List of investigational fibromyalgia drugs

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This is a list of investigational fibromyalgia drugs, or drugs that are currently under development for clinical use in the treatment of fibromyalgia but are not yet approved.

Contents

Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action [Reference]".

This list was last comprehensively updated in September 2025. It is likely to become outdated with time.

Under development

Preregistration

Phase 3

Phase 2

Research

Not under development

Suspended

No development reported

Discontinued

Clinically used drugs

Approved

Off-label drugs

See also

References

  1. ↑ Aday JS, McAfee J, Conroy DA, Hosanagar A, Tarnal V, Weston C, Scott K, Horowitz D, Geller J, Harte SE, Pouyan N, Glynos NG, Baker AK, Guss J, Davis AK, Burgess HJ, Mashour GA, Clauw DJ, Boehnke KF (2025). "Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial". Front Pain Res (Lausanne). 6 1527783. doi: 10.3389/fpain.2025.1527783 . PMC   11958999 . PMID   40171515.
  2. ↑ Czopek A, Jończyk J, Fryc M, Kluzik D, Zagórska A (June 2025). "Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives". ACS Chem Neurosci. 16 (12): 2163–2177. doi:10.1021/acschemneuro.5c00152. PMC   12183689 . PMID   40474592.
  3. 1 2 Staud R (August 2011). "Sodium oxybate for the treatment of fibromyalgia". Expert Opin Pharmacother. 12 (11): 1789–1798. doi:10.1517/14656566.2011.589836. PMID   21679091.
  4. 1 2 Swick TJ (August 2011). "Sodium oxybate: a potential new pharmacological option for the treatment of fibromyalgia syndrome". Ther Adv Musculoskelet Dis. 3 (4): 167–178. doi:10.1177/1759720X11411599. PMC   3382678 . PMID   22870476.
  5. 1 2 3 4 5 Ram PR, Jeyaraman M, Jeyaraman N, Nallakumarasamy A, Khanna M, Gupta A, Yadav S (October 2023). "Beyond the Pain: A Systematic Narrative Review of the Latest Advancements in Fibromyalgia Treatment". Cureus. 15 (10): e48032. doi: 10.7759/cureus.48032 . PMC   10687844 . PMID   38034135.{{cite journal}}: CS1 maint: article number as page number (link)
  6. ↑ Bourke SL, Schlag AK, O'Sullivan SE, Nutt DJ, Finn DP (December 2022). "Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research". Pharmacol Ther. 240 108216. doi:10.1016/j.pharmthera.2022.108216. PMID   35609718.
  7. ↑ Elijah J, Powell K, Smith MA (June 2022). "The Efficacy of Capsaicin on Sleep Quality and Fatigue in Fibromyalgia". J Pain Palliat Care Pharmacother. 36 (2): 112–116. doi:10.1080/15360288.2022.2063468. PMID   35471125.
  8. 1 2 3 4 Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT (February 2017). "EULAR revised recommendations for the management of fibromyalgia". Ann Rheum Dis. 76 (2): 318–328. doi:10.1136/annrheumdis-2016-209724. PMID   27377815.
  9. ↑ Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I (February 2018). "Combination pharmacotherapy for the treatment of fibromyalgia in adults". Cochrane Database Syst Rev. 2 (2): CD010585. doi:10.1002/14651858.CD010585.pub2. PMC   6491103 . PMID   29457627.{{cite journal}}: CS1 maint: article number as page number (link)
  10. ↑ Vaerøy H, Abrahamsen A, Førre O, Kåss E (June 1989). "Treatment of fibromyalgia (fibrositis syndrome): a parallel double blind trial with carisoprodol, paracetamol and caffeine (Somadril comp) versus placebo". Clin Rheumatol. 8 (2): 245–250. doi:10.1007/BF02030081. PMID   2667860.
  11. 1 2 3 4 5 Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F (November 2020). "Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment". Nat Rev Rheumatol. 16 (11): 645–660. doi:10.1038/s41584-020-00506-w. PMID   33024295.
  12. ↑ Cooper TE, Derry S, Wiffen PJ, Moore RA (January 2017). "Gabapentin for fibromyalgia pain in adults". Cochrane Database Syst Rev. 1 (1): CD012188. doi:10.1002/14651858.CD012188.pub2. PMC   6465053 . PMID   28045473.{{cite journal}}: CS1 maint: article number as page number (link)
  13. ↑ Hemati K, Amini Kadijani A, Sayehmiri F, Mehrzadi S, Zabihiyeganeh M, Hosseinzadeh A, Mirzaei A (February 2020). "Melatonin in the treatment of fibromyalgia symptoms: A systematic review". Complement Ther Clin Pract. 38 101072. doi:10.1016/j.ctcp.2019.101072. PMID   31783341.
  14. ↑ Tort S, Urrútia G, Nishishinya MB, Walitt B (April 2012). "Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome". Cochrane Database Syst Rev. 2012 (4): CD009807. doi:10.1002/14651858.CD009807. PMC   11729144 . PMID   22513976.{{cite journal}}: CS1 maint: article number as page number (link)
  15. ↑ Welsch P, Bernardy K, Derry S, Moore RA, Häuser W (August 2018). "Mirtazapine for fibromyalgia in adults". Cochrane Database Syst Rev. 8 (8): CD012708. doi:10.1002/14651858.CD012708.pub2. PMC   6513659 . PMID   30080242.{{cite journal}}: CS1 maint: article number as page number (link)
  16. ↑ MacLean AJ, Schwartz TL (May 2015). "Tramadol for the treatment of fibromyalgia". Expert Rev Neurother. 15 (5): 469–475. doi:10.1586/14737175.2015.1034693. PMID   25896486.
  17. ↑ da Rocha AP, Mizzaci CC, Nunes Pinto AC, da Silva Vieira AG, Civile V, Trevisani VF (March 2020). "Tramadol for management of fibromyalgia pain and symptoms: Systematic review". Int J Clin Pract. 74 (3): e13455. doi:10.1111/ijcp.13455. PMID   31799728.{{cite journal}}: CS1 maint: article number as page number (link)
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