Compartment syndrome

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Compartment syndrome
Fasciotomyforearm.jpg
A forearm following emergency surgery for acute compartment syndrome
Specialty Orthopedics
Symptoms Pain, numbness, pallor, decreased ability to move the affected limb [1]
Complications Acute: Volkmann's contracture [2]
TypesAcute, chronic [1]
Causes
Diagnostic method Based on symptoms, compartment pressure [5] [1]
Differential diagnosis Cellulitis, tendonitis, deep vein thrombosis, venous insufficiency [3]
Treatment

Compartment syndrome is a condition in which increased pressure within one of the body's anatomical compartments results in insufficient blood supply to tissue within that space. [6] [7] [8] There are two main types: acute and chronic. [6] Compartments of the leg or arm are most commonly involved. [3]

Contents

Symptoms of acute compartment syndrome (ACS) can include severe pain, poor pulses, decreased ability to move, numbness, or a pale color of the affected limb. [5] It is most commonly due to physical trauma such as a bone fracture (up to 75% of cases) or crush injury, but it can also be caused by acute exertion during sport. [3] [9] It can also occur after blood flow returns following a period of poor blood flow. [4] Diagnosis is generally based upon a person's symptoms [5] and may be supported by measurement of intracompartmental pressure before, during, and after activity. Normal compartment pressure should be within 12-18 mmHg; anything greater than that is considered abnormal and would need treatment. [10] Treatment is by surgery to open the compartment, completed in a timely manner. [5] If not treated within six hours, permanent muscle or nerve damage can result. [5] [11]

In chronic compartment syndrome (aka chronic exertional compartment syndrome), there is generally pain with exercise but the pain dissipates once activity ceases. [1] Other symptoms may include numbness. [1] Symptoms typically resolve with rest. [1] Common activities that trigger chronic compartment syndrome include running and biking. [1] Generally, this condition does not result in permanent damage. [1] Other conditions that may present similarly include stress fractures and tendinitis. [1] Treatment may include physical therapy or—if that is not effective—surgery. [1]

Acute compartment syndrome occurs in about 3% of those who have a midshaft fracture of the forearm. [12] Rates in other areas of the body and for chronic cases are unknown. [12] [13] The condition occurs more often in males and people under the age of 35, in line with the occurrence of trauma. [3] [14] Compartment syndrome was first described in 1881 by German surgeon Richard von Volkmann. [5] Untreated, acute compartment syndrome can result in Volkmann's contracture. [2]

Signs and symptoms

Compartment syndrome usually presents within a few hours of an inciting event, but may present anytime up to 48 hours after. [9] The limb affected by compartment syndrome is often associated with a firm, wooden feeling or a deep palpation, and is usually described as feeling tight. [5] [9] There may also be decreased pulses in the limb, poikilothermia, paralysis, and pallor along with associated paresthesia. [15] Usually, the pain cannot be relieved by NSAIDs. [16] Range of motion may be limited while the compartment pressure is high. In acute compartment syndrome, the pain will not be relieved with rest. In chronic exertional compartment syndrome the pain will dissipate with rest. [17]

Acute

Acute compartment syndrome with blister formation in the arm of a child Acute Compartment Syndrome with blister formation.JPG
Acute compartment syndrome with blister formation in the arm of a child

There are six characteristic signs and symptoms related to acute compartment syndrome: pain, paresthesia (reduced sensation), paralysis, pallor, poikilothermia, and pulselessness. These classical signs and symptoms may also be remembered by the 6 P's mnemonic. [5] [18] Pain and paresthesia are the early symptoms of compartment syndrome. [19] [9]

Common symptoms are:

Uncommon symptoms are:

Chronic

The symptoms of chronic exertional compartment syndrome, CECS, may involve pain, tightness, cramps, weakness, and diminished sensation. [20] This pain can occur for months, and in some cases over a period of years, and may be relieved by rest. [21] Moderate weakness in the affected region can also be observed. These symptoms are brought on by exercise and consist of a sensation of extreme tightness in the affected muscles, followed by a painful burning sensation if exercise is continued. After exercise is ceased, the pressure in the compartment will decrease within a few minutes, relieving painful symptoms. [21] [17] Symptoms will occur at a certain threshold of exercise which varies from person to person but is rather consistent for a given individual. This threshold can range anywhere from 30 seconds of running to 2–3 miles of running. CECS most commonly occurs in the lower leg, with the anterior compartment being the most frequently affected compartment. [21] Foot drop is a common symptom of CECS. [22]

