Fibromyalgia

Not to be confused with Myalgic encephalomyelitis/chronic fatigue syndrome nor with Myelofibrosis.

Fibromyalgia
Other names	Fibromyalgia syndrome
The nine possible pain sites of fibromyalgia according to the American Pain Society.
Pronunciation	/ˌfaɪbroʊmaɪˈældʒə/ [1]
Specialty	Rheumatology, neurology [2]
Symptoms	Widespread pain, feeling tired, sleep problems [3] [4]
Usual onset	Early-Middle age [5]
Duration	Long term [3]
Causes	Unknown [4] [5]
Diagnostic method	Based on symptoms after ruling out other potential causes [4] [5]
Differential diagnosis	Anemia, autoimmune disorders (such as ankylosing spondylitis, polymyalgia rheumatica, rheumatoid arthritis, scleroderma, or multiple sclerosis), Lyme disease, osteoarthritis, thyroid disease [6] [7]
Treatment	Sufficient sleep and exercise [5]
Medication	Duloxetine, milnacipran, pregabalin, gabapentin [5] [8]
Prognosis	Normal life expectancy [5]
Frequency	2% [4]

Fibromyalgia is a medical syndrome that causes chronic widespread pain, accompanied by fatigue, awakening unrefreshed, and cognitive symptoms. Other symptoms can include headaches, lower abdominal pain or cramps, and depression. ^[9] People with fibromyalgia can also experience insomnia ^[10] and general hypersensitivity. ^{[11] [12]} The cause of fibromyalgia is unknown, but is believed to involve a combination of genetic and environmental factors. ^[4] Environmental factors may include psychological stress, trauma, and some infections. ^[4] Since the pain appears to result from processes in the central nervous system, the condition is referred to as a "central sensitization syndrome". ^{[4] [13]} Although a protocol using an algometer (algesiometer) for determining central sensitization has been proposed as an objective diagnostic test, fibromyalgia continues to be primarily diagnosed by exclusion despite the high possibility of misdiagnosis. ^[14]

Fibromyalgia was first defined in 1990, with updated criteria in 2011, ^[4] 2016, ^[9] and 2019. ^[12] The term 'fibromyalgia' is from Neo-Latin fibro-, meaning 'fibrous tissues'; Greek μυο- myo-, 'muscle'; and Greek άλγος algos, 'pain'; thus, the term literally means "'muscle and fibrous connective tissue pain'. ^[15] Fibromyalgia is estimated to affect 2 to 4% of the population. ^[16] Women are affected about twice as often as men. ^{[4] [16]} Rates appear similar across areas of the world and among varied cultures. ^[4]

The treatment of fibromyalgia is symptomatic ^[17] and multidisciplinary. ^[18] The European Alliance of Associations for Rheumatology strongly recommends aerobic and strengthening exercise. ^[18] Weak recommendations are given for mindfulness, psychotherapy, acupuncture, hydrotherapy, and meditative exercise such as qigong, yoga, and tai chi. ^[18] The use of medication in the treatment of fibromyalgia is debated, ^{[18] [19]} although antidepressants can improve quality of life. ^[20] Other medications commonly considered helpful in managing fibromyalgia include serotonin–norepinephrine reuptake inhibitors, nonsteroidal anti-inflammatory drugs, and muscle relaxants. ^[21] Q10 coenzyme and vitamin D supplements may reduce pain and improve quality of life. ^[22] While symptoms of fibromyalgia are persistent in nearly all patients, they are not caused by cell damage or any organic disease. ^[19]

History

Chronic widespread pain had been described in the literature in the 19th century, but the term fibromyalgia was not first used until 1976, when Phillip Kahler Hench used it to describe these symptoms. ^[23] Many names, including muscular rheumatism, fibrositis, psychogenic rheumatism, and neurasthenia were applied historically to symptoms resembling those of fibromyalgia. ^[24] The term fibromyalgia was coined by researcher Mohammed Yunus as a synonym for fibrositis. and was first used in a scientific publication in 1981. ^[25] Fibromyalgia is from the Latin fibra (fiber) ^[26] and the Greek words myo (muscle) ^[27] and algos (pain). ^[28]

Historical perspectives on the development of the fibromyalgia concept note the "central importance" of a 1977 paper on fibrositis by Smythe and Moldofsky. ^{[29] [30]} The first clinical, controlled study of the characteristics of fibromyalgia syndrome was published in 1981, ^[31] providing support for symptom associations. In 1984, an interconnection between fibromyalgia syndrome and other similar conditions was proposed, ^[32] and in 1986, trials of the first proposed medications for fibromyalgia were published. ^[32]

A 1987 article in the Journal of the American Medical Association used the term 'fibromyalgia syndrome', while saying it was a "controversial condition". ^[33] The American College of Rheumatology (ACR) published its first classification criteria for fibromyalgia in 1990. ^[34] Later revisions were made in 2010, ^[35] 2016, ^[9] and 2019. ^[12]

Classification

Fibromyalgia is classified as a disorder of pain processing due to abnormalities in how pain signals are processed in the central nervous system. ^[36] The International Classification of Diseases (ICD-11) includes fibromyalgia in the category of "Chronic widespread pain," code MG30.01. ^[37] People with fibromyalgia differ in several dimensions: severity, adjustment, symptom profile, psychological profile and response to treatment. ^[38]

Signs and symptoms

The defining symptoms of fibromyalgia are chronic widespread pain, fatigue, and sleep disturbance. ^[12] Other symptoms may include heightened pain in response to tactile pressure (allodynia), ^[12] cognitive problems, ^[12] musculoskeletal stiffness, ^[12] environmental sensitivity, ^[12] hypervigilance, ^[12] sexual dysfunction, ^[39] and visual symptoms. ^[40] Some people with fibromyalgia experience post-exertional malaise, in which symptoms flare up a day or longer after physical exercise. ^[41]

Pain

Fibromyalgia is predominantly a chronic pain disorder. ^[12] According to the NHS, widespread pain is one major symptom, which could feel like an ache, a burning sensation, or a sharp, stabbing pain. ^[42] Patients are also highly sensitive to pain, and the slightest touch can cause pain. Pain also tends to linger for longer when a patient experiences pain. ^[43]

Fatigue

Fatigue is one of the defining symptoms of fibromyalgia. ^[12] Patients may experience physical or mental fatigue. Physical fatigue can present as a feeling of exhaustion after exercise or limitation in daily activities. ^[12]

Sleep problems

Sleep problems are a core symptom of fibromyalgia. ^[12] These include difficulty falling or staying asleep, awakening while sleeping, and waking up feeling unrefreshed. ^[12] A meta-analysis compared quantitative and qualitative sleep metrics in people with fibromyalgia and healthy people. Individuals with fibromyalgia indicated lower sleep quality and efficiency, longer wake time after sleep start, shorter sleep duration, lighter sleep, and greater trouble initiating sleep when quantitatively assessed; and more difficulty initiating sleep when qualitatively assessed. ^[10] Sleep problems may contribute to pain by decreased release of IGF-1 and human growth hormone, leading to decreased tissue repair. ^[44] Improving sleep quality can help people with fibromyalgia manage pain. ^{[45] [46]}

Cognitive problems

Many people with fibromyalgia experience cognitive problems (known as fibrofog or brain fog). One study found that approximately 50% of fibromyalgia patients experienced subjective cognitive dysfunction, and that it was associated with higher levels of pain and other fibromyalgia symptoms. ^[47] The American Pain Society recognizes these problems as a major feature of fibromyalgia, characterized by trouble concentrating, forgetfulness, and disorganized or slow thinking. ^[12] About 75% of people with fibromyalgia report significant problems with concentration, memory, and multitasking. ^[48] A 2018 meta-analysis found that the largest differences between people with fibromyalgia and healthy subjects were in inhibitory control, memory, and processing speed. ^[48] It is hypothesized that the chronic pain in fibromyalgia compromises attention systems, resulting in cognitive problems. ^[48]

Hypersensitivity

In addition to hyperalgesia, patients with fibromyalgia experience hypersensitivity to other stimuli, ^[11] such as bright lights, loud noises, perfumes, and cold. ^[12] A review article found that they have a lower cold pain threshold. ^[49] Other studies documented an acoustic hypersensitivity. ^[50]

Comorbidity

Fibromyalgia as a stand-alone diagnosis is uncommon, as most fibromyalgia patients often have other chronic overlapping pain problems or mental disorders. ^[11] Fibromyalgia is associated with mental health issues like anxiety, ^[51] posttraumatic stress disorder, ^{[4] [51]} bipolar disorder, ^[51] alexithymia, ^[52] and depression. ^{[51] [53] [54]} Patients with fibromyalgia are five times more likely to have major depression than the general population. ^[55] Experiencing pain and limited energy from having fibromyalgia leads to less activity, leading to social isolation and increased stress levels, which tends to cause anxiety and depression. ^[56]

Numerous chronic pain conditions are often comorbid with fibromyalgia. ^[53] These include chronic tension headaches, ^[51] myofascial pain syndrome, ^[51] and temporomandibular disorders. ^[51] Multiple sclerosis, post-polio syndrome, neuropathic pain, and Parkinson's disease are four neurological disorders that have been linked to pain or fibromyalgia. ^[53]

Fibromyalgia largely overlaps with several syndromes that may share the same pathogenetic mechanisms. ^{[57] [58]} These include myalgic encephalomyelitis/chronic fatigue syndrome ^{[59] [57]} and irritable bowel syndrome. ^[58]

Comorbid fibromyalgia has been reported to occur in 20–30% of individuals with rheumatic diseases. ^[53] It has been reported in people with noninflammatory musculoskeletal diseases. ^[53]

The prevalence of fibromyalgia in gastrointestinal disease has been described mostly for celiac disease ^[53] and irritable bowel syndrome (IBS). ^{[53] [51]} IBS and fibromyalgia share similar pathogenic mechanisms, involving immune system mast cells, inflammatory biomarkers, hormones, and neurotransmitters such as serotonin. Changes in the gut biome alter serotonin levels, leading to autonomic nervous system hyperstimulation. ^[60]

Fibromyalgia has also been linked with obesity. ^[61] Other conditions that are associated with fibromyalgia include connective tissue disorders, ^[62] cardiovascular autonomic abnormalities, ^[63] obstructive sleep apnea-hypopnea syndrome, ^[64] restless leg syndrome ^[65] and an overactive bladder. ^[66]

Risk factors

The cause of fibromyalgia is unknown. ^{[67] [68]} However, several risk factors, genetic and environmental, have been identified.

Genetics

Genetics play a major role in fibromyalgia, and may explain up to 50% of the disease susceptibility. ^[69] Fibromyalgia is potentially associated with polymorphisms of genes in the serotoninergic, ^[70] dopaminergic ^[70] and catecholaminergic systems. ^[70] Several genes have been suggested as candidates for susceptibility to fibromyalgia. These include SLC6A4, ^[69] TRPV2, ^[69] MYT1L, ^[69] NRXN3, ^[69] and the 5-HT2A receptor 102T/C polymorphism. ^[71] The heritability of fibromyalgia is estimated to be higher in patients younger than 50. ^[72]

Nearly all the genes suggested as potential risk factors for fibromyalgia are associated with neurotransmitters and their receptors. ^[73] Neuropathic pain and major depressive disorder often co-occur with fibromyalgia — the reason for this comorbidity appears to be due to shared genetic abnormalities, which leads to impairments in monoaminergic, glutamatergic, neurotrophic, opioid and proinflammatory cytokine signaling. In these vulnerable individuals, psychological stress or illness can cause abnormalities in inflammatory and stress pathways that regulate mood and pain. Eventually, a sensitization and kindling effect occurs in certain neurons leading to the establishment of fibromyalgia and sometimes a mood disorder. ^[74]

Stress

Stress may be an important precipitating factor in the development of fibromyalgia. ^[75] A 2021 meta-analysis found psychological trauma to be strongly associated with fibromyalgia. ^{[76] [77]} People who suffered abuse in their lifetime were three times more likely to have fibromyalgia; people who suffered medical trauma or other stressors in their lifetime were about twice as likely. ^[76]

Some authors have proposed that, because exposure to stressful conditions can alter the function of the hypothalamic-pituitary-adrenal (HPA) axis, the development of fibromyalgia may stem from stress-induced disruption of the HPA axis. ^{[78] [79]}

Personality

Studies on personality and fibromyalgia have shown inconsistent results. ^[80] Although some have suggested that fibromyalgia patients are more likely to have specific personality traits, it appears that in comparison to other diseases – when anxiety and depression are statistically controlled for –personality has far less relevance. ^[80]

Other risk markers

Other risk markers for fibromyalgia include premature birth, female sex, childhood cognitive and psychosocial problems, primary pain disorders, multiregional pain, infectious illness, hypermobility of joints, iron deficiency, and small-fiber polyneuropathy. ^[81] Metal-induced allergic inflammation has also been linked with fibromyalgia, especially in response to nickel but also inorganic mercury, cadmium, and lead. ^[82] Following the COVID-19 pandemic, some have suggested that the SARS-CoV-2 virus may trigger fibromyalgia. ^[83]

Pathophysiology

As of 2022, the pathophysiology of fibromyalgia has not yet been elucidated ^[84] and several theories have been suggested. The prevailing view is that fibromyalgia is a condition resulting from an amplification of pain by the central nervous system. ^[73] Substantial biological findings have backed up this notion, leading to development and adoption of the concept of nociplastic pain. ^[73]

Fibromyalgia is associated with the deregulation of proteins related to complement and coagulation cascades, as well as to iron metabolism. ^[85] An excessive oxidative stress response may cause dysregulation of many proteins. ^[85]

Nervous system

Pain processing abnormalities

Chronic pain can be divided into three categories. Nociceptive pain is pain caused by inflammation or damage to tissues. Neuropathic pain is pain caused by nerve damage. Nociplastic pain (or central sensitization) is less understood and is the common explanation of the pain experienced in fibromyalgia. ^{[13] [16] [86]} Because the three forms of pain can overlap, fibromyalgia patients may experience nociceptive (e.g., rheumatic illnesses) and neuropathic (e.g., small fiber neuropathy) pain, in addition to nociplastic pain. ^[16]

Nociplastic pain (central sensitization)

Main article: Nociplastic pain

Fibromyalgia can be viewed as a condition of nociplastic pain. ^[87] Nociplastic pain is caused by an altered function of pain-related sensory pathways in the periphery and the central nervous system, resulting in hypersensitivity. ^[88]

Nociplastic pain is commonly referred to as "Nociplastic pain syndrome" because it is coupled with other symptoms. ^[16] These include fatigue, sleep disturbance, cognitive disturbance, hypersensitivity to environmental stimuli, anxiety, and depression. ^[16] Nociplastic pain is caused by either (1) increased processing of pain stimuli or (2) decreased suppression of pain stimuli at several levels in the nervous system, or both. ^[16]

Neuropathic pain

An alternative hypothesis to nociplastic pain views fibromyalgia as a stress-related dysautonomia with neuropathic pain features. ^[89] This view highlights the role of autonomic and peripheral nociceptive nervous systems in the generation of widespread pain, fatigue, and insomnia. ^[90] The description of small fiber neuropathy in a subgroup of fibromyalgia patients supports the disease neuropathic-autonomic underpinning. ^[89] However, others claim that small fiber neuropathy occurs only in small groups of those with fibromyalgia. ^[19]

Autonomic nervous system

Some suggest that fibromyalgia is caused or maintained by a decreased vagal tone, which is indicated by low levels of heart rate variability, ^[75] signaling a heightened sympathetic response. ^[91] Accordingly, several studies show that clinical improvement is associated with an increase in heart rate variability. ^{[92] [91] [93]} Some examples of interventions that increase the heart rate variability and vagal tone are meditation, yoga, mindfulness and exercise. ^[75] In 2023 the Fibromyalgia: Imbalance of Threat and Soothing Systems (FITSS) model was suggested as a working hypothesis. ^[94] According to the FITSS model, the salience network (also known as the midcingulo-insular network) may remain continuously hyperactive due to an imbalance in emotion regulation, which is reflected by an overactive "threat" system and an underactive "soothing" system. This hyperactivation, along with other mechanisms, may contribute to fibromyalgia. ^[94]

