Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy.
Signal-to-noise ratio is a measure used in science and engineering that compares the level of a desired signal to the level of background noise. SNR is defined as the ratio of signal power to the noise power, often expressed in decibels. A ratio higher than 1:1 indicates more signal than noise.
Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging.
The nuclear Overhauser effect (NOE) is the transfer of nuclear spin polarization from one population of spin-active nuclei to another via cross-relaxation. A phenomenological definition of the NOE in nuclear magnetic resonance spectroscopy (NMR) is the change in the integrated intensity of one NMR resonance that occurs when another is saturated by irradiation with an RF field. The change in resonance intensity of a nucleus is a consequence of the nucleus being close in space to those directly affected by the RF perturbation.
In nuclear magnetic resonance (NMR) spectroscopy, the chemical shift is the resonant frequency of a nucleus relative to a standard in a magnetic field. Often the position and number of chemical shifts are diagnostic of the structure of a molecule. Chemical shifts are also used to describe signals in other forms of spectroscopy such as photoemission spectroscopy.
Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials with unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but the spins excited are those of the electrons instead of the atomic nuclei. EPR spectroscopy is particularly useful for studying metal complexes and organic radicals. EPR was first observed in Kazan State University by Soviet physicist Yevgeny Zavoisky in 1944, and was developed independently at the same time by Brebis Bleaney at the University of Oxford.
Diffusion-weighted magnetic resonance imaging is the use of specific MRI sequences as well as software that generates images from the resulting data that uses the diffusion of water molecules to generate contrast in MR images. It allows the mapping of the diffusion process of molecules, mainly water, in biological tissues, in vivo and non-invasively. Molecular diffusion in tissues is not free, but reflects interactions with many obstacles, such as macromolecules, fibers, and membranes. Water molecule diffusion patterns can therefore reveal microscopic details about tissue architecture, either normal or in a diseased state. A special kind of DWI, diffusion tensor imaging (DTI), has been used extensively to map white matter tractography in the brain.
Magnetic resonance angiography (MRA) is a group of techniques based on magnetic resonance imaging (MRI) to image blood vessels. Magnetic resonance angiography is used to generate images of arteries in order to evaluate them for stenosis, occlusions, aneurysms or other abnormalities. MRA is often used to evaluate the arteries of the neck and brain, the thoracic and abdominal aorta, the renal arteries, and the legs.
In MRI and NMR spectroscopy, an observable nuclear spin polarization (magnetization) is created by an RF pulse or a train of pulses applied to a sample in a homogeneous magnetic field at the resonance (Larmor) frequency of the nuclei. At thermal equilibrium, nuclear spins precess randomly about the direction of the applied field but become abruptly phase coherent when any of the resultant polarization is created orthogonal to the field. This transverse magnetization can induce a signal in an RF coil that can be detected and amplified by an RF receiver. The RF pulses cause the population of spin-states to be perturbed from their thermal equilibrium value. The return of the longitudinal component of the magnetization to its equilibrium value is termed spin-latticerelaxation while the loss of phase-coherence of the spins is termed spin-spin relaxation, which is manifest as an observed free induction decay (FID).
Magnetic resonance force microscopy (MRFM) is an imaging technique that acquires magnetic resonance images (MRI) at nanometer scales, and possibly at atomic scales in the future. MRFM is potentially able to observe protein structures which cannot be seen using X-ray crystallography and protein nuclear magnetic resonance spectroscopy. Detection of the magnetic spin of a single electron has been demonstrated using this technique. The sensitivity of a current MRFM microscope is 10 billion times greater than a medical MRI used in hospitals.
Cardiovascular magnetic resonance imaging is a medical imaging technology for non-invasive assessment of the function and structure of the cardiovascular system. Conventional MRI sequences are adapted for cardiac imaging by using ECG gating and high temporal resolution protocols. The development of CMR is an active field of research and continues to see a rapid expansion of new and emerging techniques.
Contrast-to-noise ratio (CNR) is a measure used to determine image quality. CNR is similar to the metric signal-to-noise ratio (SNR), but subtracts a term before taking the ratio. This is important when there is a significant bias in an image, such as from haze. As can be seen in the picture at right, the intensity is rather high even though the features of the image are washed out by the haze. Thus this image may have a high SNR metric, but will have a low CNR metric.
The detective quantum efficiency is a measure of the combined effects of the signal and noise performance of an imaging system, generally expressed as a function of spatial frequency. This value is used primarily to describe imaging detectors in optical imaging and medical radiography.
Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca. 20 tesla, the frequency is similar to VHF and UHF television broadcasts (60–1000 MHz). NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics and crystals as well as non-crystalline materials. NMR is also routinely used in advanced medical imaging techniques, such as in magnetic resonance imaging (MRI).
In nuclear magnetic resonance spectroscopy and magnetic resonance imaging, the Ernst angle is the flip angle for excitation of a particular spin that gives the maximal signal intensity in the least amount of time when signal averaging over many transients. In other words, the highest signal-to-noise ratio can be achieved in a given amount of time. This relationship was described by Richard R. Ernst, winner of the 1991 Nobel Prize in Chemistry.
The physics of magnetic resonance imaging (MRI) concerns fundamental physical considerations of MRI techniques and technological aspects of MRI devices. MRI is a medical imaging technique mostly used in radiology and nuclear medicine in order to investigate the anatomy and physiology of the body, and to detect pathologies including tumors, inflammation, neurological conditions such as stroke, disorders of muscles and joints, and abnormalities in the heart and blood vessels among others. Contrast agents may be injected intravenously or into a joint to enhance the image and facilitate diagnosis. Unlike CT and X-ray, MRI uses no ionizing radiation and is, therefore, a safe procedure suitable for diagnosis in children and repeated runs. Patients with specific non-ferromagnetic metal implants, cochlear implants, and cardiac pacemakers nowadays may also have an MRI in spite of effects of the strong magnetic fields. This does not apply on older devices, details for medical professionals are provided by the device's manufacturer.
Phase contrast magnetic resonance imaging (PC-MRI) is a specific type of magnetic resonance imaging used primarily to determine flow velocities. PC-MRI can be considered a method of Magnetic Resonance Velocimetry. It also provides a method of magnetic resonance angiography. Since modern PC-MRI is typically time-resolved, it provides a means of 4D imaging.
Hyperpolarized carbon-13 MRI is a functional medical imaging technique for probing perfusion and metabolism using injected substrates.
Synthetic MRI is a simulation method in Magnetic Resonance Imaging (MRI), for generating contrast weighted images based on measurement of tissue properties. The synthetic (simulated) images are generated after an MR study, from parametric maps of tissue properties. It is thereby possible to generate several contrast weightings from the same acquisition. This is different from conventional MRI, where the signal acquired from the tissue is used to generate an image directly, often generating only one contrast weighting per acquisition. The synthetic images are similar in appearance to those normally acquired with an MRI scanner.
An MRI artifact is a visual artifact in magnetic resonance imaging (MRI). It is a feature appearing in an image that is not present in the original object. Many different artifacts can occur during MRI, some affecting the diagnostic quality, while others may be confused with pathology. Artifacts can be classified as patient-related, signal processing-dependent and hardware (machine)-related.
