Daniel Peterson (physician)

Last updated

Daniel Peterson is an American physician in private practice in the state of Nevada, and has been described as a "pioneer" in the treatment of chronic fatigue syndrome (CFS). [1] [2] He graduated from the University of Rochester School of Medicine, Rochester, New York, in 1976 and was an intern and resident at the University of Utah Medical Center from 1976 to 1979. In 1979, he became a diplomate of the American Board of Internal Medicine. [3] He is president of Sierra Internal Medicine of Incline Village, established in 1981. [4]

Contents

Work in chronic fatigue syndrome

Along with Paul Cheney, Peterson was a treating physician at Incline Village during an outbreak of chronic fatigue syndrome that began in 1984 in the Lake Tahoe region. [5] From 1984 to 1987, the illness was recorded in 259 patients in the area by the two physicians. The Lake Tahoe outbreak became the subject of several studies by Peterson and others. In 1995, Peterson and other investigators started conducting a 10-year follow-up study on patients seen during the outbreak. The study results were published in 2001 by the Journal of Chronic Fatigue Syndrome. [6] In the 2000 CFS documentary I Remember Me, Peterson was interviewed about some of his experiences during the Lake Tahoe outbreak. [7]

In 1988, Peterson was the first physician to treat an extremely ill person diagnosed with CFS with the experimental drug Ampligen by obtaining compassionate-use permission from the U.S. Food and Drug Administration. Quantitative improvement in the first patient enabled the next pilot study of Ampligen in CFS patients by Peterson and other researchers. During the 1990 CFIDS Conference in Charlotte, North Carolina, Peterson described positive results in 15 CFS patents after he treated them with Ampligen for approximately 6 months. [1] In 1990 and 1991, Peterson was one of four principal investigators for the FDA approved phase II randomized placebo controlled double-blind study of the experimental intravenous drug Ampligen. The drug was administered in his Incline Village facility and three other sites. [8] Peterson and others reported that there was statistically significant improvement in the patients receiving Ampligen. [9] He is a principal investigator of the FDA-approved open-label safety and efficacy phase III drug study of Ampligen for treatment of chronic fatigue syndrome. [10] Hemispherx Biopharma's New Drug Application for marketing and sale of Ampligen to treat chronic fatigue syndrome was rejected in December 2009 because the FDA concluded that the two RCTs "did not provide credible evidence of efficacy." [11]

Peterson was a member of the International Chronic Fatigue Syndrome Study Group that coauthored the most widely used clinical and research description of CFS, [12] called the 1994 CDC definition, and the Fukuda definition. [13] He is a coauthor of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols, initiated by Health Canada and published by an international group of researchers in 2003. [14] [15] [16]

Peterson, along with Annette and Harvey Whittemore, helped establish the Whittemore Peterson Institute (WPI) for Neuro-Immune Disease at the University of Nevada in 2005 to aid patients with chronic fatigue syndrome, fibromyalgia and related illnesses. [17] In October 2009 Peterson was interviewed on National Public Radio about his views on chronic fatigue syndrome and the newly published possible association with the retrovirus XMRV. [18]

In 2010, Peterson left WPI due to personal reasons. He stated there was a lack of collaboration with him over the research direction of the institute concerning XMRV. [19] Peterson then teamed with Jay Levy, one of the original discoverers of HIV, to try to determine whether XMRV is truly present in patients by testing the same patients used in the study published in Science. [19] They did not find indications of XMRV in the blood of the patients tested, and also concluded from their experiments that XMRV does not, "survive well in human blood", so human infection is unlikely. They also stated that research results published by others suggested that laboratory contamination may have resulted in false positive results in the original study. [20]

Affiliations and awards

Peterson is a member of the board of directors and the scientific advisory board of the HHV-6 Foundation, [2] a non-profit organization promoting human herpesvirus 6 (HHV-6) associated scientific and clinical research. [21] Peterson was part of the founding board and is a past-president of the International Association for CFS/ME, [3] a professional organization advocating for the interests of CFS researchers and clinicians worldwide. [22] [23]

In 2003, he received the Rudy Perpich award, an award given to distinguished CFS/FM scientists, physicians or healthcare workers, and in 2007, received the Nelson Gantz Outstanding Clinician Award from the International Association for CFS/ME. [24]

In 1999, Peterson was commended by the Assembly and Senate of the State of Nevada for his work and dedication to persons with chronic fatigue syndrome. [25]

Selected publications

Related Research Articles

<span class="mw-page-title-main">ME Association</span> UK charitable organization

The ME Association is a UK health charitable organization that provides information, advocacy, and services to persons and families affected by ME/CFS, and raises funds for research into ME/CFS. It has been reported to be one of the two largest UK charities for ME/CFS.

