Dora Nellie Richardson (1919-1998) was a chemist who first synthesised Tamoxifen in England in 1962. [1] She was born on 1 June 1919 and died in September 1998 in England. [2]
Richardson decided to become a chemist after seeing people working in hospital laboratories while visiting her grandmother in hospital in London. She earned a Bachelor of Science in chemistry from University College London in 1941, and a PhD in 1953. [1] Her dissertation in organic chemistry was on the synthesis of heterocyclic compounds. [3]
Richardson began her career at Imperial Chemical Industries in 1943, working there until her retirement. [1] In the early 1960s, she worked on synthesising compounds, and separated the geometric isomers of a triphenylethylene, which developed the basis for Tamoxifen. [4] [5] In 1988, she published an article on the history of the development of Tamoxifen. [6]
Richardson was named on several patents. [7]
Friedrich Wöhler FRS(For) HonFRSE was a German chemist known for his work in both organic and inorganic chemistry, being the first to isolate the chemical elements beryllium and yttrium in pure metallic form. He was the first to prepare several inorganic compounds, including silane and silicon nitride.
Mauveine, also known as aniline purple and Perkin's mauve, was one of the first synthetic dyes. It was discovered serendipitously by William Henry Perkin in 1856 while he was attempting to synthesise the phytochemical quinine for the treatment of malaria. It is also among the first chemical dyes to have been mass-produced.
Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. It is taken by mouth.
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonists/antagonists (ERAAs), are a class of drugs that act on estrogen receptors (ERs). Compared to pure ER agonists–antagonists, SERMs are more tissue-specific, allowing them to selectively inhibit or stimulate estrogen-like action in various tissues.
Alfred Werner was a Swiss chemist who was a student at ETH Zurich and a professor at the University of Zurich. He won the Nobel Prize in Chemistry in 1913 for proposing the octahedral configuration of transition metal complexes. Werner developed the basis for modern coordination chemistry. He was the first inorganic chemist to win the Nobel Prize, and the only one prior to 1973.
Resorcinol (or resorcin) is a phenolic compound. It is an organic compound with the formula C6H4(OH)2. It is one of three isomeric benzenediols, the 1,3-isomer (or meta-isomer). Resorcinol crystallizes from benzene as colorless needles that are readily soluble in water, alcohol, and ether, but insoluble in chloroform and carbon disulfide.
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer.
Chlorotrianisene (CTA), also known as tri-p-anisylchloroethylene (TACE) and sold under the brand name Tace among others, is a nonsteroidal estrogen related to diethylstilbestrol (DES) which was previously used in the treatment of menopausal symptoms and estrogen deficiency in women and prostate cancer in men, among other indications, but has since been discontinued and is now no longer available. It is taken by mouth.
Robert Kenneth Callow, FRS was a British biochemist. He worked at the National Institute for Medical Research in Hampstead and Mill Hill, where his work on steroids included contributions to the isolation and characterisation of vitamin D, and the synthesis of cortisone from naturally occurring steroids. After he retired from the NIMR in 1966 he worked on insect pheromones at Rothamsted Experimental Station until 1971.
Edith Ellen Humphrey was a British inorganic chemist who carried out pioneering work in co-ordination chemistry at the University of Zurich under Alfred Werner. She is thought to be the first British woman to obtain a doctorate in chemistry and the first chemist to synthesize a chiral inorganic complex.
Bettye Washington Greene was an American industrial research chemist. She was one of the first few African American women to earn her Ph.D. in chemistry and she was the first African American female Ph.D. chemist to work in a professional position at the Dow Chemical Company. At Dow, she researched latex and polymers. Greene is considered an early African American pioneer in science.
Martha Annie Whiteley, was an English chemist and mathematician. She was instrumental in advocating for women's entry into the Chemical Society, and was best known for her dedication to advancing women's equality in the field of chemistry. She is identified as one of the Royal Society of Chemistry's 175 Faces of Chemistry.
Triphenylethylene (TPE) is a simple aromatic hydrocarbon that possesses weak estrogenic activity. Its estrogenic effects were discovered in 1937. TPE was derived from structural modification of the more potent estrogen diethylstilbestrol, which is a member of the stilbestrol group of nonsteroidal estrogens.
Sasanka Chandra Bhattacharyya was an Indian natural product chemist and the director of Bose Institute, Kolkata. He was known for his studies on structures and configurations of terpenoids and synthesis of Vetiver Oil and natural musk. He was the vice-president of the Indian National Science Academy and was an elected fellow of the academy as well as the Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1962, for his contributions to chemical sciences.
Nitromifene (INNTooltip International Nonproprietary Name; also as the citrate salt nitromifene citrate (USANTooltip United States Adopted Name), developmental code names CI-628, CN-5518, CN-55945) is a nonsteroidal selective estrogen receptor modulator (SERM) related to triphenylethylenes like tamoxifen that was never marketed. It is a mixture of (E)- and (Z)-isomers that possess similar antiestrogenic activity. The drug was described in 1966. Along with tamoxifen, nafoxidine, and clomifene, it was one of the earliest SERMs.
ERX-11, also known as ERα coregulator-binding modulator-11, is a novel antiestrogen and experimental hormonal antineoplastic agent which is being researched for the potential treatment of estrogen receptor-positive breast cancer. It is not a competitive antagonist of the estrogen receptor (ER) like conventional antiestrogens such as tamoxifen or fulvestrant; instead of binding to the ligand-binding site of the ER, ERX-11 interacts with a different part of the ERα and blocks protein–protein interactions of the ERα with coregulators that are necessary for the receptor to act and regulate gene expression. It was designed to bind to the coregulator binding region of the ERα and inhibit the ERα/coactivator interaction, although its precise binding site and mode of action have yet to be fully elucidated and understood. Nonetheless, it is clear that ERX-11 binds within the AF-2 domain of the ERα.
Elizabeth Marie Nolan is an American chemist and associate professor at Massachusetts Institute of Technology.
Sharon Loretta Haynie is an American chemist who develops biocatalysis for green chemistry. She is a Fellow of the American Chemical Society. Haynie was the first woman to be awarded the NOBCChE Henry Aaron Hill Award in 2006 and the first woman to win the Percy L. Julian Award in 2008.
Theresa M. Reineke is an American chemist and Distinguished McKnight University Professor at the University of Minnesota. She designs sustainable, environmentally friendly polymer-based delivery systems for targeted therapeutics. She is the associate editor of ACS Macro Letters.
Nellie Ivy Fisher (1907–1995) was a London-born industrial chemist and researcher who specialized in photographic chemistry and became known for her work in Australia as the first woman to lead a division of Kodak.