Neurotransmitters

Some neurochemical abnormalities that occur in fibromyalgia also regulate mood, sleep, and energy, thus explaining why mood, sleep, and fatigue problems are commonly co-morbid with fibromyalgia. ^[36] Serotonin is the most widely studied neurotransmitter in fibromyalgia. It is hypothesized that an imbalance in the serotoninergic system may lead to the development of fibromyalgia. ^[95] There is also some data that suggests altered dopaminergic and noradrenergic signaling in fibromyalgia. ^[96] Supporting the monoamine related theories is the efficacy of monoaminergic antidepressants in fibromyalgia. ^[20] Glutamate/creatine ratios within the bilateral ventrolateral prefrontal cortex were found to be significantly higher in fibromyalgia patients than in controls, and may disrupt glutamate neurotransmission. ^{[77] [97]}

Neurophysiology

Neuroimaging studies have observed that fibromyalgia patients have increased grey matter in the right postcentral gyrus and left angular gyrus, and decreased grey matter in the right cingulate gyrus, right paracingulate gyrus, left cerebellum, and left gyrus rectus. ^[98] These regions are associated with affective and cognitive functions and with motor adaptations to pain processing. ^[98] Other studies have documented decreased grey matter of the default mode network in people with fibromyalgia. ^[99] These deficits are associated with pain processing. ^[99]

Neuroendocrine system

Studies on the neuroendocrine system and HPA axis in fibromyalgia have been inconsistent. Depressed function of the HPA axis results in adrenal insufficiency and potentially chronic fatigue. ^[100]

One study found fibromyalgia patients exhibited higher plasma cortisol, more extreme peaks and troughs, and higher rates of dexamethasone non-suppression. However, other studies have only found correlations between a higher cortisol awakening response and pain, and not any other abnormalities in cortisol. ^[46] Increased baseline ACTH and increase in response to stress have been observed, hypothesized to be a result of decreased negative feedback. ^[96]

Oxidative stress

Pro-oxidative processes correlate with pain in fibromyalgia patients. ^[100] Decreased mitochondrial membrane potential, increased superoxide activity, and increased lipid peroxidation production are observed. ^[100] The high proportion of lipids in the central nervous system (CNS) makes the CNS especially vulnerable to free radical damage. Levels of lipid peroxidation products correlate with fibromyalgia symptoms. ^[100]

Immune system

Inflammation has been suggested to have a role in the pathogenesis of fibromyalgia. ^[101] People with fibromyalgia tend to have higher levels of inflammatory cytokines IL-6, ^{[95] [102] [103]} and IL-8. ^{[95] [102] [103]} There are also increased levels of the pro-inflammatory cytokines IL-1 receptor antagonist. ^{[102] [103]} Increased levels of pro-inflammatory cytokines may increase sensitivity to pain, and contribute to mood problems. ^[104] Anti-inflammatory interleukins such as IL-10 have also been associated with fibromyalgia. ^[95]

A repeated observation shows that autoimmunity triggers such as traumas and infections are among the most frequent events preceding the onset of fibromyalgia. ^[105] Neurogenic inflammation has been proposed as a contributing factor to fibromyalgia. ^[106]

Digestive system

Gut microbiome

Though there is a lack of evidence in this area, it is hypothesized that gut bacteria may play a role in fibromyalgia. ^[107] People with fibromyalgia are more likely to show dysbiosis, a decrease in microbiota diversity. ^[108] There is a bidirectional interplay between the gut and the nervous system. Therefore, the gut can affect the nervous system, but the nervous system can also affect the gut. Neurological effects mediated via the autonomic nervous system as well as the hypothalamic pituitary adrenal axis are directed to intestinal functional effector cells, which in turn are under the influence of the gut microbiota. ^[109]

Gut-brain axis

The gut-brain axis, which connects the gut microbiome to the brain via the enteric nervous system, is another area of research. Fibromyalgia patients have less varied gut flora and altered serum metabolome levels of glutamate and serine, ^[110] implying abnormalities in neurotransmitter metabolism. ^[105]

Energy metabolism

Low ATP in skeletal muscle

Patients with fibromyalgia experience exercise intolerance. Primary fibromyalgia is idiopathic (cause unknown), whereas secondary fibromyalgia is in association with a known underlying disorder (such as Ankylosing spondylitis). ^{[111] [ non-primary source needed ]} In patients with primary fibromyalgia, studies have found disruptions in energy metabolism within skeletal muscle, including: decreased levels of ATP, ADP, and phosphocreatine, and increased levels of AMP and creatine (use of creatine kinase and myokinase in the phosphagen system due to low ATP); ^{[112] [ non-primary source needed ]} increased pyruvate; ^{[113] [ non-primary source needed ]} as well as reduced capillary density impairing oxygen delivery to the muscle cells for oxidative phosphorylation. ^{[114] [115] [ non-primary source needed ]}

Low ATP in brain

Despite being a small percentage of the body's total mass, the brain consumes approximately 20% of the energy produced by the body. ^{[77] [ non-primary source needed ]} Parts of the brain—the anterior cingulate cortex (ACC), thalamus, and insula—were studied using proton magnetic resonance spectroscopy (MRS) in patients with fibromyalgia and compared to healthy controls. The fibromyalgia patients were found to have lower phosphocreatine (PCr) and lower creatine (Cr) than the control group. Phosphocreatine is used in the phosphagen system to produce ATP. The study found that low creatine and low phosphocreatine were associated with high pain, and that high stress, including PTSD, may contribute to these low levels. ^{[77] [ non-primary source needed ]}

Low phosphocreatine levels may disrupt glutamate neurotransmission within the brains of those with fibromyalgia. Glutamate/creatine ratios within the bilateral ventrolateral prefrontal cortex were found to be significantly higher than in controls. ^{[77] [97] [ non-primary source needed ]}

Diagnosis

The location of the nine paired tender points that comprise the 1990 American College of Rheumatology criteria for fibromyalgia

There is no single pathological feature, laboratory finding, or biomarker that can diagnose fibromyalgia, and there is debate over what should be considered diagnostic criteria and whether a medical diagnosis is possible to begin with. ^[81] In most cases, people with fibromyalgia symptoms may have laboratory test results that appear normal and many of their symptoms may mimic those of other rheumatic conditions such as arthritis or osteoporosis. The specific diagnostic criteria for fibromyalgia have evolved over time. ^[116]

American College of Rheumatology

The first widely accepted set of classification criteria for research purposes was elaborated in 1990 by the Multicenter Criteria Committee of the American College of Rheumatology. These criteria, which are known informally as "the ACR 1990", defined fibromyalgia according to the presence of the following criteria:

• A history of widespread pain lasting more than three months – affecting all four quadrants of the body, i.e., both sides, and above and below the waist.
• Tender points – there are 18 designated possible tender points (although a person with the disorder may feel pain in other areas as well).

The ACR criteria for the classification of patients were originally established as inclusion criteria for research purposes and were not intended for clinical diagnosis but have later become the de facto diagnostic criteria in the clinical setting. A controversial study was done by a legal team looking to prove their client's disability based primarily on tender points and their widespread presence in non-litigious communities prompted the lead author of the ACR criteria to question now the useful validity of tender points in diagnosis. ^[117] Use of control points has been used to cast doubt on whether a person has fibromyalgia, and to claim the person is malingering. ^[23]

Widespread pain index (WPI) areas

In 2010, the American College of Rheumatology approved provisional revised diagnostic criteria for fibromyalgia that eliminated the 1990 criteria's reliance on tender point testing. ^[35] The revised criteria used a widespread pain index (WPI) and symptom severity scale (SSS) in place of tender point testing under the 1990 criteria. The WPI counts up to 19 general body areas ^[a] in which the person has experienced pain in the preceding week. ^[9] The SSS rates the severity of the person's fatigue, unrefreshed waking, cognitive symptoms, and general somatic symptoms, ^[b] each on a scale from 0 to 3, for a composite score ranging from 0 to 12. ^[9] The revised criteria for diagnosis were:

• WPI ≥ 7 and SSS ≥ 5 OR WPI 3–6 and SSS ≥ 9,
• Symptoms have been present at a similar level for at least three months, and
• No other diagnosable disorder otherwise explains the pain. ^{[35] : 607}

In 2016, the provisional criteria of the American College of Rheumatology from 2010 were revised. ^[9] The new diagnosis required all of the following criteria:

1. "Generalized pain, defined as pain in at least 4 of 5 regions, is present."
2. "Symptoms have been present at a similar level for at least 3 months."
3. "Widespread pain index (WPI) ≥ 7 and symptom severity scale (SSS) score ≥ 5 OR WPI of 4–6 and SSS score ≥ 9."
4. "A diagnosis of fibromyalgia is valid irrespective of other diagnoses. A diagnosis of fibromyalgia does not exclude the presence of other clinically important illnesses." ^[9]

American Pain Society 2019

Multisite pain is defined as six or more pain sites from a total of nine possible sites (head, arms, chest, abdomen, upper back, lower back, and legs), for at least three months.

In 2019, the American Pain Society in collaboration with the U.S. Food and Drug Administration developed a new diagnostic system using two dimensions. ^[12] The first dimension included core diagnostic criteria and the second included common features. In accordance to the 2016 diagnosis guidelines, the presence of another medical condition or pain disorder does not rule out the diagnosis of fibromyalgia. Nonetheless, other conditions should be ruled out as the main explaining reason for the patient's symptoms. The core diagnostic criteria are: ^[14]

1. Multisite pain defined as six or more pain sites from a total of nine possible sites (head, arms, chest, abdomen, upper back, lower back, and legs), for at least three months
2. Moderate to severe sleep problems or fatigue, for at least three months

Common features found in fibromyalgia patients can assist the diagnosis process. These are tenderness (sensitivity to light pressure), dyscognition (difficulty to think), musculoskeletal stiffness, and environmental sensitivity or hypervigilance. ^[12]

Self-report questionnaires

Some research has suggested using a multidimensional approach taking into consideration somatic symptoms, psychological factors, psychosocial stressors and subjective belief regarding fibromyalgia. ^[118] These symptoms can be assessed by several self-report questionnaires. ^[9]

Widespread Pain Index (WPI)

The Widespread Pain Index (WPI) was introduced by the American College of Rheumatology in 2010. It measures the number of painful body regions. ^[35] The revised criteria counts up to 19 general body areas: shoulder girdle, upper arm, lower arm, hip/buttock/trochanter, upper leg, lower leg, jaw, all left & right; plus the chest, abdomen, neck and upper and lower back. ^[35] The 2016 ACR criteria required a Widespread pain index (WPI) ≥ 7 or WPI of 4–6 for higher severity pain.

Symptom Severity Scale (SSS)

The Symptom Severity Scale (SSS) assesses the severity of the fibromyalgia symptoms.

Fibromyalgia Impact Questionnaire (FIQ)

The Fibromyalgia Impact Questionnaire (FIQ) ^[119] and the Revised Fibromyalgia Impact Questionnaire (FIQR) ^[120] assess three domains: function, overall impact and symptoms. ^[120] It is considered a useful measure of disease impact. ^[121]

Other questionnaires

Other measures include the Hospital Anxiety and Depression Scale,Multiple Ability Self-Report Questionnaire, ^[122] Multidimensional Fatigue Inventory, andMedical Outcomes Study Sleep Scale.

Differential diagnosis

As of 2009, as many as two out of every three people who are told that they have fibromyalgia by a rheumatologist may have some other medical condition instead. ^[123] Fibromyalgia could be misdiagnosed in cases of early undiagnosed rheumatic diseases such as preclinical rheumatoid arthritis, early stages of inflammatory spondyloarthritis, polymyalgia rheumatica, myofascial pain syndromes and hypermobility syndrome. ^{[11] [124]} Neurological diseases with an important pain component include multiple sclerosis, Parkinson's disease and peripheral neuropathy. ^{[11] [124]} Other medical illnesses that should be ruled out are endocrine disease or metabolic disorder (hypothyroidism, hyperparathyroidism, acromegaly, vitamin D deficiency), gastro-intestinal disease (celiac and non-celiac gluten sensitivity), infectious diseases (Lyme disease, hepatitis C and immunodeficiency disease) and the early stages of a malignancy such as multiple myeloma, metastatic cancer and leukemia/lymphoma. ^{[11] [124]} Other systemic, inflammatory, endocrine, rheumatic, infectious, and neurologic disorders may cause fibromyalgia-like symptoms, such as systemic lupus erythematosus, Sjögren syndrome, ankylosing spondylitis, Ehlers-Danlos syndromes, psoriatic-related polyenthesitis, a nerve compression syndrome (such as carpal tunnel syndrome), and myasthenia gravis. ^{[125] [123] [126] [127]} In addition, several medications can also evoke pain (statins, aromatase inhibitors, bisphosphonates, and opioids). ^[12]

The differential diagnosis is made during the evaluation on the basis of the person's medical history, physical examination, and laboratory investigations. ^{[125] [123] [126] [127]} The patient's history can provide some hints to a fibromyalgia diagnosis. A family history of early chronic pain, a childhood history of pain, an emergence of broad pain following physical and/or psychosocial stress, a general hypersensitivity to touch, smell, noise, taste, hypervigilance, and various somatic symptoms (gastrointestinal, urology, gynecology, neurology), are all examples of these signals. ^[11]

Extensive laboratory tests are usually unnecessary in the differential diagnosis of fibromyalgia. ^[12] Common tests that are conducted include complete blood count, comprehensive metabolic panel, erythrocyte sedimentation rate, C-reactive protein, and thyroid function test. ^[12]

Management

Universally accepted treatments typically consist of symptom management and improving patient quality of life. ^[17] A personalized, multidisciplinary approach to treatment that includes pharmacologic considerations and begins with effective patient education is most beneficial. ^[17] Developments in the understanding of the pathophysiology of the disorder have led to improvements in treatment, which include prescription medication, behavioral intervention, and exercise.

A number of associations have published guidelines for the diagnosis and management of fibromyalgia. The European League Against Rheumatism (EULAR; 2017) ^[18] recommends a multidisciplinary approach, allowing a quick diagnosis and patient education. The recommended initial management should be non-pharmacological, later pharmacological treatment can be added. The European League Against Rheumatism gave the strongest recommendation for aerobic and strengthening exercise. Weak recommendations were given to a number of treatments, based on their outcomes. Qigong, yoga, and tai chi were weakly recommended for improving sleep and quality of life. Mindfulness was weakly recommended for improving pain and quality of life. Acupuncture and hydrotherapy were weakly recommended for improving pain. A weak recommendation was also given to psychotherapy. It was more suitable for patients with mood disorders or unhelpful coping strategies. Chiropractic was strongly recommended against, due to safety concerns. Some medications were weakly recommended for severe pain (duloxetine, pregabalin, tramadol) or sleep disturbance (amitriptyline, cyclobenzaprine, pregabalin). Others were not recommended due to a lack of efficacy (nonsteroidal anti-inflammatory drugs, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors). Growth hormone, sodium oxybate, opioids and steroids were strongly recommended against due to lack of efficacy and side effects.

The guidelines published by the Association of the Scientific Medical Societies in Germany ^[128] inform patients that self-management strategies are an important component in managing the disease. ^[129] The Canadian Pain Society ^[130] also published guidelines for the diagnosis and management of fibromyalgia.

