Postorgasmic illness syndrome

Last updated
Postorgasmic illness syndrome
Other namesPOIS
Specialty Andrology, allergy, endocrinology neurology

Postorgasmic illness syndrome (POIS) is a syndrome in which human males have chronic physical and cognitive symptoms following ejaculation. [1] The symptoms usually onset within seconds, minutes, or hours, and last for up to a week. [1] The cause and prevalence are unknown; [2] it is considered a rare disease. [3]

Contents

Signs and symptoms

The distinguishing characteristics of POIS are:

  1. the rapid onset of symptoms after ejaculation;
  2. the presence of an overwhelming systemic reaction. [1]

POIS symptoms, which are called a "POIS attack", [1] can include some combination of the following: cognitive dysfunction, aphasia, severe muscle pain throughout the body, severe fatigue, weakness, and flu-like or allergy-like symptoms, [4] such as sneezing, itchy eyes, and nasal irritation. [5] [2] [6] Additional symptoms include headache, dizziness, lightheadedness, extreme hunger, sensory and motor problems, intense discomfort, irritability, anxiety, gastrointestinal disturbances, craving for relief, susceptibility to nervous system stresses, depressed mood, and difficulty communicating, remembering words, reading and retaining information, concentrating, and socializing. [5] [7] Affected individuals may also experience intense warmth or cold. [4] An online anonymous self-report study found that 80% of respondents always experienced the symptom cluster involving fatigue, insomnia, irritation, and concentration difficulties. [8]

The symptoms usually begin within 30 minutes of ejaculation, [5] and can last for several days, sometimes up to a week. [4] In some cases, symptoms may be delayed by 2 to 3 days or may last up to 2 weeks. [9]

In some men, the onset of POIS is in puberty, while in others, the onset is later in life. [10] POIS that is manifest from the first ejaculations in adolescence is called primary type; POIS that starts later in life is called secondary type. [1]

Many individuals with POIS report lifelong premature ejaculation, with intravaginal ejaculation latency time (IELT) of less than one minute. [1] [6]

The 7 clusters of symptoms of criterion 1: [10]

  1. General: Extreme fatigue, exhaustion, palpitations, problems finding words, incoherent speech, dysarthria, concentration difficulties, quickly irritated, cannot stand noise, photophobia, depressed mood
  2. Flu-like: Feverish, extreme warmth, perspiration, shivery, ill with flu, feeling sick, feeling cold
  3. Head: Headache, foggy feeling in the head, heavy feeling in the head
  4. Eyes: Burning, red injected eyes, blurred vision, watery, irritating, itching eyes, painful eyes
  5. Nose: Congested nose, watery/runny nose, sneezing
  6. Throat: Dirty taste in mouth, dry mouth, sore throat, tickling cough, hoarse voice
  7. Muscle: Muscle tension behind neck, muscle weakness, pain in muscles, heavy legs, stiff muscles

POIS has been called by a number of other names, including "postejaculatory syndrome", [4] "postorgasm illness syndrome", [11] "post ejaculation sickness", [12] and "post orgasmic sick syndrome". [3]

Dhat syndrome is a condition , N. N. Wig first coined the term and described in 1960 in India, [13] with symptoms similar to POIS. [11] Dhat syndrome is thought to be a culture-bound psychiatric condition and is treated with cognitive behavioral therapy along with anti-anxiety and antidepressant drugs. [14]

Post-coital tristesse (PCT) is a feeling of melancholy and anxiety after sexual intercourse that lasts anywhere from five minutes to two hours. PCT, which affects both men and women, occurs only after sexual intercourse and does not require an orgasm to occur, and in that its effects are primarily emotional rather than physiological. By contrast, POIS affects only men, consists primarily of physiological symptoms that are triggered by ejaculation and that can last, in some people, for up to a week. While PCT and POIS are distinct conditions, some doctors speculate that they could be related. [11]

An array of more subtle and lingering symptoms after orgasm, which do not constitute POIS, may contribute to habituation between mates. They may show up as restlessness, irritability, increased sexual frustration, apathy, sluggishness, neediness, dissatisfaction with a mate, or weepiness [15] over the days or weeks after intense sexual stimulation. Such phenomena may be part of human mating physiology itself.

