DNAJA4

DNAJA4
Identifiers
Aliases	DNAJA4 , MST104, MSTP104, PRO1472, DnaJ heat shock protein family (Hsp40) member A4
External IDs	MGI: 1927638 HomoloGene: 23110 GeneCards: DNAJA4
Gene location (Human)
Chr.	Chromosome 15 (human) [1]
End	78,282,196 bp [1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse) [2]
End	54,716,315 bp [2]
Gene ontology
Molecular function	• protein binding ; • unfolded protein binding ; • chaperone binding ; • ATP binding ; • heat shock protein binding ; • metal ion binding ;
Cellular component	• membrane ; • cytosol ;
Biological process	• protein folding ; • negative regulation of inclusion body assembly ; • protein refolding ; • response to heat ;
	Sources:Amigo / QuickGO
Orthologs
	55466
	58233
	ENSG00000140403
	ENSMUSG00000032285
	Q8WW22
	Q9JMC3
	NM_001130182 ; NM_001130183 ; NM_018602
	NM_021422 ; NM_001357875
	NP_001123654 ; NP_001123655 ; NP_061072
	NP_067397 ; NP_001344804
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 22, 2019

DnaJ heat shock protein family (Hsp40) member A4 is a protein that in humans is encoded by the DNAJA4 gene. ^[5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Related Research Articles

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DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

Heat shock-related 70 kDa protein 2 is a protein that in humans is encoded by the HSPA2 gene.

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.

Heat shock 70 kDa protein 14 also known as HSP70-like protein 1 or heat shock protein HSP60 is a protein that in humans is encoded by the HSPA14 gene.

DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene.

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.

Heat shock 70 kDa protein 6 is a protein that in humans is encoded by the HSPA6 gene.

Selenium-binding protein 1 is a protein that in humans is encoded by the SELENBP1 gene.

Heat shock protein beta-6 is a protein that in humans is encoded by the HSPB6 gene.

DnaJ homolog subfamily C member 10 is a protein that in humans is encoded by the DNAJC10 gene.

DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.

Heat shock 70 kDa protein 4L is a protein that in humans is encoded by the HSPA4L gene.

DnaJ (Hsp40) homolog, subfamily C, member 13, also known as DNAJC13, is a human gene.

Heat shock protein beta-3 (HspB3) also known as heat shock 27kDa protein 3 is a protein that in humans is encoded by the HSPB3 gene.

DnaJ heat shock protein family (Hsp40) member C12 is a protein that in humans is encoded by the DNAJC12 gene.

DnaJ homolog subfamily C member 30 (DNAJC30), also known as Williams Beuren syndrome chromosome region 18 protein (WBSCR18), is a protein that in humans is encoded by the DNAJC30 gene. This intronless gene encodes a member of the DNAJ molecular chaperone homology domain-containing protein family. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140403 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032285 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: DnaJ heat shock protein family (Hsp40) member A4" . Retrieved 2017-05-19.

DNAJA4

Related Research Articles

References

Further reading