Daniela M. Ferreira

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Daniela M. Ferreira
Professor Daniela Ferreira.jpg
Born
Daniela M. Ferreira
Citizenship Brazilian and British
Education University of São Paulo (SP)
University of São Paulo (PhD)
Known forResearch on Respiratory Infections and Covid-19 Vaccine trials
Scientific career
Fields Respiratory tract infection, Vaccine and Immunology
Institutions University of Oxford
Liverpool School of Tropical Medicine
Butantan institute
Thesis DNA vaccines against Streptococcus pneumoniae based on PspA (Pneumococcal surface protein A) and PspC (Pneumococcal surface protein C)  (2009)

Daniela M. Ferreira is a Brazilian British immunologist. [1] She is a specialist in bacterial infection, respiratory co-infection, mucosal immunology and vaccine responses. She is currently Professor of Respiratory Infection and Vaccinology at the Oxford Vaccine Group in the Department of Paediatrics at the University of Oxford and the Director of the Liverpool Vaccine Group at the Liverpool School of Tropical Medicine. [2] [3] She leads a team of scientists studying protective immune responses against pneumococcus [4] and other respiratory pathogens such as SARS-CoV2. Her team has established a novel method of inducing pneumococcal carriage in human volunteers. [4] They use this model to:

Contents

Her team has played a substantial role in the UK covid-19 pandemic response as a trial site for several COVID-19 vaccine studies including the Oxford / Astrazeneca vaccine. [5] [6] [7]

Ferreira is part of the HIC-VAC consortium [8] and Leads the WorkStream on Human Challenge Plataform to accelerate product development in the UKRI Infection Innovation Consortium (iiCON). [9]

Research and career

Ferreira obtained a Degree and Bachelor's Degree in Biological Sciences in 2005 and a Ph.D. in Immunology in 2009, both from the University of São Paulo (São Paulo, Brazil). During her PhD, Ferreira was awarded the Robert Austrian Research Award in Pneumococcal Vaccinology. [10]

Ferreira joined the Respiratory Infection group at Liverpool School of Tropical Medicine as a postdoctoral fellow in December 2009 and together with Prof. Stephen Gordon led the development of an Experimental Human Pneumococcal Nasopharyngeal Colonization Model. Ferreira was appointed Professor and subsequent Head of Department of Clinical Sciences in 2018. [2] Her main lines of research are:

Key Publications

References

  1. "Connecting immunology in the time of COVID-19". www.eventsforce.net. Retrieved 13 October 2021.
  2. 1 2 "Professor Daniela Ferreira". LSTM. Retrieved 13 October 2021.
  3. "BBC Radio Merseyside with LSTM's Professor Daniela Ferreira". LSTM. Retrieved 13 October 2021.
  4. 1 2 3 4 5 "Experimental Human Pneumococcal Carriage consortium". Liverpool School of Tropical Medicine. LSTM. Retrieved 15 September 2021.
  5. "Oxford Covid vaccine 'safe and effective', Lancet study shows". LSTM. Retrieved 15 September 2021.
  6. "UK vaccine volunteers to help prepare for next virus at new Pandemic Institute". the Guardian. 12 September 2021. Retrieved 13 October 2021.
  7. "Brasileira que coordena testes com vacina para Covid-19 na Inglaterra explica dilema da prova de eficácia". G1 (in Brazilian Portuguese). Retrieved 13 October 2021.
  8. "HIC-VACc onsortium". HIV-VAC. Retrieved 15 September 2021.
  9. "iicon". LSTM. Retrieved 15 September 2021.
  10. "Pneumococcus Human Infection Challenge and the Effect of Respiratory Virus Co-infections on Mucosal Immunity – Prof Daniela Ferreira". Imperial College London. Retrieved 13 October 2021.
  11. Ferreira, Adler; H (2021). "Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic". Am J Respir Crit Care Med. 203 (5): 604–613. doi: 10.1164/rccm.202004-1483OC . PMC   7924584 . PMID   32941735.
  12. Ferreira, Mitsi; E (2020). "Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens". Am J Respir Crit Care Med. 201 (3): 335–347. doi: 10.1164/rccm.201903-0607OC . PMC   6999099 . PMID   31626559.
  13. Ferreira, Jochems; S (2019). "Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization". J Clin Invest. 129 (10): 4523–4538. doi: 10.1172/JCI128865 . PMC   6763269 . PMID   31361601.
  14. De Steenhuijsen Piters, Wouter A. A.; Jochems, Simon P.; Mitsi, Elena; Rylance, Jamie; Pojar, Sherin; Nikolaou, Elissavet; German, Esther L.; Holloway, Mark; Carniel, Beatriz F.; Chu, Mei Ling J. N.; Arp, Kayleigh; Sanders, Elisabeth A. M.; Ferreira, Daniela M.; Bogaert, Debby (2019). "Interaction between the nasal microbiota and S. Pneumoniae in the context of live-attenuated influenza vaccine". Nature Communications. 10 (1): 2981. Bibcode:2019NatCo..10.2981D. doi:10.1038/s41467-019-10814-9. PMC   6611866 . PMID   31278315.
  15. Ferreira, Jochems; SP (2018). "Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage". Nature Immunology. 19 (12): 1299–1308. doi: 10.1038/s41590-018-0231-y . PMC   6241853 . PMID   30374129.
  16. Ferreira, Glennie; S (2019). "Two Randomized Trials of Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization". Am J Respir Crit Care Med. 199 (9): 1160–1163. doi: 10.1164/rccm.201811-2081LE . PMC   6515882 . PMID   30758980.
  17. Ferreira, Pennington; SH (2016). "Polysaccharide-specific Memory B-cells Predict Protection Against Experimental Human Pneumococcal Carriage". Am J Respir Crit Care Med. 194 (12): 1523–1531. doi: 10.1164/rccm.201512-2467OC . PMC   5215029 . PMID   27403678.
  18. Ferreira, Mitsi; E (2017). "Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage". Mucosal Immunol. 10 (2): 385–394. doi: 10.1038/mi.2016.71 . PMC   5332540 . PMID   27579859.
  19. Ferreira, Glennie; S (2016). "Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage". Mucosal Immunol. 9 (1): 56–67. doi: 10.1038/mi.2015.35 . PMC   4703943 . PMID   25921341.
  20. Gordon, Ferreira; DM (2013). "Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults". Am J Respir Crit Care Med. 187 (8): 855–864. doi: 10.1164/rccm.201212-2277OC . PMC   3707375 . PMID   23370916.