Complications

Failure to relieve the pressure can result in the death of tissues (necrosis) in the affected anatomical compartment, since the ability of blood to enter the smallest vessels in the compartment (capillary perfusion pressure) will fall. This, in turn, leads to progressively increasing oxygen deprivation of the tissues dependent on this blood supply. Without sufficient oxygen, the tissue will die. [23] On a large scale, this can cause Volkmann's contracture in affected limbs, a permanent and irreversible process. [24] [25] [26] Other reported complications include neurological deficits of the affected limb, gangrene, and chronic regional pain syndrome. [27] Rhabdomyolysis and subsequent kidney failure are also possible complications. In some case series, rhabdomyolysis is reported in 23% of patients with ACS. [19]

Causes

Acute

Acute compartment syndrome (ACS) is a medical emergency that can develop after traumatic injuries, such as in automobile accidents or dynamic sporting activities – for example, a severe crush injury or an open or closed fracture of an extremity. Rarely, ACS can develop after a relatively minor injury, or due to another medical issue. [28] The lower legs and the forearms are the most frequent sites affected by compartment syndrome. Other areas of the body such as thigh, buttock, hand, abdomen, and foot can also be affected. [19] [14] The most common cause of acute compartment syndrome is fracture of a bone, most commonly the tibia. [29] There is no difference between acute compartment syndrome originating from an open or closed fracture. [16] Leg compartment syndrome is found in 2% to 9% of tibial fractures. It is strongly related to fractures involving the tibial diaphysis as well as other sections of the tibia. [30] Direct injury to blood vessels can lead to compartment syndrome by reducing the downstream blood supply to soft tissues. This reduction in blood supply can cause a series of inflammatory reactions that promote the swelling of the soft tissues. Such inflammation can be further worsened by reperfusion therapy. [19] Because the fascia layer that defines the compartment of the limbs does not stretch, a small amount of bleeding into the compartment, or swelling of the muscles within the compartment, can cause the pressure to rise greatly. Intravenous drug injection, casts, prolonged limb compression, crush injuries, anabolic steroid use, vigorous exercise, and eschar from burns can also cause compartment syndrome. [31] [32] Patients on anticoagulant therapy have an increased risk of bleeding into a closed compartment. [19]

Abdominal compartment syndrome occurs when the intra-abdominal pressure exceeds 20 mmHg and abdominal perfusion pressure is less than 60 mmHg. This disease process is associated with organ dysfunction and multiple organ failures. There are many causes, which can be broadly grouped into three mechanisms: primary (internal bleeding and swelling); secondary (vigorous fluid replacement as an unintended complication of resuscitative medical treatment, leading to the acute formation of ascites and a rise in intra-abdominal pressure); and recurrent (compartment syndrome that has returned after the initial treatment of secondary compartment syndrome). [33]

Compartment syndrome after snake bite is rare. [34] Its incidence varies from 0.2 to 1.36% as recorded in case reports. [35] Compartment syndrome is more common in children possibly due to inadequate volume of the bodily fluid to dilute the snake venom. [34] Increased white blood cell count of more than 1,650/μL and aspartate transaminase (AST) level of more than 33.5 U/L could increase the risk of developing compartment syndrome. Otherwise, those bitten by venomous snakes should be observed for 48 hours to exclude the possibility of compartment syndrome. [35]

Acute compartment syndrome due to severe/uncontrolled hypothyroidism is rare. [36]

Chronic

When compartment syndrome is caused by repetitive use of the muscles, it is known as chronic compartment syndrome (CCS). [37] [38] This is usually not an emergency, but the loss of circulation can cause temporary or permanent damage to nearby nerves and muscles.