Sexual headache is a distinct condition characterized by headaches that usually begin before or during orgasm. [16]

Mechanism

The cause of POIS is unknown. Some doctors hypothesize that POIS is caused by an auto-immune reaction. [17] Other doctors suspect a hormone imbalance as the cause. Different causes have also been proposed. None of the proposed causes can fully explain the disease.

Allergy hypothesis

According to one hypothesis, "POIS is caused by Type-I and Type-IV allergy to the males' own semen". [1] [18] [19] This was conditioned by another study stating "IgE-mediated semen allergy in men may not be the potential mechanism of POIS". [6]

Alternatively, POIS could be caused by an auto-immune reaction not to semen, but to a different substance released during ejaculation, such as cytokines. [11]

Hormone hypothesis

According to another hypothesis, POIS is caused by a hormone imbalance, such as low progesterone,[ medical citation needed ] low cortisol, low testosterone, elevated prolactin, hypothyroidism, or low DHEA. [20]

POIS could be caused by a defect in neurosteroid precursor synthesis. If so, the same treatment may not be effective for all individuals. Different individuals could have different missing precursors leading to a deficiency of the same neurosteroid, causing similar symptoms.[ medical citation needed ]

Withdrawal hypothesis

The majority of POIS symptoms like fatigue, muscle pains, sweating, mood disturbances, irritability, and poor concentration are also caused by withdrawal from different drug classes [21] and natural reinforcers. [22] It is unknown whether there is a relationship between hypersexuality, pornography addiction, compulsive sexual behavior and POIS. Some evidence indicates that POIS patients have a history of excessive masturbation, suggesting that POIS could be a consequence of sex addiction. There is anecdotal evidence on porn addiction internet forums, that many men experience POIS like symptoms after ejaculation. [23]

Other possibilities

POIS could be caused by hyperglycemia [20] or by chemical imbalances in the brain. [24]

Sexual activity for the first time may set the stage for an associated asthma attack or may aggravate pre-existing asthma. Intense emotional stimuli during sexual intercourse can lead to autonomic imbalance with parasympathetic over-reactivity, releasing mast cell mediators that can provoke postcoital asthma and / or rhinitis in these patients. [25]

It is also possible that the causes of POIS are different in different individuals. POIS could represent "a spectrum of syndromes of differing" causes. [11]

None of the proposed causes for POIS can fully explain the connection between POIS and lifelong premature ejaculation. [26]

Diagnosis

There is no generally agreed upon diagnostic criteria for POIS. One group has developed five preliminary criteria for diagnosing POIS. These are:

  1. one or more of the following symptoms: sensation of a flu-like state, extreme fatigue or exhaustion, weakness of musculature, experiences of feverishness or perspiration, mood disturbances and / or irritability, memory difficulties, concentration problems, incoherent speech, congestion of nose or watery nose, itching eyes;
  2. all symptoms occur immediately (e.g., seconds), soon (e.g., minutes), or within a few hours after ejaculation that is initiated by coitus, and / or masturbation, and / or spontaneously (e.g., during sleep);
  3. symptoms occur always or nearly always, e.g., in more than 90% of ejaculation events;
  4. most of these symptoms last for about 2–7 days; and
  5. disappear spontaneously. [1]

POIS is prone to being erroneously ascribed to psychological factors such as hypochondriasis or somatic symptom disorder. [4]

An online survey study suggested that only a small number of self-reported POIS fulfill entirely the five criteria. This study proposed to change the Criterion 3 with “In at least one ejaculatory setting (sex, masturbation, or nocturnal emission), symptoms occur after all or almost all ejaculations.” [8]

Management

There is no standard method of treating or managing POIS. Patients need to be thoroughly examined in an attempt to find the causes of their POIS symptoms, which are often difficult to determine, and which vary across patients. Once a cause is hypothesized, an appropriate treatment can be attempted. At times, more than one treatment is attempted, until one that works is found.[ citation needed ]

Affected individuals typically avoid sexual activity, [4] especially ejaculation, [1] or schedule it for times when they can rest and recover for several days afterwards. [5] In case post-coital tristesse (PCT) is suspected, patients could be treated with selective serotonin reuptake inhibitors. [11] [24]

In one patient, the POIS symptoms were so severe, that he decided to undergo removal of the testicles, prostate, and seminal vesicles in order to relieve them. The POIS symptoms were cured by this. [27]