Exercise

Exercise is the only fibromyalgia treatment that has been given a strong recommendation by the European Alliance of Associations for Rheumatology (EULAR). There is strong evidence indicating that exercise improves fitness, sleep and quality of life and may reduce pain and fatigue for people with fibromyalgia. ^{[131] [22] [132]} Exercise has an added benefit in that it does not cause any serious adverse effects. ^[132] There are a number of hypothesized biological mechanisms. ^[133] Exercise may improve pain modulation ^{[134] [135]} through serotoninergic pathways. ^[135] It may reduce pain by altering the hypothalamic-pituitary-adrenal axis and reducing cortisol levels. ^[136] It also has anti-inflammatory effects that may improve fibromyalgia symptoms. ^{[137] [138]} Aerobic exercise can improve muscle metabolism and pain through mitochondrial pathways. ^[137]

When different exercise programs are compared, aerobic exercise is capable of modulating the autonomic nervous function of fibromyalgia patients, whereas resistance exercise does not show such effects. ^[139] A 2022 meta-analysis found that aerobic training showed a high effect size while strength interventions showed moderate effects. ^[140] Meditative exercise seems preferable for improving sleep, ^{[141] [142]} with no differences between resistance, flexibility and aquatic exercise in their favorable effects on fatigue. ^[141]

Despite its benefits, exercise is a challenge for patients with fibromyalgia, due to the chronic fatigue and pain they experience. ^[143] They may also feel that those who recommend or deliver exercise interventions do not fully understand the possible negative impact of exercise on fatigue and pain. ^[144] This is especially true for non-personalized exercise programs. ^[144] Adherence is higher when the exercise program is recommended by doctors or supervised by nurses. ^[145]

Sufferers perceive exercise as more effortful than healthy adults. ^[146] Depression and higher pain intensity serve as barriers to physical activity. ^[147] Exercise may intimidate them, in fear that they will be asked to do more than they are capable of. ^[144]

A recommended approach to a graded exercise program begins with small, frequent exercise periods and builds up from there. ^{[140] [148]} In order to reduce pain the use of an exercise program of 13 to 24 weeks is recommended, with each session lasting 30 to 60 minutes. ^[140]

Aerobic

Aerobic exercise for fibromyalgia patients is the most investigated type of exercise. ^[132] It includes activities such as walking, jogging, spinning, cycling, dancing and exercising in water, ^{[137] [139]} with walking being named as one of the best methods. ^[149] A 2017 Cochrane summary concluded that aerobic exercise probably improves quality of life, slightly decreases pain and improves physical function and makes no difference in fatigue and stiffness. ^[150] A 2019 meta-analysis showed that exercising aerobically can reduce autonomic dysfunction and increase heart rate variability. ^[139] This happens when patients exercise at least twice a week, for 45–60 minutes at about 60%-80% of the maximum heart rate. ^[139] Aerobic exercise also decreases anxiety and depression and improves the quality of life. ^[139]

Flexibility

Combinations of different exercises such as flexibility and aerobic training may improve stiffness. ^[151] However, the evidence is of low-quality. ^[151] It is not clear if flexibility training alone compared to aerobic training is effective at reducing symptoms or has any adverse effects. ^[152]

Resistance

In resistance exercise, participants apply a load to their body using weights, elastic band, body weight or other measures.

Two meta-analyses on fibromyalgia have shown that resistance training can reduce anxiety and depression, ^{[139] [153]} one found that it decreases pain and disease severity ^[154] and one found that it improves quality of life. ^[139] Resistance training may also improve sleep, with a greater effect than that of flexibility training and a similar effect to that of aerobic exercise. ^[155]

The dosage of resistance exercise for women with fibromyalgia was studied in a 2022 meta-analysis. ^[156] Effective dosages were found when exercising twice a week, for at least eight weeks. Symptom improvement was found for even low dosages such as 1–2 sets of 4–20 repetitions. ^[156] Most studies use moderate exercise intensity of 40% to 85% one-repetition maximum. This intensity was effective in reducing pain. ^[156] Some treatment regimes increase the intensity over time (from 40% to 80%), whereas others increase it when the participant is able to perform 12 repetitions. ^[156] High-intensity exercises may cause lower treatment adherence.

Meditative

A 2021 meta-analysis found that meditative exercise programs (tai chi, yoga, qigong) were superior to other forms of exercise (aerobic, flexibility, resistance) in improving sleep quality. ^[141] Other meta-analyses also found positive effects of tai chi for sleep, ^[157] fibromyalgia symptoms, ^[158] and pain, fatigue, depression and quality of life. ^[159] These tai chi interventions frequently included 1-hour sessions practiced 1-3 times a week for 12 weeks. Meditative exercises, as a whole, may achieve desired outcomes through biological mechanisms such as antioxidation, anti-inflammation, reduction in sympathetic activity and modulation of glucocorticoid receptor sensitivity. ^[137]

Aquatic

Several reviews and meta-analyses suggest that aquatic training can improve symptoms and wellness in people with fibromyalgia. ^{[160] [161] [162] [163] [164] [165]} It is recommended to practice aquatic therapy at least twice a week using a low to moderate intensity. ^[164] However, aquatic therapy does not appear to be superior to other types of exercise. ^[166]

Other

Limited evidence suggests vibration training in combination with exercise may improve pain, fatigue, and stiffness. ^[167]

Medications

A few countries have published guidelines for the management and treatment of fibromyalgia. As of 2018, all of them emphasize that medications are not required. However, medications, though imperfect, continue to be a component of treatment strategy for fibromyalgia patients. The German guidelines outlined parameters for drug therapy termination and recommended considering drug holidays after six months. ^[19]

Health Canada and the US Food and Drug Administration (FDA) have approved pregabalin ^[168] (an anticonvulsant) and duloxetine (a serotonin–norepinephrine reuptake inhibitor) for the management of fibromyalgia. The FDA also approved milnacipran (another serotonin–norepinephrine reuptake inhibitor), but the European Medicines Agency refused marketing authority. ^[169]

The medications duloxetine, milnacipran, or pregabalin have been approved by the US Food and Drug Administration (FDA) for the management of fibromyalgia. ^[170]

Antidepressants

Antidepressants are one of the common drugs for fibromyalgia. A 2021 meta-analysis concluded that antidepressants can improve the quality of life for fibromyalgia patients in the medium-term. ^[20] For most people with fibromyalgia, the potential benefits of treatment with the serotonin and norepinephrine reuptake inhibitors duloxetine and milnacipran and the tricyclic antidepressants, such as amitriptyline, are outweighed by significant adverse effects (more adverse effects than benefits), however, a small number of people may experience relief from symptoms with these medications. ^{[171] [172] [173]}

The length of time that antidepressant medications take to be effective at reducing symptoms can vary. Any potential benefits from the antidepressant amitriptyline may take up to three months to take effect and it may take between three and six months for duloxetine, milnacipran, and pregabalin to be effective at improving symptoms. ^[174] Some medications have the potential to cause withdrawal symptoms when stopping so gradual discontinuation may be warranted particularly for antidepressants and pregabalin. ^[23]

Serotonin and norepinephrine reuptake inhibitors

A 2023 meta analysis found that duloxetine improved fibromyalgia symptoms, regardless of the dosage. ^[175] SSRIs may be also be used to treat depression in people diagnosed with fibromyalgia. ^[176]

Tricyclic antidepressants

While amitriptyline has been used as a first line treatment, the quality of evidence to support this use and comparison between different medications is poor. ^{[177] [173]} Very weak evidence indicates that a very small number of people may benefit from treatment with the tetracyclic antidepressant mirtazapine, however, for most, the potential benefits are not great and the risk of adverse effects and potential harm outweighs any potential for benefit. ^[178] As of 2018, the only tricyclic antidepressant that has sufficient evidence is amitriptyline. ^{[19] [177]}

Monoamine oxidase inhibitors

Tentative evidence suggests that monoamine oxidase inhibitors (MAOIs) such as pirlindole and moclobemide are moderately effective for reducing pain. ^[179] Very low-quality evidence suggests pirlindole as more effective at treating pain than moclobemide. ^[179] Side effects of MAOIs may include nausea and vomiting. ^[179]

Central nervous system depressants

Central nervous system depressants include drug categories such as sedatives, tranquilizers, and hypnotics. A 2021 meta-analysis concluded that such drugs can improve the quality of life for fibromyalgia patients in the medium-term. ^[20]

Anti-seizure medication

The anti-convulsant medications gabapentin and pregabalin may be used to reduce pain. ^[8] There is tentative evidence that gabapentin may be of benefit for pain in about 18% of people with fibromyalgia. ^[8] It is not possible to predict who will benefit, and a short trial may be recommended to test the effectiveness of this type of medication. Approximately 6/10 people who take gabapentin to treat pain related to fibromyalgia experience unpleasant side effects such as dizziness, abnormal walking, or swelling from fluid accumulation. ^[180] Pregabalin demonstrates a benefit in about 9% of people. ^[181] Pregabalin reduced time off work by 0.2 days per week. ^[182]

Cannabinoids

Cannabinoids may have some benefits for people with fibromyalgia. However, as of 2022, the data on the topic is still limited. ^{[183] [184] [185]} Cannabinoids may also have adverse effects and may negatively interact with common rheumatological drugs. ^[186]

Opioids

The use of opioids is controversial. As of 2015, no opioid is approved for use in this condition by the FDA. ^[187] A 2016 Cochrane review concluded that there is no good evidence to support or refute the suggestion that oxycodone, alone or in combination with naloxone, reduces pain in fibromyalgia. ^[188] The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) in 2014 stated that there was a lack of evidence for opioids for most people. ^[5] The Association of the Scientific Medical Societies in Germany in 2012 made no recommendation either for or against the use of weak opioids because of the limited amount of scientific research addressing their use in the treatment of fibromyalgia. They strongly advise against using strong opioids. ^[128] The Canadian Pain Society in 2012 said that opioids, starting with a weak opioid like tramadol, can be tried but only for people with moderate to severe pain that is not well-controlled by non-opioid painkillers. They discourage the use of strong opioids and only recommend using them while they continue to provide improved pain and functioning. Healthcare providers should monitor people on opioids for ongoing effectiveness, side effects, and possible unwanted drug behaviors. ^[130]

A 2015 review found fair evidence to support tramadol use if other medications do not work. ^[187] A 2018 review found little evidence to support the combination of paracetamol (acetaminophen) and tramadol over a single medication. ^[189] Goldenberg et al suggest that tramadol works via its serotonin and norepinephrine reuptake inhibition, rather than via its action as a weak opioid receptor agonist. ^[190]

A large study of US people with fibromyalgia found that between 2005 and 2007 37.4% were prescribed short-acting opioids and 8.3% were prescribed long-acting opioids, ^[3] with around 10% of those prescribed short-acting opioids using tramadol; ^[191] and a 2011 Canadian study of 457 people with fibromyalgia found 32% used opioids and two-thirds of those used strong opioids. ^[130]

Topical treatment

Capsaicin has been suggested as a topical pain reliever. Preliminary results suggest that it may improve sleep quality and fatigue, but there are not enough studies to support this claim. ^[192]

Unapproved or unfounded

Sodium oxybate increases growth hormone production levels through increased slow-wave sleep patterns. However, this medication was not approved by the FDA for the indication for use in people with fibromyalgia due to the concern for abuse. ^[193]

The muscle relaxants cyclobenzaprine, carisoprodol with acetaminophen and caffeine, and tizanidine are sometimes used to treat fibromyalgia; however, as of 2015 they are not approved for this use in the United States. ^{[194] [195]} The use of nonsteroidal anti-inflammatory drugs is not recommended as first-line therapy. ^[196] Moreover, nonsteroidal anti-inflammatory drugs cannot be considered as useful in the management of fibromyalgia. ^[197]

Very low-quality evidence suggests quetiapine may be effective in fibromyalgia. ^[198]

No high-quality evidence exists that suggests synthetic THC (nabilone) helps with fibromyalgia. ^[199]

Nutrition and dietary supplements

Nutrition is related to fibromyalgia in several ways. Some nutritional risk factors for fibromyalgia complications are obesity, nutritional deficiencies, food allergies and consuming food additives. ^[200] The consumption of fruits and vegetables, low-processed foods, high-quality proteins, and healthy fats may have some benefits. ^[200] Low-quality evidence found some benefits of a vegetarian or vegan diet. ^[201]

Although dietary supplements have been widely investigated in relation to fibromyalgia, most of the evidence, as of 2021, is of poor quality. It is therefore difficult to reach conclusive recommendations. ^[202] It appears that Q10 coenzyme and vitamin D supplements can reduce pain and improve quality of life for fibromyalgia patients. ^{[22] [203]} Q10 coenzyme has beneficial effects on fatigue in fibromyalgia patients, with most studies using doses of 300 mg per day for three months. ^[204] Q10 coenzyme is hypothesized to improve mitochondrial activity and decrease inflammation. ^[205] Vitamin D has been shown to improve some fibromyalgia measures, but not others. ^{[203] [206]}

Two review articles found that melatonin treatment has several positive effects on fibromyalgia patients, including the improvement of sleep quality, pain, and disease impact. ^{[207] [208]} No major adverse events were reported. ^[207]

Psychotherapy

Due to the uncertainty about the pathogenesis of fibromyalgia, current treatment approaches focus on management of symptoms to improve quality of life, ^[209] using integrated pharmacological and non-pharmacological approaches. ^[4] There is no single intervention shown to be effective for all patients. ^[210] In a 2020 Cochrane review, cognitive behavioral therapy was found to have a small but beneficial effect for reducing pain and distress but adverse events were not well evaluated. ^[211] Cognitive behavioral therapy and related psychological and behavioural therapies have a small to moderate effect in reducing symptoms of fibromyalgia. ^{[212] [213]} Effect sizes tend to be small when cognitive behavioral therapy is used as a stand-alone treatment for patients with fibromyalgia, but these improve significantly when it is part of a wider multidisciplinary treatment program. ^[213]

A 2010 systematic review of 14 studies reported that cognitive behavioral therapy improves self-efficacy or coping with pain and reduces the number of physician visits at post-treatment, but has no significant effect on pain, fatigue, sleep, or health-related quality of life at post-treatment or follow-up. Depressed mood was also improved but this could not be distinguished from some risks of bias. ^[214] A 2022 meta-analysis found that cognitive behavioral therapy reduces insomnia in people with chronic pain, including people with fibromyalgia. ^[215] Acceptance and commitment therapy, a type of cognitive behavioral therapy, has also proven effective. ^[216]

Patient education

Patient education is recommended by the European League Against Rheumatism (EULAR) as an important treatment component. ^[18] As of 2022, there is only low-quality evidence showing that patient education can decrease pain and fibromyalgia impact. ^{[217] [218]}

Sleep hygiene interventions show low effectiveness in improving insomnia in people with chronic pain. ^[215]

Physical therapy

Patients with chronic pain, including those with fibromyalgia, can benefit from techniques such as manual therapy, cryotherapy, and balneotherapy. ^[219] These can lessen the experience of chronic pain and increase both the amount and quality of sleep. Patients' quality of life is also improved by decreasing pain mechanisms and increasing sleep quality, particularly during the REM phase, sleep efficiency, and alertness. ^[219]

Manual therapy

A 2021 meta-analysis concluded that massage and myofascial release diminish pain in the medium-term. ^[20] As of 2015, there was no good evidence for the benefit of other mind-body therapies. ^[220]

Acupuncture

A 2013 review found moderate-level evidence on the usage of acupuncture with electrical stimulation for improvement of the overall well-being. Acupuncture alone will not have the same effects, but will enhance the influence of exercise and medication in pain and stiffness. ^[221]

Electrical neuromodulation

Several forms of electrical neuromodulation, including transcutaneous electrical nerve stimulation (TENS) and transcranial direct current stimulation (tDCS), have been used to treat fibromyalgia. In general, they have been found to be helpful in reducing pain and depression and improving functioning. ^{[222] [223]}

Transcutaneous electrical nerve stimulation (TENS)

Transcutaneous electrical nerve stimulation (TENS) is the delivery of pulsed electrical currents to the skin to stimulate peripheral nerves. TENS is widely used to treat pain and is considered to be a low-cost, safe, and self-administered treatment. ^[224] As such, it is commonly recommended by clinicians to people suffering from pain. ^[225] On 2019, an overview of eight Cochrane reviews was conducted, covering 51 TENS-related randomized controlled trials. ^[225] The review concluded that the quality of the available evidence was insufficient to make any recommendations. ^[225] A later review concluded that transcutaneous electrical nerve stimulation may diminish pain in the short-term, but there was uncertainty about the relevance of the results. ^[20]

Preliminary findings suggest that electrically stimulating the vagus nerve through an implanted device can potentially reduce fibromyalgia symptoms. ^[226] However, there may be adverse reactions to the procedure. ^[226]

Noninvasive brain stimulation

Noninvasive brain stimulation includes methods such as transcranial direct current stimulation and high-frequency repetitive transcranial magnetic stimulation (TMS). Both methods have been found to improve pain scores in neuropathic pain and fibromyalgia. ^[227]

