DFL23916

Last updated
DFL23916
DFL23916 structure.png
Identifiers
  • 7-[3-[(4-fluoro-2-methyl-5-phenylphenyl)sulfamoyl]phenyl]heptanoic acid
PubChem CID
Chemical and physical data
Formula C26H28FNO4S
Molar mass 469.57 g·mol−1
3D model (JSmol)
  • CC1=CC(=C(C=C1NS(=O)(=O)C2=CC=CC(=C2)CCCCCCC(=O)O)C3=CC=CC=C3)F
  • InChI=1S/C26H28FNO4S/c1-19-16-24(27)23(21-12-6-4-7-13-21)18-25(19)28-33(31,32)22-14-9-11-20(17-22)10-5-2-3-8-15-26(29)30/h4,6-7,9,11-14,16-18,28H,2-3,5,8,10,15H2,1H3,(H,29,30)
  • Key:VDGLRVBSCZCZGY-UHFFFAOYSA-N

DFL23916 is an experimental drug which acts as a mixed agonist for the free fatty acid receptors FFAR1 (GPR40) and FFAR4 (GPR120). Unlike the older drug GW9508 which is selective for FFAR1, DFL23916 has a balanced efficacy at both receptor targets. It increases GLP-1 secretion and improved glucose homeostasis in mice. [1] [2]

References

  1. ↑ Bianchini G, Nigro C, Sirico A, Novelli R, Prevenzano I, Miele C, Beguinot F, Aramini A. A new synthetic dual agonist of GPR120/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice. Biomed Pharmacother. 2021 Jul;139:111613. doi : 10.1016/j.biopha.2021.111613 PMID   33895521
  2. ↑ Brunetti K, Catalani E, Del Quondam S, Romano N, Ceci M, Clerici G, Gordin M, Bianchini G, Brandolini L, Aramini A, Cervia D. A novel free fatty acid receptor agonist improving metabolic health in Drosophila models. Pharmacol Res. 2025 Jun;216:107769. doi : 10.1016/j.phrs.2025.107769 PMID   40348099


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