Another patient, in whom POIS was suspected to be caused by cytokine release, was successfully treated with nonsteroidal anti-inflammatory drugs (NSAIDs) just prior to and for a day or two after ejaculation. The patient took diclofenac 75 mg 1 to 2 hours prior to sexual activity with orgasm, and continued twice daily for 24 to 48 hours. [11]

One POIS patient with erectile dysfunction and premature ejaculation had much lower severity of symptoms on those occasions when he was able to maintain penile erection long enough to achieve vaginal penetration and ejaculate inside his partner. The patient took tadalafil to treat his erectile dysfunction and premature ejaculation. This increased the number of occasions on which he was able to ejaculate inside his partner, and decreased the number of occasions on which he experienced POIS symptoms. This patient is thought to have Dhat syndrome rather than true POIS. [11]

Two patients, in whom POIS was suspected to be caused by auto-immune reaction to their own semen, were successfully treated by allergen immunotherapy with their own autologous semen. They were given multiple subcutaneous injections of their own semen for three years. [1] Treatment with autologous semen "might take 3 to 5 years before any clinically relevant symptom reduction would become manifest". [1]

Treatments are not always successful, especially when the cause of POIS in a particular patient has not been determined. In one patient, all of whose routine laboratory tests were normal, the following were attempted, all without success: ibuprofen, 400 mg on demand; tramadol 50 mg one hour pre-coitally; and escitalopram 10 mg daily at bedtime for 3 months. [20]

Epidemiology

The prevalence of POIS is unknown. [2] POIS is listed as a rare disease by the American National Institutes of Health [3] and the European Orphanet. [28] It is thought to be underdiagnosed and underreported. [7] POIS seems to affect mostly men from around the world, of various ages and relationship statuses. [8]

Women

It is possible that a similar disease exists in women, though, as of 2016, there is only one documented female patient. [1]

Related Research Articles

<span class="mw-page-title-main">Myalgia</span> Painful sensations in muscle tissue

Myalgia or muscle pain is a painful sensation evolving from muscle tissue. It is a symptom of many diseases. The most common cause of acute myalgia is the overuse of a muscle or group of muscles; another likely cause is viral infection, especially when there has been no injury.

Anorgasmia is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate sexual stimulation. Anorgasmia is far more common in females (4.6%) than in males and is especially rare in younger men. The problem is greater in women who are post-menopausal. In males, it is most closely associated with delayed ejaculation. Anorgasmia can often cause sexual frustration.

<span class="mw-page-title-main">Retrograde ejaculation</span> Redirection of ejaculated semen into the urinary bladder

Retrograde ejaculation occurs when semen which would be ejaculated via the urethra is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts before ejaculation, inhibiting urination and preventing a reflux of semen into the bladder. The semen is forced to exit via the urethra, the path of least resistance. When the bladder sphincter does not function properly, retrograde ejaculation may occur. It can also be induced deliberately by a male as a primitive form of male birth control or as part of certain alternative medicine practices. The retrograde-ejaculated semen is excreted from the bladder during the next urination.

Persistent genital arousal disorder (PGAD), originally called persistent sexual arousal syndrome (PSAS), is spontaneous, persistent, unwanted and uncontrollable genital arousal in the absence of sexual stimulation or sexual desire, and is typically not relieved by orgasm. Instead, multiple orgasms over hours or days may be required for relief.

<span class="mw-page-title-main">Ejaculatory duct</span> Male anatomical structures

The ejaculatory ducts are paired structures in the male reproductive system. Each ejaculatory duct is formed by the union of the vas deferens with the duct of the seminal vesicle. They pass through the prostate, and open into the urethra above the seminal colliculus. During ejaculation, semen passes through the prostate gland, enters the urethra and exits the body via the urinary meatus.

Sexual dysfunction is difficulty experienced by an individual or partners during any stage of normal sexual activity, including physical pleasure, desire, preference, arousal, or orgasm. The World Health Organization defines sexual dysfunction as a "person's inability to participate in a sexual relationship as they would wish". This definition is broad and is subject to many interpretations. A diagnosis of sexual dysfunction under the DSM-5 requires a person to feel extreme distress and interpersonal strain for a minimum of six months. Sexual dysfunction can have a profound impact on an individual's perceived quality of sexual life. The term sexual disorder may not only refer to physical sexual dysfunction, but to paraphilias as well; this is sometimes termed disorder of sexual preference.