<span class="mw-page-title-main">Human herpesvirus 6</span> Informal grouping of viruses which caused human herpesvirus 6 Infection

Human herpesvirus 6 (HHV-6) is the common collective name for human betaherpesvirus 6A (HHV-6A) and human betaherpesvirus 6B (HHV-6B). These closely related viruses are two of the nine known herpesviruses that have humans as their primary host.

Rintatolimod, sold under the tradename Ampligen, is a medication intended for treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). There is some evidence it may improve some ME/CFS symptoms.

<span class="mw-page-title-main">Xenotropic murine leukemia virus–related virus</span> Species of virus

Xenotropic murine leukemia virus–related virus (XMRV) is a retrovirus which was first described in 2006 as an apparently novel human pathogen found in tissue samples from men with prostate cancer. Initial reports erroneously linked the virus to prostate cancer and later to chronic fatigue syndrome (CFS), leading to considerable interest in the scientific and patient communities, investigation of XMRV as a potential cause of multiple medical conditions, and public-health concerns about the safety of the donated blood supply.

<span class="mw-page-title-main">History of ME/CFS</span> Review of the topic

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has a long history with an evolution in medical understanding, diagnoses and social perceptions.

Treatment of ME/CFS is variable and uncertain, and the condition is primarily managed rather than cured.

<span class="mw-page-title-main">Controversies related to ME/CFS</span>

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness with a long history of controversy. Some professionals within the medical community do not recognize ME/CFS as a genuine condition, nor is there agreement on its prevalence. There has been much disagreement over the pathophysiology of chronic fatigue syndrome, how it should be diagnosed, and how to treat it.

<span class="mw-page-title-main">Clinical descriptions of ME/CFS</span> Review of the topic

Clinical descriptions of ME/CFS vary. Different groups have produced sets of diagnostic criteria that share many similarities. The biggest differences between criteria are whether post-exertional malaise (PEM) is required, and the number of symptoms needed. The pathology of ME/CFS is unknown, and it can be a difficult condition to diagnose because there is no standard test, many symptoms are non-specific, and because doctors and patients may be unfamiliar with post-exertional malaise. Subgroup analysis suggests that, depending on the applied definition, CFS may represent a variety of conditions rather than a single disease entity.

The Lightning Process (LP) is a three-day personal training programme developed and trademarked by British osteopath Phil Parker. It makes unsubstantiated claims to be beneficial for various conditions, including chronic fatigue syndrome, depression and chronic pain.

Patricia A. Fennell is the chief executive officer of Albany Health Management Associates. She is a clinician, research scientist, educator, and author specializing in chronic illness, chronic and post-viral syndromes, trauma, forensics, hospice, global health care concerns, autoimmune and post-viral disease, clinical education, and training.

Graded exercise therapy (GET) is a programme of physical activity that starts very slowly and gradually increases over time, intended as a treatment for chronic fatigue syndrome. Most public health bodies, including the CDC and NICE, consider it ineffective, and its safety is disputed. However, GET still enjoys support among a minority of clinicians and organizations.

David Sheffield Bell is an American physician who has done extensive research on the clinical aspects of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). He has also conducted evaluations and research in pediatric ME/CFS and written numerous articles about the condition.

Dr. José Gilberto Montoya is a prominent researcher known for his contributions to the field of infectious diseases, particularly in the area of chronic fatigue syndrome (CFS) and the role of infectious agents in its development. His research has shed light on the potential involvement of pathogens and immune dysregulation in the pathophysiology of CFS. He was a Professor of Medicine in Infectious Disease at the Stanford University School of Medicine, where he led Stanford's Initiative on Chronic Fatigue Syndrome. He has worked on a wide variety of projects, including research focused on the efficacy of new smallpox vaccines. Additionally, he was the founder and co-director of the Immunocompromised Host Service and works at the Positive Care Clinic at Stanford. He is originally from Cali, Colombia.

