U.S. Route 5 (US 5) is a north–south United States Numbered Highway running through the New England states of Connecticut, Massachusetts, and Vermont. Significant cities along the route include New Haven, Connecticut; Hartford, Connecticut; and Springfield, Massachusetts. From Hartford northward to St. Johnsbury, Vermont, the road closely follows the route of the Connecticut River.
U.S. Route 258 is a spur of US 58 in the U.S. states of North Carolina and Virginia. The U.S. Highway runs 220.15 miles (354.30 km) from US 17 Business and NC 24 Business in Jacksonville, North Carolina north to Virginia State Route 143 at Fort Monroe in Hampton, Virginia. In North Carolina, US 258 connects Jacksonville with the Inner Banks communities of Kinston, Snow Hill, Farmville, Tarboro, and Murfreesboro. The U.S. Highway continues through the Virginia city of Franklin, where the highway intersects US 58, and the town of Smithfield on its way to the Hampton Roads metropolitan area. US 258 crosses the James River on the James River Bridge and follows Mercury Boulevard through Newport News and Hampton.
Route 22 is a 14.07-mile-long (22.64 km) secondary state route within the U.S. state of Connecticut. Route 22 is an L-shaped road that is signed east–west from Hamden to the western junction of Route 80 in North Branford, and north–south to its eastern terminus in Guilford. It was designated in 1951 as a bypass of New Haven, connecting the Wilbur Cross Parkway and Route 80.
Route 75 in the U.S. states of Connecticut and Massachusetts is a 17.5-mile-long (28.2 km) scenic route connecting the Hartford, Connecticut, and Springfield, Massachusetts, areas. The route begins at Route 159 in the town of Windsor, Connecticut, and ends at the junction of Route 159/Route 147 in the city of Agawam, Massachusetts.
Massachusetts Route 32 is a state highway in the U.S. state of Massachusetts. The highway runs 60.66 miles (97.62 km) from the Connecticut state line north to the New Hampshire state line, where it continues as NH 32. Route 32 connects several towns on the eastern edge of Western Massachusetts. The highway serves Palmer in eastern Hampden County, Ware in eastern Hampshire County, and Barre and Athol in northwestern Worcester County. Route 32 intersects major east–west routes including U.S. Route 20 and the Massachusetts Turnpike in Palmer, Route 9 in Ware, and US 202 and Route 2 in Athol. The highway has an alternate route, Route 32A, through Hardwick and Petersham.
Route 45 is a Connecticut state highway from US 202 in Washington to US 7 in Cornwall, in the rural northwest of the state. It is 10.29 miles (16.56 km) long and runs north–south.
Route 150 is a state highway in southern Connecticut running for 9.04 miles (14.55 km) from the village of Northford, in the town of North Branford, through the center of Wallingford, to the village of Yalesville in Wallingford.
Route 47 is a Connecticut state highway from US 6 in Woodbury to US 202 in Washington, in the western south-central part of the state. It is 12.27 miles (19.75 km) long and runs roughly northwest-southeast, signed north–south.
Route 74 is a state highway in Connecticut in the eastern part of the Greater Hartford area. It runs from Route 194 in South Windsor to US 44 in Ashford, going through the towns of Ellington, Vernon, Tolland, and Willington. East of its junction with I-84, it becomes a rural collector road.
Route 73 is an east–west state highway in Connecticut connecting the town center of Watertown to the Route 8 expressway in Waterbury via the village of Oakville. The road is classified as an urban principal arterial road and carries traffic volumes of about 16,400 vehicles per day.
U.S. Route 5 (US 5), a north–south United States Numbered Highway that is generally paralleled by Interstate 91 (I-91), begins at the city of New Haven in Connecticut and heads north through western Massachusetts and eastern Vermont to the international border with Canada. Within Connecticut, US 5 proceeds north from New Haven and passes through Meriden and Hartford toward Springfield, Massachusetts.
Route 108 in the U.S. state of Connecticut, locally called Nichols Avenue and Huntington Turnpike, is a two-lane state highway that runs northerly from US 1, Boston Post Road in Stratford, through Trumbull, to Route 110 in downtown Shelton. Originally called the Farm Highway, it was laid out to the south side of Mischa Hill in Trumbull on December 7, 1696 and is considered to be the third oldest documented highway in Connecticut after the Mohegan Road in Norwich (1670) and the Boston Post Road or US 1 (1673).
Route 128 is a minor state highway in northwestern Connecticut, running from U.S. Route 7 in Sharon to Route 4 in Cornwall.
Route 112 is a state highway in northwestern Connecticut, running entirely within the town of Salisbury. The route serves the village of Lime Rock.
Route 187 is a 27.23-mile-long (43.82 km) secondary state route in the U.S. states of Connecticut and Massachusetts. It begins in the city of Hartford at Albany Avenue, travels north through the towns of Bloomfield, Windsor, East Granby and Suffield until the Connecticut-Massachusetts state line. Route 187 continues north across the state line through Agawam into Westfield, where the route ends at US 20 east of Westfield center. Route 187 crosses the Farmington River between the towns of Bloomfield and East Granby.
Route 191 is a state highway in northern Connecticut, running from East Windsor to Enfield.
Route 197 is a 14.17-mile-long (22.80 km) state highway in northeastern Connecticut and southern Massachusetts, running from Union, Connecticut, to Dudley, Massachusetts. The Connecticut section is signed as an east–west route, while the Massachusetts section is signed north–south.
Route 218 is a 7.00-mile (11.27 km) state highway in the U.S. state of Connecticut. It is located in the northwestern suburbs of Hartford, traveling in an L-shaped pattern from West Hartford to Windsor.
U.S. Route 5 (US 5) is a part of the United States Numbered Highway System that runs from New Haven, Connecticut, to the Canada–United States border at Derby Line, Vermont. In Vermont, the road runs south–north from the Massachusetts state line near Guilford to the international border. The 192.317 miles (309.504 km) that lie in Vermont are maintained by the Vermont Agency of Transportation (VTrans) and run largely parallel to Interstate 91 (I-91). US 5 also follows the path of the Connecticut River from the Massachusetts border to St. Johnsbury, where the river turns northeast while US 5 continues north. The highway serves the major towns of Brattleboro, Hartford, and St. Johnsbury, along with the city of Newport near the Canadian border.
State Route 215 (SR 215) is a state highway in the U.S. state of Maine. It runs for about 17 miles (27 km) between Newcastle at U.S. Route 1 Business and Jefferson at SR 32, entirely in Lincoln County.
US 5 in South Windsor 
Route 30 in South Windsor