Sexual medicine or psychosexual medicine as defined by Masters and Johnsons in their classic Textbook of Sexual Medicine, is "that branch of medicine that focuses on the evaluation and treatment of sexual disorders, which have a high prevalence rate." Examples of disorders treated with sexual medicine are erectile dysfunction, hypogonadism, and prostate cancer. Sexual medicine often uses a multidisciplinary approach involving physicians, mental health professionals, social workers, and sex therapists. Sexual medicine physicians often approach treatment with medicine and surgery, while sex therapists often focus on behavioral treatments.

Dhat syndrome is a condition found in the cultures of South Asia in which male patients report that they suffer from premature ejaculation or impotence, and believe that they are passing semen in their urine. The condition has no known organic cause.

Sexual headache is a type of headache that occurs in the skull and neck during sexual activity, including masturbation or orgasm. These headaches are usually benign, but occasionally are caused by intracranial hemorrhage and cerebral infarction, especially if the pain is sudden and severe. They may be caused by general exertion, sexual excitement, or contraction of the neck and facial muscles. Most cases can be successfully treated with medication.

Post-concussion syndrome (PCS), also known as persisting symptoms after concussion, is a set of symptoms that may continue for weeks, months, or years after a concussion. PCS is medically classified as a mild traumatic brain injury (TBI). About 35% of people with concussion experience persistent or prolonged symptoms 3 to 6 months after injury. Prolonged concussion is defined as having concussion symptoms for over four weeks following the first accident in youth and for weeks or months in adults.

La petite mort is an expression that refers to a brief loss or weakening of consciousness, and in modern usage refers specifically to a post-orgasm sensation as likened to death.

Sex and drugs refers to the influence of substances on sexual function and experience. Sex and drugs date back to ancient humans and have been interlocked throughout human history. Sexual performance is known as the execution of the act of sex and the quality of sexual activity. This includes elements such as libido, sexual function, sensation. Drugs are termed as any chemical substance that produces a physiological and or psychological change in an organism. Drugs categorized as psychoactive drugs, antihypertensive drugs, antihistamines, cancer treatment, and hormone medication have a significant impact on sexual performance. Various drugs result in different effects, both positive and negative. Negative effects may include low libido, erection issues, vaginal dryness and anorgasmia. Positive effects usually address these issues, overall enhancing sexual performance and contributing to a more enjoyable sexual experience. It is crucial to know that the impact of drugs on sexual performance varies among individuals, especially among different genders.

Delayed ejaculation (DE) is a man's inability or persistent difficulty in achieving orgasm, despite typical sexual desire and sexual stimulation. Generally, a man can reach orgasm within a few minutes of active thrusting during sexual intercourse, whereas a man with delayed ejaculation either does not have orgasms at all or cannot have an orgasm until after prolonged intercourse which might last for 30–45 minutes or more. Delayed ejaculation is closely related to anorgasmia.

<span class="mw-page-title-main">Silodosin</span> Chemical compound

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Odynorgasmia, or painful ejaculation, also referred to as dysejaculation, dysorgasmia, and orgasmalgia, is a physical syndrome described by pain or burning sensation of the urethra or perineum during or following ejaculation. Causes include: infections associated with urethritis, prostatitis, epididymitis; use of anti-depressants; cancer of the prostate or of other related structures; calculi or cysts obstructing related structures; trauma to the region.

<span class="mw-page-title-main">Ejaculation</span> Semen discharge from the male reproductive tract

Ejaculation is the discharge of semen from the penis through the urethra. It is the final stage and natural objective of male sexual stimulation, and an essential component of natural conception. After forming an erection, many men emit pre-ejaculatory fluid during stimulation prior to ejaculating. Ejaculation involves involuntary contractions of the pelvic floor and is normally linked with orgasm. It is a normal part of male human sexual development.

Sexual anhedonia, also known as pleasure dissociative orgasmic disorder, is a condition in which an individual cannot feel pleasure from an orgasm. It is thought to be a variant of hypoactive sexual desire disorder.

