Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms. Pneumonic plague infects the lungs, causing shortness of breath, coughing and chest pain; bubonic plague affects the lymph nodes, making them swell; and septicemic plague infects the blood and can cause tissues to turn black and die.
Yersinia pestis is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both Yersinia enterocolitica and Yersinia pseudotuberculosis, the pathogen from which Y. pestis evolved and responsible for the Far East scarlet-like fever. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea. It causes the disease plague, which caused the Plague of Justinian and the Black Death, the deadliest pandemic in recorded history. Plague takes three main forms: pneumonic, septicemic, and bubonic. Yersinia pestis is a parasite of its host, the rat flea, which is also a parasite of rats, hence Y. pestis is a hyperparasite.
Pneumonic plague is a severe lung infection caused by the bacterium Yersinia pestis. Symptoms include fever, headache, shortness of breath, chest pain, and coughing. They typically start about three to seven days after exposure. It is one of three forms of plague, the other two being septicemic plague and bubonic plague.
Unit 731, short for Manshu Detachment 731 and also known as the Kamo Detachment and the Ishii Unit, was a covert biological and chemical warfare research and development unit of the Imperial Japanese Army that engaged in lethal human experimentation and biological weapons manufacturing during the Second Sino-Japanese War (1937–1945) and World War II. It killed an estimated 200,000 to 300,000 people. It was based in the Pingfang district of Harbin, the largest city in the Japanese puppet state of Manchukuo and had active branch offices throughout China and Southeast Asia.
Crayfish plague is a water mold that infects crayfish, most notably the European Astacus which dies within a few weeks of being infected. When experimentally tested, species from Australia, New Guinea and Japan were also found to be susceptible to the infection.
Unit 100 was an Imperial Japanese Army facility called the Kwantung Army Warhorse Disease Prevention Shop that focused on the development of biological weapons during World War II. It was operated by the Kempeitai, the Japanese military police. Its headquarters was located in Mokotan, Manchukuo, a village just south of the city of Changchun. It had branches in Dairen and Hailar. The Hailar branch was later transferred to Foshan. Between 600 and 800 people worked at Unit 100.
The third plague pandemic was a major bubonic plague pandemic that began in Yunnan, China, in 1855. This episode of bubonic plague spread to all inhabited continents, and ultimately led to more than 12 million deaths in India and China, and at least 10 million Indians were killed in British Raj India alone, making it one of the deadliest pandemics in history. According to the World Health Organization, the pandemic was considered active until 1960 when worldwide casualties dropped to 200 per year. Plague deaths have continued at a lower level for every year since.
The Kaimingjie germ weapon attack was a secret biological warfare launched by Japan in October 1940 against the Kaiming Street area of Ningbo, Zhejiang, China. A joint operation of the Imperial Japanese Army's Unit 731 and Unit 1644, this attack was operated by military planes taking off from Jianqiao Airport in Hangzhou,which airdropped wheat, corn, cotton scraps, and sand infected with plague fleas to target locations. From September 1940, Ningbo, Quzhou, and other places were subjected to various forms of biological warfares until the end of October 1940, when the attacks triggered a plague epidemic in Ningbo.
The Zhejiang-Jiangxi campaign or the Chekiang–Kiangsi campaign, also known as Operation Sei-go, was a campaign by the China Expeditionary Army of the Imperial Japanese Army under Shunroku Hata and Chinese 3rd War Area forces under Gu Zhutong in Chinese provinces of Zhejiang and Jiangxi from mid May to early September 1942.
Unit Ei 1644 — also known as Unit 1644, Detachment Ei 1644, Detachment Ei, Detachment Tama, The Nanking Detachment, or simply Unit Ei, was a Japanese laboratory and biological warfare facility under control of the Epidemic Prevention and Water Purification Department. It was established in 1939 in Japanese-occupied Nanjing as a satellite unit of Unit 731. It had 12 branches and employed about 1,500 men.
Unit Nami 8604, officially the South China Epidemic Prevention and Water Purification Department, was a disease research unit under the South China Area Army of the Imperial Japanese Army. This unit extensively and secretly researched biological warfare and other subjects through human experimentation during the Second Sino-Japanese War from 1938 to 1945.
Bubonic plague is one of three types of plague caused by the bacterium Yersinia pestis. One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. Acral necrosis, the dark discoloration of skin, is another symptom. Occasionally, swollen lymph nodes, known as "buboes", may break open.
Entomological warfare (EW) is a type of biological warfare that uses insects to interrupt supply lines by damaging crops, or to directly harm enemy combatants and civilian populations. There have been several programs which have attempted to institute this methodology; however, there has been limited application of entomological warfare against military or civilian targets, Japan being the only state known to have verifiably implemented the method against another state, namely the Chinese during World War II. However, EW was used more widely in antiquity, in order to repel sieges or cause economic harm to states. Research into EW was conducted during both World War II and the Cold War by numerous states such as the Soviet Union, United States, Germany and Canada. There have also been suggestions that it could be implemented by non-state actors in a form of bioterrorism. Under the Biological and Toxic Weapons Convention of 1972, use of insects to administer agents or toxins for hostile purposes is deemed to be against international law.
Before the 20th century, the use of biological agents took three major forms:
During the Great Northern War (1700–1721), many towns and areas around the Baltic Sea and East-Central Europe had a severe outbreak of the plague with a peak from 1708 to 1712. This epidemic was probably part of a pandemic affecting an area from Central Asia to the Mediterranean. Most probably via Constantinople, it spread to Pińczów in southern Poland, where it was first recorded in a Swedish military hospital in 1702. The plague then followed trade, travel and army routes, reached the Baltic coast at Prussia in 1709, affected areas all around the Baltic Sea by 1711 and reached Hamburg by 1712. Therefore, the course of the war and the course of the plague mutually affected each other: while soldiers and refugees were often agents of the plague, the death toll in the military as well as the depopulation of towns and rural areas sometimes severely impacted the ability to resist enemy forces or to supply troops.
Operation PX, also known as Operation Cherry Blossoms at Night, was a planned Japanese military attack on civilians in the United States using biological weapons, devised during World War II. The proposal was for Imperial Japanese Navy submarines to launch seaplanes that would deliver weaponized bubonic plague, developed by Unit 731 of the Imperial Japanese Army, to the West Coast of the United States. The operation was abandoned shortly after its planning was finalized in March 1945 due to the strong opposition of General Yoshijirō Umezu, Chief of the Army General Staff.
Biological warfare (BW)—also known as bacteriological warfare, or germ warfare—has had a presence in popular culture for over 100 years. Public interest in it became intense during the Cold War, especially the 1960s and '70s, and continues unabated. This article comprises a list of popular culture works referencing BW or bioterrorism, but not those pertaining to natural, or unintentional, epidemics.
Unit 1855 was a unit for human experimentation that belonged to the central Epidemic Prevention and Water Purification Department of the North China Army of the Imperial Japanese Army, stationed in Beijing between 1938 and 1945.
The 1623 Malta plague outbreak was a minor outbreak of plague on the island of Malta, then ruled by the Order of St John. It was probably caused by infected materials from a major epidemic in 1592–1593, and it was successfully contained after causing 40 to 45 deaths.
The 1894 Hong Kong plague, part of the third plague pandemic, was a major outbreak of the bubonic plague in Hong Kong. While the plague was harshest in 1894, it returned annually between 1895 and 1929, and killed over 20,000 in total, with a fatality rate of more than 93%. The plague was a major turning point in the history of colonial Hong Kong, as it forced the colonial government to reexamine its policy towards the Chinese community, and invest in the wellbeing of the Chinese.