A 2023 meta analysis of 16 RCTs found that transcranial direct current stimulation (tDCS) of over 4 weeks can decrease pain in patients with fibromyalgia. ^[228]

A 2021 meta-analysis of multiple intervention types concluded that magnetic field therapy and transcranial magnetic stimulation may diminish pain in the short-term, but conveyed an uncertainty about the relevance of the result. ^[20] Several 2022 meta-analyses focusing on transcranial magnetic stimulation found positive effects on fibromyalgia. ^{[229] [230] [231]} Repetitive transcranial magnetic stimulation improved pain in the short-term ^{[230] [231]} and quality of life after 5–12 weeks. ^{[230] [231]} Repetitive transcranial magnetic stimulation did not improve anxiety, depression, and fatigue. ^[231] Transcranial magnetic stimulation to the left dorsolateral prefrontal cortex was also ineffective. ^[230]

EEG neurofeedback

A systematic review of EEG neurofeedback for treatment of fibromyalgia found most treatments showed significant improvements of the main symptoms of the disease. ^[232] However, the protocols were so different, and the lack of controls or randomization impede drawing conclusive results. ^[232]

Hyperbaric oxygen therapy

Hyperbaric oxygen therapy (HBOT) has shown beneficial effects in treating chronic pain by reducing inflammation and oxidative stress. ^[100] However, treating fibromyalgia with hyperbaric oxygen therapy is still controversial, in light of the scarcity of large-scale clinical trials. ^[137] In addition, hyperbaric oxygen therapy raises safety concerns due to the oxidative damage that may follow it. ^[137] An evaluation of nine trials with 288 patients in total found that HBOT was more effective at relieving fibromyalgia patients' pain than the control intervention. In most of the trials HBOT improved sleep disturbance, multidimensional function, patient satisfaction, and tender spots. 24% of the patients experienced negative outcomes. ^[233]

Prognosis

Although in itself fibromyalgia is neither degenerative nor fatal, the chronic pain of fibromyalgia is pervasive and persistent. Most people with fibromyalgia report that their symptoms do not improve over time. However, most patients learn to adapt to the symptoms over time. The German guidelines for patients explain that:

1. The symptoms of fibromyalgia are persistent in nearly all patients.
2. Total relief of symptoms is seldom achieved.
3. The symptoms do not lead to disablement and do not shorten life expectancy. ^[129]

An 11-year follow-up study on 1,555 patients found that most remained with high levels of self-reported symptoms and distress.^{[ non-primary source needed ] [234]} However, there was a great deal of patient heterogeneity accounting for almost half of the variance. At the final observation, 10% of the patients showed substantial improvement with minimal symptoms. An additional 15% had moderate improvement. This state, though, may be transient, given the fluctuations in symptom severity.^{[ non-primary source needed ] [234]}

A study of 97 adolescents diagnosed with fibromyalgia followed them for eight years.^{[ non-primary source needed ]} After eight years, the majority of youth still experienced pain and disability in physical, social, and psychological areas. At the last follow-up, all participants reported experiencing one or more fibromyalgia symptoms such as pain, fatigue, and/or sleep problems, with 58% matching the complete ACR 2010 criteria for fibromyalgia. Based on the WPI and SS score cut-points, the remaining 42% exhibited subclinical symptoms. Pain and emotional symptom trajectories, on the other hand, displayed a variety of longitudinal patterns. The study concluded that while most patient's fibromyalgia symptoms endure, the severity of their pain tends to reduce over time. ^[235]

Baseline depressive symptoms in adolescents appear to predict worse pain at follow-up periods. ^{[236] [237]}

A meta-analysis based on close to 200,000 fibromyalgia patients found that they were at a higher risk for all-cause mortality. Specific mortality causes that were suggested were accidents, infections and suicide. ^[238]

Epidemiology

Fibromyalgia is estimated to affect 1.8% of the population. ^[239]

Despite the fact that more than 90% of fibromyalgia patients are women, only 60% of people with fibromyalgia symptoms are female in the general population. ^[240]

Society and culture

Economics

People with fibromyalgia generally have higher healthcare costs and utilization rates. A review of 36 studies found that fibromyalgia causes a significant economic burden on health care systems. ^[241] Annual costs per patient were estimated to be up to $35,920 in the US and $8,504 in Europe. ^[241]

Controversies

Fibromyalgia was defined relatively recently. In the past, it was a disputed diagnosis. Rheumatologist Frederick Wolfe, lead author of the 1990 paper that first defined the diagnostic guidelines for fibromyalgia, stated in 2008 that he believed it "clearly" not to be a disease but instead a physical response to depression and stress. ^[242] In 2013, Wolfe added that its causes "are controversial in a sense" and "there are many factors that produce these symptoms – some are psychological and some are physical and it does exist on a continuum". ^[243] Some members of the medical community do not consider fibromyalgia a disease because of a lack of abnormalities on physical examination and the absence of objective diagnostic tests. ^{[29] [244]}

In the past, some psychiatrists have viewed fibromyalgia as a type of affective disorder, or a somatic symptom disorder. These controversies do not engage healthcare specialists alone; some patients object to fibromyalgia being described in purely somatic terms. ^[245]

As of 2022, neurologists and pain specialists tend to view fibromyalgia as a pathology due to dysfunction of muscles and connective tissue as well as functional abnormalities in the central nervous system. Rheumatologists define the syndrome in the context of "central sensitization" – heightened brain response to normal stimuli in the absence of disorders of the muscles, joints, or connective tissues. Because of this symptomatic overlap, some researchers have proposed that fibromyalgia and other analogous syndromes be classified together as central sensitivity syndromes. ^{[246] [13]}

Notes

1. Shoulder girdle (left & right), upper arm (left & right), lower arm (left & right), hip/buttock/trochanter (left & right), upper leg (left & right), lower leg (left & right), jaw (left & right), chest, abdomen, back (upper & lower), and neck. ^{[35] : 607}
2. Somatic symptoms include, but are not limited to: muscle pain, irritable bowel syndrome, fatigue or tiredness, problems thinking or remembering, muscle weakness, headache, pain or cramps in the abdomen, numbness or tingling, dizziness, insomnia, depression, constipation, pain in the upper abdomen, nausea, nervousness, chest pain, blurred vision, fever, diarrhea, dry mouth, itching, wheezing, Raynaud's phenomenon, hives or welts, ringing in the ears, vomiting, heartburn, oral ulcers, loss of or changes in taste, seizures, dry eyes, shortness of breath, loss of appetite, rash, sun sensitivity, hearing difficulties, easy bruising, hair loss, frequent or painful urination, and bladder spasms. ^{[35] : 607}