A subset of chronic compartment syndrome is chronic exertional compartment syndrome (CECS), often called exercise-induced compartment syndrome (EICS). [39] Oftentimes, CECS is a diagnosis of exclusion. [40] CECS of the leg is a condition caused by exercise which results in increased tissue pressure within an anatomical compartment due to an acute increase in muscle volume – as much as 20% is possible during exercise. [41] When this happens, pressure builds up in the tissues and muscles causing tissue ischemia. [41] An increase in muscle weight will reduce the compartment volume of the surrounding fascial borders and result in an increased compartment pressure. [39] An increase in the pressure of the tissue can force fluid to leak into the interstitial space (extracellular fluid), leading to a disruption of the micro-circulation of the leg. [39] This condition occurs commonly in the lower leg and various other locations within the body, such as the foot or forearm. CECS can be seen in athletes who train rigorously in activities that involve constant repetitive actions or motions. [39]

Pathophysiology

In a normal human body, blood flow from the arterial system (higher pressure) to venous system (lower pressure) requires a pressure gradient. When this pressure gradient is diminished, blood flow from the artery to the vein is reduced. This causes a backup of blood and excessive fluid to leak from the capillary wall into spaces between the soft tissue's cells, causing swelling of the extracellular space and a rise in intracompartmental pressure. This swelling of the soft tissues surrounding the blood vessels compresses the blood and lymphatic vessels further, causing more fluid to enter the extracellular spaces, leading to additional compression. The pressure continues to increase due to the non-compliant nature of the fascia containing the compartment. [9] This worsening cycle can eventually lead to a lack of sufficient oxygen in the soft tissues (tissue ischemia) and tissue death (necrosis). Tingling and abnormal sensation (paresthesia) can begin as early as 30 minutes from the start of tissue ischemia and permanent damage can occur as early as 12 hours from the onset of the inciting injury. [19]

Diagnosis

Compartment syndrome is a clinical diagnosis, meaning that a medical provider's examination and the patient's history usually give the diagnosis. [14] Apart from the typical signs and symptoms, measurement of intracompartmental pressure can also be important for diagnosis. [42] [14] Using a combination of clinical diagnosis and serial intracompartmental pressure measurements increases both the sensitivity and specificity of diagnosing compartment syndrome. [10] A transducer connected to a catheter is inserted 5 cm into the zone of injury. [5]

A compartment pressure no less than 30 mmHg of the diastolic pressure in a conscious or unconscious person is associated with compartment syndrome. [43] Fasciotomy is indicated in that case. For those patients with low blood pressure (hypotension), a pressure of 20 mmHg higher than the intracompartmental pressure is associated with compartmental syndrome. [19] Noninvasive methods of diagnosis such as near-infraredspectroscopy (NIRS) which uses sensors on the skin, shows promise in controlled settings. However, with limited data in uncontrolled settings, clinical presentation and intracompartmental pressure remain the gold standard for diagnosis. [44]

Chronic exertional compartment syndrome is usually a diagnosis of exclusion, with the hallmark finding being absence of symptoms at rest. Measurement of intracompartmental pressures during symptom reproduction (usually immediately following running) is the most useful test. Imaging studies (X-ray, CT, MRI) can be useful in ruling out other more common diagnoses instead of confirming the diagnosis of compartment syndrome. [45] Additionally, MRI has been shown to be effective in diagnosing chronic exertional compartment syndrome. [46] The average duration of symptoms prior to diagnosis is 28 months. [47]

Treatment

Acute

Use of a skin graft to close a fasciotomy wound. Fasciotomy (Post Skin-Graft).jpg
Use of a skin graft to close a fasciotomy wound.

Any external compression (tourniquet, orthopedic casts or dressings applied on the affected limb) should be removed. Cutting of the cast will reduce the intracompartmental pressure by 65%, followed by 10 to 20% pressure reduction once padding is cut. After removal of the external compression the limb should be placed at the level of the heart. The vital signs of the patient should be closely monitored. If the clinical condition does not improve, then fasciotomy is indicated to decompress the compartments. An incision large enough to decompress all the compartments is necessary. This surgical procedure is performed inside an operating theater under general or local anesthesia. [19] The timing of the fasciotomy wound closure is debated. Some surgeons suggest wound closure should be done seven days after fasciotomy. [19] Multiple techniques exist for closure of the surgical site including vacuum-assisted and shoelace. Both techniques are acceptable methods for closure, but the vacuum-assisted technique has led to longer hospitalization time. [48] A skin graft may be required to close the wound, which would complicate the treatment with a much longer hospitalization stay. [48]