Shenkui is a traditional Chinese medicinal term in which the individual suffers withdrawal like symptoms including chills, nausea, and even flu-like symptoms with anxiety, believed to be caused by an orgasm and loss of semen. The symptoms can last weeks to months after a single orgasm. In Traditional Chinese Medicine, shen (kidney) is the reservoir of vital essence in semen (ching) and k’uei signifies deficiency.

Functional somatic syndrome (FSS) is any of a group of chronic diagnoses with no identifiable organic cause. This term was coined by Hemanth Samkumar. It encompasses disorders such as fibromyalgia, chronic widespread pain, temporomandibular disorder, irritable bowel syndrome, lower back pain, tension headache, atypical face pain, non-cardiac chest pain, insomnia, palpitation, dyspepsia and dizziness. General overlap exists between this term, somatization and somatoform. The status of ME/CFS as a functional somatic syndrome is contested. Although the aetiology remains unclear, there are consistent findings of biological abnormalities, and major health bodies such as the NAM, WHO, and NIH, classify it as an organic disease.

Pelvic floor physical therapy (PFPT) is a specialty area within physical therapy focusing on the rehabilitation of muscles in the pelvic floor after injury or dysfunction. It can be used to address issues such as muscle weakness or tightness post childbirth, dyspareunia, vaginismus, vulvodynia, constipation, fecal or urinary incontinence, pelvic organ prolapse, and sexual dysfunction. Licensed physical therapists with specialized pelvic floor physical therapy training address dysfunction in individuals across the gender and sex spectra, though PFPT is often associated with women's health for its heavy focus on addressing issues of pelvic trauma after childbirth.