References

1. "fibromyalgia". Collins Dictionaries. Archived from the original on 4 October 2015. Retrieved 16 March 2016.
2. "Neurology Now: Fibromyalgia: Is Fibromyalgia Real? | American Academy of Neurology". tools.aan.com. October 2009. Retrieved 1 June 2018.^{[ permanent dead link ‍]}
3. Ngian GS, Guymer EK, Littlejohn GO (February 2011). "The use of opioids in fibromyalgia". International Journal of Rheumatic Diseases. 14 (1): 6–11. doi:10.1111/j.1756-185X.2010.01567.x. PMID   21303476. S2CID   29000267.
4. Clauw DJ (April 2014). "Fibromyalgia: a clinical review". JAMA. 311 (15): 1547–1555. doi:10.1001/jama.2014.3266. PMID   24737367. S2CID   43693607.
5. "Questions and Answers about Fibromyalgia". NIAMS. July 2014. Archived from the original on 15 March 2016. Retrieved 15 March 2016.
6. Ferri FF (2010). "Chapter F". Ferri's differential diagnosis: a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders (2nd ed.). Philadelphia, PA: Elsevier/Mosby. ISBN   978-0-323-07699-9.
7. Schneider MJ, Brady DM, Perle SM (2006). "Commentary: differential diagnosis of fibromyalgia syndrome: proposal of a model and algorithm for patients presenting with the primary symptom of chronic widespread pain". Journal of Manipulative and Physiological Therapeutics. 29 (6): 493–501. doi:10.1016/j.jmpt.2006.06.010. PMID   16904498.
8. Cooper TE, Derry S, Wiffen PJ, Moore RA (January 2017). "Gabapentin for fibromyalgia pain in adults". The Cochrane Database of Systematic Reviews. 1 (1): CD012188. doi:10.1002/14651858.CD012188.pub2. PMC   6465053 . PMID   28045473.
9. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, et al. (December 2016). "2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria". Seminars in Arthritis and Rheumatism. 46 (3): 319–329. doi:10.1016/j.semarthrit.2016.08.012. PMID   27916278.
10. Wu YL, Chang LY, Lee HC, Fang SC, Tsai PS (May 2017). "Sleep disturbances in fibromyalgia: A meta-analysis of case-control studies". Journal of Psychosomatic Research. 96: 89–97. doi:10.1016/j.jpsychores.2017.03.011. PMID   28545798.
11. Häuser W, Sarzi-Puttini P, Fitzcharles MA (2019). "Fibromyalgia syndrome: under-, over- and misdiagnosis". Clinical and Experimental Rheumatology. 37 (1 Suppl 116): 90–97. PMID   30747096.
12. Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, et al. (June 2019). "AAPT Diagnostic Criteria for Fibromyalgia". The Journal of Pain. 20 (6): 611–628. doi: 10.1016/j.jpain.2018.10.008 . hdl: 2434/632765 . PMID   30453109. S2CID   53872511.
13. Mezhov V, Guymer E, Littlejohn G (December 2021). "Central sensitivity and fibromyalgia". Internal Medicine Journal. 51 (12): 1990–1998. doi: 10.1111/imj.15430 . PMID   34139045. S2CID   235471910.
14. Galvez-Sánchez CM, Reyes Del Paso GA (April 2020). "Diagnostic Criteria for Fibromyalgia: Critical Review and Future Perspectives". Journal of Clinical Medicine. 9 (4): 1219. doi: 10.3390/jcm9041219 . PMC   7230253 . PMID   32340369. Furthermore, in many cases the FMS diagnosis is fundamentally based on the exclusion of other similar diseases; in spite of that practice not being recommended because of its lack of precision and the high possibility of misdiagnosis.
15. Bergmann U (2012). Neurobiological foundations for EMDR practice. New York: Springer Pub. Co. p. 165. ISBN   978-0-8261-0938-5.
16. Fitzcharles MA, Cohen SP, Clauw DJ, Littlejohn G, Usui C, Häuser W (May 2021). "Nociplastic pain: towards an understanding of prevalent pain conditions". Lancet. 397 (10289): 2098–2110. doi:10.1016/s0140-6736(21)00392-5. PMID   34062144. S2CID   235245552.
17. Prabhakar A, Kaiser JM, Novitch MB, Cornett EM, Urman RD, Kaye AD (March 2019). "The Role of Complementary and Alternative Medicine Treatments in Fibromyalgia: a Comprehensive Review". Current Rheumatology Reports. 21 (5): 14. doi:10.1007/s11926-019-0814-0. PMID   30830504. S2CID   73482737.
18. Macfarlane GJ, Kronisch C, Atzeni F, Häuser W, Choy EH, Amris K, et al. (December 2017). "EULAR recommendations for management of fibromyalgia" (PDF). Annals of the Rheumatic Diseases. 76 (12): e54. doi:10.1136/annrheumdis-2017-211587. PMID   28476880. S2CID   26251476. Archived (PDF) from the original on 8 February 2023. Retrieved 4 March 2023.
19. Häuser W, Fitzcharles MA (March 2018). "Facts and myths pertaining to fibromyalgia". Dialogues in Clinical Neuroscience. 20 (1): 53–62. doi:10.31887/dcns.2018.20.1/whauser. PMC   6016048 . PMID   29946212.
20. Mascarenhas RO, Souza MB, Oliveira MX, Lacerda AC, Mendonça VA, Henschke N, Oliveira VC (January 2021). "Association of Therapies With Reduced Pain and Improved Quality of Life in Patients With Fibromyalgia: A Systematic Review and Meta-analysis". JAMA Internal Medicine. 181 (1): 104–112. doi:10.1001/jamainternmed.2020.5651. PMC   7589080 . PMID   33104162.
21. Kia S, Choy E (May 2017). "Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology". Biomedicines. 5 (2): 20. doi: 10.3390/biomedicines5020020 . PMC   5489806 . PMID   28536363.
22. Ibáñez-Vera AJ, Alvero-Cruz JR, García-Romero JC (2018). "Therapeutic physical exercise and supplements to treat fibromyalgia". Apunts. Medicina de l'Esport. 53 (197): 33–41. doi:10.1016/j.apunts.2017.07.001.
23. Häuser W, Eich W, Herrmann M, Nutzinger DO, Schiltenwolf M, Henningsen P (June 2009). "Fibromyalgia syndrome: classification, diagnosis, and treatment". Deutsches Ärzteblatt International. 106 (23): 383–391. doi:10.3238/arztebl.2009.0383. PMC   2712241 . PMID   19623319.
24. Health Information Team (February 2004). "Fibromyalgia". BUPA insurance. Archived from the original on 22 June 2006. Retrieved 24 August 2006.
25. Yunus M, Masi AT, Calabro JJ, Miller KA, Feigenbaum SL (August 1981). "Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls". Seminars in Arthritis and Rheumatism. 11 (1): 151–171. doi:10.1016/0049-0172(81)90096-2. PMID   6944796.
26. "Fibro-". Dictionary.com. Archived from the original on 13 December 2009. Retrieved 21 May 2008.
27. "Meaning of myo". 12 April 2009. Archived from the original on 12 April 2009. Retrieved 26 August 2012.
28. "Meaning of algos". 12 April 2009. Archived from the original on 12 April 2009. Retrieved 26 August 2012.
29. Wolfe F (April 2009). "Fibromyalgia wars". The Journal of Rheumatology. 36 (4): 671–678. doi: 10.3899/jrheum.081180 . PMID   19342721. S2CID   2091976.
30. Smythe HA, Moldofsky H (1977). "Two contributions to understanding of the "fibrositis" syndrome". Bulletin on the Rheumatic Diseases. 28 (1): 928–931. PMID   199304.
31. Winfield JB (June 2007). "Fibromyalgia and related central sensitivity syndromes: twenty-five years of progress". Seminars in Arthritis and Rheumatism. 36 (6): 335–338. doi:10.1016/j.semarthrit.2006.12.001. PMID   17303220.
32. Inanici F, Yunus MB (October 2004). "History of fibromyalgia: past to present". Current Pain and Headache Reports. 8 (5): 369–378. doi:10.1007/s11916-996-0010-6. PMID   15361321. S2CID   42573740.
33. Goldenberg DL (May 1987). "Fibromyalgia syndrome. An emerging but controversial condition". JAMA. 257 (20): 2782–2787. doi:10.1001/jama.257.20.2782. PMID   3553636.
34. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. (February 1990). "The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee". Arthritis and Rheumatism. 33 (2): 160–172. doi:10.1002/art.1780330203. PMID   2306288.
35. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. (May 2010). "The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity". Arthritis Care & Research. 62 (5): 600–610. doi:10.1002/acr.20140. hdl: 2027.42/75772 . PMID   20461783. S2CID   17154205.
36. Clauw DJ, Arnold LM, McCarberg BH (September 2011). "The science of fibromyalgia". Mayo Clinic Proceedings. 86 (9): 907–911. doi:10.4065/mcp.2011.0206. PMC   3258006 . PMID   21878603.
37. "ICD-11 for Mortality and Morbidity Statistics". icd.who.int. Archived from the original on 1 August 2018. Retrieved 9 April 2022.
38. Gianlorenço AC, Costa V, Fabris-Moraes W, Menacho M, Alves LG, Martinez-Magallanes D, Fregni F (15 May 2024). "Cluster analysis in fibromyalgia: a systematic review". Rheumatology International. doi:10.1007/s00296-024-05616-2. ISSN   1437-160X. PMID   38748219.
39. Besiroglu MD, Dursun MD (July 2019). "The association between fibromyalgia and female sexual dysfunction: a systematic review and meta-analysis of observational studies". International Journal of Impotence Research. 31 (4): 288–297. doi:10.1038/s41443-018-0098-3. PMID   30467351. S2CID   53717513.
40. Zdebik N, Zdebik A, Bogusławska J, Przeździecka-Dołyk J, Turno-Kręcicka A (January 2021). "Fibromyalgia syndrome and the eye – A review". Survey of Ophthalmology. 66 (1): 132–137. doi:10.1016/j.survophthal.2020.05.006. PMID   32512032. S2CID   219548664.
41. "Archived copy". academic.oup.com. Archived from the original on 21 May 2023. Retrieved 11 February 2024.
42. "Fibromyalgia – Symptoms". nhs.uk. 20 October 2017. Archived from the original on 23 March 2018. Retrieved 21 October 2020.
43. "Fibromyalgia - Symptoms". nhs.uk. 20 October 2017. Retrieved 11 April 2024.
44. Kimura S, Toyoura M, Toyota Y, Takaoka Y (December 2020). "Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children". Journal of Clinical Sleep Medicine. 16 (12): 2073–2078. doi:10.5664/jcsm.8778. PMC   7848940 . PMID   32876042.
45. Spaeth M, Rizzi M, Sarzi-Puttini P (April 2011). "Fibromyalgia and sleep". Best Practice & Research. Clinical Rheumatology. 25 (2): 227–239. doi:10.1016/j.berh.2011.03.004. PMID   22094198.
46. Bradley LA (December 2009). "Pathophysiology of fibromyalgia". The American Journal of Medicine. 122 (12 Suppl): S22–S30. doi:10.1016/j.amjmed.2009.09.008. PMC   2821819 . PMID   19962493.
47. Wolfe F, Rasker JJ, Ten Klooster P, Häuser W (December 2021). "Subjective Cognitive Dysfunction in Patients With and Without Fibromyalgia: Prevalence, Predictors, Correlates, and Consequences". Cureus. 13 (12): e20351. doi: 10.7759/cureus.20351 . PMC   8752385 . PMID   35036191.
48. Bell T, Trost Z, Buelow MT, Clay O, Younger J, Moore D, Crowe M (September 2018). "Meta-analysis of cognitive performance in fibromyalgia". Journal of Clinical and Experimental Neuropsychology. 40 (7): 698–714. doi:10.1080/13803395.2017.1422699. PMC   6151134 . PMID   29388512.
49. Berwick RJ, Siew S, Andersson DA, Marshall A, Goebel A (May 2021). "A Systematic Review Into the Influence of Temperature on Fibromyalgia Pain: Meteorological Studies and Quantitative Sensory Testing". The Journal of Pain. 22 (5): 473–486. doi: 10.1016/j.jpain.2020.12.005 . PMID   33421589. S2CID   231437516.
50. Staud R, Godfrey MM, Robinson ME (August 2021). "Fibromyalgia Patients Are Not Only Hypersensitive to Painful Stimuli But Also to Acoustic Stimuli". The Journal of Pain. 22 (8): 914–925. doi: 10.1016/j.jpain.2021.02.009 . PMID   33636370. S2CID   232066286.
51. Kleykamp BA, Ferguson MC, McNicol E, Bixho I, Arnold LM, Edwards RR, et al. (February 2021). "The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review". Seminars in Arthritis and Rheumatism. 51 (1): 166–174. doi:10.1016/j.semarthrit.2020.10.006. PMID   33383293. S2CID   229948862.
52. Habibi Asgarabad M, Salehi Yegaei P, Jafari F, Azami-Aghdash S, Lumley MA (March 2023). "The relationship of alexithymia to pain and other symptoms in fibromyalgia: A systematic review and meta-analysis". European Journal of Pain. 27 (3): 321–337. doi:10.1002/ejp.2064. PMID   36471652. S2CID   254273680.
53. Fitzcharles MA, Perrot S, Häuser W (October 2018). "Comorbid fibromyalgia: A qualitative review of prevalence and importance". European Journal of Pain. 22 (9): 1565–1576. doi: 10.1002/ejp.1252 . PMID   29802812. S2CID   44068037.
54. Yepez D, Grandes XA, Talanki Manjunatha R, Habib S, Sangaraju SL (May 2022). "Fibromyalgia and Depression: A Literature Review of Their Shared Aspects". Cureus. 14 (5): e24909. doi: 10.7759/cureus.24909 . PMC   9187156 . PMID   35698706.
55. Løge-Hagen JS, Sæle A, Juhl C, Bech P, Stenager E, Mellentin AI (February 2019). "Prevalence of depressive disorder among patients with fibromyalgia: Systematic review and meta-analysis". Journal of Affective Disorders. 245: 1098–1105. doi:10.1016/j.jad.2018.12.001. PMID   30699852. S2CID   73411416.
56. Bruce DF, PhD. "Fibromyalgia and Depression". WebMD. Retrieved 1 April 2024.
57. Ramírez-Morales R, Bermúdez-Benítez E, Martínez-Martínez LA, Martínez-Lavín M (August 2022). "Clinical overlap between fibromyalgia and myalgic encephalomyelitis. A systematic review and meta-analysis". Autoimmunity Reviews. 21 (8): 103129. doi: 10.1016/j.autrev.2022.103129 . PMID   35690247.
58. Goldenberg DL (2024). "How to understand the overlap of long COVID, chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia and irritable bowel syndromes". Seminars in Arthritis and Rheumatism. 67: 152455. doi:10.1016/j.semarthrit.2024.152455. PMID   38761526.
59. Anderson G, Maes M (December 2020). "Mitochondria and immunity in chronic fatigue syndrome". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 103: 109976. doi:10.1016/j.pnpbp.2020.109976. PMID   32470498. S2CID   219104988.
60. Valencia C, Fatima H, Nwankwo I, Anam M, Maharjan S, Amjad Z, et al. (October 2022). "A Correlation Between the Pathogenic Processes of Fibromyalgia and Irritable Bowel Syndrome in the Middle-Aged Population: A Systematic Review". Cureus. 14 (10): e29923. doi: 10.7759/cureus.29923 . PMC   9635936 . PMID   36381861.
61. D'Onghia M, Ciaffi J, Lisi L, Mancarella L, Ricci S, Stefanelli N, et al. (April 2021). "Fibromyalgia and obesity: A comprehensive systematic review and meta-analysis". Seminars in Arthritis and Rheumatism. 51 (2): 409–424. doi:10.1016/j.semarthrit.2021.02.007. PMID   33676126. S2CID   232136088.
62. Alsiri N, Alhadhoud M, Alkatefi T, Palmer S (February 2023). "The concomitant diagnosis of fibromyalgia and connective tissue disorders: A systematic review" (PDF). Seminars in Arthritis and Rheumatism. 58: 152127. doi:10.1016/j.semarthrit.2022.152127. PMID   36462303. S2CID   253650110. Archived (PDF) from the original on 7 January 2024. Retrieved 7 January 2024.
63. Kocyigit BF, Akyol A (March 2023). "Coexistence of fibromyalgia syndrome and inflammatory rheumatic diseases, and autonomic cardiovascular system involvement in fibromyalgia syndrome". Clinical Rheumatology. 42 (3): 645–652. doi:10.1007/s10067-022-06385-8. PMID   36151442. S2CID   252496799.
64. He J (2024). "Fibromyalgia in Obstructive Sleep Apnea-hypopnea Syndrome: A Systematic Review and Meta-analysis". Frontiers in Physiology. 15. doi: 10.3389/fphys.2024.1394865 . PMC   11144865 . PMID   38831795.
65. Padhan P, Maikap D, Pathak M (2023). "Restless leg syndrome in rheumatic conditions: Its prevalence and risk factors, a meta-analysis". International Journal of Rheumatic Diseases. 26 (6): 1111–1119. doi:10.1111/1756-185X.14710. ISSN   1756-1841. PMID   37137528. S2CID   258484602. Archived from the original on 28 July 2023. Retrieved 28 July 2023.
66. Goldberg N, Tamam S, Weintraub AY (December 2022). "The association between overactive bladder and fibromyalgia: A systematic review and meta-analysis". International Journal of Gynaecology and Obstetrics. 159 (3): 630–641. doi:10.1002/ijgo.14290. PMID   35641437. S2CID   249236213.
67. Sarzi-Puttini P, Atzeni F, Mease PJ (April 2011). "Chronic widespread pain: from peripheral to central evolution". Best Practice & Research. Clinical Rheumatology. 25 (2): 133–139. doi:10.1016/j.berh.2011.04.001. ISSN   1532-1770. PMID   22094190.
68. Schmidt-Wilcke T, Clauw DJ (19 July 2011). "Fibromyalgia: from pathophysiology to therapy". Nature Reviews. Rheumatology. 7 (9): 518–527. doi:10.1038/nrrheum.2011.98. ISSN   1759-4804. PMID   21769128.
69. D'Agnelli S, Arendt-Nielsen L, Gerra MC, Zatorri K, Boggiani L, Baciarello M, Bignami E (January 2019). "Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers". Molecular Pain. 15: 1744806918819944. doi:10.1177/1744806918819944. PMC   6322092 . PMID   30486733.
70. Ablin JN, Buskila D (February 2015). "Update on the genetics of the fibromyalgia syndrome". Best Practice & Research. Clinical Rheumatology. 29 (1): 20–28. doi:10.1016/j.berh.2015.04.018. PMID   26266996.