Whittemore Peterson Institute (WPI) is a 501(c)(3) nonprofit medical research institute dedicated to scientific discovery surrounding complex neuroimmune diseases including chronic fatigue syndrome (CFS) and other similarly presenting illnesses. Founded in 2005, it is currently located within the Center for Molecular Medicine at the University of Nevada, Reno. It was founded in 2005.

Judy Anne Mikovits is an American former research scientist who is known for her discredited medical claims, such as that murine endogenous retroviruses are linked to chronic fatigue syndrome (CFS). As an outgrowth of these claims, she has engaged in anti-vaccination activism, promoted conspiracy theories, and been accused of scientific misconduct. She has made false claims about vaccines, COVID-19, and CFS, among others.

<span class="mw-page-title-main">Myalgic encephalomyelitis/chronic fatigue syndrome</span> Medical condition

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating long-term medical condition. People with ME/CFS experience lengthy flare-ups of the illness following relatively minor physical or mental activity. This is known as post-exertional malaise (PEM) and is the hallmark symptom of the illness. Other core symptoms are a greatly reduced ability to do tasks that were previously routine, severe fatigue, and sleep disturbances. The baseline fatigue in ME/CFS does not improve much with rest. Orthostatic intolerance, memory and concentration problems, and chronic pain are common. About a quarter of people with ME/CFS are severely affected and unable to leave their bed or home.

Konstance K. Knox is an American virologist and entrepreneur who founded Coppe Laboratories, Viracor, the Wisconsin Viral Research Group (WVRG) and Viracor's Institute for Viral Pathogenesis (IVP). In 2000, Viracor became the first biotechnology company in the United States to correlate multiple sclerosis with human herpesvirus 6 (HHV-6).

<span class="mw-page-title-main">Post-exertional malaise</span> Worsening of symptoms with activity

Post-exertional malaise (PEM), sometimes referred to as post-exertional symptom exacerbation (PESE), is a worsening of symptoms that occurs after minimal exertion. It is the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and common in long COVID. PEM is often severe enough to be disabling, and is triggered by ordinary activities that healthy people tolerate. Typically, it begins 12–48 hours after the activity that triggers it, and lasts for days, but this is highly variable and may persist much longer. Management of PEM is symptom-based, and patients are recommended to pace their activities to avoid triggering PEM.

Idiopathic chronic fatigue (ICF) or chronic idiopathic fatigue or insufficient/idiopathic fatigue is characterized by unexplained fatigue that lasts at least six consecutive months. which does not meet the criteria for chronic fatigue syndrome. It is widely understood to have a profound effect on the lives of patients who experience it.

Carmen Scheibenbogen is a German professor, doctor and acting director of the Institute for Medical Immunology of the Charité university hospital in Berlin. She specialises in hematology, oncology and immunology. She leads the Outpatient Clinic for Immunodeficiency and the Fatigue Centre at the Charité hospital. She is one of the few doctors specialised in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in Germany, and also researches Long COVID.