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 Waldinger MD (2016). "Post-Orgasmic Illness Syndrome". In Levine S, Risen CB, Althof SE (eds.). Handbook of Clinical Sexuality for Mental Health Professionals (3rd ed.). Routledge. p. 380. ISBN   9781317507451.
  2. 1 2 3 Wylie KR, ed. (2015). ABC of Sexual Health. John Wiley & Sons. p. 75. ISBN   9781118665565.
  3. 1 2 3 "Postorgasmic illness syndrome". Genetic and Rare Diseases Information Center (GARD). National Institutes of Health. 2015. Archived from the original on 5 March 2016. Retrieved 30 July 2015.
  4. 1 2 3 4 5 6 Waldinger, MD; Schweitzer, DH (May 2002). "Postorgasmic illness syndrome: two cases". Journal of Sex & Marital Therapy . 28 (3): 251–5. doi:10.1080/009262302760328280. PMID   11995603. S2CID   27162173.
  5. 1 2 3 4 Balon R, Segraves RT, eds. (2005). Handbook of Sexual Dysfunction. Taylor & Francis. ISBN   9780824758264.
  6. 1 2 3 Jiang N, Xi G, Li H, Yin J (Mar 2015). "Postorgasmic illness syndrome (POIS) in a Chinese man: no proof for IgE-mediated allergy to semen". The Journal of Sexual Medicine . 12 (3): 840–5. doi:10.1111/jsm.12813. PMID   25630453.
  7. 1 2 Nguyen HM, Bala A, Gabrielson AT, Hellstrom WJ (January 6, 2018). "Post-Orgasmic Illness Syndrome: A Review". Sexual Medicine Reviews. 6 (1): 11–15. doi: 10.1016/j.sxmr.2017.08.006 . PMID   29128269.
  8. 1 2 3 Strashny, Alex (September 2019). "First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS)". International Journal of Impotence Research. 31 (5): 369–373. doi:10.1038/s41443-019-0154-7. ISSN   1476-5489. PMID   31171851. S2CID   174814433.
  9. ↑ Bolanos J, Morgentaler A (March 2020). "Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin". Urol Case Rep. 29: 101078. doi:10.1016/j.eucr.2019.101078. PMC   6889685 . PMID   31832334.
  10. 1 2 Paulos, Mark R.; Avelliino, Gabriella J. (2020-01-01). "Post-orgasmic illness syndrome: history and current perspectives". Fertility and Sterility. 113 (1): 13–15. doi: 10.1016/j.fertnstert.2019.11.021 . ISSN   0015-0282. PMID   32033716. S2CID   211064753.
  11. 1 2 3 4 5 6 7 8 Ashby, J; Goldmeier, D (May 2010). "Postorgasm illness syndrome--a spectrum of illnesses". The Journal of Sexual Medicine . 7 (5): 1976–81. doi:10.1111/j.1743-6109.2010.01707.x. PMID   20214722.
  12. ↑ Goldstein A (10 Aug 2011). "Urology: Post ejaculation sickness". AllExperts. Archived from the original on 17 April 2016. Retrieved 30 July 2015.
  13. ↑ Rao, T. S. Sathyanarayana (2021). "History and mystery of Dhat syndrome: A critical look at the current understanding and future directions". Indian Journal of Psychiatry. 63 (4): 317–325. doi: 10.4103/psychiatry.IndianJPsychiatry_791_20 . ISSN   0019-5545. PMC   8363894 . PMID   34456344.
  14. ↑ Lim, Russell F. (2015). Clinical Manual of Cultural Psychiatry (2d ed.). American Psychiatric Pub. p. 521. ISBN   978-1-58562-439-3.
  15. ↑ Burri AV, Spector TD (Jun 2011). "An epidemiological survey of post-coital psychological symptoms in a UK population sample of female twins". Twin Res Hum Genet. 14 (3): 240–8. doi: 10.1375/twin.14.3.240 . PMID   21623654. S2CID   24204845.
  16. ↑ "Sexual headaches: What are they, who gets them and are they dangerous?". Global News. 28 June 2017. Retrieved 24 February 2020.
  17. ↑ Sáenz-Herrero, Margarita (2019). Psychopathology in Women: Incorporating Gender Perspective into Descriptive Psychopathology (2d ed.). Springer. p. 256. ISBN   978-3-030-15178-2.
  18. ↑ Farley SJ (March 2011). "Sexual dysfunction: Postorgasmic illness syndrome". Nature Reviews Urology . 8 (3): 121. doi: 10.1038/nrurol.2011.17 . PMID   21513019.
  19. ↑ "Dutch Doctor Identifies Post-Orgasmic Syndrome". Reuters Health. Amsterdam. Reuters. April 12, 2002. Retrieved 30 July 2015.
  20. 1 2 3 Attia AM, Yasien HA, Al-Ziny MH (2013). "Post-orgasmic illness syndrome: a case report". F1000Research . 2 (113): 113. doi: 10.12688/f1000research.2-113.v1 .
  21. ↑ West, Robert; Gossop, Michael (1994). "Overview: A comparison of withdrawal symptoms from different drug classes". Addiction. 89 (11): 1483–1489. doi:10.1111/j.1360-0443.1994.tb03747.x. ISSN   1360-0443. PMID   7841860.
  22. ↑ Olsen, Christopher M. (2011-12-01). "Natural rewards, neuroplasticity, and non-drug addictions". Neuropharmacology. Synaptic Plasticity and Addiction. 61 (7): 1109–1122. doi:10.1016/j.neuropharm.2011.03.010. ISSN   0028-3908. PMC   3139704 . PMID   21459101.
  23. ↑ Tsai, Chengchung; Li, Minyi (October 2019). "A New Exploration of the Combined Treatment of Symptoms and Social Work Psychology in Male Sexual Addiction Patients". Proceedings of the 2nd International Conference on Contemporary Education, Social Sciences and Ecological Studies (CESSES 2019). Atlantis Press. doi: 10.2991/cesses-19.2019.118 . ISBN   978-94-6252-816-1.
  24. 1 2 Friedman, Richard A. (January 19, 2009). "Sex and Depression: In the Brain, if Not the Mind". The New York Times. Retrieved 30 July 2015.
  25. ↑ Shah A (Jul 2001). "Asthma and sex" (PDF). Indian J Chest Dis Allied Sci. 43 (3): 135–7. PMID   11529431.[ permanent dead link ]
  26. ↑ Abdessater, Maher; Elias, Sandra; Mikhael, Elie; Alhammadi, Abdalla; Beley, Sebastien (2019-09-03). "Post orgasmic illness syndrome: what do we know till now?". Basic and Clinical Andrology. 29: 13. doi: 10.1186/s12610-019-0093-7 . ISSN   2051-4190. PMC   6721082 . PMID   31508233.
  27. ↑ "Weight For It & Desperate Measures". Strange Sex . Season 2. May 22, 2011. TLC. Archived from the original on 2021-12-15.
  28. ↑ "Postorgasmic illness syndrome". Orphanet. 2015. Retrieved 7 August 2015.
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