Fasciotomy is overused and non-therapeutic in many cases of compartment syndrome due to snake bites due to Crotalid (rattlesnake) and related snakes such as lance-head [49] . [50] [51] Compartment syndrome due to snake bite should be treated with antivenom, and, unlike more common causes, fasciotomy is rarely indicated. [52] If the pressure does not reduce after administration of antivenom, the treatment is to administer more antivenom. Compartment pressure should be measured before and after administration of antivenom, and only those patients who fail to respond to additional antivenom should receive a fasciotomy. [53] [54] [55] [56]

Chronic

Treatment for chronic exertional compartment syndrome can include decreasing or subsiding exercise and/or exacerbating activities, massage, non-steroidal anti-inflammatory medication, and physiotherapy. Chronic compartment syndrome in the lower leg can be treated conservatively or surgically. Conservative treatment includes rest, anti-inflammatory medications, and manual decompression. Warming the affected area with a heating pad may help to loosen the fascia prior to exercise. Icing the area may result in further constriction of the fascia and is not recommended before or after exercise. The use of devices that apply external pressure to the area, such as splints, casts, and tight wound dressings, should be avoided. [57] If symptoms persist after conservative treatment or if an individual does not wish to give up the physical activities which bring on symptoms, compartment syndrome can be treated by a surgery known as a fasciotomy.

A US military study conducted in 2012 found that teaching individuals with lower leg chronic exertional compartment syndrome to change their running style to a forefoot running technique abated symptoms in those with symptoms limited to the anterior compartment. [58] Running with a forefoot strike limits use of the tibialis anterior muscle which may explain the relief in symptoms in those with anterior compartment syndrome.

Hyperbaric oxygen therapy has been suggested by case reports – though as of 2011 not proven in randomized control trials – to be an effective adjunctive therapy for crush injury, compartment syndrome, and other acute traumatic ischemias, by improving wound healing and reducing the need for repetitive surgery. [59] [60]

Prognosis

A mortality rate of 47% has been reported for acute compartment syndrome of the thigh. According to one study the rate of fasciotomy for acute compartment syndrome varied from 2% to 24%. [19] This is due to uncertainty and differences in labeling a condition as acute compartment syndrome. The most significant prognostic factor in people with acute compartment syndrome is time to diagnosis and subsequent fasciotomy. [28] In people with a missed or late diagnosis of acute compartment syndrome, limb amputation may be necessary for survival. [61] [42] Following a fasciotomy, some symptoms may be permanent depending on factors such as which compartment, time until fasciotomy, and muscle necrosis. Muscle necrosis can occur quickly, within 3 hours of original injury in some studies. [42] Fasciotomy of the lateral compartment of the leg may lead to symptoms due to the nerves and muscles in that compartment. These may include foot drop, numbness along leg, numbness of big toe, pain, and loss of foot eversion. [11]

Epidemiology

In one case series of 164 people with acute compartment syndrome, 69% of the cases had an associated fracture. The authors of that article also calculated an annual incidence of acute compartment syndrome of 1 to 7.3 per 100,000. [62] There are significant differences in the incidence of acute compartment syndrome based on age and gender in the setting of trauma. [14] Men are ten times more likely than women to develop ACS. The mean age for ACS in men is 30 years while the mean age is 44 years for women. [19] Acute compartment syndrome may occur more often in individuals less than 35 years old due to increased muscle mass within the compartments . [9] The anterior compartment of the leg is the most common site for ACS. [9] [63]

See also

Related Research Articles

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A repetitive strain injury (RSI) is an injury to part of the musculoskeletal or nervous system caused by repetitive use, vibrations, compression or long periods in a fixed position. Other common names include repetitive stress injury, repetitive stress disorders, cumulative trauma disorders (CTDs), and overuse syndrome.

<span class="mw-page-title-main">Carpal tunnel syndrome</span> Compression of the median nerve in the wrist

Carpal tunnel syndrome (CTS) is a nerve compression syndrome associated with the collected signs and symptoms of compression of the median nerve at the carpal tunnel in the wrist. Carpal tunnel syndrome is an idiopathic syndrome but there are environmental, and medical risk factors associated with the condition. CTS can affect both wrists.

