Dyserythropoiesis

Dyserythropoiesis
A peripheral blood smear of a patient with iron-deficiency anemia, an example of an acquired dyserythropoiesis

Dyserythropoiesis refers to the defective development of red blood cells, also called erythrocytes. ^[1] This problem can be congenital, acquired, or inherited. ^[2] Some red blood cells may be destroyed within the bone marrow during the maturation process, whereas others can enter the circulation with abnormalities. ^[3] These abnormalities can be functional and/or morphological, which can lead to anemia since there may be increased turnover of red blood cells. ^{[1] [2]} There are a number of diseases that cause dyserythropoiesis. Congenital/inherited causes include congenital dyserythropoietic anemia, thalassemia, pyruvate kinase deficiency, hereditary pyropoikilocytosis, and abetalipoproteinemia. ^[2] Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV infection, and certain medications (e.g. zidovudine). ^[2]

See also

• Erythropoiesis
• Erythrocyte
• Congenital dyserythropoietic anemia

References

1. Orkin, S.H.; Nathan, D.G. (2009). Nathan and Oski's Hematology of Infancy and Childhood. ClinicalKey 2012. Saunders/Elsevier. p. 360. ISBN   978-1-4160-3430-8 . Retrieved 2017-10-31.
2. Shinton, N.K. (2007). Desk Reference for Hematology, Second Edition. CRC Press. p. 267. ISBN   978-1-4200-0512-7 . Retrieved 2017-10-31.
3. Hoffbrand, A.V.; Catovsky, D.; Tuddenham, E.G.D. (2008). Postgraduate Haematology (in German). Wiley. p. 202. ISBN   978-1-4051-4353-0 . Retrieved 2017-10-31.