Claudia Fischbach

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Claudia Fischbach
Alma mater University of Regensburg
Harvard University
Scientific career
Institutions Cornell University
Harvard University
Thesis Adipose tissue engineering development of a 3-D model system of adipogenesis.  (2004)

Claudia Fischbach is a German bioengineer who serves as the James M. and Marsha McCormick Director of Biomedical Engineering and the Stanley Bryer 1946 Professor of Biomedical Engineering at Cornell University. She is Director of the Cornell Physical Sciences Oncology Center on the Physics of Cancer Metabolism.

Contents

Early life and education

Fischbach earned a master's degree in pharmacy from the Ludwig Maximilian University of Munich. She worked toward her doctorate in pharmaceutical technology at the University of Regensburg. She then moved to Harvard University, where she worked in tissue engineering. [1]

Research and career

In 2007, Fischbach joined Cornell University, [2] where she started using biomedical engineering to better understand how to treat cancer. [3] The progression of cancer is influenced by interactions with nearby cells and the extracellular matrix. Despite that, the majority of cancer studies do not replicate conditions outside of the body. Fischbach uses tissue engineering to design systems that let her lab model and investigate how these interactions influence tumor cells. She uses model systems to understand the biological strategies tumors adopt to modify bodily function, become more aggressive, and metastasize. [4]

Fischbach has extensively investigated the fundamental mechanisms that underpin breast cancer. For example, she showed that obesity can change the composition of breast tissue, which can promote disease progression. [5] [6] Moreover, she was supported by the Human Frontier Science Program to study the impact of breast cancer on the material properties of bone. [7] [8] She showed that exercise, which is often prescribed to prevent bone loss, could also help to protect people against metastatic cancer. [9] In addition, her research demonstrated that breast cancer can trigger distant bone growth, which could be a preemptive defense against metastasis. [10]

Awards and honors

Selected publications

Related Research Articles

<span class="mw-page-title-main">Breast cancer</span> Cancer that originates in mammary glands

Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.

<span class="mw-page-title-main">Prostate cancer</span> Male reproductive organ cancer

Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Abnormal growth of prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels. Those with high levels of PSA in their blood are at increased risk for developing prostate cancer. Diagnosis requires a biopsy of the prostate. If cancer is present, the pathologist assigns a Gleason score, and a higher score represents a more dangerous tumor. Medical imaging is performed to look for cancer that has spread outside the prostate. Based on the Gleason score, PSA levels, and imaging results, a cancer case is assigned a stage 1 to 4. A higher stage signifies a more advanced, more dangerous disease.

<span class="mw-page-title-main">Metastasis</span> Spread of a disease inside a body

Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues.

<span class="mw-page-title-main">E-selectin</span> Mammalian protein found in Homo sapiens

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene.

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<span class="mw-page-title-main">Metastatic breast cancer</span> Type of cancer

Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumors, secondaries or stage IV breast cancer, is a stage of breast cancer where the breast cancer cells have spread to distant sites beyond the axillary lymph nodes. There is no cure for metastatic breast cancer; there is no stage after IV.

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<span class="mw-page-title-main">Tumor microenvironment</span> Surroundings of tumors including nearby cells and blood vessels

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Abituzumab is a humanized IgG2 monoclonal antibody (mAb) targeted at CD51 currently in development by Merck KGaA Darmstadt, Germany in an attempt to prevent bone lesion metastases in castration-resistant prostate cancer.

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Debra Auguste is an American chemical engineer and professor at Northeastern University in the department of chemical engineering. Auguste is dedicated to developing treatments for triple negative breast cancer, one of the most aggressive and fatal cancers that disproportionately affects African American women. Her lab characterizes biomarkers of triple negative breast cancer and develops novel biocompatible therapeutic technologies to target and destroy metastatic cancer cells. Auguste received the 2012 Presidential Early Career Award for Scientists and Engineers and in 2010 was named in the 50 Most Influential African-Americans in Technology. In 2020, Auguste became an Elected Fellow of the American Institute for Medical and Biological Engineering.

Elizabeth Cosgriff-Hernandez is an American biomedical engineer who is a professor at the University of Texas at Austin. Her work involves the development of polymeric biomaterials for medical devices and tissue regeneration. She is a co-founder of Rhythio Medical, on the scientific advisory board of ECM Biosurgery, and a consultant to several companies on biostability evaluation of medical devices. Dr. Cosgriff-Hernandez is an associate editor of the Journal of Materials Chemistry B and Fellow of the International Union of Societies for Biomaterials Science and Engineering, Biomedical Engineering Society, Tissue Engineering and Regenerative Medicine International Society, American Chemical Society Division of Polymeric Materials: Science and Engineering, Royal Society of Chemistry, and the American Institute for Medical and Biological Engineering.

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References

  1. 1 2 "Claudia Fischbach". mooneylab.seas.harvard.edu. Retrieved 6 January 2023.
  2. ↑ "Principal Investigator – THE FISCHBACH LAB". www.fischbachlab.org. Retrieved 6 January 2023.
  3. ↑ "Research – THE FISCHBACH LAB". www.fischbachlab.org. Retrieved 6 January 2023.
  4. ↑ "Claudia Fischbach | Cornell Engineering". www.engineering.cornell.edu. Retrieved 6 January 2023.
  5. ↑ "Stiffer breast tissue in obese women promotes tumors". Cornell Chronicle. Retrieved 6 January 2023.
  6. ↑ Ramanujan-Cornell, Krishna (25 August 2015). "Obesity makes breast tissue stiff and scarred". Futurity. Retrieved 6 January 2023.
  7. ↑ "Study to focus on breast cancer's effect on bone composition". Cornell Chronicle. Retrieved 6 January 2023.
  8. ↑ "Metastatic breast cancer affects bone mineral before spreading". Cornell Chronicle. Retrieved 6 January 2023.
  9. ↑ "Exercise could reduce bone tumor growth". Cornell Chronicle. Retrieved 6 January 2023.
  10. ↑ "Researchers link breast cancer and bone growth". Cornell Chronicle. Retrieved 6 January 2023.
  11. ↑ "Stories by Claudia Fischbach". Scientific American. Retrieved 6 January 2023.
  12. ↑ "Claudia Fischbach-Teschl Claudia Fischbach-Teschl, Ph.D. To be Inducted into Medical and Biological Engineering Elite - AIMBE" . Retrieved 6 January 2023.
  13. ↑ "Claudia Fischbach-Teschl, Ph.D. COF-1951 - AIMBE" . Retrieved 6 January 2023.
  14. ↑ "Prof. Dr. Claudia Fischbach-Teschl - Alexander von Humboldt-Stiftung".
  15. ↑ "EPICC Awards honor faculty, staff exemplifying college's core values | Cornell Engineering". www.engineering.cornell.edu. Retrieved 6 January 2023.
  16. ↑ "Claudia Fischbach-Teschl wins 2023 CMBE Momentum Award | Meinig School of Biomedical Engineering". www.bme.cornell.edu. Retrieved 6 January 2023.
  17. ↑ "CMBE Momentum Award - Biomedical Engineering Society". www.bmes.org. Retrieved 6 January 2023.
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