Retrieved 29 March 2020.
  14. "면역세포 간 생존 경쟁이 면역계 균형 유지: IBS, 희소한 선천성 림프 세포가 다수 T세포와 경쟁·공생하는 관계 밝혀". Nobel Science (in Korean). 23 August 2017. Archived from the original on 2 March 2021. Retrieved 29 March 2020.