71. Lee YH, Choi SJ, Ji JD, Song GG (February 2012). "Candidate gene studies of fibromyalgia: a systematic review and meta-analysis". Rheumatology International. 32 (2): 417–426. doi:10.1007/s00296-010-1678-9. PMID   21120487. S2CID   6239018.
72. Dutta D, Brummett CM, Moser SE, Fritsche LG, Tsodikov A, Lee S, et al. (May 2020). "Heritability of the Fibromyalgia Phenotype Varies by Age". Arthritis & Rheumatology. 72 (5): 815–823. doi:10.1002/art.41171. PMC   8372844 . PMID   31736264.
73. Pinto AM, Luís M, Geenen R, Palavra F, Lumley MA, Ablin JN, Amris K, Branco J, Buskila D, Castelhano J, Castelo-Branco M, Crofford LJ, Fitzcharles MA, Häuser W, Kosek E (2023). "Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model". Neuroscience & Biobehavioral Reviews. 151: 105235. doi:10.1016/j.neubiorev.2023.105235. hdl: 1874/429361 . ISSN   0149-7634. PMID   37207842. S2CID   258745974.
74. Maletic V, Raison CL (June 2009). "Neurobiology of depression, fibromyalgia and neuropathic pain". Frontiers in Bioscience. 14 (14): 5291–5338. doi: 10.2741/3598 . PMID   19482616.
75. Martins DF, Viseux FJ, Salm DC, Ribeiro AC, da Silva HK, Seim LA, et al. (December 2021). "The role of the vagus nerve in fibromyalgia syndrome". Neuroscience and Biobehavioral Reviews. 131: 1136–1149. doi:10.1016/j.neubiorev.2021.10.021. PMID   34710514. S2CID   239772451.
76. Kaleycheva N, Cullen AE, Evans R, Harris T, Nicholson T, Chalder T (January 2021). "The role of lifetime stressors in adult fibromyalgia: systematic review and meta-analysis of case-control studies". Psychological Medicine. 51 (2): 177–193. doi: 10.1017/S0033291720004547 . PMID   33602373. S2CID   231955641.
77. Jung YH, Kim H, Lee D, Lee JY, Moon JY, Choi SH, Kang DH (January 2021). "Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects". Molecular Pain. 17: 17448069211012833. doi:10.1177/17448069211012833. PMC   8113919 . PMID   33940974.
78. Schmidt-Wilcke T, Clauw DJ (July 2011). "Fibromyalgia: from pathophysiology to therapy". Nature Reviews. Rheumatology. 7 (9): 518–527. doi:10.1038/nrrheum.2011.98. PMID   21769128. S2CID   20678671.
79. Casale R, Sarzi-Puttini P, Botto R, Alciati A, Batticciotto A, Marotto D, Torta R (January 2019). "Fibromyalgia and the concept of resilience". Clinical and Experimental Rheumatology. 37 (1): 105–113. PMID   30747098. Archived from the original on 9 April 2022. Retrieved 9 April 2022.
80. Conversano C, Marchi L, Rebecca C, Carmassi C, Contena B, Bazzichi LM, Gemignani A (28 September 2018). "Personality Traits in Fibromyalgia (FM): Does FM Personality Exists? A Systematic Review". Clinical Practice and Epidemiology in Mental Health. 14 (1): 223–232. doi:10.2174/1745017901814010223. PMC   6166394 . PMID   30294356. Personality traits are often studied in patients with rheumatic diseases and, most of all, in those with fibromyalgia. However, the literature on this topic presents inconsistent results...Although in many studies FM patients are compared with healthy controls and personality differences are found, when comparison is made with other disorders with controlled depression, personality traits appear to be less relevant than before.
81. Tan AC, Jaaniste T, Champion D (5 May 2019). "Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People". Pain Research & Management. 2019: 6584753. doi: 10.1155/2019/6584753 . PMC   6525804 . PMID   31191788.
82. Roach K, Roberts J (August 2022). "A comprehensive summary of disease variants implicated in metal allergy". Journal of Toxicology and Environmental Health Part B: Critical Reviews. 25 (6): 279–341. Bibcode:2022JTEHB..25..279R. doi:10.1080/10937404.2022.2104981. PMC   9968405 . PMID   35975293. S2CID   251623384.
83. Fialho MF, Brum ES, Oliveira SM (2023). "Could the fibromyalgia syndrome be triggered or enhanced by COVID-19?". Inflammopharmacology. 31 (2): 633–651. doi:10.1007/s10787-023-01160-w. ISSN   0925-4692. PMC   9970139 . PMID   36849853.
84. de Tommaso M, Vecchio E, Nolano M (March 2022). "The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence". Neurological Sciences. 43 (3): 1667–1684. doi:10.1007/s10072-021-05806-x. PMID   35028777. S2CID   245909381.
85. Gkouvi A, Tsiogkas SG, Bogdanos DP, Gika H, Goulis DG, Grammatikopoulou MG (23 April 2024). "Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies". Current Pain and Headache Reports. doi: 10.1007/s11916-024-01244-4 . ISSN   1531-3433. PMC   11271354 . PMID   38652420.
86. den Boer C, Dries L, Terluin B, van der Wouden JC, Blankenstein AH, van Wilgen CP, et al. (February 2019). "Central sensitization in chronic pain and medically unexplained symptom research: A systematic review of definitions, operationalizations and measurement instruments". Journal of Psychosomatic Research. 117: 32–40. doi:10.1016/j.jpsychores.2018.12.010. PMID   30665594. S2CID   58565532.
87. Bidari A, Ghavidel-Parsa B (October 2022). "Nociplastic pain concept, a mechanistic basis for pragmatic approach to fibromyalgia". Clinical Rheumatology. 41 (10): 2939–2947. doi:10.1007/s10067-022-06229-5. PMID   35701625. S2CID   249650477.
88. Nijs J, Lahousse A, Kapreli E, Bilika P, Saraçoğlu İ, Malfliet A, et al. (July 2021). "Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future". Journal of Clinical Medicine. 10 (15): 3203. doi: 10.3390/jcm10153203 . PMC   8347369 . PMID   34361986.
89. Martínez-Lavín M (December 2018). "Fibromyalgia and small fiber neuropathy: the plot thickens!". Clinical Rheumatology. 37 (12): 3167–3171. doi:10.1007/s10067-018-4300-2. PMID   30238382. S2CID   52306843.
90. Martínez-Lavín M (February 2021). "Dorsal root ganglia: fibromyalgia pain factory?". Clinical Rheumatology. 40 (2): 783–787. doi:10.1007/s10067-020-05528-z. PMC   7787228 . PMID   33409721.
91. Martinez-Lavin M, Holman AJ (2021). "Heart rate variability analysis in rheumatology: past, present… and future?". Clinical and Experimental Rheumatology. 39 (5): 927–930. doi: 10.55563/clinexprheumatol/nmvth1 . PMID   34464245. S2CID   237375381.
92. Figueroa A, Kingsley JD, McMillan V, Panton LB (January 2008). "Resistance exercise training improves heart rate variability in women with fibromyalgia". Clinical Physiology and Functional Imaging. 28 (1): 49–54. doi: 10.1111/j.1475-097X.2007.00776.x . PMID   18005081. S2CID   40592827.
93. Park HY, Jung WS, Kim J, Hwang H, Lim K (March 2020). "Twelve Weeks of Aerobic Exercise at the Lactate Threshold Improves Autonomic Nervous System Function, Body Composition, and Aerobic Performance in Women with Obesity". Journal of Obesity & Metabolic Syndrome. 29 (1): 67–75. doi:10.7570/jomes19063. PMC   7118007 . PMID   32045515.
94. Pinto AM, Geenen R, Wager TD, Lumley MA, Häuser W, Kosek E, et al. (January 2023). "Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia". Nature Reviews. Rheumatology. 19 (1): 44–60. doi:10.1038/s41584-022-00873-6. hdl: 1874/426650 . PMID   36471023. S2CID   254273384.
95. Singh L, Kaur A, Bhatti MS, Bhatti R (July 2019). "Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities". Neurochemical Research. 44 (7): 1517–1532. doi:10.1007/s11064-019-02805-5. PMID   31004261. S2CID   123945497.
96. Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, Blonna D (1 January 2012). "Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment". Pain Research and Treatment. 2012: 426130. doi: 10.1155/2012/426130 . PMC   3503476 . PMID   23213512.
97. Feraco P, Bacci A, Pedrabissi F, Passamonti L, Zampogna G, Pedrabissi F, et al. (October 2011). "Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study". AJNR. American Journal of Neuroradiology. 32 (9): 1585–1590. doi:10.3174/ajnr.A2550. PMC   7965402 . PMID   21799042.
98. Xin M, Qu Y, Peng X, Zhu D, Cheng S (9 May 2023). "A systematic review and meta-analysis of voxel-based morphometric studies of fibromyalgia". Frontiers in Neuroscience. 17. doi: 10.3389/fnins.2023.1164145 . ISSN   1662-453X. PMC   10203234 . PMID   37229427.
99. Lin C, Lee SH, Weng HH (1 January 2016). "Gray Matter Atrophy within the Default Mode Network of Fibromyalgia: A Meta-Analysis of Voxel-Based Morphometry Studies". BioMed Research International. 2016: 7296125. doi: 10.1155/2016/7296125 . PMC   5220433 . PMID   28105430.
100. Assavarittirong C, Samborski W, Grygiel-Górniak B (2022). "Oxidative Stress in Fibromyalgia: From Pathology to Treatment". Oxidative Medicine and Cellular Longevity . 2022: 1582432. doi: 10.1155/2022/1582432 . PMC   9556195 . PMID   36246401.
101. Coskun Benlidayi I (May 2019). "Role of inflammation in the pathogenesis and treatment of fibromyalgia". Rheumatology International. 39 (5): 781–791. doi:10.1007/s00296-019-04251-6. PMID   30756137. S2CID   131775636.
102. Uçeyler N, Häuser W, Sommer C (October 2011). "Systematic review with meta-analysis: cytokines in fibromyalgia syndrome". BMC Musculoskeletal Disorders. 12: 245. doi: 10.1186/1471-2474-12-245 . PMC   3234198 . PMID   22034969.
103. Rodriguez-Pintó I, Agmon-Levin N, Howard A, Shoenfeld Y (October 2014). "Fibromyalgia and cytokines". Immunology Letters. 161 (2): 200–203. doi:10.1016/j.imlet.2014.01.009. PMID   24462815.
104. Dell'Osso L, Bazzichi L, Baroni S, Falaschi V, Conversano C, Carmassi C, Marazziti D (1 January 2015). "The inflammatory hypothesis of mood spectrum broadened to fibromyalgia and chronic fatigue syndrome". Clinical and Experimental Rheumatology. 33 (1 Suppl 88): S109–S116. PMID   25786052.
105. Bazzichi L, Giacomelli C, Consensi A, Giorgi V, Batticciotto A, Di Franco M, Sarzi-Puttini P (2020). "One year in review 2020: fibromyalgia". Clinical and Experimental Rheumatology. 38 (1): 3–8. PMID   32116216.
106. Littlejohn G (November 2015). "Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome". Nature Reviews. Rheumatology. 11 (11): 639–648. doi:10.1038/nrrheum.2015.100. PMID   26241184. S2CID   4368913.
107. Erdrich S, Hawrelak JA, Myers SP, Harnett JE (March 2020). "Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review". BMC Musculoskeletal Disorders. 21 (1): 181. doi: 10.1186/s12891-020-03201-9 . PMC   7083062 . PMID   32192466.
108. Wang Y, Wei J, Zhang W, Doherty M, Zhang Y, Xie H, et al. (June 2022). "Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies". eBioMedicine. 80: 104055. doi:10.1016/j.ebiom.2022.104055. PMC   9120231 . PMID   35594658.
109. Minerbi A, Fitzcharles MA (January 2020). "Gut microbiome: pertinence in fibromyalgia". Clinical and Experimental Rheumatology. 38 (1): 99–104. PMID   32116215.
110. Clos-Garcia M, Andrés-Marin N, Fernández-Eulate G, Abecia L, Lavín JL, van Liempd S, et al. (August 2019). "Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia". eBioMedicine. 46: 499–511. doi:10.1016/j.ebiom.2019.07.031. PMC   6710987 . PMID   31327695.
111. Borenstein D (April 1995). "Prevalence and treatment outcome of primary and secondary fibromyalgia in patients with spinal pain". Spine. 20 (7): 796–800. doi:10.1097/00007632-199504000-00011. PMID   7701393. S2CID   30837539.
112. Bengtsson A, Henriksson KG, Larsson J (July 1986). "Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia". Arthritis and Rheumatism. 29 (7): 817–821. doi:10.1002/art.1780290701. PMID   3741498.
113. Gerdle B, Ghafouri B, Lund E, Bengtsson A, Lundberg P, Ettinger-Veenstra HV, et al. (October 2020). "Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance". Journal of Clinical Medicine. 9 (11): 3527. doi: 10.3390/jcm9113527 . PMC   7693920 . PMID   33142767.
114. Srikuea R, Symons TB, Long DE, Lee JD, Shang Y, Chomentowski PJ, et al. (February 2013). "Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women". Arthritis and Rheumatism. 65 (2): 519–528. doi:10.1002/art.37763. PMC   3558634 . PMID   23124535.
115. Shang Y, Gurley K, Symons B, Long D, Srikuea R, Crofford LJ, et al. (November 2012). "Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia". Arthritis Research & Therapy. 14 (6): R236. doi: 10.1186/ar4079 . PMC   3674608 . PMID   23116302.
116. Häuser W, Fitzcharles MA (March 2018). "Facts and myths pertaining to fibromyalgia". Dialogues in Clinical Neuroscience. 20 (1): 53–62. doi:10.31887/DCNS.2018.20.1/whauser. PMC   6016048 . PMID   29946212.
117. Wolfe F (August 2003). "Stop using the American College of Rheumatology criteria in the clinic". The Journal of Rheumatology. 30 (8): 1671–1672. PMID   12913920. Archived from the original on 14 October 2011.
118. Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU (June 2015). "Fibromyalgia diagnosis: a review of the past, present and future". Expert Review of Neurotherapeutics. 15 (6): 667–679. doi:10.1586/14737175.2015.1046841. PMID   26035624. S2CID   2412984.
119. Burckhardt CS, Clark SR, Bennett RM (May 1991). "The fibromyalgia impact questionnaire: development and validation". The Journal of Rheumatology. 18 (5): 728–733. PMID   1865419. Archived from the original on 16 May 2022. Retrieved 18 June 2022.
120. Bennett RM, Friend R, Jones KD, Ward R, Han BK, Ross RL (1 January 2009). "The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties". Arthritis Research & Therapy. 11 (4): R120. doi: 10.1186/ar2783 . PMC   2745803 . PMID   19664287.
121. "Fibromyalgia Impact Questionnaire (FIQ)". American College of Rheumatology. Archived from the original on 1 July 2022. Retrieved 18 June 2022.
122. Seidenberg M, Haltiner A, Taylor MA, Hermann BB, Wyler A (February 1994). "Development and validation of a Multiple Ability Self-Report Questionnaire". Journal of Clinical and Experimental Neuropsychology. 16 (1): 93–104. doi:10.1080/01688639408402620. PMID   8150893.
123. Goldenberg DL (December 2009). "Diagnosis and differential diagnosis of fibromyalgia". The American Journal of Medicine (Review). 122 (12 Suppl): S14–S21. doi:10.1016/j.amjmed.2009.09.007. PMID   19962492.
124. Häuser W, Perrot S, Sommer C, Shir Y, Fitzcharles MA (May 2017). "Diagnostic confounders of chronic widespread pain: not always fibromyalgia". Pain Reports. 2 (3): e598. doi:10.1097/PR9.0000000000000598. PMC   5741304 . PMID   29392213.
125. Rossi A, Di Lollo AC, Guzzo MP, Giacomelli C, Atzeni F, Bazzichi L, Di Franco M (2015). "Fibromyalgia and nutrition: what news?". Clinical and Experimental Rheumatology. 33 (1 Suppl 88): S117–S125. PMID   25786053.
126. Marchesoni A, De Marco G, Merashli M, McKenna F, Tinazzi I, Marzo-Ortega H, McGonagle DG (January 2018). "The problem in differentiation between psoriatic-related polyenthesitis and fibromyalgia". Rheumatology (Review). 57 (1): 32–40. doi:10.1093/rheumatology/kex079. PMID   28387854. S2CID   205309871.
127. Palazzi C, D'Amico E, D'Angelo S, Gilio M, Olivieri I (January 2016). "Rheumatic manifestations of hepatitis C virus chronic infection: Indications for a correct diagnosis". World Journal of Gastroenterology (Review). 22 (4): 1405–1410. doi: 10.3748/wjg.v22.i4.1405 . PMC   4721975 . PMID   26819509.
128. Sommer C, Häuser W, Alten R, Petzke F, Späth M, Tölle T, et al. (June 2012). "[Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline]" (PDF). Schmerz. 26 (3): 297–310. doi:10.1007/s00482-012-1172-2. PMID   22760463. S2CID   1348989. Archived from the original (PDF) on 16 February 2013.
129. Fitzcharles MA, Shir Y, Ablin JN, Buskila D, Amital H, Henningsen P, Häuser W (2013). "Classification and clinical diagnosis of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guidelines". Evidence-Based Complementary and Alternative Medicine. 2013: 528952. doi: 10.1155/2013/528952 . PMC   3860136 . PMID   24379886.
130. "Management | Canadian Guidelines for the Diagnosis and Management of Fibromyalgia". Archived from the original on 11 June 2013.
131. Busch AJ, Barber KA, Overend TJ, Peloso PM, Schachter CL (October 2007). "Exercise for treating fibromyalgia syndrome". The Cochrane Database of Systematic Reviews (4): CD003786. doi:10.1002/14651858.CD003786.pub2. PMID   17943797.
132. Andrade A, Dominski FH, Sieczkowska SM (December 2020). "What we already know about the effects of exercise in patients with fibromyalgia: An umbrella review". Seminars in Arthritis and Rheumatism. 50 (6): 1465–1480. doi:10.1016/j.semarthrit.2020.02.003. PMID   32147091. S2CID   212638860.