References

  1. 1 2 Verrillo, Erica F.; Gellman, Lauren M. (1998). Chronic Fatigue Syndrome: A Treatment Guide. Macmillan. p. 152. ISBN   978-0-312-18066-9.
  2. 1 2 "HHV-6 Foundation Board of Directors". HHV-6 Foundation. 2004. Archived from the original on 2010-01-28. Retrieved 2009-03-18.
  3. 1 2 "executive staff". The Whittemore Peterson Institute. 2008. Archived from the original on 2009-10-11. Retrieved 2009-01-11.
  4. ↑ "Sierra Internal Medicine". Dun & Bradstreet. 2008. Retrieved 2009-01-12.
  5. ↑ Sam Donaldson, Nancy Snyderman, Paul Cheney, David Bell, Elaine DeFreitas, Hillary Johnson, PWC's, Paul Pollard, Mrs. Dailor, Philip Lee (1996-03-27). Sick & Tired (Television). ABC News.
  6. ↑ Strickland, Paula S., PhD, MPH; Levine, Paul H., MD; Peterson, Daniel L., MD; O'Brien, Karen, BS; Fears, Thomas, PhD (2001). "Neuromyasthenia and Chronic Fatigue Syndrome (CFS) in Northern Nevada/California: A Ten-Year Follow-Up of an Outbreak". Journal of Chronic Fatigue Syndrome. 9. 3/4: 3–14. doi:10.1300/J092v09n03_02. Archived from the original on 2009-02-01.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ↑ Ebert, Roger (December 7, 2001). "I remember Me". Movie Review. Roger Ebert Chicago Suntimes. Retrieved 2009-01-07.
  8. ↑ Johnson, Hillary (1996). Osler's web: inside the labyrinth of the chronic fatigue syndrome epidemic. New York: Crown Publishers. p. 385. ISBN   978-0-517-70353-3.
  9. ↑ Strayer, D.R.; Carter, W.A.; Brodsky, I.; et al. (January 1994). "A controlled clinical trial with a specifically configured RNA drug, poly(I).poly(C12U), in chronic fatigue syndrome". Clin. Infect. Dis. 18. Suppl 1: S88–95. doi:10.1093/clinids/18.supplement_1.s88. PMID   8148460.
  10. ↑ "Study of Ampligen in Chronic Fatigue Syndrome". U.S. National Institutes of Health. September 2005. Retrieved 2009-01-06.
  11. ↑ George, John (December 3, 2009). "FDA rejects Hemispherx's chronic fatigue drug Ampligen". Philadelphia Business Journal. Retrieved 6 April 2020.
  12. ↑ Wyller, V.B. (2007). "The chronic fatigue syndrome--an update". Acta Neurologica Scandinavica. Supplementum. 187 (s187): 7–14. doi: 10.1111/j.1600-0404.2007.00840.x . PMID   17419822. S2CID   11247547.
  13. ↑ Fukuda, K.; Straus, S.; Hickie, I.; Sharpe, M.; Dobbins, J.; Komaroff, A. (1994). "The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group". Ann Intern Med. 121 (12): 953–9. doi:10.7326/0003-4819-121-12-199412150-00009. PMID   7978722. S2CID   510735.
  14. ↑ Carruthers, B.M.; et al. (2003). "Myalgic encephalomyalitis/chronic fatigue syndrome: Clinical working definition, diagnostic and treatment protocols" (PDF). Journal of Chronic Fatigue Syndrome. 11 (1): 7–36. doi:10.1300/J092v11n01_02. Archived from the original (PDF) on 2008-12-16.
  15. ↑ Carruthers, B.M. (February 2007). "Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works". J. Clin. Pathol. 60 (2): 117–9. doi:10.1136/jcp.2006.042754. PMC   1860613 . PMID   16935963.
  16. ↑ Khot, Alex; Polmear, Andrew (24 April 2006). Practical General Practice: Guidelines for Effective Clinical Management (5th New ed.). Elsevier Health Sciences. pp. 419–421. ISBN   978-0-7506-8867-3.
  17. ↑ Powers, Lenita (1 November 2009). "Daughter's illness led family to seek help, start institute" (PDF). Reno Gazette-Journal. Archived from the original (PDF) on 2 December 2010. Retrieved 10 February 2010.
  18. ↑ Montagne, Renee (October 9, 2009). "Virus Tied To Chronic Fatigue Syndrome". National Public Radio. Retrieved 2010-03-06.
  19. 1 2 Callaway, Ewen (14 March 2011). "Virology: Fighting for a cause". Nature. 471 (7338): 282–85. Bibcode:2011Natur.471..282C. doi: 10.1038/471282a . PMID   21412308.
  20. ↑ Jay A. Levy and Daniel L. Peterson (September 30, 2011). "The mystery of chronic fatigue syndrome". Los Angeles Times. Retrieved 10 February 2011.
  21. ↑ "HHV-6 Foundation". National Institute of Neurological Disorders and Stroke. Retrieved 2009-02-15.
  22. ↑ Friedberg, F.; Sohl, S.; Schmeizer, B. (August 2007). "Publication trends in chronic fatigue syndrome: comparisons with fibromyalgia and fatigue: 1995–2004". J Psychosom Res. 63 (2): 143–6. doi:10.1016/j.jpsychores.2007.03.003. PMID   17662750.
  23. ↑ David Tuller, "Expert Q&A, Learning Firsthand about Chronic Fatigue Syndrome" Interview with Leonard Jason, "Chronic Fatigue - Expert Q & A - Learning Firsthand About Chronic Fatigue Syndrome - NY Times Health". Archived from the original on 2009-10-13. Retrieved 2012-04-26. April 30, 2008
  24. ↑ "Former IACFS/ME awardees". International Association for CFS/ME. Archived from the original on 2009-01-03. Retrieved 2009-01-07.
  25. ↑ "AJR14". Nevada Legislative Counsel Bureau. April 8, 1999. Retrieved 2010-10-13.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.