<span class="mw-page-title-main">Myalgia</span> Painful sensations in muscle tissue

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<span class="mw-page-title-main">Back pain</span> Area of body discomfort

Back pain is pain felt in the back. It may be classified as neck pain (cervical), middle back pain (thoracic), lower back pain (lumbar) or coccydynia based on the segment affected. The lumbar area is the most common area affected. An episode of back pain may be acute, subacute or chronic depending on the duration. The pain may be characterized as a dull ache, shooting or piercing pain or a burning sensation. Discomfort can radiate to the arms and hands as well as the legs or feet, and may include numbness or weakness in the legs and arms.

<span class="mw-page-title-main">Rhabdomyolysis</span> Human disease (condition) in which damaged skeletal muscle breaks down rapidly

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<span class="mw-page-title-main">Ischemia</span> Restriction in blood supply to tissues

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<span class="mw-page-title-main">Fasciotomy</span> Surgical cutting of connective tissue (fascia) to restore blood circulation in an area

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<span class="mw-page-title-main">Popliteal artery entrapment syndrome</span> Abnormal popliteal artery compression by surrounding structures

The popliteal artery entrapment syndrome (PAES) is an uncommon pathology that occurs when the popliteal artery is compressed by the surrounding popliteal fossa myofascial structures. This results in claudication and chronic leg ischemia. This condition mainly occurs more in young athletes than in the elderlies. Elderlies, who present with similar symptoms, are more likely to be diagnosed with peripheral artery disease with associated atherosclerosis. Patients with PAES mainly present with intermittent feet and calf pain associated with exercises and relieved with rest. PAES can be diagnosed with a combination of medical history, physical examination, and advanced imaging modalities such as duplex ultrasound, computer tomography, or magnetic resonance angiography. Management can range from non-intervention to open surgical decompression with a generally good prognosis. Complications of untreated PAES can include stenotic artery degeneration, complete popliteal artery occlusion, distal arterial thromboembolism, or even formation of an aneurysm.

A compartment syndrome is an increased pressure within a muscular compartment that compromises the circulation to the muscles.

<span class="mw-page-title-main">Musculoskeletal injury</span> Damage of muscular or skeletal systems

Musculoskeletal injury refers to damage of muscular or skeletal systems, which is usually due to a strenuous activity and includes damage to skeletal muscles, bones, tendons, joints, ligaments, and other affected soft tissues. In one study, roughly 25% of approximately 6300 adults received a musculoskeletal injury of some sort within 12 months—of which 83% were activity-related. Musculoskeletal injury spans into a large variety of medical specialties including orthopedic surgery, sports medicine, emergency medicine and rheumatology.

<span class="mw-page-title-main">Nerve compression syndrome</span> Symptoms resulting from chronic, direct pressure on a peripheral nerve

Nerve compression syndrome, or compression neuropathy, or nerve entrapment syndrome, is a medical condition caused by chronic, direct pressure on a peripheral nerve. It is known colloquially as a trapped nerve, though this may also refer to nerve root compression. Its symptoms include pain, tingling, numbness and muscle weakness. The symptoms affect just one particular part of the body, depending on which nerve is affected. The diagnosis is largely clinical and can be confirmed with diagnostic nerve blocks. Occasionally imaging and electrophysiology studies aid in the diagnosis. Timely diagnosis is important as untreated chronic nerve compression may cause permanent damage. A surgical nerve decompression can relieve pressure on the nerve but cannot always reverse the physiological changes that occurred before treatment. Nerve injury by a single episode of physical trauma is in one sense an acute compression neuropathy but is not usually included under this heading, as chronic compression takes a unique pathophysiological course.

<span class="mw-page-title-main">Limb infarction</span> Medical condition

A limb infarction is an area of tissue death of an arm or leg. It may cause skeletal muscle infarction, avascular necrosis of bones, or necrosis of a part of or an entire limb.

Exertional rhabdomyolysis (ER) is the breakdown of muscle from extreme physical exertion. It is one of many types of rhabdomyolysis that can occur, and because of this, the exact prevalence and incidence are unclear.

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