Crc (protein)

Last updated
Crc
4f1r pdb structure.jpg
Crystal structure of Crc in Pseudomonas aeruginosa. [1]
Identifiers
SymbolCrc
Pfam PF03372
CDD cd08372
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. [2] Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted. [3] Crc-mediated regulation impact processes such as biofilm formation, [4] virulence [5] and antibiotic susceptibility. [6]

Contents

Interactions

A consensus sequence targeted by Crc mediated regulation CRC binding-secondary-structure.svg
A consensus sequence targeted by Crc mediated regulation

Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation. [7]

See also

References

  1. ↑ Wei Y, Zhang H, Gao ZQ, Xu JH, Liu QS, Dong YH (January 2013). "Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa". IUBMB Life. 65 (1): 50–7. doi:10.1002/iub.1103. PMID   23281037.
  2. ↑ Ramos, Juan-Luis (2004-06-17). Virulence and Gene Regulation. Springer Science & Business Media. ISBN   978-0-306-48376-9.
  3. ↑ Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics. 10 (6) e1004440. doi: 10.1371/journal.pgen.1004440 . PMC   4063720 . PMID   24945892.
  4. ↑ O'Toole, GA; Gibbs, KA; Hager, PW; Phibbs, PV jr; Kolter, R (2000). "The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa". J Bacteriol. 182 (2): 425–431. doi:10.1128/jb.182.2.425-431.2000. PMC   94292 . PMID   10629189.
  5. ↑ Zhang L, Chiang WC, Gao Q, Givskov M, Tolker-Nielsen T, Yang L, Zhang G (December 2012). "The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms". Microbiology. 158 (Pt 12): 3014–9. doi: 10.1099/mic.0.061192-0 . PMID   23023972.
  6. ↑ Yeung AT, Bains M, Hancock RE (February 2011). "The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa". Journal of Bacteriology. 193 (4): 918–31. doi:10.1128/jb.00911-10. PMC   3028677 . PMID   21169488.
  7. ↑ Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics. 10 (6) e1004440. doi: 10.1371/journal.pgen.1004440 . PMC   4063720 . PMID   24945892.
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