Endocrine disease

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Endocrine glands
Illu endocrine system.png
Major endocrine glands. (Male left, female right.) 1. Pineal gland 2. Pituitary gland 3. Thyroid gland 4. Thymus 5. Adrenal gland 6. Pancreas 7. Ovary 8. Testes
Specialty Endocrinology   OOjs UI icon edit-ltr-progressive.svg

Endocrine diseases are disorders of the endocrine system. The branch of medicine associated with endocrine disorders is known as endocrinology.

Contents

Types of disease

Broadly speaking, endocrine disorders may be subdivided into three groups: [1]

  1. Endocrine gland hypofunction/hyposecretion (leading to hormone deficiency)
  2. Endocrine gland hyperfunction/hypersecretion (leading to hormone excess)
  3. Tumours (benign or malignant) of endocrine glands

Endocrine disorders are often quite complex, involving a mixed picture of hyposecretion and hypersecretion because of the feedback mechanisms involved in the endocrine system. For example, most forms of hyperthyroidism are associated with an excess of thyroid hormone and a low level of thyroid stimulating hormone. [2]

List of diseases

Glucose homeostasis disorders

Thyroid disorders

Calcium homeostasis disorders and Metabolic bone disease

Pituitary gland disorders

Posterior pituitary

Anterior pituitary

Adrenal gland disorders

Sex hormone disorders

Tumours of the endocrine glands not mentioned elsewhere

Multiple endocrine neoplasia types. Multiple endocrine neoplasia.png
Multiple endocrine neoplasia types.

See also separate organs

Endocrine emergencies

In endocrinology, medical emergencies include diabetic ketoacidosis, hyperosmolar hyperglycemic state, hypoglycemic coma, acute adrenocortical insufficiency, phaeochromocytoma crisis, hypercalcemic crisis, thyroid storm, myxoedema coma and pituitary apoplexy. [7]

Emergencies arising from decompensated pheochromocytomas or parathyroid adenomas are sometimes referred for emergency resection when aggressive medical therapies fail to control the patient's state, however the surgical risks are significant, especially blood pressure lability and the possibility of cardiovascular collapse after resection (due to a brutal drop in respectively catecholamines and calcium, which must be compensated with gradual normalization). [8] [9] It remains debated when emergency surgery is appropriate as opposed to urgent or elective surgery after continued attempts to stabilize the patient, notably in view of newer and more efficient medications and protocols. [10] [11] [12]

See also

References

  1. ↑ "Endocrine Disorders". webmd.
  2. ↑ "Diagnosing Hyperthyroidism: Overactivity of the Thyroid Gland". endocrineweb.
  3. ↑ D'Souza, Donna M.; Al-Sajee, Dhuha; Hawke, Thomas J. (2013-12-20). "Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells". Frontiers in Physiology. 4: 379. doi: 10.3389/fphys.2013.00379 . ISSN   1664-042X. PMC   3868943 . PMID   24391596.
  4. ↑ Sharma, Vikas; Borah, Papori; Basumatary, Lakshya J.; Das, Marami; Goswami, Munindra; Kayal, Ashok K. (July 2014). "Myopathies of endocrine disorders: A prospective clinical and biochemical study". Annals of Indian Academy of Neurology. 17 (3): 298–302. doi: 10.4103/0972-2327.138505 . ISSN   0972-2327. PMC   4162016 . PMID   25221399.
  5. ↑ Fariduddin, Maria M.; Bansal, Nidhi (2023), "Hypothyroid Myopathy", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID   30137798 , retrieved 2023-08-25
  6. 1 2 3 4 Rodolico, Carmelo; Bonanno, Carmen; Pugliese, Alessia; Nicocia, Giulia; Benvenga, Salvatore; Toscano, Antonio (September 2020). "Endocrine myopathies: clinical and histopathological features of the major forms". Acta Myologica: Myopathies and Cardiomyopathies. 39 (3): 130–135. doi:10.36185/2532-1900-017. ISSN   2532-1900. PMC   7711326 . PMID   33305169.
  7. ↑ Savage, M W; P Mah; A Weetman; J Newell-Price (1 September 2004). "Endocrine emergencies". Postgraduate Medical Journal. 80 (947): 506–515. doi:10.1136/pgmj.2003.013474. PMC   1743094 . PMID   15356351.
  8. ↑ Brouwers, FM; Eisenhofer, G; Lenders, JW; Pacak, K (December 2006). "Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma". Endocrinology and Metabolism Clinics of North America. 35 (4): 699–724, viii. doi:10.1016/j.ecl.2006.09.014. PMID   17127142.
  9. ↑ Tahim, AS; Saunders, J; Sinha, P (2010). "A parathyroid adenoma: benign disease presenting with hyperparathyroid crisis". Case Reports in Medicine. 2010: 1–4. doi: 10.1155/2010/596185 . PMC   3014839 . PMID   21209735.
  10. ↑ Newell, KA; Prinz, RA; Pickleman, J; Braithwaite, S; Brooks, M; Karson, TH; Glisson, S (August 1988). "Pheochromocytoma multisystem crisis. A surgical emergency". Archives of Surgery. 123 (8): 956–9. doi:10.1001/archsurg.1988.01400320042007. PMID   2899426.
  11. ↑ Scholten, A.; Cisco, R. M.; Vriens, M. R.; Cohen, J. K.; Mitmaker, E. J.; Liu, C.; Tyrrell, J. B.; Shen, W. T.; Duh, Q.-Y. (2 January 2013). "Pheochromocytoma Crisis Is Not a Surgical Emergency". Journal of Clinical Endocrinology & Metabolism. 98 (2): 581–591. doi: 10.1210/jc.2012-3020 . PMID   23284003.
  12. ↑ Phitayakorn, R; McHenry, CR (June 2008). "Hyperparathyroid crisis: use of bisphosphonates as a bridge to parathyroidectomy". Journal of the American College of Surgeons. 206 (3): 1106–15. doi:10.1016/j.jamcollsurg.2007.11.010. PMID   18501807.
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