133. ^{[ unreliable medical source? ]}Masquelier E, D'haeyere J (October 2021). "Physical activity in the treatment of fibromyalgia". Joint Bone Spine. 88 (5): 105202. doi:10.1016/j.jbspin.2021.105202. PMID   33962033.
134. McLoughlin MJ, Stegner AJ, Cook DB (June 2011). "The relationship between physical activity and brain responses to pain in fibromyalgia". The Journal of Pain. 12 (6): 640–651. doi:10.1016/j.jpain.2010.12.004. PMC   3111901 . PMID   21330218.
135. Valim V, Natour J, Xiao Y, Pereira AF, Lopes BB, Pollak DF, et al. (November 2013). "Effects of physical exercise on serum levels of serotonin and its metabolite in fibromyalgia: a randomized pilot study". Revista Brasileira de Reumatologia (in Spanish). 53 (6): 538–541. doi: 10.1016/j.rbr.2013.02.001 . PMID   24477734.
136. Genc A, Tur BS, Aytur YK, Oztuna D, Erdogan MF (July 2015). "Does aerobic exercise affect the hypothalamic-pituitary-adrenal hormonal response in patients with fibromyalgia syndrome?". Journal of Physical Therapy Science. 27 (7): 2225–2231. doi:10.1589/jpts.27.2225. PMC   4540854 . PMID   26311959.
137. El-Shewy KM, Kunbaz A, Gad MM, Al-Husseini MJ, Saad AM, Sammour YM, Abdel-Daim MM (January 2019). "Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review". Biomedicine & Pharmacotherapy. 109: 629–638. doi: 10.1016/j.biopha.2018.10.157 . PMID   30399600. S2CID   53240356.
138. Andrade A, Vilarino GT, Sieczkowska SM, Coimbra DR, Steffens RA, Vietta GG (March 2018). "Acute effects of physical exercises on the inflammatory markers of patients with fibromyalgia syndrome: A systematic review". Journal of Neuroimmunology. 316: 40–49. doi:10.1016/j.jneuroim.2017.12.007. PMID   29254627. S2CID   46879701.
139. Andrade A, Vilarino GT, Serafim TT, Pereira Júnior AA, de Souza CA, Sieczkowska SM (October 2019). "Modulation of Autonomic Function by Physical Exercise in Patients with Fibromyalgia Syndrome: A Systematic Review". PM&R. 11 (10): 1121–1131. doi:10.1002/pmrj.12158. PMID   30900831. S2CID   85448644.
140. Albuquerque ML, Monteiro D, Marinho DA, Vilarino GT, Andrade A, Neiva HP (November 2022). "Effects of different protocols of physical exercise on fibromyalgia syndrome treatment: systematic review and meta-analysis of randomized controlled trials". Rheumatology International. 42 (11): 1893–1908. doi:10.1007/s00296-022-05140-1. hdl: 10400.8/7188 . PMID   35604435. S2CID   248970279.
141. Estévez-López F, Maestre-Cascales C, Russell D, Álvarez-Gallardo IC, Rodriguez-Ayllon M, Hughes CM, et al. (April 2021). "Effectiveness of Exercise on Fatigue and Sleep Quality in Fibromyalgia: A Systematic Review and Meta-analysis of Randomized Trials". Archives of Physical Medicine and Rehabilitation. 102 (4): 752–761. doi: 10.1016/j.apmr.2020.06.019 . hdl: 10481/68683 . PMID   32721388. S2CID   220847961.
142. Cuenca-Martínez F, Suso-Martí L, Fernández-Carnero J, Muñoz-Alarcos V, Sempere-Rubio N (2023). "Exercise-based interventions on sleep quality in patients with fibromyalgia syndrome: An umbrella and mapping review with meta-analysis". Seminars in Arthritis and Rheumatism. 61: 152216. doi: 10.1016/j.semarthrit.2023.152216 . PMID   37229847. S2CID   258597720.
143. McVeigh JG, Lucas A, Hurley DA, Basford JR, Baxter GD (September 2003). "Patients' perceptions of exercise therapy in the treatment of fibromyalgia syndrome: a survey". Musculoskeletal Care. 1 (2): 98–107. doi:10.1002/msc.45. PMID   20217670.
144. Russell D, Álvarez Gallardo IC, Wilson I, Hughes CM, Davison GW, Sañudo B, McVeigh JG (March 2018). "'Exercise to me is a scary word': perceptions of fatigue, sleep dysfunction, and exercise in people with fibromyalgia syndrome-a focus group study". Rheumatology International. 38 (3): 507–515. doi:10.1007/s00296-018-3932-5. PMID   29340774. S2CID   3395036.
145. Sanz-Baños Y, Pastor-Mira MÁ, Lledó A, López-Roig S, Peñacoba C, Sánchez-Meca J (October 2018). "Do women with fibromyalgia adhere to walking for exercise programs to improve their health? Systematic review and meta-analysis". Disability and Rehabilitation. 40 (21): 2475–2487. doi:10.1080/09638288.2017.1347722. PMID   28687050. S2CID   9032840.
146. Barhorst EE, Andrae WE, Rayne TJ, Falvo MJ, Cook DB, Lindheimer JB (December 2020). "Elevated Perceived Exertion in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Meta-analysis". Medicine and Science in Sports and Exercise. 52 (12): 2615–2627. doi:10.1249/MSS.0000000000002421. PMC   10200687 . PMID   32555018. S2CID   219918068.
147. Vancampfort D, McGrath RL, Hemmings L, Gillis V, Bernar K, Van Damme T (November 2022). "Physical activity correlates in people with fibromyalgia: a systematic review". Disability and Rehabilitation. 45 (25): 4165–4174. doi:10.1080/09638288.2022.2146911. PMID   36398698. S2CID   253627372.
148. Ryan S (2013). "Care of patients with fibromyalgia: assessment and management". Nursing Standard. 28 (13): 37–43. doi:10.7748/ns2013.11.28.13.37.e7722. PMID   24279570.
149. Majdoub F, Ben Nessib D, Ferjani HL, Kaffel D, Triki W, Maatallah K, Hamdi W (February 2023). "Non-pharmacological therapies in Fibromyalgia: New horizons for physicians, new hopes for patients". Musculoskeletal Care. 21 (3): 603–610. doi:10.1002/msc.1741. PMID   36757930. S2CID   256696861.
150. Bidonde J, Busch AJ, Schachter CL, Overend TJ, Kim SY, Góes SM, et al. (June 2017). "Aerobic exercise training for adults with fibromyalgia". The Cochrane Database of Systematic Reviews. 2017 (6): CD012700. doi:10.1002/14651858.cd012700. PMC   6481524 . PMID   28636204.
151. Bidonde J, Busch AJ, Schachter CL, Webber SC, Musselman KE, Overend TJ, et al. (May 2019). "Mixed exercise training for adults with fibromyalgia". The Cochrane Database of Systematic Reviews. 2019 (5): CD013340. doi:10.1002/14651858.cd013340. PMC   6931522 . PMID   31124142.
152. Kim SY, Busch AJ, Overend TJ, Schachter CL, van der Spuy I, Boden C, et al. (September 2019). "Flexibility exercise training for adults with fibromyalgia". The Cochrane Database of Systematic Reviews. 2019 (9): CD013419. doi:10.1002/14651858.CD013419. PMC   6718217 . PMID   31476271.
153. Vilarino GT, Andreato LV, de Souza LC, Branco JH, Andrade A (November 2021). "Effects of resistance training on the mental health of patients with fibromyalgia: a systematic review". Clinical Rheumatology. 40 (11): 4417–4425. doi:10.1007/s10067-021-05738-z. PMID   33987785. S2CID   234489153.
154. Rodríguez-Domínguez ÁJ, Rebollo-Salas M, Chillón-Martínez R, Rosales-Tristancho A, Jiménez-Rejano JJ (17 July 2023). "Clinical relevance of resistance training in women with fibromyalgia: A systematic review and meta-analysis". European Journal of Pain. 28 (1): 21–36. doi: 10.1002/ejp.2161 . ISSN   1090-3801. PMID   37458315. S2CID   259949000.
155. Bastos AC, Vilarino GT, de Souza LC, Dominski FH, Branco JH, Andrade A (15 May 2023). "Effects of resistance training on sleep of patients with fibromyalgia: A systematic review". Journal of Health Psychology. 28 (11): 1072–1084. doi:10.1177/13591053231172288. ISSN   1359-1053. PMID   37183814. S2CID   258687258. Archived from the original on 28 July 2023. Retrieved 28 July 2023.
156. da Silva JM, de Barros BS, Almeida GJ, O'Neil J, Imoto AM (March 2022). "Dosage of resistance exercises in fibromyalgia: evidence synthesis for a systematic literature review up-date and meta-analysis". Rheumatology International. 42 (3): 413–429. doi:10.1007/s00296-021-05025-9. PMID   34652480. S2CID   238991065.
157. Li H, Chen J, Xu G, Duan Y, Huang D, Tang C, Liu J (September 2020). "The Effect of Tai Chi for Improving Sleep Quality: A Systematic Review and Meta-analysis". Journal of Affective Disorders. 274: 1102–1112. doi:10.1016/j.jad.2020.05.076. PMID   32663938. S2CID   219743962.
158. Vasileios P, Styliani P, Nifon G, Pavlos S, Aris F, Ioannis P (November 2022). "Managing fibromyalgia with complementary and alternative medical exercise: a systematic review and meta-analysis of clinical trials". Rheumatology International. 42 (11): 1909–1923. doi:10.1007/s00296-022-05151-y. PMID   35796820. S2CID   250317143.
159. Cheng CA, Chiu YW, Wu D, Kuan YC, Chen SN, Tam KW (October 2019). "Effectiveness of Tai Chi on fibromyalgia patients: A meta-analysis of randomized controlled trials". Complementary Therapies in Medicine. 46: 1–8. doi:10.1016/j.ctim.2019.07.007. PMID   31519264. S2CID   199039433.
160. Bidonde J, Busch AJ, Webber SC, Schachter CL, Danyliw A, Overend TJ, et al. (October 2014). "Aquatic exercise training for fibromyalgia". The Cochrane Database of Systematic Reviews. 2014 (10): CD011336. doi:10.1002/14651858.cd011336. PMC   10638613 . PMID   25350761.
161. Lima TB, Dias JM, Mazuquin BF, da Silva CT, Nogueira RM, Marques AP, et al. (October 2013). "The effectiveness of aquatic physical therapy in the treatment of fibromyalgia: a systematic review with meta-analysis". Clinical Rehabilitation. 27 (10): 892–908. doi:10.1177/0269215513484772. PMID   23818412. S2CID   25701866.
162. Perraton L, Machotka Z, Kumar S (November 2009). "Components of effective randomized controlled trials of hydrotherapy programs for fibromyalgia syndrome: A systematic review". Journal of Pain Research. 2: 165–173. doi: 10.2147/JPR.S8052 . PMC   3004626 . PMID   21197303.
163. Galvão-Moreira LV, de Castro LO, Moura EC, de Oliveira CM, Nogueira Neto J, Gomes LM, Leal PD (July 2021). "Pool-based exercise for amelioration of pain in adults with fibromyalgia syndrome: A systematic review and meta-analysis". Modern Rheumatology. 31 (4): 904–911. doi:10.1080/14397595.2020.1829339. PMID   32990113. S2CID   222167851.
164. Calles Plata I, Ortiz-Rubio A, Torres Sánchez I, Cabrera Martos I, Calvache Mateo A, Heredia-Ciuró A, Valenza MC (February 2023). "Effectiveness of aquatic therapy on sleep in persons with fibromyalgia. A meta-analysis". Sleep Medicine. 102: 76–83. doi:10.1016/j.sleep.2022.12.016. PMID   36603514. S2CID   255217819.
165. Ma J, Zhang T, Li X, Chen X, Zhao Q (September 2022). "Effects of aquatic physical therapy on clinical symptoms, physical function, and quality of life in patients with fibromyalgia: A systematic review and meta-analysis". Physiotherapy Theory and Practice. 40 (2): 205–223. doi:10.1080/09593985.2022.2119906. PMID   36062580. S2CID   252079586.
166. Correyero-León M, Medrano-de-la-Fuente R, Hernando-Garijo I, Jiménez-Del-Barrio S, Hernández-Lázaro H, Ceballos-Laita L, Mingo-Gómez MT (July 2023). "Effectiveness of aquatic training based on aerobic and strengthening exercises in patients with fibromyalgia: systematic review with meta-analysis". Explore. 20 (1): 27–38. doi:10.1016/j.explore.2023.07.003. PMID   37460329. S2CID   259580881.
167. Bidonde J, Busch AJ, van der Spuy I, Tupper S, Kim SY, Boden C (September 2017). "Whole body vibration exercise training for fibromyalgia". The Cochrane Database of Systematic Reviews. 2017 (9): CD011755. doi:10.1002/14651858.cd011755.pub2. PMC   6483692 . PMID   28950401.
168. "FDA Approves First Drug for Treating Fibromyalgia" (Press release). U.S. Food and Drug Administration. 21 June 2007. Archived from the original on 21 February 2008. Retrieved 14 January 2008.
169. European Medicines Agency. "Questions and answers on the recommendati on for the refusal of the marketing authorisation for Milnacipran Pierre Fabre Médicament/Impulsor" (PDF). European Medicines Agency. Archived (PDF) from the original on 22 February 2014. Retrieved 30 May 2013.
170. Martinez JE, Guimarães I (February 2024). ""Fibromyalgia - are there any new approaches?"". Best Pract Res Clin Rheumatol: 101933. doi:10.1016/j.berh.2024.101933. PMID   38355316.
171. Häuser W, Wolfe F, Tölle T, Uçeyler N, Sommer C (April 2012). "The role of antidepressants in the management of fibromyalgia syndrome: a systematic review and meta-analysis". CNS Drugs. 26 (4): 297–307. doi:10.2165/11598970-000000000-00000. PMID   22452526. S2CID   207301478.
172. Cording M, Derry S, Phillips T, Moore RA, Wiffen PJ (October 2015). "Milnacipran for pain in fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 2015 (10): CD008244. doi:10.1002/14651858.CD008244.pub3. PMC   6481368 . PMID   26482422.
173. Welsch P, Üçeyler N, Klose P, Walitt B, Häuser W (February 2018). "Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia". The Cochrane Database of Systematic Reviews. 2 (2): CD010292. doi:10.1002/14651858.CD010292.pub2. PMC   5846183 . PMID   29489029.
174. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ (May 2019). "Amitriptyline for fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 5 (7): CD011824. doi:10.1002/14651858.CD011824. PMC   6485478 . PMID   35658166.
175. Migliorini F, Maffulli N, Eschweiler J, Baroncini A, Bell A, Colarossi G (17 July 2023). "Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis". Journal of Orthopaedic Surgery and Research. 18 (1): 504. doi: 10.1186/s13018-023-03995-z . ISSN   1749-799X. PMC   10351165 . PMID   37461044.
176. Walitt B, Urrútia G, Nishishinya MB, Cantrell SE, Häuser W (June 2015). "Selective serotonin reuptake inhibitors for fibromyalgia syndrome". The Cochrane Database of Systematic Reviews. 2015 (6): CD011735. doi:10.1002/14651858.cd011735. PMC   4755337 . PMID   26046493.
177. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ (July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane Database of Systematic Reviews. 2015 (7): CD008242. doi:10.1002/14651858.CD011824. PMC   6485478 . PMID   26146793.
178. Welsch P, Bernardy K, Derry S, Moore RA, Häuser W (August 2018). "Mirtazapine for fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 8 (8): CD012708. doi:10.1002/14651858.CD012708.pub2. PMC   6513659 . PMID   30080242.
179. Tort S, Urrútia G, Nishishinya MB, Walitt B (April 2012). "Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome". The Cochrane Database of Systematic Reviews (4): CD009807. doi:10.1002/14651858.cd009807. PMID   22513976.
180. Wiffen PJ, Derry S, Bell RF, Rice AS, Tölle TR, Phillips T, Moore RA (June 2017). "Gabapentin for chronic neuropathic pain in adults". The Cochrane Database of Systematic Reviews. 6 (6): CD007938. doi:10.1002/14651858.CD007938.pub4. PMC   6452908 . PMID   28597471.
181. Derry S, Cording M, Wiffen PJ, Law S, Phillips T, Moore RA (September 2016). "Pregabalin for pain in fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 9 (9): CD011790. doi:10.1002/14651858.CD011790.pub2. PMC   6457745 . PMID   27684492.
182. Straube S, Moore RA, Paine J, Derry S, Phillips CJ, Hallier E, McQuay HJ (June 2011). "Interference with work in fibromyalgia: effect of treatment with pregabalin and relation to pain response". BMC Musculoskeletal Disorders. 12: 125. doi: 10.1186/1471-2474-12-125 . PMC   3118156 . PMID   21639874.
183. Nowell WB, Gavigan K, L Silverman S (May 2022). "Cannabis for Rheumatic Disease Pain: a Review of Current Literature". Current Rheumatology Reports. 24 (5): 119–131. doi:10.1007/s11926-022-01065-7. PMID   35486218. S2CID   248423563.
184. Boehnke KF, Häuser W, Fitzcharles MA (July 2022). "Cannabidiol (CBD) in Rheumatic Diseases (Musculoskeletal Pain)". Current Rheumatology Reports. 24 (7): 238–246. doi:10.1007/s11926-022-01077-3. PMC   9062628 . PMID   35503198.
185. Bourke SL, Schlag AK, O'Sullivan SE, Nutt DJ, Finn DP (December 2022). "Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research". Pharmacology & Therapeutics. 240: 108216. doi: 10.1016/j.pharmthera.2022.108216 . PMID   35609718. S2CID   248973512.
186. Jain N, Moorthy A (June 2022). "Cannabinoids in rheumatology: Friend, foe or a bystander?". Musculoskeletal Care. 20 (2): 416–428. doi:10.1002/msc.1636. PMC   9322323 . PMID   35476898.
187. MacLean AJ, Schwartz TL (May 2015). "Tramadol for the treatment of fibromyalgia". Expert Review of Neurotherapeutics. 15 (5): 469–475. doi:10.1586/14737175.2015.1034693. PMID   25896486. S2CID   26613022.
188. Gaskell H, Moore RA, Derry S, Stannard C, et al. (Cochrane Pain, Palliative and Supportive Care Group) (September 2016). "Oxycodone for pain in fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 2016 (9): CD012329. doi:10.1002/14651858.CD012329. PMC   6457853 . PMID   27582266.
189. Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I (February 2018). "Combination pharmacotherapy for the treatment of fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 2 (2): CD010585. doi:10.1002/14651858.CD010585.pub2. PMC   6491103 . PMID   29457627.
190. Goldenberg DL, Clauw DJ, Palmer RE, Clair AG (May 2016). "Opioid Use in Fibromyalgia: A Cautionary Tale". Mayo Clinic Proceedings (Review). 91 (5): 640–648. doi: 10.1016/j.mayocp.2016.02.002 . PMID   26975749. S2CID   20228209.
191. Berger A. Patterns of use of opioids in patients with fibromyalgia In: EULAR; 2009:SAT0461
192. Elijah J, Powell K, Smith MA (June 2022). "The Efficacy of Capsaicin on Sleep Quality and Fatigue in Fibromyalgia". Journal of Pain & Palliative Care Pharmacotherapy. 36 (2): 112–116. doi:10.1080/15360288.2022.2063468. PMID   35471125. S2CID   248389141.
193. Staud R (August 2011). "Sodium oxybate for the treatment of fibromyalgia". Expert Opinion on Pharmacotherapy. 12 (11): 1789–1798. doi:10.1517/14656566.2011.589836. PMID   21679091. S2CID   33026097.
194. See S, Ginzburg R (August 2008). "Choosing a skeletal muscle relaxant". American Family Physician. 78 (3): 365–370. PMID   18711953. Archived from the original on 1 April 2016.
195. Kaltsas G, Tsiveriotis K (2000). "Fibromyalgia". Endotext. MDText.com, Inc. PMID   25905317. Archived from the original on 6 August 2020. Retrieved 20 February 2017.
196. Heymann RE, Paiva ED, Helfenstein M, Pollak DF, Martinez JE, Provenza JR, et al. (2010). "Brazilian consensus on the treatment of fibromyalgia". Revista Brasileira de Reumatologia. 50 (1): 56–66. doi: 10.1590/S0482-50042010000100006 . PMID   21125141.
197. Derry S, Wiffen PJ, Häuser W, Mücke M, Tölle TR, Bell RF, Moore RA (March 2017). "Oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 3 (3): CD012332. doi:10.1002/14651858.CD012332.pub2. PMC   6464559 . PMID   28349517.
198. Walitt B, Klose P, Üçeyler N, Phillips T, Häuser W (June 2016). "Antipsychotics for fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 2016 (6): CD011804. doi:10.1002/14651858.cd011804.pub2. PMC   6457603 . PMID   27251337.
199. Walitt B, Klose P, Fitzcharles MA, Phillips T, Häuser W (July 2016). "Cannabinoids for fibromyalgia". The Cochrane Database of Systematic Reviews. 7 (7): CD011694. doi:10.1002/14651858.cd011694.pub2. PMC   6457965 . PMID   27428009.
200. Kadayifci FZ, Bradley MJ, Onat AM, Shi HN, Zheng S (November 2022). "Review of nutritional approaches to fibromyalgia". Nutrition Reviews. 80 (12): 2260–2274. doi:10.1093/nutrit/nuac036. PMID   35674686.
201. Nadal-Nicolás Y, Miralles-Amorós L, Martínez-Olcina M, Sánchez-Ortega M, Mora J, Martínez-Rodríguez A (May 2021). "Vegetarian and Vegan Diet in Fibromyalgia: A Systematic Review". International Journal of Environmental Research and Public Health. 18 (9): 4955. doi: 10.3390/ijerph18094955 . PMC   8125538 . PMID   34066603.
202. Haddad HW, Mallepalli NR, Scheinuk JE, Bhargava P, Cornett EM, Urits I, Kaye AD (December 2021). "The Role of Nutrient Supplementation in the Management of Chronic Pain in Fibromyalgia: A Narrative Review". Pain and Therapy. 10 (2): 827–848. doi:10.1007/s40122-021-00266-9. PMC   8586285 . PMID   33909266.
203. Qu K, Li MX, Zhou YL, Yu P, Dong M (April 2022). "The efficacy of vitamin D in treatment of fibromyalgia: a meta-analysis of randomized controlled studies and systematic review". Expert Review of Clinical Pharmacology. 15 (4): 433–442. doi:10.1080/17512433.2022.2081151. PMID   35596576. S2CID   248948241.
204. Mehrabani S, Askari G, Miraghajani M, Tavakoly R, Arab A (April 2019). "Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies". Complementary Therapies in Medicine. 43: 181–187. doi:10.1016/j.ctim.2019.01.022. PMID   30935528. S2CID   86467031.
205. Hargreaves IP, Mantle D (2021). "Targeted Treatment of Age-Related Fibromyalgia with Supplemental Coenzyme Q10" (PDF). In Guest PC (ed.). Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology. Vol. 1286. Cham: Springer International Publishing. pp. 77–85. doi:10.1007/978-3-030-55035-6_5. ISBN   978-3-030-55034-9. PMID   33725346. S2CID   232261388. Archived (PDF) from the original on 30 May 2023. Retrieved 17 May 2023.
206. Erkilic B, Dalgic GS (January 2023). "The preventive role of vitamin D in the prevention and management of Fibromyalgia syndrome". Nutrition and Health. 29 (2): 223–229. doi:10.1177/02601060221144801. PMID   36591895. S2CID   255471623.
207. Hemati K, Amini Kadijani A, Sayehmiri F, Mehrzadi S, Zabihiyeganeh M, Hosseinzadeh A, Mirzaei A (February 2020). "Melatonin in the treatment of fibromyalgia symptoms: A systematic review". Complementary Therapies in Clinical Practice. 38: 101072. doi:10.1016/j.ctcp.2019.101072. PMID   31783341. S2CID   208497324.
208. de Carvalho JF, Skare TL (2023). "Melatonin supplementation improves rheumatological disease activity: A systematic review". Clinical Nutrition ESPEN. 55: 414–419. doi:10.1016/j.clnesp.2023.04.011. PMID   37202076. S2CID   258273314. Archived from the original on 5 January 2024. Retrieved 28 July 2023.
209. Arnold LM, Gebke KB, Choy EH (February 2016). "Fibromyalgia: management strategies for primary care providers". International Journal of Clinical Practice. 70 (2): 99–112. doi:10.1111/ijcp.12757. PMC   6093261 . PMID   26817567.
210. Okifuji A, Hare BD (December 2013). "Management of fibromyalgia syndrome: review of evidence". Pain and Therapy. 2 (2): 87–104. doi:10.1007/s40122-013-0016-9. PMC   4107911 . PMID   25135147.
211. Williams AC, Fisher E, Hearn L, Eccleston C (August 2020). "Psychological therapies for the management of chronic pain (excluding headache) in adults". The Cochrane Database of Systematic Reviews. 8 (8): CD007407. doi:10.1002/14651858.CD007407.pub4. PMC   7437545 . PMID   32794606.
212. Bernardy K, Klose P, Busch AJ, Choy EH, Häuser W (September 2013). "Cognitive behavioural therapies for fibromyalgia". The Cochrane Database of Systematic Reviews. 2013 (9): CD009796. doi:10.1002/14651858.CD009796.pub2. PMC   6481397 . PMID   24018611.
213. Glombiewski JA, Sawyer AT, Gutermann J, Koenig K, Rief W, Hofmann SG (November 2010). "Psychological treatments for fibromyalgia: a meta-analysis". Pain. 151 (2): 280–295. doi:10.1016/j.pain.2010.06.011. PMID   20727679. S2CID   10513179.
214. Bernardy K, Füber N, Köllner V, Häuser W (October 2010). "Efficacy of cognitive-behavioral therapies in fibromyalgia syndrome - a systematic review and metaanalysis of randomized controlled trials". The Journal of Rheumatology. 37 (10): 1991–2005. doi: 10.3899/jrheum.100104 . PMID   20682676. S2CID   11357808.
215. Whale K, Dennis J, Wylde V, Beswick A, Gooberman-Hill R (May 2022). "The effectiveness of non-pharmacological sleep interventions for people with chronic pain: a systematic review and meta-analysis". BMC Musculoskeletal Disorders. 23 (1): 440. doi: 10.1186/s12891-022-05318-5 . PMC   9092772 . PMID   35546397.
216. Eastwood F, Godfrey E (12 December 2023). "The efficacy, acceptability and safety of acceptance and commitment therapy for fibromyalgia – a systematic review and meta-analysis". British Journal of Pain. 18 (3): 243–256. doi: 10.1177/20494637231221451 . ISSN   2049-4637. PMC   11092929 . PMID   38751564.
217. Suso-Martí L, Cuenca-Martínez F, Alba-Quesada P, Muñoz-Alarcos V, Herranz-Gómez A, Varangot-Reille C, et al. (October 2022). "Effectiveness of Pain Neuroscience Education in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis". Pain Medicine. 23 (11): 1837–1850. doi:10.1093/pm/pnac077. PMID   35587171.
218. Duhn P, Wæhrens E, Pedersen M, Nielsen S, Locht H, Bliddal H, Christensen R, Amris K (10 May 2023). "Effectiveness of patient education as a stand-alone intervention for patients with chronic widespread pain and fibromyalgia: a systematic review and meta-analysis of randomized trials". Scandinavian Journal of Rheumatology. 52 (6): 654–663. doi:10.1080/03009742.2023.2192450. ISSN   0300-9742. PMID   37162478. S2CID   258588927. Archived from the original on 28 July 2023. Retrieved 28 July 2023.
219. Navarro-Ledesma S, Hamed-Hamed D, Gonzalez-Muñoz A, Pruimboom L (2024). "Impact of physical therapy techniques and common interventions on sleep quality in patients with chronic pain: A systematic review". Sleep Medicine Reviews. 76: 101937. doi: 10.1016/j.smrv.2024.101937 . hdl: 10481/92720 . PMID   38669729.
220. Theadom A, Cropley M, Smith HE, Feigin VL, McPherson K (April 2015). "Mind and body therapy for fibromyalgia". The Cochrane Database of Systematic Reviews. 2015 (4): CD001980. doi:10.1002/14651858.CD001980.pub3. PMC   8409283 . PMID   25856658.
221. Deare JC, Zheng Z, Xue CC, Liu JP, Shang J, Scott SW, Littlejohn G (May 2013). "Acupuncture for treating fibromyalgia". The Cochrane Database of Systematic Reviews. 2013 (5): CD007070. doi:10.1002/14651858.CD007070.pub2. PMC   4105202 . PMID   23728665.
222. Cheng YC, Hsiao CY, Su MI, Chiu CC, Huang YC, Huang WL (February 2023). "Treating fibromyalgia with electrical neuromodulation: A systematic review and meta-analysis". Clinical Neurophysiology. 148: 17–28. doi:10.1016/j.clinph.2023.01.011. PMID   36774784. S2CID   256461558.
223. Gikaro JM, Bigambo FM, Minde VM, Swai EA (20 April 2023). "Efficacy of electrophysical agents in fibromyalgia: A systematic review and network meta-analysis". Clinical Rehabilitation. 37 (10): 1295–1310. doi:10.1177/02692155231170450. ISSN   0269-2155. PMID   37082791. S2CID   258258250. Archived from the original on 28 July 2023. Retrieved 28 July 2023.
224. Johnson MI, Claydon LS, Herbison GP, Jones G, Paley CA, et al. (Cochrane Pain, Palliative and Supportive Care Group) (October 2017). "Transcutaneous electrical nerve stimulation (TENS) for fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 2017 (10): CD012172. doi:10.1002/14651858.CD012172.pub2. PMC   6485914 . PMID   28990665.
225. Gibson W, Wand BM, Meads C, Catley MJ, O'Connell NE (April 2019). "Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane Reviews". The Cochrane Database of Systematic Reviews. 4 (4): CD011890. doi:10.1002/14651858.CD011890.pub3. PMC   6446021 . PMID   30941745.
226. Lange G, Janal MN, Maniker A, Fitzgibbons J, Fobler M, Cook D, Natelson BH (September 2011). "Safety and efficacy of vagus nerve stimulation in fibromyalgia: a phase I/II proof of concept trial". Pain Medicine. 12 (9): 1406–1413. doi:10.1111/j.1526-4637.2011.01203.x. PMC   3173600 . PMID   21812908.
227. Gao C, Zhu Q, Gao Z, Zhao J, Jia M, Li T (October 2022). "Can noninvasive Brain Stimulation Improve Pain and Depressive Symptoms in Patients With Neuropathic Pain? A Systematic Review and Meta-Analysis". Journal of Pain and Symptom Management. 64 (4): e203–e215. doi:10.1016/j.jpainsymman.2022.05.002. PMID   35550165. S2CID   248715312.
228. Teixeira PE, Pacheco-Barrios K, Branco LC, de Melo PS, Marduy A, Caumo W, et al. (November 2022). "The Analgesic Effect of Transcranial Direct Current Stimulation in Fibromyalgia: A Systematic Review, Meta-Analysis, and Meta-Regression of Potential Influencers of Clinical Effect". Neuromodulation. 26 (4): 715–727. doi:10.1016/j.neurom.2022.10.044. PMC   10203058 . PMID   36435660. S2CID   253933442.
229. Fernandes AM, Graven-Nielsen T, de Andrade DC (June 2022). "New updates on transcranial magnetic stimulation in chronic pain". Current Opinion in Supportive and Palliative Care. 16 (2): 65–70. doi:10.1097/SPC.0000000000000591. PMID   35639571. S2CID   249208885.
230. Choo YJ, Kwak SG, Chang MC (July 2022). "Effectiveness of Repetitive Transcranial Magnetic Stimulation on Managing Fibromyalgia: A Systematic Meta-Analysis". Pain Medicine. 23 (7): 1272–1282. doi:10.1093/pm/pnab354. PMID   34983056.
231. Sun P, Fang L, Zhang J, Liu Y, Wang G, Qi R (March 2022). "Repetitive Transcranial Magnetic Stimulation for Patients with Fibromyalgia: A Systematic Review with Meta-Analysis". Pain Medicine. 23 (3): 499–514. doi:10.1093/pm/pnab276. PMID   34542624.
232. Torres CB, Barona E, Manso J (2023). "A systematic review of EEG neurofeedback in fibromyalgia to treat psychological variables, chronic pain and general health". European Archives of Psychiatry and Clinical Neuroscience . 274 (4): 981–999. doi: 10.1007/s00406-023-01612-y . PMC   11127810 . PMID   37179502.
233. Chen X, You J, Ma H, Zhou M, Huang C (January 2023). "Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-analysis". BMJ Open. 13 (1): e062322. doi:10.1136/bmjopen-2022-062322. PMC   9872467 . PMID   36690401.
234. ^{[ unreliable medical source? ]}Walitt B, Fitzcharles MA, Hassett AL, Katz RS, Häuser W, Wolfe F (October 2011). "The longitudinal outcome of fibromyalgia: a study of 1555 patients". The Journal of Rheumatology. 38 (10): 2238–2246. doi: 10.3899/jrheum.110026 . PMID   21765102. S2CID   207672626.
235. ^{[ unreliable medical source? ]}Kashikar-Zuck S, Cunningham N, Peugh J, Black WR, Nelson S, Lynch-Jordan AM, et al. (February 2019). "Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time". Pain. 160 (2): 433–441. doi:10.1097/j.pain.0000000000001415. PMC   6344278 . PMID   30335681.
236. Leino-Arjas P, Rajaleid K, Mekuria G, Nummi T, Virtanen P, Hammarström A (January 2018). "Trajectories of musculoskeletal pain from adolescence to middle age: the role of early depressive symptoms, a 27-year follow-up of the Northern Swedish Cohort". Pain. 159 (1): 67–74. doi:10.1097/j.pain.0000000000001065. PMID   28937577. S2CID   22164186.
237. Meuser T, Pietruck C, Radbruch L, Stute P, Lehmann KA, Grond S (September 2001). "Symptoms during cancer pain treatment following WHO-guidelines: a longitudinal follow-up study of symptom prevalence, severity and etiology". Pain. 93 (3): 247–257. doi:10.1016/s0304-3959(01)00324-4. PMID   11514084. S2CID   25457728.
238. Treister-Goltzman Y, Peleg R (2023). "Fibromyalgia and mortality: a systematic review and meta-analysis". RMD Open. 9 (3): e003005. doi:10.1136/rmdopen-2023-003005. PMC   10335452 . PMID   37429737. S2CID   259502501.
239. Heidari F, Afshari M, Moosazadeh M (September 2017). "Prevalence of fibromyalgia in general population and patients, a systematic review and meta-analysis". Rheumatology International. 37 (9): 1527–1539. doi:10.1007/s00296-017-3725-2. ISSN   0172-8172. PMID   28447207. S2CID   5043754.
240. Wolfe F, Walitt B, Perrot S, Rasker JJ, Häuser W (13 September 2018). Sommer C (ed.). "Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias". PLOS ONE. 13 (9): e0203755. Bibcode:2018PLoSO..1303755W. doi: 10.1371/journal.pone.0203755 . ISSN   1932-6203. PMC   6136749 . PMID   30212526.
241. D'Onghia M, Ciaffi J, Ruscitti P, Cipriani P, Giacomelli R, Ablin JN, Ursini F (October 2022). "The economic burden of fibromyalgia: A systematic literature review". Seminars in Arthritis and Rheumatism. 56: 152060. doi:10.1016/j.semarthrit.2022.152060. PMID   35849890. S2CID   250271053.
242. Berenson A (14 January 2008). "Drug Approved. Is Disease Real?". The New York Times. Archived from the original on 10 May 2015. Retrieved 26 March 2014.
243. "Fibromyalgia: An interview with Dr Frederick Wolfe, University of Kansas School of Medicine". 22 March 2013. Archived from the original on 29 May 2014. Retrieved 28 May 2014.
244. Goldenberg DL (January 1995). "Fibromyalgia: why such controversy?". Annals of the Rheumatic Diseases. 54 (1): 3–5. doi:10.1136/ard.54.1.3. PMC   1005499 . PMID   7880118.
245. Hadlandsmyth K, Dailey DL, Rakel BA, Zimmerman MB, Vance CG, Merriwether EN, et al. (May 2020). "Somatic symptom presentations in women with fibromyalgia are differentially associated with elevated depression and anxiety". Journal of Health Psychology. 25 (6): 819–829. doi:10.1177/1359105317736577. PMC   6287969 . PMID   29076404.
246. Yunus MB (June 2007). "Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes". Seminars in Arthritis and Rheumatism. 36 (6): 339–356. doi:10.1016/j.semarthrit.2006.12.009. PMID   17350675.

External links

• Arthritis – Types – Fibromyalgia by the CDC
• Fibromyalgia by the National Institute of Arthritis and Musculoskeletal and Skin Diseases
• Fibromyalgia by the American College of Rheumatology
• Fibromyalgia by the NHS